AiPD: Autoinhibited Protein Database

O95747

Gene name	OXSR1
Protein name	Serine/threonine-protein kinase OSR1
Names	Oxidative stress-responsive 1 protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9943
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-41 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

163-191 (Activation loop from InterPro)

Target domain	17-291 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for O95747

Entry ID	Method	Resolution	Chain	Position	Source
2V3S	X-ray	170 A	A/B	433-527	PDB
2VWI	X-ray	215 A	A/B/C/D	1-303	PDB
3DAK	X-ray	225 A	A/B/C/D	6-295	PDB
7OKW	X-ray	162 A	A/B	423-527	PDB
AF-O95747-F1	Predicted				AlphaFoldDB

296 variants for O95747

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA352137813 rs1217690582	2	S>F		No	ClinGen gnomAD
rs780215814 CA2316267	2	S>P		No	ClinGen ExAC gnomAD
rs457661 CA2316268	3	E>D		No	ClinGen ExAC TOPMed gnomAD
CA352137827 rs1225194943	4	D>E		No	ClinGen gnomAD
CA352137821 rs1487409831	4	D>N		No	ClinGen gnomAD
CA72898815 rs868322856	5	S>*		No	ClinGen Ensembl
CA72898808 rs1050863016	5	S>P		No	ClinGen Ensembl
CA72898825 rs1021823020	6	S>T		No	ClinGen TOPMed
rs967136834 CA72898830	7	A>T		No	ClinGen TOPMed
rs545168129 CA2316270	7	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs749182199 CA2316271	10	W>*		No	ClinGen ExAC gnomAD
CA72898866 rs867232819	12	I>S		No	ClinGen Ensembl
rs774248337 CA2316273	13	N>S		No	ClinGen ExAC TOPMed gnomAD
rs759376560 CA2316275	15	D>E		No	ClinGen ExAC TOPMed gnomAD
CA352137891 rs1325289302	15	D>N		No	ClinGen gnomAD
rs1226906632 CA352137919	18	E>D		No	ClinGen TOPMed gnomAD
CA352137921 rs1435726525	19	L>V		No	ClinGen TOPMed gnomAD
rs1302847738 CA352137930	20	Q>L		No	ClinGen TOPMed
rs775271026 CA2316276	22	V>M		No	ClinGen ExAC TOPMed gnomAD
CA352100712 rs1268336812	27	A>T		No	ClinGen TOPMed
rs1188967434 CA352100842	34	A>V		No	ClinGen gnomAD
CA72882825 rs552561847	35	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs552561847 CA2316306	35	Y>S		No	ClinGen 1000Genomes ExAC gnomAD
rs138580801 CA2316307	37	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1425492233 CA352100863	38	P>S		No	ClinGen gnomAD
rs779382388 CA72882880	47	R>Q		No	ClinGen Ensembl
rs1051857953 CA72882867	47	R>W		No	ClinGen Ensembl
CA2316310 rs745736039	48	I>V		No	ClinGen ExAC gnomAD
rs1559502914 CA352100987	55	T>I		No	ClinGen Ensembl
rs888899542 CA72882884	57	M>V		No	ClinGen Ensembl
rs943585565 CA72882887	58	D>G		No	ClinGen TOPMed
TCGA novel	59	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352101021 rs1334869560	60	L>F		No	ClinGen gnomAD
rs1575321471 CA352104249	63	E>K		No	ClinGen Ensembl
rs756270734 CA2316328	66	A>V		No	ClinGen ExAC TOPMed gnomAD
CA352104362 rs1575321483	67	M>V		No	ClinGen Ensembl
rs1259331334 CA352104488	70	C>Y		No	ClinGen gnomAD
CA352104625 rs1422999486	74	N>H		No	ClinGen TOPMed
CA2316330 rs750413522	75	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1258246873 CA352104719	77	S>Y		No	ClinGen TOPMed
CA352104815 rs1193857731	80	T>I		No	ClinGen gnomAD
rs1480228300 CA352104886	83	V>L		No	ClinGen TOPMed
rs1419916937 CA352104908	84	V>I		No	ClinGen gnomAD
rs754714205 CA2316334	86	D>V		No	ClinGen ExAC gnomAD
rs1575321547 CA352105136	91	V>F		No	ClinGen Ensembl
CA352105171 rs1575321550	93	K>E		No	ClinGen Ensembl
rs780962712 CA2316335	97	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1373190488 CA352108126	98	G>A		No	ClinGen gnomAD
TCGA novel	98	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1203335124 CA352108200	102	D>Y		No	ClinGen TOPMed
CA352108405 rs1265157000	107	I>T		No	ClinGen TOPMed
CA72893320 rs988386341	110	K>N		No	ClinGen TOPMed
rs769044451 CA2316365	111	G>E		No	ClinGen ExAC gnomAD
rs1361197996 CA352108526	111	G>R		No	ClinGen gnomAD
CA352108569 rs1269576776	112	E>D		No	ClinGen TOPMed
CA352108535 rs1303581649	112	E>K		No	ClinGen gnomAD
rs1232867769 CA352108681	115	S>N		No	ClinGen gnomAD
rs776976832 CA2316367	116	G>E		No	ClinGen ExAC TOPMed gnomAD
CA352108799 rs1489369304	117	V>G		No	ClinGen gnomAD
TCGA novel	121	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765160768 CA2316369	121	S>P		No	ClinGen ExAC gnomAD
rs949405988 CA72893348	125	T>A		No	ClinGen TOPMed gnomAD
rs751527084 CA2316370	125	T>M		No	ClinGen ExAC gnomAD
CA72893362 rs982645009	126	I>M		No	ClinGen gnomAD
CA72893356 rs750858309 COSM3945431 COSM3945430	126	I>V	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA72893366 rs926710398 COSM3664625 COSM3664624	128	R>*	NS [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1379993593 CA352109156	128	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	133	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA72893390 rs1037511366	135	E>D		No	ClinGen Ensembl
rs752529090 CA352109612	140	N>K		No	ClinGen ExAC TOPMed gnomAD
CA2316375 rs777470323	144	H>Q		No	ClinGen ExAC gnomAD
rs755890218 CA2316374	144	H>Y		No	ClinGen ExAC gnomAD
rs1458698850 CA352116683	151	N>K		No	ClinGen gnomAD
rs1270768774 CA352116677	151	N>S		No	ClinGen gnomAD
CA352116687 rs1178659323	152	I>V		No	ClinGen gnomAD
CA352116706 rs1247334392	153	L>P		No	ClinGen TOPMed
CA2316408 rs189939988	159	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1042664306 CA72911381	167	V>I		No	ClinGen TOPMed gnomAD
rs1559518421 CA352118501	168	S>G		No	ClinGen Ensembl
rs1559518424 CA352118515	169	A>G		No	ClinGen Ensembl
rs1559518427	171	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2316429 rs756496384	172	A>E		No	ClinGen ExAC gnomAD
CA72911385 rs2650093	172	A>P		No	ClinGen Ensembl
rs778926610 CA2316433	177	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM1422710 COSM1422709 CA352118784 rs1296395342	179	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1371453875 CA352118812	180	N>K		No	ClinGen gnomAD
CA72911420 rs2936810	181	K>*		No	ClinGen Ensembl
rs201145646 CA2316434	181	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA352118840 rs1364559194	182	V>M		No	ClinGen TOPMed
CA2316435 rs768633823	184	K>R		No	ClinGen ExAC gnomAD
CA72911430 rs902855725	186	F>L		No	ClinGen TOPMed
rs776621148 CA2316436	187	V>I		No	ClinGen ExAC gnomAD
CA352118942 rs776621148	187	V>L		No	ClinGen ExAC gnomAD
CA72911445 rs998513186	189	T>S		No	ClinGen TOPMed gnomAD
rs761576446 CA2316438	190	P>H		No	ClinGen ExAC TOPMed gnomAD
rs761576446 CA72911449	190	P>L		No	ClinGen ExAC TOPMed gnomAD
CA352119055 rs1200680512	192	W>L		No	ClinGen TOPMed
rs148501279 CA2316451	202	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1311024425 CA352119694	202	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2316453 rs746001398	205	D>G		No	ClinGen ExAC gnomAD
rs934019667 CA352119779	205	D>N		No	ClinGen TOPMed
CA72912863 rs934019667	205	D>Y		No	ClinGen TOPMed
rs1291235013 CA352119918	209	D>G		No	ClinGen gnomAD
CA2316454 rs772139791	209	D>N		No	ClinGen ExAC gnomAD
CA352119987 rs1354638025	212	S>N		No	ClinGen gnomAD
rs145105894 CA2316455	218	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	219	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233643126 CA352120198	222	T>A		No	ClinGen TOPMed gnomAD
rs773022296 CA2316458	222	T>I		No	ClinGen ExAC gnomAD
rs913448864 CA72912910	224	A>T		No	ClinGen Ensembl
rs762812182 CA2316459	224	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1180184058 CA352120237	227	Y>C		No	ClinGen gnomAD
rs1315338353 CA352120245	228	H>R		No	ClinGen gnomAD
TCGA novel	229	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352120288 rs1475844937	231	P>L		No	ClinGen gnomAD
CA352120315 rs1157317775	233	M>R		No	ClinGen TOPMed
CA2316473 rs748069034	235	V>A		No	ClinGen ExAC gnomAD
rs1296116472 CA352121295	237	M>V		No	ClinGen TOPMed gnomAD
rs745877149 CA72913358	239	T>A		No	ClinGen Ensembl
CA352121354 rs374106391	240	L>V		No	ClinGen ESP ExAC gnomAD
rs770845634 CA2316477	243	D>G		No	ClinGen ExAC gnomAD
rs1415525011 CA352121474	244	P>A		No	ClinGen TOPMed gnomAD
rs967688919 CA72913378	244	P>L		No	ClinGen Ensembl
CA352121513 rs1296439730	246	S>P		No	ClinGen TOPMed gnomAD
rs1306972803 CA352121584	250	G>D		No	ClinGen gnomAD
CA2316479 rs745468647	253	D>N		No	ClinGen ExAC gnomAD
rs1258015244 CA352121692	254	K>N		No	ClinGen gnomAD
TCGA novel	255	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	260	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775103796 CA2316481	264	F>Y		No	ClinGen ExAC gnomAD
rs1167622259 CA352122207	275	D>E		No	ClinGen gnomAD
CA352122190 rs1261878297	275	D>N		No	ClinGen gnomAD
rs1427440846 CA352122204	275	D>V		No	ClinGen gnomAD
rs1434934825 CA352122222	276	P>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA352122210 rs1396522157	276	P>T		No	ClinGen gnomAD
CA352122252 rs1345216496	277	E>A		No	ClinGen TOPMed gnomAD
CA352122241 rs1172859188	277	E>K		No	ClinGen gnomAD
CA352122287 rs1432869913	278	K>I		No	ClinGen gnomAD
CA352123064 rs1274561793	282	A>T		No	ClinGen gnomAD
CA352123100 rs1318851210	282	A>V		No	ClinGen gnomAD
CA352123103 rs1468557929	283	A>T		No	ClinGen gnomAD
rs765632096 CA72916468	283	A>V		No	ClinGen Ensembl
rs762262863 CA2316503	284	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	286	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2316504 rs770177968	287	R>G		No	ClinGen ExAC gnomAD
rs1406969795 CA352123192	287	R>K		No	ClinGen gnomAD
rs773609974 CA2316505	288	H>Q		No	ClinGen ExAC gnomAD
CA72916488 rs1057068960	289	K>R		No	ClinGen TOPMed gnomAD
rs774655961 CA2316529	297	K>R		No	ClinGen ExAC TOPMed gnomAD
rs375186809 CA2316530	301	Q>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	303	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1339550610 CA352123597	304	T>A		No	ClinGen gnomAD
CA2316531 rs6599079 VAR_023232	304	T>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	306	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352123678 rs1485327340	307	R>K		No	ClinGen gnomAD
CA2316533 rs760822205	307	R>S		No	ClinGen ExAC gnomAD
CA2316536 rs758221566	310	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2316537 rs142820192	311	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1174729097 CA352123750	313	E>G		No	ClinGen gnomAD
rs1436798799 CA352123742	313	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA352123761 rs1375184332	314	R>K		No	ClinGen gnomAD
CA352123774 rs1320876775	315	A>E		No	ClinGen gnomAD
CA2316538 rs751259596	315	A>T		No	ClinGen ExAC gnomAD
CA2316539 rs754668810	316	K>E		No	ClinGen ExAC gnomAD
CA72916814 rs1008993948	317	K>Q		No	ClinGen Ensembl
rs767226612 CA2316558	319	R>Q		No	ClinGen ExAC gnomAD
COSM3392371 rs895952611 CA352125774 COSM3392372	319	R>W	pancreas Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs755636046 CA2316560	327	R>C		No	ClinGen ExAC gnomAD
rs777107244 COSM1186237 CA2316561	327	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs372927731 CA72920014	330	K>R		No	ClinGen ESP TOPMed
CA352126089 rs1252616587	333	D>G		No	ClinGen gnomAD
CA2316562 rs748799742	334	G>R		No	ClinGen ExAC TOPMed gnomAD
rs757750921 CA2316563	335	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1364708444 CA352126183	337	E>G		No	ClinGen gnomAD
rs1364708444 CA352126181	337	E>V		No	ClinGen gnomAD
rs1157619252 CA352126188	338	W>G		No	ClinGen gnomAD
rs1420604041 CA352126210	339	S>G		No	ClinGen gnomAD
CA2316564 rs551708596	339	S>I		No	ClinGen 1000Genomes ExAC gnomAD
CA352126226 rs746299066	339	S>R		No	ClinGen ExAC gnomAD
rs1575365806 CA352126236	340	D>H		No	ClinGen Ensembl
CA352126342 rs1393354505	344	D>E		No	ClinGen TOPMed gnomAD
CA352126422 rs1559525177	347	S>N		No	ClinGen Ensembl
TCGA novel	350	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772495728 CA2316566	354	I>V		No	ClinGen ExAC TOPMed gnomAD
rs775863821 CA2316567	355	S>A		No	ClinGen ExAC gnomAD
COSM163221 rs747176039 CA2316568	355	S>L	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1392952930 CA352126740	356	Q>*		No	ClinGen TOPMed
CA352097715 rs769847615	361	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs374794688 CA72873085	364	E>D		No	ClinGen Ensembl
rs369634764 CA2316591	366	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs991262562 CA72873089	366	I>V		No	ClinGen TOPMed gnomAD
rs917553702 CA72873119	367	S>A		No	ClinGen TOPMed gnomAD
rs917553702 CA72873113	367	S>T		No	ClinGen TOPMed gnomAD
rs1197495868 CA352097852	369	S>T		No	ClinGen TOPMed
CA2316594 rs771966064	370	E>G		No	ClinGen ExAC TOPMed gnomAD
rs769786839 CA2316609	371	L>F		No	ClinGen ExAC TOPMed gnomAD
CA2316608 rs769786839	371	L>I		No	ClinGen ExAC TOPMed gnomAD
rs772055910 CA2316611	373	P>A		No	ClinGen ExAC gnomAD
CA352098692 rs1465426673	375	T>A		No	ClinGen TOPMed
CA2316612 rs775400116	377	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1175022268 CA352098751	378	V>M		No	ClinGen gnomAD
rs1173133062 CA352098775	379	G>D		No	ClinGen TOPMed
CA352098806 rs1455282660	381	L>F		No	ClinGen gnomAD
rs1413740765 CA352098812	382	L>F		No	ClinGen TOPMed
rs1387964926 CA352098849	383	Q>H		No	ClinGen TOPMed gnomAD
CA352098869 rs1575375481	384	V>A		No	ClinGen Ensembl
CA2316615 rs776167759	385	P>A		No	ClinGen ExAC gnomAD
CA352098903 rs1559528644	386	E>G		No	ClinGen Ensembl
CA352098892 rs1305933296	386	E>Q		No	ClinGen gnomAD
TCGA novel	389	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761482215 CA2316616	390	A>T		No	ClinGen ExAC gnomAD
CA2316617 rs764761772	390	A>V		No	ClinGen ExAC gnomAD
rs1177689077 CA352098985	391	H>R		No	ClinGen TOPMed
CA2316618 rs201009720	391	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2316620 rs767063485	393	P>R		No	ClinGen ExAC gnomAD
rs974723559 CA72874743	393	P>S		No	ClinGen Ensembl
rs376982746 CA72874746	395	P>Q		No	ClinGen ESP TOPMed gnomAD
rs369899701 CA2316621	396	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1206207661 CA352099140	400	A>V		No	ClinGen gnomAD
CA352099195 rs1319578333	404	T>I		No	ClinGen gnomAD
rs912700802 CA72874776	404	T>S		No	ClinGen TOPMed gnomAD
CA352099199 rs1468633150	405	Q>E		No	ClinGen gnomAD
CA2316624 rs752894235	408	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	408	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420853122 CA352099258	410	P>A		No	ClinGen gnomAD
CA72874790 rs113919536	412	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2316627 rs113919536	412	A>T		No	ClinGen ExAC TOPMed gnomAD
CA352099300 rs1327938811	413	E>G		No	ClinGen gnomAD
rs1468582542 CA352099350	416	K>R		No	ClinGen gnomAD
rs562635647 CA72874830	417	T>P		No	ClinGen Ensembl
CA352099401 rs1292188052	418	A>V		No	ClinGen gnomAD
rs1451631468 CA352099702	422	S>F		No	ClinGen TOPMed
rs35295772 VAR_025181 CA2316645	425	S>T		No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
CA2316646 rs754000162	426	G>D		No	ClinGen ExAC gnomAD
rs143136743 CA2316647	428	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1422714 CA2316649 COSM1422715 rs745902557	433	P>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
VAR_040969	433	P>S	a metastatic melanoma sample; somatic mutation [UniProt]	No	UniProt
CA2316650 rs754988370	434	I>V		No	ClinGen ExAC TOPMed gnomAD
CA352100122 rs1410743876	440	L>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2316653 rs769649864	441	R>K		No	ClinGen ExAC gnomAD
rs2588458 CA72877581	444	K>Q		No	ClinGen Ensembl
CA352101532 rs1346433538	448	N>S		No	ClinGen gnomAD
CA352101606 rs1435130969	451	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1296423815 COSM1044171 COSM1044172 CA352101610	451	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA72877591 rs774370241	453	E>D		No	ClinGen Ensembl
CA352101757 rs1207402579	456	P>L		No	ClinGen TOPMed
rs1016963523 CA72877602	456	P>S		No	ClinGen TOPMed gnomAD
rs770757632 CA2316675	457	G>R		No	ClinGen ExAC gnomAD
rs1300635762 CA352102413	459	D>V		No	ClinGen gnomAD
rs769206279 CA2316700	461	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1374173557 CA352102533	462	E>K		No	ClinGen gnomAD
CA352102760 rs1472548142 COSM1315911 COSM1315910	469	I>V	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
CA2316704 rs145431865	475	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM2986092 COSM2986091 CA2316706 rs766592272	476	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA352103196 rs1384878495	481	I>M		No	ClinGen gnomAD
CA352103190 rs1575379862	481	I>T		No	ClinGen Ensembl
CA72879180 rs1047929290	483	A>S		No	ClinGen Ensembl
rs759699767 CA2316728	484	A>G		No	ClinGen ExAC gnomAD
rs1470224021 CA352103744	487	Q>H		No	ClinGen TOPMed
rs1194762500 CA352103729	487	Q>R		No	ClinGen TOPMed
CA72879194 rs112280434	490	V>A		No	ClinGen Ensembl
rs1254834800 CA352103856	491	E>D		No	ClinGen gnomAD
rs767656231 CA2316729	491	E>G		No	ClinGen ExAC gnomAD
rs1008813523 CA72879218	493	P>L		No	ClinGen Ensembl
CA72879210 rs887320930	493	P>S		No	ClinGen Ensembl
CA352104044 rs765195729	497	R>L		No	ClinGen ExAC gnomAD
rs765195729 CA2316733	497	R>P		No	ClinGen ExAC gnomAD
rs765195729 CA2316732	497	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1444372436 CA352104054	498	S>C		No	ClinGen gnomAD
rs758205017 CA2316734	500	T>A		No	ClinGen ExAC TOPMed gnomAD
CA352104113 rs1166420798	500	T>S		No	ClinGen gnomAD
CA352104385 rs1388271523	504	A>S		No	ClinGen gnomAD
rs1388271523 CA352104378	504	A>T		No	ClinGen gnomAD
CA352104424 rs1433135948	506	G>A		No	ClinGen gnomAD
rs1295707091 CA352104433	507	V>F		No	ClinGen gnomAD
CA72879509 rs191643511	508	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA352104451 rs191643511	508	E>Q		No	ClinGen 1000Genomes TOPMed gnomAD
rs1559531557 CA352104514	510	S>L		No	ClinGen Ensembl
CA352104544 rs1159523908	511	D>G		No	ClinGen TOPMed
CA2316754 rs557160772	511	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs528270834 CA2316755	512	I>T		No	ClinGen ExAC TOPMed gnomAD
CA72879515 rs1007940574	512	I>V		No	ClinGen TOPMed
rs1250929170 CA352104586	513	P>S		No	ClinGen TOPMed
rs755028275 COSM1647674 CA2316756 COSM730992	515	D>N	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1328112515 CA352104684	516	G>D		No	ClinGen gnomAD
rs778154420 CA2316758	519	I>R		No	ClinGen ExAC gnomAD
CA72879533 rs757709802	519	I>V		No	ClinGen Ensembl
rs971239388 CA72879534	520	G>A		No	ClinGen gnomAD
CA352104789 rs971239388	520	G>E		No	ClinGen gnomAD
TCGA novel	520	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268072416 CA352104806	521	F>I		No	ClinGen TOPMed
rs982201179 CA72879535	522	A>V		No	ClinGen Ensembl
CA2316760 rs757727581	524	L>V		No	ClinGen ExAC gnomAD
CA352104920 rs1411309028	525	S>G		No	ClinGen gnomAD
CA352104964 rs1455666543	525	S>R		No	ClinGen gnomAD
rs1484999536 CA352104999	527	S>T		No	ClinGen TOPMed

No associated diseases with O95747

3 regional properties for O95747

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	17 - 291	IPR000719
binding_site	Protein kinase, ATP binding site	23 - 46	IPR017441
domain	Serine/threonine-protein kinase OSR1/WNK, CCT domain	434 - 491	IPR024678

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

14 GO annotations of biological process

Name	Definition
cellular hypotonic response	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
cellular response to chemokine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
chemokine (C-C motif) ligand 21 signaling pathway	The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
chemokine (C-X-C motif) ligand 12 signaling pathway	The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of potassium ion transmembrane transporter activity	Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.
osmosensory signaling pathway	The series of molecular signals initiated in response to osmotic change.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of T cell chemotaxis	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9C0K7	STRADB	STE20-related kinase adapter protein beta	Homo sapiens (Human)	PR
Q7RTN6	STRADA	STE20-related kinase adapter protein alpha	Homo sapiens (Human)	PR
Q9H2G2	SLK	STE20-like serine/threonine-protein kinase	Homo sapiens (Human)	PR
O94804	STK10	Serine/threonine-protein kinase 10	Homo sapiens (Human)	PR
Q9UEW8	STK39	STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (Human)	PR
Q9Y4K4	MAP4K5	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (Human)	PR
Q92918	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (Human)	EV
Q12851	MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (Human)	EV
Q8IVH8	MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (Human)	SS
Q9P289	STK26	Serine/threonine-protein kinase 26	Homo sapiens (Human)	PR
Q9Y6E0	STK24	Serine/threonine-protein kinase 24	Homo sapiens (Human)	PR
O00506	STK25	Serine/threonine-protein kinase 25	Homo sapiens (Human)	PR
Q8K4T3	Stradb	STE20-related kinase adapter protein beta	Mus musculus (Mouse)	PR
Q3UUJ4	Strada	STE20-related kinase adapter protein alpha	Mus musculus (Mouse)	PR
Q6P9R2	Oxsr1	Serine/threonine-protein kinase OSR1	Mus musculus (Mouse)	PR
Q9Z1W9	Stk39	STE20/SPS1-related proline-alanine-rich protein kinase	Mus musculus (Mouse)	PR
Q863I2	OXSR1	Serine/threonine-protein kinase OSR1	Sus scrofa (Pig)	PR
Q7TNZ6	Strada	STE20-related kinase adapter protein alpha	Rattus norvegicus (Rat)	PR
O88506	Stk39	STE20/SPS1-related proline-alanine-rich protein kinase	Rattus norvegicus (Rat)	PR
O23304	BLUS1	Serine/threonine-protein kinase BLUS1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSEDSSALPW	SINRDDYELQ	EVIGSGATAV	VQAAYCAPKK	EKVAIKRINL	EKCQTSMDEL
70	80	90	100	110	120
LKEIQAMSQC	HHPNIVSYYT	SFVVKDELWL	VMKLLSGGSV	LDIIKHIVAK	GEHKSGVLDE
130	140	150	160	170	180
STIATILREV	LEGLEYLHKN	GQIHRDVKAG	NILLGEDGSV	QIADFGVSAF	LATGGDITRN
190	200	210	220	230	240
KVRKTFVGTP	CWMAPEVMEQ	VRGYDFKADI	WSFGITAIEL	ATGAAPYHKY	PPMKVLMLTL
250	260	270	280	290	300
QNDPPSLETG	VQDKEMLKKY	GKSFRKMISL	CLQKDPEKRP	TAAELLRHKF	FQKAKNKEFL
310	320	330	340	350	360
QEKTLQRAPT	ISERAKKVRR	VPGSSGRLHK	TEDGGWEWSD	DEFDEESEEG	KAAISQLRSP
370	380	390	400	410	420
RVKESISNSE	LFPTTDPVGT	LLQVPEQISA	HLPQPAGQIA	TQPTQVSLPP	TAEPAKTAQA
430	440	450	460	470	480
LSSGSGSQET	KIPISLVLRL	RNSKKELNDI	RFEFTPGRDT	AEGVSQELIS	AGLVDGRDLV
490	500	510	520
IVAANLQKIV	EEPQSNRSVT	FKLASGVEGS	DIPDDGKLIG	FAQLSIS