AiPD: Autoinhibited Protein Database

O95466

Gene name	FMNL1 (C17orf1, C17orf1B, FMNL, FRL1)
Protein name	Formin-like protein 1
Names	CLL-associated antigen KW-13, Leukocyte formin
Species	Homo sapiens (Human)
KEGG Pathway	hsa:752
EC number
Protein Class

Descriptions

(Annotation from UniProt)
The DAD domain may regulate activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition may be released upon competitive binding of an activated GTPase. The release of DAD may allow the FH2 domain to nucleate and elongate nonbranched actin filaments.

Autoinhibitory domains (AIDs)

1059-1090 (DAD domain) SS

Target domain	27-468 (GBD/FH3 domain)
Relief mechanism	Partner binding
Assay

AID

1059-1090 (DAD domain)

Target domain

27-468 (GBD/FH3 domain)

Relief mechanism

Partner binding (Competitive binding of an activated GTPase)

Assay

Accessory elements

No accessory elements

References

Higashi T et al. (2010) "Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase", The Journal of biological chemistry, 285, 16231-8

Ramabhadran V et al. (2013) "Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction", The Journal of biological chemistry, 288, 26847-55

Dollar G et al. (2016) "Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila", Genetics, 202, 1135-51

Autoinhibited structure

Activated structure

2 structures for O95466

Entry ID	Method	Resolution	Chain	Position	Source
4YDH	X-ray	380 A	A/C	1-458	PDB
AF-O95466-F1	Predicted				AlphaFoldDB

743 variants for O95466

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA399863307 rs1419994531	3	N>K		No	ClinGen TOPMed
CA291046323 rs886083105	4	A>T		No	ClinGen TOPMed
CA399863339 rs1239275753	6	G>C		No	ClinGen gnomAD
rs1283770205 CA399863345	6	G>D		No	ClinGen gnomAD
CA399863420 rs1433536186	9	E>K		No	ClinGen TOPMed
CA291046324 rs1005893430	12	A>V		No	ClinGen TOPMed gnomAD
CA8612379 rs530698237	13	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399863496 rs1296596251	14	P>S		No	ClinGen gnomAD
rs1382427058 CA399863505	15	A>S		No	ClinGen TOPMed gnomAD
CA399863510 rs1382427058	15	A>T		No	ClinGen TOPMed gnomAD
rs1288897757 CA399863523	16	A>S		No	ClinGen TOPMed gnomAD
rs1288897757 CA399863518	16	A>T		No	ClinGen TOPMed gnomAD
rs969828095 CA291046325	17	P>A		No	ClinGen TOPMed gnomAD
CA399863536 rs969828095	17	P>S		No	ClinGen TOPMed gnomAD
rs1001732920 CA291046326	18	P>S		No	ClinGen TOPMed
CA8612380 rs751701039	19	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399863572 rs751701039	19	P>R		No	ClinGen ExAC TOPMed gnomAD
CA399863584 rs1339778172	20	K>R		No	ClinGen TOPMed gnomAD
CA399863602 rs1243731403	21	Q>L		No	ClinGen gnomAD
rs1270049654 CA399863621	22	P>L		No	ClinGen TOPMed
rs1360472972 CA399863614	22	P>T		No	ClinGen TOPMed
rs1310714541 CA399863644	24	P>L		No	ClinGen TOPMed
rs1359244228 CA399863661	25	P>R		No	ClinGen TOPMed
rs1433669521 CA399863656	25	P>S		No	ClinGen TOPMed
rs1176288708 CA399863673	26	K>R		No	ClinGen TOPMed gnomAD
CA291046328 rs149811878	28	P>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA399863714 rs149811878	28	P>R		No	ClinGen 1000Genomes TOPMed gnomAD
CA399863708 rs1474093859	28	P>S		No	ClinGen gnomAD
CA399863726 rs1171177379	29	M>I		No	ClinGen TOPMed
rs1401363805 CA399863743	31	A>T		No	ClinGen gnomAD
rs1483014828 CA399864319	40	N>S		No	ClinGen TOPMed
rs1567951845 CA399864340	42	A>V		No	ClinGen Ensembl
rs771544630 CA8612390	44	N>K		No	ClinGen ExAC gnomAD
CA8612391 rs777320562	49	P>S		No	ClinGen ExAC gnomAD
rs550614169 CA8612392	50	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1410891182 CA399865873	54	Q>R		No	ClinGen Ensembl
rs770080353 CA8612393	61	N>D		No	ClinGen ExAC gnomAD
rs202024994 CA8612394	61	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA399865954 rs1278671931	62	E>D		No	ClinGen gnomAD
rs764430700 CA8612396	62	E>K		No	ClinGen ExAC TOPMed gnomAD
rs774388607 CA8612397	68	I>V		No	ClinGen ExAC gnomAD
rs1264415918 CA399866054	71	Q>R		No	ClinGen gnomAD
rs766398009 CA8612420	73	R>Q		No	ClinGen ExAC gnomAD
rs1222744787 CA399866145	73	R>W		No	ClinGen TOPMed
CA399866210 rs1295137518	79	P>A		No	ClinGen TOPMed gnomAD
CA399866212 rs1295137518	79	P>S		No	ClinGen TOPMed gnomAD
rs759417988 CA8612422	81	A>T		No	ClinGen ExAC TOPMed gnomAD
CA399866243 rs1385888110	82	A>V		No	ClinGen gnomAD
rs544712237 CA291047493	84	I>V		No	ClinGen Ensembl
rs764945252 CA8612423	89	S>G		No	ClinGen ExAC TOPMed gnomAD
CA399866311 rs764945252	89	S>R		No	ClinGen ExAC TOPMed gnomAD
rs752425707 CA8612424	90	Y>C		No	ClinGen ExAC gnomAD
rs1567960336 CA399866350	92	D>A		No	ClinGen Ensembl
rs370795739 CA8612425	93	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA399866392 rs1598188762	96	V>G		No	ClinGen Ensembl
CA399866397 rs1353708359	97	S>N		No	ClinGen gnomAD
CA399866398 rs1353708359	97	S>T		No	ClinGen gnomAD
CA399866435 rs1598188790	100	V>G		No	ClinGen Ensembl
CA399866497 COSM1710384 rs1209499276	106	S>F	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8612430 rs749568309	107	N>K		No	ClinGen ExAC TOPMed gnomAD
CA399866662 rs1245574309	113	R>*		No	ClinGen TOPMed gnomAD
CA291047572 rs950822529	113	R>Q		No	ClinGen Ensembl
CA399866680 rs1452009852	115	Q>E		No	ClinGen gnomAD
rs867891866 CA291047573	115	Q>R		No	ClinGen Ensembl
CA8612463 COSM2155395 rs762893518	118	T>M	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs867315062 CA291047575	119	Q>H		No	ClinGen Ensembl
rs763793800 CA291047576	122	R>L		No	ClinGen ExAC gnomAD
rs763793800 CA8612464	122	R>Q		No	ClinGen ExAC gnomAD
rs1158351749 CA399866749	122	R>W		No	ClinGen gnomAD
CA399866754 rs1324432585	123	E>K		No	ClinGen gnomAD
rs868241353 CA291047577	124	L>M		No	ClinGen TOPMed gnomAD
CA399866771 rs1349554179	125	E>K		No	ClinGen gnomAD
rs867051797 CA291047578	127	S>P		No	ClinGen Ensembl
rs867650581 CA291047579	129	R>S		No	ClinGen Ensembl
rs1333511551 CA399866825	130	T>I		No	ClinGen gnomAD
rs1239341827 CA399866833	131	N>S		No	ClinGen TOPMed gnomAD
CA399866840 rs1170710748	132	H>Y		No	ClinGen TOPMed
rs777816100 CA8612473	136	V>E		No	ClinGen ExAC gnomAD
CA399866922 rs777816100	136	V>G		No	ClinGen ExAC gnomAD
CA399866961 rs1316728318	139	F>L		No	ClinGen TOPMed gnomAD
CA291047609 rs866288268	140	L>F		No	ClinGen Ensembl
CA8612475 rs373663989	141	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs867268487 CA291047610	142	E>K		No	ClinGen Ensembl
CA291047611 rs113346719	144	N>D		No	ClinGen Ensembl
rs1257260283 CA399867007	144	N>S		No	ClinGen gnomAD
CA8612478 rs367724765	145	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8612479 rs148973232	145	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749054379 CA8612481	148	D>H		No	ClinGen ExAC gnomAD
CA8612480 rs749054379	148	D>Y		No	ClinGen ExAC gnomAD
CA399867048 rs1461518344	149	V>M		No	ClinGen gnomAD
rs375380299 CA8612483	152	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8612484 rs771688761	155	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1333216956 CA399867113	155	A>V		No	ClinGen gnomAD
CA8612485 rs772678322	162	T>M		No	ClinGen ExAC gnomAD
CA8612506 rs775915127	165	M>I		No	ClinGen ExAC gnomAD
CA8612505 rs770429242	165	M>R		No	ClinGen ExAC TOPMed gnomAD
CA399867233 rs770429242	165	M>T		No	ClinGen ExAC TOPMed gnomAD
CA291047641 rs200640751	166	E>G		No	ClinGen gnomAD
CA399867251 rs1439516512	167	S>I		No	ClinGen gnomAD
rs372127527 CA8612507	168	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1242990462 CA399867269	169	D>G		No	ClinGen gnomAD
rs375374786 CA291047642	169	D>N		No	ClinGen ESP TOPMed gnomAD
CA399867287 rs7209538	170	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8612510 rs369927345	171	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA399867376 rs1228289595	178	N>I		No	ClinGen gnomAD
CA399867394 rs1267456009	180	P>A		No	ClinGen gnomAD
rs1031970859 CA291047643	180	P>L		No	ClinGen Ensembl
rs1213081352 CA399867465	186	E>D		No	ClinGen gnomAD
rs767742597 CA399867472	187	D>A		No	ClinGen ExAC gnomAD
rs767742597 CA8612512	187	D>V		No	ClinGen ExAC gnomAD
CA399867478 rs1179201681	188	L>I		No	ClinGen gnomAD
CA399867516 rs780269020	191	G>D		No	ClinGen ExAC gnomAD
CA8612515 rs780269020	191	G>V		No	ClinGen ExAC gnomAD
CA291047645 rs974533292	192	P>S		No	ClinGen gnomAD
rs754038484 CA399867531	193	P>A		No	ClinGen ExAC
CA8612516 rs754038484	193	P>S		No	ClinGen ExAC
CA399867554 rs1368670891	195	S>F		No	ClinGen gnomAD
CA8612518 COSM1734486 rs778765351	196	V>M	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1446949290 CA399867567	197	P>S		No	ClinGen gnomAD
CA8612521 rs771793020	198	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1390021801 CA399867595	199	S>R		No	ClinGen gnomAD
rs777337969 CA8612522	200	R>C		No	ClinGen ExAC TOPMed gnomAD
rs373132848 CA8612523	200	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs373132848 CA8612524	200	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs769161697 CA8612527	205	K>E		No	ClinGen ExAC gnomAD
rs374960639 CA8612568	208	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs778447690 CA8612567	208	P>S		No	ClinGen ExAC gnomAD
CA8612569 rs771426176	210	H>Y		No	ClinGen ExAC gnomAD
CA8612570 rs776852929	212	R>G		No	ClinGen ExAC gnomAD
rs759663688 CA8612571	212	R>T		No	ClinGen ExAC gnomAD
rs200547847 CA8612572	216	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA399868196 rs1213714217	216	R>W		No	ClinGen TOPMed gnomAD
rs763065736 CA8612574	219	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1235140964 CA399868216	219	R>H		No	ClinGen gnomAD
rs763983223 CA8612575	220	I>V		No	ClinGen ExAC gnomAD
rs767205834 CA8612578	221	V>I		No	ClinGen ExAC gnomAD
CA8612579 rs144714204	222	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs535461614 CA8612580	223	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs767012221 CA8612582	225	D>E		No	ClinGen ExAC TOPMed gnomAD
CA8612584 rs778357711	227	V>I		No	ClinGen ExAC gnomAD
COSM1383787 rs781402859 CA8612587	229	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs769880915 CA8612589	232	M>T		No	ClinGen ExAC gnomAD
CA8612590 rs775801071	235	R>C		No	ClinGen ExAC gnomAD
CA8612591 rs762957389	235	R>H		No	ClinGen ExAC TOPMed gnomAD
rs774475483 CA291049055	236	A>S		No	ClinGen ExAC TOPMed gnomAD
rs774475483 CA8612593	236	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8612594 rs201153167	237	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767532251 CA399868422	238	M>L		No	ClinGen ExAC TOPMed gnomAD
rs767532251 CA8612595	238	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1207203007 CA399868461	241	Q>K		No	ClinGen TOPMed
CA8612612 rs748278646	242	S>Y		No	ClinGen ExAC gnomAD
rs771856191 CA8612613	246	L>R		No	ClinGen ExAC gnomAD
CA291049267 rs1037067048	247	V>I		No	ClinGen gnomAD
CA399868641 rs1393805916	248	M>T		No	ClinGen TOPMed
CA291049269 rs200827907	249	N>S		No	ClinGen ExAC gnomAD
CA8612614 rs200827907	249	N>T		No	ClinGen ExAC gnomAD
rs760319880 CA8612615	250	H>P		No	ClinGen ExAC gnomAD
rs766209725 CA8612616	251	P>Q		No	ClinGen ExAC gnomAD
CA291049274 rs918577044	252	A>V		No	ClinGen Ensembl
rs1555630186 CA399868706	258	A>T		No	ClinGen Ensembl
CA8612617 rs531104370	263	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs879249761 CA291049277	266	P>S		No	ClinGen Ensembl
rs569280215 CA8612638	270	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1394613409 CA399868836	270	A>V		No	ClinGen gnomAD
rs764928976 CA8612639	271	L>V		No	ClinGen ExAC gnomAD
CA399868875 rs1393442708	277	A>V		No	ClinGen gnomAD
rs868773576 CA291049332	278	A>D		No	ClinGen Ensembl
rs35909374 CA291049330	278	A>P		No	ClinGen Ensembl
CA399868884 rs1598198433	279	V>G		No	ClinGen Ensembl
CA8612643 rs200464299	279	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1335511245 CA399868907	283	R>Q		No	ClinGen gnomAD
rs138651184 CA8612645	283	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1481585863 CA399868960	291	A>S		No	ClinGen TOPMed gnomAD
CA399868969 rs1177505062	292	A>V		No	ClinGen gnomAD
CA8612647 rs755368952	294	D>G		No	ClinGen ExAC gnomAD
rs1416891635 CA399868989	295	N>S		No	ClinGen gnomAD
rs758604980 CA8612650	296	F>L		No	ClinGen ExAC TOPMed
rs752976420 CA8612649	296	F>L		No	ClinGen ExAC gnomAD
CA8612673 rs781205836	299	V>L		No	ClinGen ExAC gnomAD
CA8612674 rs781205836	299	V>M		No	ClinGen ExAC gnomAD
CA8612675 rs769920910	301	G>A		No	ClinGen ExAC gnomAD
rs779872309 CA8612676	302	E>V		No	ClinGen ExAC gnomAD
rs749089786 CA8612677	303	Q>*		No	ClinGen ExAC gnomAD
CA399869052 rs749089786	303	Q>E		No	ClinGen ExAC gnomAD
CA8612679 rs373612875	305	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs761248488 CA8612680	305	R>H		No	ClinGen ExAC gnomAD
rs1443637227 CA399869085	307	E>D		No	ClinGen Ensembl
CA291049519 rs929854823	309	L>V		No	ClinGen TOPMed gnomAD
CA399869106 rs1294767562	310	M>I		No	ClinGen gnomAD
rs146945062 CA8612682	314	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8612681 rs771585864	314	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1280821092 CA399869212	319	N>K		No	ClinGen gnomAD
rs760030224 CA399869216	320	I>F		No	ClinGen ExAC TOPMed gnomAD
CA8612683 rs760030224	320	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1243523167 CA399869244	322	F>Y		No	ClinGen gnomAD
CA8612685 rs753082691	323	M>K		No	ClinGen ExAC TOPMed gnomAD
rs750485206 CA8612709	328	Q>L		No	ClinGen ExAC gnomAD
rs1598200870 CA399869406	332	I>T		No	ClinGen Ensembl
rs1188214863 CA399869471	338	E>V		No	ClinGen TOPMed
CA8612711 rs766273108	339	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1370228268 CA399869531	343	R>C		No	ClinGen gnomAD
rs1433955464 CA399869533	343	R>H		No	ClinGen gnomAD
CA399869563 rs1281079121	346	L>V		No	ClinGen gnomAD
CA399869589 rs1457994999	348	Y>C		No	ClinGen TOPMed
rs755002467 CA8612713	349	E>A		No	ClinGen ExAC gnomAD
CA8612714 rs778567189	351	T>A		No	ClinGen ExAC gnomAD
rs1056201780 CA291049611	352	H>R		No	ClinGen TOPMed
CA399869670 rs1265911402	356	D>N		No	ClinGen gnomAD
CA8612716 rs758023511	358	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA399869798 rs1005428446	361	R>M		No	ClinGen TOPMed gnomAD
rs1410539610 CA399869802	361	R>S		No	ClinGen TOPMed
CA291049922 rs1005428446	361	R>T		No	ClinGen TOPMed gnomAD
rs771223137 CA8612748	363	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8612747 rs760805391	363	R>W		No	ClinGen ExAC gnomAD
CA291049927 rs543302959	364	L>F		No	ClinGen 1000Genomes TOPMed
rs1311941497 CA399869827	364	L>P		No	ClinGen gnomAD
CA399869847 rs1272414859	366	E>G		No	ClinGen gnomAD
COSM1521385 rs565193966 CA8612751	366	E>K	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA399869864 rs1598203681	367	S>R		No	ClinGen Ensembl
CA399869922 rs1598203689	372	V>G		No	ClinGen Ensembl
rs963600945 CA291049930	373	Q>H		No	ClinGen TOPMed
rs752631528 CA399869968	376	A>E		No	ClinGen ExAC gnomAD
CA8612752 rs752631528	376	A>V		No	ClinGen ExAC gnomAD
CA399869981 rs1231886279	378	L>Q		No	ClinGen TOPMed
rs148254640 CA291049935	383	D>N		No	ClinGen ESP
rs371140378 CA399870067	386	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8612756 rs756839810	386	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8612757 rs371140378	386	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs755658968 CA8612759	389	E>G		No	ClinGen ExAC TOPMed gnomAD
rs886583447 CA291049943	390	D>N		No	ClinGen TOPMed gnomAD
CA399870160 rs1448797548	392	E>K		No	ClinGen gnomAD
rs1396636310 CA399870231	396	A>T		No	ClinGen TOPMed gnomAD
rs772773705 CA8612763	399	E>Q		No	ClinGen ExAC gnomAD
CA399870321 rs1567967496	401	M>T		No	ClinGen Ensembl
rs1366650487 CA399870372	404	L>M		No	ClinGen TOPMed
rs1383352870 CA399870413	406	E>K		No	ClinGen gnomAD
rs1165864513 CA399870444	407	Q>H		No	ClinGen TOPMed
rs146321570 CA8612767	409	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747448773 CA8612765	409	A>T		No	ClinGen ExAC gnomAD
rs146321570 CA8612766	409	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1247085318 CA399871049	414	R>W		No	ClinGen TOPMed
CA291050054 rs1032578186	416	R>P		No	ClinGen Ensembl
rs759150835 CA291050052	416	R>W		No	ClinGen TOPMed gnomAD
rs1397242212 CA399871088	418	A>V		No	ClinGen gnomAD
CA8612792 rs767331731	420	N>K		No	ClinGen ExAC gnomAD
rs964683515 CA291050057	423	M>T		No	ClinGen Ensembl
rs1390344636 CA399871136	423	M>V		No	ClinGen TOPMed
rs772948351 CA8612793	426	I>T		No	ClinGen ExAC TOPMed gnomAD
CA399871191 rs1393567002	428	E>K		No	ClinGen gnomAD
rs1308849198 CA399871211	429	L>P		No	ClinGen gnomAD
CA399871215 rs1299865558	430	E>Q		No	ClinGen TOPMed
CA8612794 rs118179136	434	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8612795 rs368818105	436	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs368818105 CA8612796	436	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA399871311 rs1259272395	439	E>K		No	ClinGen TOPMed gnomAD
rs752120142 CA8612799	439	E>V		No	ClinGen ExAC gnomAD
rs1196222115 CA399871336	441	E>K		No	ClinGen gnomAD
rs1196222115 CA399871338	441	E>Q		No	ClinGen gnomAD
rs1250543294 CA399871362	442	T>N		No	ClinGen gnomAD
rs1417982331 CA399871386	444	R>Q		No	ClinGen gnomAD
CA8612803 rs202029598	444	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754046916 CA8612825	446	R>H		No	ClinGen ExAC
CA399871518 rs1207365920	449	E>K		No	ClinGen gnomAD
CA399871536 rs1261996852	450	S>W		No	ClinGen gnomAD
CA8612827 rs779023560	451	T>N		No	ClinGen ExAC
rs1598205389 CA399871542	451	T>P		No	ClinGen Ensembl
rs1161474577 CA399871552	452	A>D		No	ClinGen TOPMed
rs771999782 CA8612829	452	A>S		No	ClinGen ExAC gnomAD
CA399871548 rs771999782	452	A>T		No	ClinGen ExAC gnomAD
rs777882396 CA8612830	453	M>T		No	ClinGen ExAC TOPMed gnomAD
CA291050121 rs796625018	455	P>A		No	ClinGen Ensembl
CA8612834 rs7219366	455	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399871597 rs7219366	455	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8612835 rs7219366	455	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399871609 rs1173986938	456	S>A		No	ClinGen TOPMed gnomAD
CA8612836 rs759257998	456	S>F		No	ClinGen ExAC TOPMed gnomAD
CA399871607 rs1173986938	456	S>P		No	ClinGen TOPMed gnomAD
CA399871621 rs1319790085	457	R>K		No	ClinGen gnomAD
CA399871637 rs769370872	458	R>H		No	ClinGen ExAC TOPMed gnomAD
rs769370872 CA8612837	458	R>L		No	ClinGen ExAC TOPMed gnomAD
CA399871645 rs1275249356	459	P>A		No	ClinGen gnomAD
CA399871646 rs1275249356	459	P>S		No	ClinGen gnomAD
CA399871658 rs1366409174	460	P>A		No	ClinGen TOPMed gnomAD
CA8612838 rs775042183	460	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399871673 rs1308745132	461	E>A		No	ClinGen TOPMed gnomAD
rs1308745132 CA399871676	461	E>G		No	ClinGen TOPMed gnomAD
CA399871755 rs1329228630	466	P>L		No	ClinGen gnomAD
CA399871763 rs1207621487	467	P>S		No	ClinGen gnomAD
CA291050139 rs556132624	468	A>T		No	ClinGen gnomAD
rs1463938368 CA399871777	468	A>V		No	ClinGen gnomAD
rs868043319 CA291050142	470	P>L		No	ClinGen TOPMed gnomAD
rs1224186989 CA399871796	470	P>S		No	ClinGen gnomAD
CA399871820 rs1189665997	472	R>Q		No	ClinGen gnomAD
rs762390081 CA8612839	472	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8612840 rs768002965	473	P>R		No	ClinGen ExAC gnomAD
CA8612841 rs750943458	475	A>T		No	ClinGen ExAC gnomAD
CA291050155 rs868390620	475	A>V		No	ClinGen Ensembl
rs1462964234 CA399871885	477	E>Q		No	ClinGen gnomAD
CA399871905 rs1161588648	478	L>R		No	ClinGen TOPMed
CA399871915 rs1468333791	479	K>N		No	ClinGen TOPMed
rs1324181602 CA399871919	480	V>L		No	ClinGen gnomAD
CA399871965 rs1338070705	481	E>G		No	ClinGen gnomAD
CA399871937 rs1428656093	481	E>K		No	ClinGen TOPMed
rs1349057743 CA399871972	482	E>K		No	ClinGen gnomAD
rs1371778754 CA399872053	485	E>D		No	ClinGen TOPMed
CA399872150 rs1285948748	490	R>C		No	ClinGen gnomAD
rs1327645798 CA399872154	490	R>P		No	ClinGen gnomAD
rs1230509044 CA399872182	492	L>V		No	ClinGen gnomAD
CA291050186 rs754245263	493	R>L		No	ClinGen ExAC TOPMed gnomAD
rs754245263 CA8612845	493	R>P		No	ClinGen ExAC TOPMed gnomAD
CA399872197 rs754245263	493	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1451391359 CA399872190	493	R>W		No	ClinGen gnomAD
rs1483520503 CA399872210	494	G>A		No	ClinGen TOPMed gnomAD
rs1473840101 CA399872245	496	G>E		No	ClinGen gnomAD
rs752780093 CA399872253	497	D>N		No	ClinGen ExAC TOPMed gnomAD
rs752780093 CA8612848	497	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1033052094 CA399872271	499	V>F		No	ClinGen TOPMed gnomAD
CA399872270 rs1033052094	499	V>I		No	ClinGen TOPMed gnomAD
CA291050201 rs1033052094	499	V>L		No	ClinGen TOPMed gnomAD
rs375284482 CA291050207	504	L>I		No	ClinGen ESP TOPMed gnomAD
rs1356786290 CA399872364	505	P>L		No	ClinGen gnomAD
rs1305853629 CA399872360	505	P>S		No	ClinGen gnomAD
CA399872357 rs1305853629	505	P>T		No	ClinGen gnomAD
rs1356263403 CA399872380	507	A>D		No	ClinGen gnomAD
rs1226922432 CA399872395	509	A>P		No	ClinGen gnomAD
rs4792898 CA8612852	511	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1277234979 CA399872415	511	P>T		No	ClinGen gnomAD
CA8612853 rs781102841	512	S>G		No	ClinGen ExAC TOPMed gnomAD
rs745698209 CA8612854	512	S>N		No	ClinGen ExAC TOPMed gnomAD
CA399872432 rs1236763616	513	G>D		No	ClinGen gnomAD
CA8612855 rs200190513	513	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA291050237 rs199738233	514	G>C		No	ClinGen 1000Genomes ExAC gnomAD
rs199738233 CA8612856	514	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA399872497 rs1190215997	517	P>L		No	ClinGen gnomAD
CA291050240 rs974665123	518	T>N		No	ClinGen Ensembl
CA399872518 rs1390541195	519	P>L		No	ClinGen TOPMed gnomAD
rs1390541195 CA399872515	519	P>Q		No	ClinGen TOPMed gnomAD
CA399872523 rs1166328867	520	G>R		No	ClinGen gnomAD
rs1414473769 CA399872535	521	V>M		No	ClinGen gnomAD
rs183400333 COSM3667995 CA8612860	523	T>I	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs773918631 CA8612859	523	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1300498650 CA399872568	524	G>S		No	ClinGen TOPMed gnomAD
rs776935088 CA8612862	525	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1343786178 CA399872591	526	P>R		No	ClinGen TOPMed
CA8612863 rs983483815	526	P>S		No	ClinGen TOPMed gnomAD
rs983483815 CA291050256	526	P>T		No	ClinGen TOPMed gnomAD
rs1347405463 CA399872594	527	S>G		No	ClinGen gnomAD
CA8612865 rs759852033	527	S>N		No	ClinGen ExAC gnomAD
rs1278033370 CA399872615	528	P>S		No	ClinGen gnomAD
rs1440818740 CA399872627	529	D>N		No	ClinGen gnomAD
rs1281404380 CA399872767	535	E>Q		No	ClinGen TOPMed
CA291050352 rs987750486	536	P>S		No	ClinGen TOPMed gnomAD
rs1413292315 CA399872837	539	G>E		No	ClinGen gnomAD
CA399872858 rs1598206745	540	A>E		No	ClinGen Ensembl
CA291050356 rs911779080	541	A>V		No	ClinGen TOPMed
CA399872892 rs1457199081	542	P>L		No	ClinGen gnomAD
rs1393288303 CA399872904	543	P>L		No	ClinGen gnomAD
CA399872934 rs1343889813	545	P>L		No	ClinGen gnomAD
CA399872962 rs1230236354	547	P>Q		No	ClinGen TOPMed gnomAD
rs1230236354 CA399872964	547	P>R		No	ClinGen TOPMed gnomAD
rs776860279 CA8612878	549	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399872986 rs1226460594	550	G>C		No	ClinGen TOPMed gnomAD
CA399872991 rs1267214512	550	G>V		No	ClinGen gnomAD
CA399872994 rs1488676854	551	L>F		No	ClinGen gnomAD
CA399873001 rs1598206853	551	L>P		No	ClinGen Ensembl
rs540975102 CA8612879	552	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs540975102 CA399873012	552	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1209036166 CA399873005	552	P>T		No	ClinGen gnomAD
CA399873017 rs1483850863	553	S>A		No	ClinGen TOPMed gnomAD
CA399873020 rs1598206880	553	S>F		No	ClinGen Ensembl
CA399873016 rs1483850863	553	S>P		No	ClinGen TOPMed gnomAD
rs1483477244 CA399873028	554	P>R		No	ClinGen TOPMed gnomAD
rs1485366236 CA399873025	554	P>S		No	ClinGen TOPMed
CA291050369 rs866238820	555	Q>H		No	ClinGen TOPMed
CA399873038 rs1222043449	555	Q>L		No	ClinGen TOPMed gnomAD
CA291050372 rs930323590	557	A>V		No	ClinGen TOPMed gnomAD
CA8612880 rs559226659	559	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1303563302 CA399873089	560	S>P		No	ClinGen TOPMed
rs1157555335 CA399873096	561	A>P		No	ClinGen gnomAD
CA399873102 rs1212995419	561	A>V		No	ClinGen TOPMed
CA399873111 rs1192767612	562	P>H		No	ClinGen TOPMed gnomAD
rs915682673 CA291050376	569	P>S		No	ClinGen TOPMed gnomAD
rs915682673 CA399873178	569	P>T		No	ClinGen TOPMed gnomAD
rs1335993158 CA399873203	570	G>A		No	ClinGen TOPMed
CA399873189 rs1403728815	570	G>S		No	ClinGen TOPMed
CA8612881 rs777005438	572	P>A		No	ClinGen ExAC gnomAD
rs1360362501 CA399873273	574	P>H		No	ClinGen TOPMed
CA399873295 rs1308902731	575	P>L		No	ClinGen TOPMed gnomAD
CA399873293 rs1308902731	575	P>R		No	ClinGen TOPMed gnomAD
rs1411871340 CA399873287	575	P>S		No	ClinGen gnomAD
rs950236257 CA291050388	576	P>T		No	ClinGen TOPMed gnomAD
CA399873324 rs1167656804	578	P>L		No	ClinGen TOPMed gnomAD
CA291050392 rs1046330350	579	P>L		No	ClinGen TOPMed
rs1243742735 CA399873355	581	P>S		No	ClinGen gnomAD
rs1263480376 CA399873384	583	D>H		No	ClinGen TOPMed gnomAD
rs903398118 CA291050395	585	P>L		No	ClinGen TOPMed gnomAD
rs999082421 CA291050399	586	P>H		No	ClinGen TOPMed gnomAD
CA399873437 rs999082421	586	P>L		No	ClinGen TOPMed gnomAD
CA399873435 rs999082421	586	P>R		No	ClinGen TOPMed gnomAD
rs765502971 CA399873450	587	P>Q		No	ClinGen ExAC gnomAD
CA8612883 rs765502971	587	P>R		No	ClinGen ExAC gnomAD
CA399873478 rs1424936519	589	P>L		No	ClinGen gnomAD
CA399873477 rs1424936519	589	P>R		No	ClinGen gnomAD
CA399873473 rs1258794359	589	P>S		No	ClinGen gnomAD
rs1187518930 CA399873484	590	P>S		No	ClinGen TOPMed gnomAD
rs574253266 CA291050407	593	P>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA8612884 rs542025302	594	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1370198478 CA399873529	594	P>S		No	ClinGen gnomAD
rs1379741593 CA399873543	595	P>L		No	ClinGen TOPMed gnomAD
rs1304692188 CA399873536	595	P>T		No	ClinGen gnomAD
rs1395362880 CA399873552	596	G>D		No	ClinGen TOPMed gnomAD
rs1395362880 CA399873555	596	G>V		No	ClinGen TOPMed gnomAD
CA399873589 rs1567969752	599	G>E		No	ClinGen Ensembl
CA8612885 rs763054769	599	G>R		No	ClinGen ExAC TOPMed gnomAD
CA399873586 rs763054769	599	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1228949181 CA399873603	600	P>L		No	ClinGen gnomAD
CA399873613 rs1258888850	601	V>A		No	ClinGen TOPMed
CA399873616 rs1258888850	601	V>G		No	ClinGen TOPMed
CA399873610 rs1424854837	601	V>L		No	ClinGen TOPMed
rs1019213170 CA291050423	602	P>L		No	ClinGen TOPMed gnomAD
CA291050420 rs1008691820	602	P>S		No	ClinGen TOPMed gnomAD
rs1289848416 CA399873646	603	P>L		No	ClinGen gnomAD
CA399873657 rs1256048685	604	P>L		No	ClinGen gnomAD
rs1241890918 CA399873667	605	P>L		No	ClinGen gnomAD
CA399873663 rs1200380409	605	P>S		No	ClinGen gnomAD
CA399873689 rs1389739605	607	P>S		No	ClinGen TOPMed gnomAD
CA399873705 rs1426984384	608	P>L		No	ClinGen TOPMed gnomAD
CA399873734 rs1472577744	610	P>L		No	ClinGen TOPMed
rs1472577744 CA399873733	610	P>R		No	ClinGen TOPMed
rs1261989429 CA399873740	611	P>S		No	ClinGen Ensembl
rs1465666959 CA399873750	612	P>L		No	ClinGen TOPMed gnomAD
CA399873747 rs1266952635	612	P>S		No	ClinGen TOPMed
rs1598207478 CA399873757	614	G>S		No	ClinGen Ensembl
rs1435462948 CA399873767	615	P>R		No	ClinGen gnomAD
CA399873776 rs1296642758	616	P>R		No	ClinGen gnomAD
rs1359374317 CA399873779	617	D>N		No	ClinGen gnomAD
CA399873815 rs1220561565	619	L>P		No	ClinGen gnomAD
rs1311088549 CA399873847	622	R>G		No	ClinGen gnomAD
rs767507016 CA399873854	622	R>H		No	ClinGen ExAC gnomAD
rs767507016 CA8612895	622	R>L		No	ClinGen ExAC gnomAD
rs1258795251 CA399873901	626	L>S		No	ClinGen TOPMed
rs750316481 CA8612896	628	P>A		No	ClinGen ExAC TOPMed gnomAD
rs766367035 CA8612916	630	V>L		No	ClinGen ExAC gnomAD
rs376978325 CA8612917	632	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8612921 rs752331026	633	K>N		No	ClinGen ExAC TOPMed gnomAD
CA8612919 rs778476856	633	K>R		No	ClinGen ExAC gnomAD
CA8612924 rs770151475	639	K>Q		No	ClinGen ExAC gnomAD
CA399874205 rs1567970335	646	N>K		No	ClinGen Ensembl
rs1359240457 CA399874225	648	V>M		No	ClinGen gnomAD
rs1483388713 CA399874277	652	P>A		No	ClinGen TOPMed gnomAD
CA399874300 rs1231062141	654	Q>*		No	ClinGen gnomAD
rs780265965 CA291050570	654	Q>H		No	ClinGen Ensembl
rs369374854 CA8612927	656	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA8612931 rs773120228	664	N>S		No	ClinGen ExAC gnomAD
CA399874460 rs1428468465	666	E>G		No	ClinGen gnomAD
CA291050584 rs11555736	667	K>E		No	ClinGen Ensembl
rs766165718 CA8612933	667	K>T		No	ClinGen ExAC gnomAD
rs1285346859 CA399874507	670	Q>K		No	ClinGen TOPMed gnomAD
rs1181551870 CA399874513	670	Q>R		No	ClinGen TOPMed
CA399875551 rs1389984189	671	E>Q		No	ClinGen gnomAD
rs1478029492 CA399875580	673	D>N		No	ClinGen gnomAD
rs1289821901 CA399875596	674	M>L		No	ClinGen TOPMed
rs775215714 CA8612954	675	S>N		No	ClinGen ExAC TOPMed gnomAD
CA399875672 rs1429139126	677	F>S		No	ClinGen gnomAD
rs763585700 CA8612956	680	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA8612957 rs530324471	682	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs756927704 CA8612958	685	S>F		No	ClinGen ExAC TOPMed gnomAD
rs767106750 CA8612960	689	S>G		No	ClinGen ExAC TOPMed gnomAD
rs767106750 CA8612959	689	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1282755238 CA399875896	690	L>V		No	ClinGen gnomAD
CA8612961 rs147957951	692	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA399875952 rs779599301	693	S>R		No	ClinGen ExAC TOPMed gnomAD
rs76949926 CA8612963	694	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1448941080 CA399875981	695	L>R		No	ClinGen gnomAD
rs1451842144 CA399876100	703	A>D		No	ClinGen TOPMed gnomAD
rs1451842144 CA399876096	703	A>G		No	ClinGen TOPMed gnomAD
rs778060319 CA8612965	704	P>S		No	ClinGen ExAC gnomAD
CA8612966 rs563838155	706	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs370784492 CA8612967	707	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA399876170 rs1453413599	708	T>A		No	ClinGen TOPMed gnomAD
CA399876171 rs1453413599	708	T>S		No	ClinGen TOPMed gnomAD
rs745966484 CA8612969	710	I>T		No	ClinGen ExAC gnomAD
CA8612971 rs775410415	713	N>S		No	ClinGen ExAC gnomAD
rs762595987 CA8612972	714	R>Q		No	ClinGen ExAC gnomAD
rs1302823411 CA399876242	714	R>W		No	ClinGen gnomAD
CA399876352 rs1598209649	721	T>P		No	ClinGen Ensembl
rs1221835506 CA399876376	723	R>Q		No	ClinGen gnomAD
rs1236549310 CA399876373	723	R>W		No	ClinGen TOPMed gnomAD
CA399876414 rs1266964463	725	G>V		No	ClinGen gnomAD
CA8612975 rs146935438	730	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs377137839 CA8612976	731	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs749913183 CA8612977	731	R>H		No	ClinGen ExAC gnomAD
rs1180352819 CA399876525	734	Q>H		No	ClinGen gnomAD
CA8612978 rs760270356	734	Q>K		No	ClinGen ExAC gnomAD
CA399876521 rs1419028293	734	Q>P		No	ClinGen gnomAD
CA8612979 rs765786466	737	E>V		No	ClinGen ExAC gnomAD
rs955601103 CA291053105	738	A>S		No	ClinGen gnomAD
rs973119713 CA291053107	738	A>V		No	ClinGen TOPMed gnomAD
CA8612996 rs760464589	739	Y>C		No	ClinGen ExAC gnomAD
CA8612998 rs753325510	740	D>N		No	ClinGen ExAC gnomAD
rs1598210564 CA399876689	742	Q>K		No	ClinGen Ensembl
CA8612999 rs201901138	743	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8613001 rs751908102	745	G>S		No	ClinGen ExAC gnomAD
CA8613003 rs781333055	748	F>C		No	ClinGen ExAC gnomAD
CA8613002 rs757622766	748	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1174247103 CA399876833	751	L>M		No	ClinGen gnomAD
rs756393210 CA8613005	753	M>V		No	ClinGen ExAC gnomAD
CA8613006 rs780161644	754	R>C		No	ClinGen ExAC gnomAD
rs780161644 CA8613007	754	R>G		No	ClinGen ExAC gnomAD
CA8613008 rs768597957	754	R>H		No	ClinGen ExAC TOPMed gnomAD
rs773211654 CA8613012	760	Y>C		No	ClinGen ExAC
rs771982074 CA8613011	760	Y>D		No	ClinGen ExAC gnomAD
CA8613013 rs140767111	762	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs770753366 CA8613014	762	R>H		No	ClinGen ExAC gnomAD
CA8613015 rs776153031	763	S>G		No	ClinGen ExAC gnomAD
CA399877056 rs1216976473	765	I>F		No	ClinGen gnomAD
rs1260313959 CA399877072	766	T>N		No	ClinGen gnomAD
CA8613016 rs201792365	767	R>C		No	ClinGen ExAC TOPMed gnomAD
rs150127230 CA8613017	767	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399877081 rs150127230	767	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1750089 rs938536726 CA291053310	770	R>Q	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs774732222 CA8613018	770	R>W		No	ClinGen ExAC TOPMed gnomAD
rs762365100 CA8613019	771	E>G		No	ClinGen ExAC gnomAD
rs1414092802 CA399877133	772	Q>K		No	ClinGen gnomAD
rs1422624335 CA399877155	773	R>Q		No	ClinGen TOPMed
CA8613020 rs371426654	773	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8613022 rs756280599	775	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8613021 rs201146629	775	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766542702 CA8613023	776	E>*		No	ClinGen ExAC gnomAD
rs531139502 CA291053324	776	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA8613024 rs531139502	776	E>V		No	ClinGen 1000Genomes ExAC gnomAD
CA399877275 rs1598210910	782	D>A		No	ClinGen Ensembl
CA8613026 rs779109591	783	R>C		No	ClinGen ExAC gnomAD
rs545973902 CA8613027	783	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1305354353 CA399877318	785	M>I		No	ClinGen gnomAD
rs138585179 CA8613028	788	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA399877374 rs1196016475	790	R>C		No	ClinGen TOPMed
rs112546177 CA8613030	790	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs112546177 CA399877376	790	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8613031 COSM1479660 rs770575234	792	P>L	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1049942929 COSM1644616 CA291053339	793	R>C	salivary_gland [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA8613033 rs376185893	795	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA399877423 rs1425409048	795	P>S		No	ClinGen gnomAD
CA399877439 rs1422164677	796	E>G		No	ClinGen gnomAD
CA291053346 rs1006652541	796	E>K		No	ClinGen TOPMed
CA8613036 rs138140582	797	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1679877 rs768034689 CA8613038	797	R>H	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs768034689 CA8613037	797	R>L		No	ClinGen ExAC TOPMed gnomAD
rs867770416 CA291053357	798	M>I		No	ClinGen Ensembl
CA8613039 rs200065435	808	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399877612 rs1243814433	809	D>E		No	ClinGen TOPMed gnomAD
CA399877621 rs1431799553	810	T>R		No	ClinGen gnomAD
CA399877623 rs1275182718	811	A>T		No	ClinGen gnomAD
rs142695981 CA8613041	812	Q>H		No	ClinGen ESP ExAC gnomAD
CA8613042 rs755296947	813	L>M		No	ClinGen ExAC gnomAD
CA399877688 rs1231111963	816	P>L		No	ClinGen gnomAD
CA291053373 COSM560953 rs867659204	816	P>S	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1187333085 CA399877744	817	Q>E		No	ClinGen TOPMed
CA8613066 rs751528209	819	N>S		No	ClinGen ExAC TOPMed gnomAD
CA399877814 rs1450925557	822	I>T		No	ClinGen gnomAD
rs1230055512 CA399877828	823	A>G		No	ClinGen gnomAD
rs750281251 CA8613069	826	M>V		No	ClinGen ExAC gnomAD
CA291053440 rs924585621	828	I>V		No	ClinGen Ensembl
CA8613071 rs375366550	829	K>Q		No	ClinGen ESP ExAC gnomAD
CA399877915 rs1274890491	829	K>R		No	ClinGen gnomAD
rs1262504603 CA399877970	832	D>E		No	ClinGen gnomAD
rs1321066530 CA399878013	835	R>C		No	ClinGen TOPMed gnomAD
CA8613073 rs768142969	836	Q>R		No	ClinGen ExAC gnomAD
CA399878066 rs1284457108	839	E>K		No	ClinGen gnomAD
CA399878065 rs1284457108	839	E>Q		No	ClinGen gnomAD
CA399879412 rs1189352173	840	I>V		No	ClinGen gnomAD
CA399879440 rs1271364656	843	A>T		No	ClinGen TOPMed
rs764262508 CA8613082	844	F>V		No	ClinGen ExAC TOPMed gnomAD
CA399879531 rs1423011824	848	M>I		No	ClinGen TOPMed gnomAD
CA8613083 rs777832776	848	M>L		No	ClinGen ExAC TOPMed gnomAD
rs777832776 CA399879514	848	M>V		No	ClinGen ExAC TOPMed gnomAD
rs767522144 CA8613085	853	R>C		No	ClinGen ExAC gnomAD
rs750118534 CA8613086	853	R>H		No	ClinGen ExAC TOPMed gnomAD
rs755952090 CA8613087	855	A>P		No	ClinGen ExAC gnomAD
rs774880082 CA291053602	856	A>V		No	ClinGen Ensembl
CA399879703 COSM3691625 rs1329541247	857	Y>C	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1316661489 CA399879760	860	R>Q		No	ClinGen TOPMed gnomAD
rs201789328 CA8613090	866	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA8613104 rs760674178	870	M>I		No	ClinGen ExAC gnomAD
rs773190000 CA8613103	870	M>T		No	ClinGen ExAC gnomAD
CA399880021 rs1334216884	872	S>L		No	ClinGen TOPMed
rs753685956 CA8613106	874	D>N		No	ClinGen ExAC gnomAD
CA8613107 rs754579127	875	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8613108 rs764905564	875	R>H		No	ClinGen ExAC gnomAD
rs1278665149 CA399880074	876	K>E		No	ClinGen TOPMed
rs752076747 CA8613109	878	T>M		No	ClinGen ExAC gnomAD
rs777203363 CA8613111	879	L>V		No	ClinGen ExAC gnomAD
CA8613112 rs746379373	881	H>Q		No	ClinGen ExAC gnomAD
CA399880256 rs1567973323	887	I>L		No	ClinGen Ensembl
rs1440130320 CA399880292	888	A>V		No	ClinGen TOPMed
CA399880295 rs1598212936	889	E>K		No	ClinGen Ensembl
CA399880327 rs929657813	890	K>N		No	ClinGen TOPMed gnomAD
CA8613113 rs756724766	891	Y>D		No	ClinGen ExAC gnomAD
CA399880339 rs1598212974	891	Y>S		No	ClinGen Ensembl
rs1463982347 CA399880354	892	P>A		No	ClinGen gnomAD
CA8613114 rs780542974	892	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8613115 rs749692341	893	Q>K		No	ClinGen ExAC gnomAD
CA8613116 rs768933779	896	G>V		No	ClinGen ExAC gnomAD
CA8613120 rs376766535	900	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs533362698 CA8613122	902	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA399880521 rs1265611166	902	H>R		No	ClinGen gnomAD
CA8613121 rs562693449	902	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399880565 rs1204975227	905	D>N		No	ClinGen gnomAD
CA399880621 rs1466671388	908	G>C		No	ClinGen gnomAD
rs141887433 CA8613147	913	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA291053757 rs1044059525	914	S>G		No	ClinGen TOPMed gnomAD
rs751074259 CA8613148	915	V>A		No	ClinGen ExAC TOPMed gnomAD
CA291053762 rs1002636776	917	A>T		No	ClinGen Ensembl
CA8613149 rs150643495	917	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1360618342 CA399880748	918	D>V		No	ClinGen TOPMed
rs1378125033 CA399880759	920	R>C		No	ClinGen TOPMed gnomAD
CA8613152 rs755479906 COSM1383789	920	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1567973665 CA399880769	922	L>V		No	ClinGen Ensembl
rs753028987 CA8613154	924	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs374954022 CA8613155	925	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1229565731 CA399880817	930	Q>E		No	ClinGen gnomAD
CA8613156 rs777867078	930	Q>H		No	ClinGen ExAC gnomAD
rs1224698219 CA399880843	933	F>S		No	ClinGen gnomAD
rs377725425 CA399880852	935	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399880853 rs1351822937	935	R>Q		No	ClinGen gnomAD
CA8613157 rs377725425	935	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1292556709 CA399880860	936	Q>R		No	ClinGen gnomAD
rs781312546 CA8613159	942	L>F		No	ClinGen ExAC
CA399880912 rs1451162967	943	K>R		No	ClinGen TOPMed gnomAD
rs1011860629 CA291053790	946	L>V		No	ClinGen Ensembl
CA399880943 rs1476471320	948	A>T		No	ClinGen TOPMed
CA399880953 rs1480810131	949	N>S		No	ClinGen TOPMed gnomAD
COSM3402943 CA8613162 rs775304686	950	S>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1021453769 CA291053797	951	P>S		No	ClinGen Ensembl
rs1446065231 CA399880984	954	D>Y		No	ClinGen gnomAD
rs1403103144 CA399881013	958	A>V		No	ClinGen gnomAD
rs147281184 CA8613165	959	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761626118 CA8613166	961	K>M		No	ClinGen ExAC TOPMed gnomAD
CA8613167 rs767106626	962	T>A		No	ClinGen ExAC TOPMed gnomAD
CA399881038 rs750004915	962	T>K		No	ClinGen ExAC TOPMed gnomAD
rs750004915 CA8613168	962	T>M		No	ClinGen ExAC TOPMed gnomAD
rs774659812 CA8613212	965	E>G		No	ClinGen ExAC gnomAD
rs761065324 CA291053911	966	A>V		No	ClinGen Ensembl
CA399881123 rs1258560359	968	E>D		No	ClinGen TOPMed
rs762170948 CA8613214	974	F>Y		No	ClinGen ExAC gnomAD
CA8613215 rs544427015	975	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA399881188 rs1316660672	978	P>A		No	ClinGen TOPMed
CA399881189 rs1316660672	978	P>S		No	ClinGen TOPMed
rs750598051 CA8613216	979	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8613217 rs760997426	980	T>I		No	ClinGen ExAC TOPMed gnomAD
CA399881200 rs1598214305	980	T>P		No	ClinGen Ensembl
CA399881216 rs1381177347	982	S>F		No	ClinGen gnomAD
CA399881218 rs945650795	983	P>A		No	ClinGen TOPMed gnomAD
rs945650795 CA291053921	983	P>S		No	ClinGen TOPMed gnomAD
rs1393028157 CA399881224	984	G>D		No	ClinGen TOPMed
CA291053923 rs1043681001	984	G>S		No	ClinGen TOPMed gnomAD
rs754924270 CA8613222	990	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1329066576 CA399881265	990	F>L		No	ClinGen gnomAD
CA291053935 rs201948794	991	S>G		No	ClinGen 1000Genomes
CA8613223 rs778995612	992	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8613224 rs145693762	992	R>H		No	ClinGen ESP ExAC gnomAD
CA291053942 rs560470776	994	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8613225 rs560470776	994	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399881303 rs1237574342	996	A>G		No	ClinGen gnomAD
rs1366834705 CA399881341	1000	A>T		No	ClinGen gnomAD
rs1171384730 CA399881349	1001	E>*		No	ClinGen gnomAD
rs1379483740 CA399881378	1005	E>*		No	ClinGen gnomAD
CA8613246 rs780903704	1006	Q>E		No	ClinGen ExAC gnomAD
CA291054004 rs914087894	1006	Q>P		No	ClinGen TOPMed gnomAD
rs1309933440 CA399881397	1007	W>*		No	ClinGen gnomAD
rs745326051 CA8613247	1010	E>K		No	ClinGen ExAC gnomAD
rs769281801 CA8613248	1011	A>T		No	ClinGen ExAC gnomAD
CA8613250 rs748632258	1012	A>T		No	ClinGen ExAC TOPMed gnomAD
CA399881437 rs1197164603	1013	A>V		No	ClinGen TOPMed gnomAD
CA8613251 rs772655362	1014	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs773406820 CA8613252	1015	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1313278764 CA399881457	1016	A>V		No	ClinGen TOPMed
rs1254168226 CA399881460	1017	G>D		No	ClinGen gnomAD
CA8613253 rs143059535	1017	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143059535 CA8613254	1017	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8613256 rs201370247 COSM1207295	1018	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs151174346 CA8613258	1021	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs151174346 CA8613259	1021	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA399881490 rs1465219444	1022	G>D		No	ClinGen TOPMed gnomAD
CA399881486 rs1359578900	1022	G>S		No	ClinGen gnomAD
rs1598214971 CA399881492	1023	K>Q		No	ClinGen Ensembl
rs751247758 CA8613261	1024	G>A		No	ClinGen ExAC TOPMed gnomAD
rs757090305 CA399881505	1025	E>K		No	ClinGen ExAC TOPMed gnomAD
rs757090305 CA8613262	1025	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8613263 rs767275037 COSM1710385	1027	P>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA291054032 rs765383101	1027	P>S		No	ClinGen Ensembl
CA399881522 rs1195770774	1028	A>T		No	ClinGen TOPMed
rs1318650247 CA399881531	1029	P>L		No	ClinGen TOPMed
CA8613265 rs534181387	1029	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA8613309 rs757747056	1032	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399882364 rs1450511148	1033	P>S		No	ClinGen gnomAD
rs1384947964 CA399882405	1035	A>S		No	ClinGen TOPMed gnomAD
rs199676283 CA291054122	1035	A>V		No	ClinGen 1000Genomes
rs750761402 CA399882416	1036	R>G		No	ClinGen ExAC TOPMed gnomAD
rs142743370 CA8613312	1036	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750761402 CA8613311	1036	R>W		No	ClinGen ExAC TOPMed gnomAD
rs780634604 CA8613313	1037	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs946995269 CA291054128	1037	R>W		No	ClinGen TOPMed gnomAD
CA399882494 rs1598215809	1041	D>N		No	ClinGen Ensembl
rs768810674 CA399882544	1044	S>C		No	ClinGen ExAC gnomAD
rs768810674 CA8613315	1044	S>F		No	ClinGen ExAC gnomAD
rs779009445 CA8613316	1048	R>G		No	ClinGen ExAC gnomAD
rs150981509 CA8613317	1048	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779009445 CA291054142	1048	R>W		No	ClinGen ExAC gnomAD
CA8613319 rs773117099	1049	R>K		No	ClinGen ExAC gnomAD
CA291054150 rs200730343	1052	K>Q		No	ClinGen TOPMed gnomAD
CA8613320 rs760670070	1056	I>T		No	ClinGen ExAC gnomAD
rs1170369143 CA399882776	1059	S>G		No	ClinGen gnomAD
rs1233516687 CA399882780	1059	S>N		No	ClinGen TOPMed
rs35569365 CA399882791	1059	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs181564542 CA8613322	1060	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs181564542 CA8613323	1060	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA291054157 rs923283973	1061	R>H		No	ClinGen TOPMed gnomAD
CA399882831 rs1598215945	1062	D>N		No	ClinGen Ensembl
rs1298489561 CA399882856	1063	G>R		No	ClinGen TOPMed
CA399883833 rs1370317879	1073	K>Q		No	ClinGen gnomAD
rs775396711 CA8613366	1074	T>M		No	ClinGen ExAC TOPMed gnomAD
rs775396711 CA399883859	1074	T>R		No	ClinGen ExAC TOPMed gnomAD
CA399883872 rs1567975480	1076	P>H		No	ClinGen Ensembl
rs748927571 CA8613367	1077	F>C		No	ClinGen ExAC gnomAD
CA8613369 rs768445927	1078	T>M		No	ClinGen ExAC TOPMed gnomAD
rs768445927 CA8613368	1078	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1331562332 CA399883921	1079	A>D		No	ClinGen gnomAD
COSM980130 rs761421986 CA399883935	1080	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8613370 rs761421986	1080	R>P		No	ClinGen ExAC gnomAD
rs767111106 CA8613372	1081	T>S		No	ClinGen ExAC gnomAD
rs1399567544 CA399883968	1082	G>A		No	ClinGen TOPMed
CA399883957 rs1340627486	1082	G>S		No	ClinGen TOPMed gnomAD
CA399883974 rs1332130709	1083	K>Q		No	ClinGen TOPMed
rs760126685 CA8613375	1084	R>P		No	ClinGen ExAC gnomAD
rs370763888 CA291054265	1087	R>Q		No	ClinGen gnomAD
CA399884038 rs1467307071	1087	R>W		No	ClinGen TOPMed
CA291054268 rs896139824	1089	L>F		No	ClinGen TOPMed gnomAD
rs1259153511 CA399884113	1092	A>D		No	ClinGen gnomAD
CA399884121 rs1164404485	1093	S>G		No	ClinGen TOPMed
CA291054276 rs1013246358	1095	G>V		No	ClinGen TOPMed
rs1443079375 CA399884240	1101	L>E		No	ClinGen gnomAD
rs1415727757 CA399884243	1101	L>W		No	ClinGen TOPMed

No associated diseases with O95466

5 regional properties for O95466

Type	Name	Position	InterPro Accession
domain	Formin, FH3 domain	284 - 637	IPR010472
domain	Formin, GTPase-binding domain	27 - 281	IPR010473
domain	Diaphanous autoregulatory (DAD) domain	1059 - 1090	IPR014767
domain	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	27 - 468	IPR014768
domain	Formin, FH2 domain	632 - 1067	IPR015425

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane ; Lipid-anchor Cytoplasmic vesicle, phagosome	Recruited to actin-rich phagosomes during phagocytosis Translocates to the plasma membrane upon activation by RAC1 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
bleb	A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
GTPase activating protein binding	Binding to a GTPase activating protein.
small GTPase binding	Binding to a small monomeric GTPase.

4 GO annotations of biological process

Name	Definition
actin filament severing	The process in which an actin filament is broken down into smaller filaments.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
regulation of cell shape	Any process that modulates the surface configuration of a cell.

18 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A0A1D5P556	DAAM2	Disheveled-associated activator of morphogenesis 2	Gallus gallus (Chicken)	SS
Q9VUC6	Frl	Formin-like protein	Drosophila melanogaster (Fruit fly)	EV
Q27J81	INF2	Inverted formin-2	Homo sapiens (Human)	EV
Q9Y4D1	DAAM1	Disheveled-associated activator of morphogenesis 1	Homo sapiens (Human)	EV
Q86T65	DAAM2	Disheveled-associated activator of morphogenesis 2	Homo sapiens (Human)	SS
Q8IVF7	FMNL3	Formin-like protein 3	Homo sapiens (Human)	SS
Q96PY5	FMNL2	Formin-like protein 2	Homo sapiens (Human)	SS
Q80U19	Daam2	Disheveled-associated activator of morphogenesis 2	Mus musculus (Mouse)	SS
Q8BPM0	Daam1	Disheveled-associated activator of morphogenesis 1	Mus musculus (Mouse)	PR
Q0GNC1	Inf2	Inverted formin-2	Mus musculus (Mouse)	SS
Q0QWG9	Grid2ip	Delphilin	Mus musculus (Mouse)	PR
A2APV2	Fmnl2	Formin-like protein 2	Mus musculus (Mouse)	SS
Q6ZPF4	Fmnl3	Formin-like protein 3	Mus musculus (Mouse)	SS
Q9JL26	Fmnl1	Formin-like protein 1	Mus musculus (Mouse)	SS
Q9C7S1	FH12	Formin-like protein 12	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LH02	FH17	Formin-like protein 17	Arabidopsis thaliana (Mouse-ear cress)	PR
P0C5K4	FH21A	Putative formin-like protein 21a	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FF14	FH19	Formin-like protein 19	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MGNAAGSAEQ	PAGPAAPPPK	QPAPPKQPMP	AAGELEERFN	RALNCMNLPP	DKVQLLSQYD
70	80	90	100	110	120
NEKKWELICD	QERFQVKNPP	AAYIQKLKSY	VDTGGVSRKV	AADWMSNLGF	KRRVQESTQV
130	140	150	160	170	180
LRELETSLRT	NHIGWVQEFL	NEENRGLDVL	LEYLAFAQCS	VTYDMESTDN	GASNSEKNKP
190	200	210	220	230	240
LEQSVEDLSK	GPPSSVPKSR	HLTIKLTPAH	SRKALRNSRI	VSQKDDVHVC	IMCLRAIMNY
250	260	270	280	290	300
QSGFSLVMNH	PACVNEIALS	LNNKNPRTKA	LVLELLAAVC	LVRGGHDIIL	AAFDNFKEVC
310	320	330	340	350	360
GEQHRFEKLM	EYFRNEDSNI	DFMVACMQFI	NIVVHSVENM	NFRVFLQYEF	THLGLDLYLE
370	380	390	400	410	420
RLRLTESDKL	QVQIQAYLDN	IFDVGALLED	TETKNAVLEH	MEELQEQVAL	LTERLRDAEN
430	440	450	460	470	480
ESMAKIAELE	KQLSQARKEL	ETLRERFSES	TAMGPSRRPP	EPEKAPPAAP	TRPSALELKV
490	500	510	520	530	540
EELEEKGLIR	ILRGPGDAVS	IEILPVAVAT	PSGGDAPTPG	VPTGSPSPDL	APAAEPAPGA
550	560	570	580	590	600
APPPPPPLPG	LPSPQEAPPS	APPQAPPLPG	SPEPPPAPPL	PGDLPPPPPP	PPPPPGTDGP
610	620	630	640	650	660
VPPPPPPPPP	PPGGPPDALG	RRDSELGPGV	KAKKPIQTKF	RMPLLNWVAL	KPSQITGTVF
670	680	690	700	710	720
TELNDEKVLQ	ELDMSDFEEQ	FKTKSQGPSL	DLSALKSKAA	QKAPSKATLI	EANRAKNLAI
730	740	750	760	770	780
TLRKGNLGAE	RICQAIEAYD	LQALGLDFLE	LLMRFLPTEY	ERSLITRFER	EQRPMEELSE
790	800	810	820	830	840
EDRFMLCFSR	IPRLPERMTT	LTFLGNFPDT	AQLLMPQLNA	IIAASMSIKS	SDKLRQILEI
850	860	870	880	890	900
VLAFGNYMNS	SKRGAAYGFR	LQSLDALLEM	KSTDRKQTLL	HYLVKVIAEK	YPQLTGFHSD
910	920	930	940	950	960
LHFLDKAGSV	SLDSVLADVR	SLQRGLELTQ	REFVRQDDCM	VLKEFLRANS	PTMDKLLADS
970	980	990	1000	1010	1020
KTAQEAFESV	VEYFGENPKT	TSPGLFFSLF	SRFIKAYKKA	EQEVEQWKKE	AAAQEAGADT
1030	1040	1050	1060	1070	1080
PGKGEPPAPK	SPPKARRPQM	DLISELKRRQ	QKEPLIYESD	RDGAIEDIIT	VIKTVPFTAR
1090
TGKRTSRLLC	EASLGEEMPL