O94955
EV
Gene name |
RHOBTB3 (KIAA0878) |
Protein name |
Rho-related BTB domain-containing protein 3 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:22836 |
EC number |
|
Protein Class |
SPECKLE-TYPE POZ PROTEIN (PTHR24413) |
Descriptions
Rho GTPases are key regulators of the actin-based cytoskeleton and Rab GTPases are key regulators of membrane traffic. RhoBTB3, an atypical Rho GTPase family member, binds directly to Rab9 GTPase and together with Rab9 functions in protein transport from endosomes to the trans-Golgi network.
Full-length RhoBTB3 protein displays 50% the rate of ATP hydrolysis seen for the Rho domain (GTPase domain, 1-220) alone, representing autoinhibition in RhoBTB3. Rab9 binding to the C-terminal BTB domain (residues 420-611) of RhoBTB3 opens the autoinhibited RhoBTB3 protein to permit maximal ATP hydrolysis.
Autoinhibitory domains (AIDs)
Target domain |
1-220 (GTPase domain) |
Relief mechanism |
Partner binding |
Assay |
Mutagenesis experiment, Deletion assay |
Accessory elements
No accessory elements
References
- Espinosa EJ et al. (2009) "RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport", Cell, 137, 938-48
- Berthold J et al. (2008) "Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism", Experimental cell research, 314, 3453-65
Autoinhibited structure
Activated structure
1 structures for O94955
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94955-F1 | Predicted | AlphaFoldDB |
377 variants for O94955
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs149956516 CA3348819 |
4 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3348821 rs781495649 |
5 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA122891694 rs1019106897 |
6 | V>L | No |
ClinGen TOPMed |
|
|
rs746046822 CA3348822 |
7 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs749659452 CA360458812 |
10 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360458874 rs1473617751 |
12 | G>V | No |
ClinGen gnomAD |
|
|
rs761435177 CA360459011 |
16 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs771439160 CA3348829 |
17 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs902070849 CA122891721 |
17 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA360459056 rs1327025969 |
18 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs772952921 CA3348830 |
19 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs17855649 VAR_030490 CA3348831 |
20 | R>Q | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
|
VAR_018481 rs2302980 CA3348832 |
21 | P>R | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA3348835 rs765265379 |
27 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748228613 CA3348836 |
28 | Y>* | No |
ClinGen ExAC |
|
|
rs971690730 CA122891755 |
28 | Y>* | No |
ClinGen TOPMed |
|
|
rs922934590 CA122891760 |
32 | S>N | No |
ClinGen Ensembl |
|
|
rs1270376379 CA360459426 |
32 | S>R | No |
ClinGen gnomAD |
|
|
CA360459517 rs1187949372 |
36 | S>F | No |
ClinGen gnomAD |
|
|
rs370855401 CA3348838 |
37 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA360459536 rs1458318580 |
38 | D>N | No |
ClinGen TOPMed |
|
|
COSM1311404 CA3348841 rs374008783 |
39 | E>D | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA360459562 rs1202447258 |
39 | E>G | No |
ClinGen TOPMed |
|
|
rs781066409 CA3348840 |
39 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3348839 rs781066409 |
39 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780420448 CA3348842 |
41 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs749710875 CA3348843 |
41 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA360459693 rs768880509 |
45 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768880509 CA3348844 |
45 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360459725 rs1327511662 |
46 | A>V | No |
ClinGen Ensembl |
|
|
rs771619736 CA3348847 |
47 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360459742 rs1279315590 |
47 | A>T | No |
ClinGen gnomAD |
|
|
CA122891807 rs61749615 |
49 | T>M | No |
ClinGen gnomAD |
|
|
CA360459812 rs61749615 |
49 | T>R | No |
ClinGen gnomAD |
|
|
rs1346658651 CA360459828 |
50 | V>I | No |
ClinGen gnomAD |
|
|
CA3348849 rs760167265 |
51 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA360459919 rs1277651501 |
54 | V>A | No |
ClinGen gnomAD |
|
|
rs1378568871 CA360459994 |
58 | Y>C | No |
ClinGen TOPMed |
|
|
CA360460016 rs1263755040 |
59 | Q>R | No |
ClinGen gnomAD |
|
|
CA360460059 rs1477474480 |
61 | S>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1477474480 CA360460064 |
61 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA3348851 rs776241054 |
61 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA360460048 rs1295973784 |
61 | S>R | No |
ClinGen TOPMed |
|
|
CA360460085 rs1354519015 |
62 | A>V | No |
ClinGen TOPMed |
|
|
rs1478470398 CA360460130 |
64 | G>V | No |
ClinGen gnomAD |
|
|
rs764900657 CA3348853 |
66 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs762739313 CA3348855 |
72 | D>Y | No |
ClinGen ExAC |
|
|
CA360460323 rs1299213441 |
73 | C>Y | No |
ClinGen gnomAD |
|
|
CA360460344 rs764077790 |
74 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs764077790 CA3348856 |
74 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1332390389 CA360460367 |
75 | V>A | No |
ClinGen gnomAD |
|
|
rs1292804902 CA360460353 |
75 | V>I | No |
ClinGen gnomAD |
|
|
CA360462674 rs1291298104 |
78 | I>M | No |
ClinGen gnomAD |
|
|
CA360462670 rs1413946864 |
78 | I>T | No |
ClinGen gnomAD |
|
|
rs752912885 CA3348901 |
79 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs1219288562 CA360462687 |
79 | F>S | No |
ClinGen gnomAD |
|
|
rs758717486 CA3348902 |
81 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3348904 rs752073677 |
86 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA122894813 rs144248494 |
87 | R>* | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs144248494 CA360462822 |
87 | R>G | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs757819060 CA3348905 |
87 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs749939214 CA3348907 |
90 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1186561236 CA360462943 |
91 | G>A | No |
ClinGen gnomAD |
|
|
rs755630454 CA3348908 |
92 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs779596557 CA3348909 |
93 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs748932209 CA3348910 |
95 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360462998 rs1433816759 |
96 | I>V | No |
ClinGen gnomAD |
|
|
rs768576337 CA3348911 |
97 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1288353904 CA360463034 |
98 | I>M | No |
ClinGen gnomAD |
|
|
rs1049450616 CA122894864 |
99 | K>T | No |
ClinGen Ensembl |
|
|
rs1360042927 CA360463063 |
100 | Y>C | No |
ClinGen gnomAD |
|
|
CA3348914 rs139206452 |
102 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs773173572 CA3348915 |
103 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA3348916 rs759555357 |
103 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA360463111 rs1182829765 |
104 | D>Y | No |
ClinGen TOPMed |
|
|
CA3348918 rs775574971 |
112 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs764286650 CA3348920 |
115 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA3348921 rs751985334 |
117 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs762133850 CA3348922 |
118 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA3348924 rs144735826 |
119 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA360463242 rs1395270314 |
121 | R>T | No |
ClinGen gnomAD |
|
|
rs755611194 CA3348925 |
122 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1024674800 CA122894955 |
124 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA3348927 rs753450088 |
125 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA360463280 rs1294225556 |
127 | P>L | No |
ClinGen gnomAD |
|
|
CA360463296 rs1439043156 |
130 | I>V | No |
ClinGen gnomAD |
|
|
rs778707106 CA3348929 |
131 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1580395631 CA360463315 |
133 | V>F | No |
ClinGen Ensembl |
|
|
rs1580395634 CA360463323 |
134 | G>V | No |
ClinGen Ensembl |
|
|
CA3348931 rs771941215 |
137 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs777599710 CA3348932 |
137 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1438076063 CA360464999 |
140 | E>* | No |
ClinGen gnomAD |
|
|
rs1216435580 CA360465013 |
142 | P>A | No |
ClinGen TOPMed |
|
|
rs200242583 CA3348946 |
144 | T>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA360465048 rs1188653364 |
147 | L>P | No |
ClinGen gnomAD |
|
|
rs777561402 CA3348951 |
148 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746766713 CA3348952 |
149 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA122905353 rs920247446 |
151 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA360465068 rs1409661141 |
151 | D>N | No |
ClinGen gnomAD |
|
|
CA122905350 rs974342889 |
151 | D>V | No |
ClinGen TOPMed gnomAD |
|
|
CA3348954 rs147895436 |
153 | G>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3348955 rs141752089 |
154 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3348957 rs199742018 |
157 | S>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3348956 rs199742018 |
157 | S>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3348958 rs748303313 |
158 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs768484335 CA3348959 |
159 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs768484335 CA122905378 |
159 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs1339630614 CA360465120 |
159 | T>S | No |
ClinGen gnomAD |
|
|
CA3348961 rs372105539 |
160 | E>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766951981 CA3348962 |
162 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777259122 CA3348963 |
164 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA122905409 rs1052208738 |
165 | A>G | No |
ClinGen Ensembl |
|
|
rs1484674144 CA360465183 |
169 | G>E | No |
ClinGen gnomAD |
|
|
rs375717037 CA3348964 |
170 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3348968 rs369025051 |
176 | H>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA360465227 rs1427548527 |
176 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1316937624 CA360465235 |
177 | S>N | No |
ClinGen TOPMed |
|
|
CA3348970 rs771158755 |
178 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781210737 CA3348971 |
179 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA122905456 rs1013676244 |
181 | F>L | No |
ClinGen gnomAD |
|
|
CA3348972 rs745767162 |
182 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1561443851 CA360465275 |
183 | I>V | No |
ClinGen Ensembl |
|
|
rs1226062612 CA360465308 |
187 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA122905477 rs1044948036 |
187 | F>S | No |
ClinGen TOPMed |
|
|
rs1416259036 CA360465310 |
188 | G>R | No |
ClinGen gnomAD |
|
|
CA3348974 rs539990691 |
190 | V>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA360465325 rs539990691 |
190 | V>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3348996 rs747130667 |
195 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA3348997 rs771337735 |
198 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360465959 rs1265344652 |
200 | N>Y | No |
ClinGen TOPMed |
|
|
CA360466024 rs1195648752 |
204 | S>G | No |
ClinGen TOPMed |
|
|
CA360466075 rs1363696380 |
207 | M>L | No |
ClinGen gnomAD |
|
|
rs1469049580 CA360466110 |
208 | K>R | No |
ClinGen TOPMed |
|
|
CA360466234 rs1452317609 |
213 | S>G | No |
ClinGen gnomAD |
|
|
CA3349000 rs746227477 |
214 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA122909151 rs113282719 |
214 | N>S | No |
ClinGen Ensembl |
|
|
rs1368357894 CA360466326 |
217 | H>R | No |
ClinGen gnomAD |
|
|
rs770463319 CA3349001 |
218 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA360466381 rs1561445301 |
221 | P>L | No |
ClinGen Ensembl |
|
|
CA3349002 rs776118895 |
223 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA360466429 rs1275123427 |
225 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1261757878 CA360466453 |
226 | Q>R | No |
ClinGen TOPMed |
|
|
CA3349023 rs757617291 |
231 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1297611958 CA360467274 |
232 | V>D | No |
ClinGen TOPMed |
|
|
CA122912163 rs956462421 |
232 | V>I | No |
ClinGen gnomAD |
|
|
CA122912187 rs527633862 |
234 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA3349025 rs763502813 |
237 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs923965257 CA122912192 |
237 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA3349024 rs763502813 |
237 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360467403 rs1485651916 |
240 | Y>C | No |
ClinGen gnomAD |
|
|
CA360467397 rs1376249596 |
240 | Y>D | No |
ClinGen TOPMed |
|
|
rs1356627670 CA360467439 |
242 | S>A | No |
ClinGen Ensembl |
|
|
rs1561446480 CA360467534 |
250 | C>R | No |
ClinGen Ensembl |
|
|
rs1429927308 CA360467544 |
251 | C>R | No |
ClinGen gnomAD |
|
|
CA3349028 rs553064220 |
253 | C>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs768225814 CA3349029 |
254 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1423586223 CA360467640 |
256 | V>M | No |
ClinGen TOPMed |
|
|
CA3349033 rs150266098 |
257 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3349032 rs150266098 |
257 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA360467701 rs1414153492 |
259 | Y>H | No |
ClinGen gnomAD |
|
|
rs926554219 CA360467735 |
260 | N>K | No |
ClinGen gnomAD |
|
|
rs776641165 CA3349037 |
261 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs776641165 CA3349036 |
261 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA3349038 rs34899 VAR_018482 |
262 | N>D | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA360467755 rs34899 |
262 | N>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs34899 CA360467759 |
262 | N>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1235181660 CA360467810 |
264 | K>R | No |
ClinGen TOPMed |
|
|
rs1281549204 CA360467853 |
266 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs767873417 CA3349041 |
267 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA3349040 rs757389717 |
267 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA360467911 rs1244342522 |
269 | A>V | No |
ClinGen gnomAD |
|
|
rs1486529098 CA360467931 |
270 | H>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1486529098 CA360467928 |
270 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs779429428 CA122912366 |
272 | I>F | No |
ClinGen Ensembl |
|
|
CA360467986 rs141051942 |
272 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780226430 CA3349044 |
273 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1561446552 CA360468030 |
275 | C>G | No |
ClinGen Ensembl |
|
|
CA122912376 rs908400182 |
275 | C>S | No |
ClinGen Ensembl |
|
|
rs186733002 CA3349047 |
276 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs186733002 CA3349046 |
276 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs780948576 CA122912400 |
276 | A>V | No |
ClinGen Ensembl |
|
|
CA360468119 rs1433872750 |
279 | H>L | No |
ClinGen gnomAD |
|
|
rs1304919870 CA360468144 |
280 | V>G | No |
ClinGen TOPMed |
|
|
rs1171615653 CA360468166 |
282 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
CA360468182 rs1423467920 |
283 | L>M | No |
ClinGen TOPMed |
|
|
CA122912419 rs948253213 |
283 | L>Q | No |
ClinGen TOPMed |
|
|
rs1479127180 CA360468207 |
284 | L>I | No |
ClinGen TOPMed |
|
|
rs1425113751 CA360468237 |
286 | N>D | No |
ClinGen TOPMed |
|
|
rs1045697097 CA122912428 |
287 | V>A | No |
ClinGen TOPMed |
|
|
rs138557068 CA3349048 |
289 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1041168004 CA122912442 |
290 | P>S | No |
ClinGen Ensembl |
|
|
CA3349049 rs146973484 |
293 | I>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA122912472 rs146973484 |
293 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs772887011 CA3349050 |
298 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA360468439 rs1443460057 |
299 | I>V | No |
ClinGen gnomAD |
|
|
CA3349051 rs746600859 |
300 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA3349053 rs776352969 |
307 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1318083661 CA360468511 |
308 | I>V | No |
ClinGen gnomAD |
|
|
rs1215844453 CA360468523 |
309 | N>K | No |
ClinGen gnomAD |
|
|
CA3349055 rs759342338 |
311 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA3349054 rs759342338 |
311 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs775447703 CA3349056 |
312 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA3349057 rs183162694 |
312 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs183162694 CA3349058 |
312 | T>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA360468552 rs1257256634 |
314 | F>Y | No |
ClinGen TOPMed |
|
|
rs559872744 CA122912558 |
315 | P>Q | No |
ClinGen 1000Genomes |
|
|
CA3349059 rs750687863 |
318 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA3349060 rs756462984 |
320 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs528922224 CA3349061 COSM168631 |
321 | S>Y | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC gnomAD |
|
rs754196974 CA3349062 |
322 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs1031812301 CA122912603 |
322 | S>L | No |
ClinGen Ensembl |
|
|
CA122912573 rs754196974 |
322 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA360468617 rs1386637024 |
325 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA3349064 rs375504922 |
326 | P>L | No |
ClinGen ESP ExAC TOPMed |
|
|
CA3349065 rs755935034 |
328 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349066 rs755935034 |
328 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349067 rs777319373 |
328 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777319373 CA360468634 |
328 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349068 rs777319373 |
328 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360468642 rs1394057050 |
330 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs770527619 CA3349069 |
331 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs780872797 CA3349070 |
333 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA3349072 rs769589148 |
334 | A>S | No |
ClinGen ExAC TOPMed |
|
|
CA360468668 COSM1071389 rs769589148 |
334 | A>T | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed |
|
CA360468724 rs1243064667 |
342 | D>A | No |
ClinGen Ensembl |
|
|
CA3349075 rs768702870 |
342 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs368758398 CA3349077 |
343 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs368758398 CA3349078 |
343 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs754045614 CA3349079 |
345 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA122912737 rs759852028 |
345 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349080 rs759852028 |
345 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349081 rs765575970 |
347 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA3349107 rs780695100 |
350 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs749886141 CA3349108 |
353 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs779822703 CA3349110 |
356 | E>* | No |
ClinGen ExAC |
|
|
CA360469521 rs1211595559 |
359 | E>A | No |
ClinGen TOPMed gnomAD |
|
|
CA360469529 rs1440723662 |
360 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1242884157 CA360469539 |
361 | I>M | No |
ClinGen gnomAD |
|
|
CA3349113 rs779028242 |
361 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs748053618 CA3349114 |
362 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1167083146 CA360469549 |
363 | K>T | No |
ClinGen gnomAD |
|
|
CA360469565 rs1372139810 |
365 | L>S | No |
ClinGen TOPMed |
|
|
rs141806007 CA3349115 |
367 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1478642689 CA360469586 |
368 | S>A | No |
ClinGen TOPMed |
|
|
CA3349116 rs776833934 |
368 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs202036278 CA360469592 |
369 | G>A | No |
ClinGen 1000Genomes TOPMed |
|
|
CA122918734 rs969573267 |
369 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA122918739 rs202036278 |
369 | G>V | No |
ClinGen 1000Genomes TOPMed |
|
|
rs770047415 CA3349118 |
372 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775637359 CA3349119 |
373 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs926953625 CA122918757 |
373 | N>K | No |
ClinGen TOPMed |
|
|
rs762440009 CA360469666 |
380 | C>F | No |
ClinGen ExAC |
|
|
CA3349124 rs762440009 |
380 | C>Y | No |
ClinGen ExAC |
|
|
CA3349125 rs539979625 |
382 | L>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA360469685 rs1234778525 |
383 | K>T | No |
ClinGen gnomAD |
|
|
rs1338883829 CA360469692 |
384 | T>A | No |
ClinGen TOPMed |
|
|
CA360469703 rs1249774848 |
386 | G>R | No |
ClinGen TOPMed |
|
|
rs752581957 CA3349151 |
392 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1334172546 CA360470124 |
393 | N>S | No |
ClinGen TOPMed |
|
|
CA360470136 rs1251685131 |
395 | K>E | No |
ClinGen gnomAD |
|
|
CA360470143 rs1482388419 |
396 | T>P | No |
ClinGen gnomAD |
|
|
rs1482388419 CA360470145 |
396 | T>S | No |
ClinGen gnomAD |
|
|
CA360470187 rs899529990 |
402 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA3349153 rs777794232 |
402 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs899529990 CA122922969 |
402 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA360470197 rs756196984 COSM1071391 |
404 | W>R | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs756196984 CA3349155 COSM1071391 |
404 | W>R | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1028846729 CA122922997 |
406 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1477966609 CA360470232 |
408 | T>S | No |
ClinGen gnomAD |
|
|
CA3349156 rs780165004 |
409 | S>F | No |
ClinGen ExAC TOPMed |
|
|
rs953352234 CA122923004 |
409 | S>P | No |
ClinGen Ensembl |
|
|
CA3349159 rs768905935 |
417 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA360470306 rs1395541097 |
419 | L>F | No |
ClinGen gnomAD |
|
|
rs1206115383 CA360470309 |
419 | L>R | No |
ClinGen TOPMed |
|
|
CA3349164 rs368331385 |
421 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs771554966 CA3349165 |
422 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201479791 CA3349167 |
425 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1258841322 CA360470355 |
426 | I>M | No |
ClinGen gnomAD |
|
|
rs1312167003 CA360470395 |
428 | G>D | No |
ClinGen gnomAD |
|
|
rs41276257 CA3349184 |
429 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1486642574 CA360470418 |
430 | T>I | No |
ClinGen gnomAD |
|
|
rs1477097478 CA360470678 |
437 | I>L | No |
ClinGen TOPMed |
|
|
rs775218445 CA3349187 |
441 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762569814 CA3349188 |
441 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs763796871 CA3349189 |
442 | C>* | No |
ClinGen ExAC gnomAD |
|
|
CA3349190 rs751395803 |
443 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA122933387 rs376618967 |
445 | M>L | No |
ClinGen ESP TOPMed |
|
|
rs1443816459 CA360470745 |
447 | A>V | No |
ClinGen TOPMed |
|
|
CA3349191 rs199795870 |
450 | N>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA360470819 rs767418081 |
453 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA3349192 rs140018802 |
454 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA122933401 rs1022140248 |
458 | S>N | No |
ClinGen TOPMed |
|
|
rs1301203105 CA360470898 |
460 | L>R | No |
ClinGen TOPMed |
|
|
rs267600738 CA122933407 |
461 | I>N | No |
ClinGen Ensembl |
|
|
rs267600739 CA122933421 |
462 | P>H | No |
ClinGen gnomAD |
|
|
rs267600739 CA360470915 |
462 | P>L | No |
ClinGen gnomAD |
|
|
CA3349193 rs750321389 |
462 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202221789 CA3349196 |
463 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202221789 CA3349195 |
463 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs977587498 CA122933452 |
464 | Y>C | No |
ClinGen TOPMed |
|
|
rs977587498 CA360470930 |
464 | Y>S | No |
ClinGen TOPMed |
|
|
rs1356521564 CA360471005 |
470 | T>I | No |
ClinGen Ensembl |
|
|
CA3349197 rs758619162 |
471 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs778114482 CA3349198 |
472 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1172072485 CA360471031 |
473 | S>P | No |
ClinGen TOPMed |
|
|
rs1267057561 CA360471077 |
476 | E>D | No |
ClinGen gnomAD |
|
|
CA122933485 rs1027913373 |
477 | Y>H | No |
ClinGen Ensembl |
|
|
CA360471117 rs1215316551 |
480 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1247135817 CA360471121 |
480 | T>R | No |
ClinGen gnomAD |
|
|
CA3349199 rs757571783 |
482 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360471141 rs1488038053 |
482 | S>T | No |
ClinGen gnomAD |
|
|
CA122936445 rs1021866302 |
486 | A>V | No |
ClinGen Ensembl |
|
|
CA3349218 rs751794670 |
488 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs533229431 CA3349217 |
488 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA360471466 rs1389671354 |
492 | M>V | No |
ClinGen gnomAD |
|
|
rs1306723049 CA360471482 |
494 | L>I | No |
ClinGen gnomAD |
|
|
rs1309766597 CA360471514 |
499 | E>K | No |
ClinGen gnomAD |
|
|
CA360471543 rs1236973678 |
502 | Q>R | No |
ClinGen TOPMed |
|
|
rs546495498 CA3349221 |
509 | I>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3349224 rs768785366 |
514 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774022482 CA3349226 |
517 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1274928285 CA561269729 |
518 | L>* | No |
ClinGen gnomAD |
|
|
rs191658530 CA122936514 |
521 | M>V | No |
ClinGen 1000Genomes |
|
|
rs376160299 CA3349227 |
522 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3349228 rs201279260 |
523 | S>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA122936520 rs1021216075 COSM333464 |
523 | S>R | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs1408106891 CA360471688 |
524 | R>G | No |
ClinGen gnomAD |
|
|
rs201144175 CA3349230 |
524 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs549144030 CA3349229 |
524 | R>T | No |
ClinGen 1000Genomes ExAC |
|
|
CA122936546 rs960499037 |
527 | A>E | No |
ClinGen Ensembl |
|
|
rs766280501 CA3349231 |
529 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs776569745 CA3349232 |
532 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs762977461 CA3349233 |
533 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA3349234 rs764223665 |
534 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360471764 rs1339498302 |
535 | D>E | No |
ClinGen gnomAD |
|
|
CA360471765 rs1445449510 |
536 | L>M | No |
ClinGen TOPMed gnomAD |
|
|
CA3349236 rs762167988 |
539 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA360471791 rs1580429287 |
540 | A>T | No |
ClinGen Ensembl |
|
|
rs1350014861 CA360471796 |
540 | A>V | No |
ClinGen gnomAD |
|
|
CA3349237 rs767849147 |
541 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA122940531 rs1021366794 |
544 | H>R | No |
ClinGen Ensembl |
|
|
CA3349251 rs770724246 |
546 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs1452555394 CA360472728 |
554 | H>R | No |
ClinGen gnomAD |
|
|
rs756214266 CA122940559 |
558 | T>A | No |
ClinGen Ensembl |
|
|
rs1195146317 CA360472799 |
560 | Y>H | No |
ClinGen Ensembl |
|
|
rs767865649 CA3349257 |
564 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1160801880 CA360472843 |
565 | Q>R | No |
ClinGen gnomAD |
|
|
CA3349258 rs750592912 |
567 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349259 rs759336231 |
568 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764271718 CA3349260 |
571 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745672890 CA3349287 |
577 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349288 rs369189307 |
577 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA360473095 rs369189307 |
577 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780172728 CA3349289 |
578 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1424089978 CA360473111 |
580 | V>I | No |
ClinGen gnomAD |
|
|
CA360473137 rs1332209436 |
583 | H>R | No |
ClinGen TOPMed |
|
|
rs1436725232 CA360473151 |
585 | W>* | No |
ClinGen TOPMed |
|
|
rs1580435522 CA360473161 |
586 | P>L | No |
ClinGen Ensembl |
|
|
rs1366429293 CA360473159 |
586 | P>S | No |
ClinGen gnomAD |
|
|
CA360473168 rs1169091458 COSM167902 |
587 | S>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1187505874 CA360473181 |
589 | M>I | No |
ClinGen TOPMed |
|
|
rs747053110 CA122943842 |
589 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349293 rs747053110 |
589 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1403169469 CA360473186 |
590 | Y>C | No |
ClinGen gnomAD |
|
|
CA3349294 rs771239787 |
590 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs190681125 CA3349295 |
593 | Q>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs148767115 CA3349296 COSM3141787 |
595 | A>V | prostate [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs765540949 CA3349297 |
600 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1486407480 CA360473256 |
600 | Y>H | No |
ClinGen TOPMed |
|
|
rs763493521 CA3349299 |
603 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs374462478 CA3349301 |
604 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3349300 rs368977972 |
604 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756665667 CA3349302 |
605 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349303 rs767205027 |
607 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3349304 rs200421879 |
607 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780043401 CA3349306 |
609 | L>F | No |
ClinGen ExAC |
|
|
rs749058736 CA3349307 |
611 | M>T | No |
ClinGen ExAC gnomAD |
No associated diseases with O94955
2 regional properties for O94955
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BTB/POZ domain | 245 - 386 | IPR000210-1 |
| domain | BTB/POZ domain | 414 - 518 | IPR000210-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24413 | SPECKLE-TYPE POZ PROTEIN |
| PANTHER Subfamily | PTHR24413:SF237 | RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 3 |
| PANTHER Protein Class |
ubiquitin-protein ligase
protein modifying enzyme |
|
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network membrane | The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| small GTPase binding | Binding to a small monomeric GTPase. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| cortical cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. |
| establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61585 | RHOA | Transforming protein RhoA | Bos taurus (Bovine) | PR |
| Q1RMJ6 | RHOC | Rho-related GTP-binding protein RhoC | Bos taurus (Bovine) | PR |
| Q17QI8 | Rhov | Rho-related GTP-binding protein RhoV | Bos taurus (Bovine) | PR |
| Q2HJ68 | RND1 | Rho-related GTP-binding protein Rho6 | Bos taurus (Bovine) | PR |
| Q3ZBW5 | RHOB | Rho-related GTP-binding protein RhoB | Bos taurus (Bovine) | PR |
| Q9PSX7 | RHOC | Rho-related GTP-binding protein RhoC | Gallus gallus (Chicken) | PR |
| P48148 | Rho1 | Ras-like GTP-binding protein Rho1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96L33 | RHOV | Rho-related GTP-binding protein RhoV | Homo sapiens (Human) | PR |
| P62745 | RHOB | Rho-related GTP-binding protein RhoB | Homo sapiens (Human) | PR |
| P08134 | RHOC | Rho-related GTP-binding protein RhoC | Homo sapiens (Human) | PR |
| Q92730 | RND1 | Rho-related GTP-binding protein Rho6 | Homo sapiens (Human) | PR |
| P61587 | RND3 | Rho-related GTP-binding protein RhoE | Homo sapiens (Human) | PR |
| P61586 | RHOA | Transforming protein RhoA | Homo sapiens (Human) | PR |
| O94844 | RHOBTB1 | Rho-related BTB domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q6IQ16 | SPOPL | Speckle-type POZ protein-like | Homo sapiens (Human) | PR |
| Q62159 | Rhoc | Rho-related GTP-binding protein RhoC | Mus musculus (Mouse) | PR |
| Q8BLR7 | Rnd1 | Rho-related GTP-binding protein Rho6 | Mus musculus (Mouse) | PR |
| Q9QUI0 | Rhoa | Transforming protein RhoA | Mus musculus (Mouse) | PR |
| P61588 | Rnd3 | Rho-related GTP-binding protein RhoE | Mus musculus (Mouse) | PR |
| Q8VDU1 | Rhov | Rho-related GTP-binding protein RhoV | Mus musculus (Mouse) | PR |
| P62746 | Rhob | Rho-related GTP-binding protein RhoB | Mus musculus (Mouse) | PR |
| Q9DAK3 | Rhobtb1 | Rho-related BTB domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q9CTN4 | Rhobtb3 | Rho-related BTB domain-containing protein 3 | Mus musculus (Mouse) | SS |
| O77683 | RND3 | Rho-related GTP-binding protein RhoE | Sus scrofa (Pig) | PR |
| Q6SA80 | Rnd3 | Rho-related GTP-binding protein RhoE | Rattus norvegicus (Rat) | PR |
| P62747 | Rhob | Rho-related GTP-binding protein RhoB | Rattus norvegicus (Rat) | PR |
| Q9Z1Y0 | Rhov | Rho-related GTP-binding protein RhoV | Rattus norvegicus (Rat) | PR |
| P61589 | Rhoa | Transforming protein RhoA | Rattus norvegicus (Rat) | PR |
| Q9SSX0 | RAC1 | Rac-like GTP-binding protein 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z808 | RAC3 | Rac-like GTP-binding protein 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q68Y52 | RAC2 | Rac-like GTP-binding protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q67VP4 | RAC4 | Rac-like GTP-binding protein 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q22038 | rho-1 | Ras-like GTP-binding protein rhoA | Caenorhabditis elegans | PR |
| Q9SU67 | ARAC8 | Rac-like GTP-binding protein ARAC8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O82480 | ARAC7 | Rac-like GTP-binding protein ARAC7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38903 | ARAC2 | Rac-like GTP-binding protein ARAC2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O82481 | ARAC10 | Rac-like GTP-binding protein ARAC10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIHIVALGN | EGDTFHQDNR | PSGLIRTYLG | RSPLVSGDES | SLLLNAASTV | ARPVFTEYQA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAFGNVKLVV | HDCPVWDIFD | SDWYTSRNLI | GGADIIVIKY | NVNDKFSFHE | VKDNYIPVIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RALNSVPVII | AAVGTRQNEE | LPCTCPLCTS | DRGSCVSTTE | GIQLAKELGA | TYLELHSLDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FYIGKYFGGV | LEYFMIQALN | QKTSEKMKKR | KMSNSFHGIR | PPQLEQPEKM | PVLKAEASHY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NSDLNNLLFC | CQCVDVVFYN | PNLKKVVEAH | KIVLCAVSHV | FMLLFNVKSP | TDIQDSSIIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTQDLFAINR | DTAFPGASHE | SSGNPPLRVI | VKDALFCSCL | SDILRFIYSG | AFQWEELEED |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IRKKLKDSGD | VSNVIEKVKC | ILKTPGKINC | LRNCKTYQAR | KPLWFYNTSL | KFFLNKPMLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DVVFEIQGTT | VPAHRAILVA | RCEVMAAMFN | GNYMEAKSVL | IPVYGVSKET | FLSFLEYLYT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSCCPAGIFQ | AMCLLICAEM | YQVSRLQHIC | ELFIITQLQS | MPSRELASMN | LDIVDLLKKA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KFHHSDCLST | WLLHFIATNY | LIFSQKPEFQ | DLSVEERSFV | EKHRWPSNMY | LKQLAEYRKY |
| 610 | |||||
| IHSRKCRCLV | M |