AiPD: Autoinhibited Protein Database

O94921

Gene name	CDK14 (KIAA0834, PFTK1)
Protein name	Cyclin-dependent kinase 14
Names	Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1, hPFTAIRE1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5218
EC number	2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-160 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-160 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

273-296 (Activation loop from InterPro)

Target domain	135-419 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O94921

Entry ID	Method	Resolution	Chain	Position	Source
AF-O94921-F1	Predicted				AlphaFoldDB

347 variants for O94921

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1201400034 CA368108298	2	C>R		No	ClinGen gnomAD
rs1353862383 CA368108332	6	E>V		No	ClinGen TOPMed
rs767030755 CA4334540	7	P>L		No	ClinGen ExAC gnomAD
rs944644674 CA162745618	9	P>L		No	ClinGen TOPMed
CA368108362 rs1188966920	11	E>A		No	ClinGen TOPMed
CA4334541 rs752104845	12	K>N		No	ClinGen ExAC gnomAD
CA368108378 rs1394150405	13	I>T		No	ClinGen gnomAD
CA368108375 rs1304354462	13	I>V		No	ClinGen gnomAD
TCGA novel	14	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1307709951 CA368108381	14	G>S		No	ClinGen gnomAD
rs1584730056 CA368108392	15	K>N		No	ClinGen Ensembl
CA4334544 rs753068640	15	K>R		No	ClinGen ExAC TOPMed gnomAD
rs550041012 CA368108397	16	M>K		No	ClinGen 1000Genomes ExAC
rs550041012 CA4334545	16	M>T		No	ClinGen 1000Genomes ExAC
rs1299731501 CA368108423	19	L>F		No	ClinGen gnomAD
CA4334546 rs778036398	20	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	21	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368108440 rs749371723	22	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4334547 rs749371723	22	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1482303257 CA368108446	23	L>F		No	ClinGen TOPMed gnomAD
rs1203975906 CA368108453	24	S>L		No	ClinGen TOPMed gnomAD
TCGA novel	25	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334550 rs746964099	28	S>G		No	ClinGen ExAC gnomAD
rs768515404 CA368108488	29	R>H		No	ClinGen ExAC TOPMed gnomAD
rs768515404 CA4334551	29	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1150781 CA368108486 rs1266126189	29	R>S	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs776440501 CA368108490	30	I>L		No	ClinGen ExAC TOPMed gnomAD
rs776440501 CA4334552	30	I>V		No	ClinGen ExAC TOPMed gnomAD
rs192282583 CA4334584	32	L>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1236941425 CA368109287	33	K>T		No	ClinGen TOPMed gnomAD
rs1266101877 CA368109316	35	D>E		No	ClinGen gnomAD
CA4334585 rs765393318	36	D>V		No	ClinGen ExAC TOPMed gnomAD
CA368109330 rs1249633992	37	T>I		No	ClinGen TOPMed gnomAD
CA4334588 rs17866277	38	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4334589 rs748100236	39	F>L		No	ClinGen ExAC TOPMed gnomAD
CA368109339 rs1424404109	39	F>S		No	ClinGen gnomAD
rs755942380 CA4334590	40	D>N		No	ClinGen ExAC gnomAD
CA162760361 rs959594994	42	I>V		No	ClinGen Ensembl
rs1478599493 CA368108528	44	V>I		No	ClinGen TOPMed
rs1365708827 CA368108537	45	T>A		No	ClinGen gnomAD
CA162760362 rs973588185	46	K>N		No	ClinGen Ensembl
CA368108578 rs1375098549	47	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs140679817 CA4334645	50	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA368108615 rs763175488	50	R>W		No	ClinGen ExAC TOPMed gnomAD
CA576222089 rs1563058726	52	C>*		No	ClinGen Ensembl
CA4334646 rs774434672	53	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs759722377 CA4334647	55	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	56	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334649 rs775644986	61	P>S		No	ClinGen ExAC gnomAD
rs1324588039 CA368108804	62	L>P		No	ClinGen TOPMed
rs765218989 CA4334651	66	P>S		No	ClinGen ExAC gnomAD
TCGA novel	71	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758095992 CA4334653	72	R>G		No	ClinGen ExAC gnomAD
rs879151175 CA162760364	73	V>I		No	ClinGen gnomAD
rs879151175 CA368108882	73	V>L		No	ClinGen gnomAD
TCGA novel	76	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	77	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751157761 CA4334655	84	E>G		No	ClinGen ExAC gnomAD
CA368108968 rs1273931921	85	K>E		No	ClinGen gnomAD
rs754600917 CA4334656	88	N>Y		No	ClinGen ExAC
CA4334657 rs780681256	90	V>A		No	ClinGen ExAC gnomAD
TCGA novel	90	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1453304812 CA368109017	92	R>K		No	ClinGen TOPMed
rs747614328 CA4334658	93	V>M		No	ClinGen ExAC TOPMed gnomAD
rs773614665 CA162760366	94	H>P		No	ClinGen ExAC TOPMed gnomAD
rs773614665 CA4334659	94	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1249775566 CA368109041	96	E>K		No	ClinGen gnomAD
rs749730201 CA4334661	97	N>S		No	ClinGen ExAC gnomAD
CA4334662 rs771189909	98	N>H		No	ClinGen ExAC gnomAD
rs367981209 CA4334663	98	N>K		No	ClinGen ESP ExAC gnomAD
rs1268084853 CA368109087	101	I>M		No	ClinGen gnomAD
CA4334664 rs746086232	102	N>D		No	ClinGen ExAC gnomAD
rs1254579326 CA368109100	103	F>C		No	ClinGen gnomAD
TCGA novel	103	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1188263077 CA368109112	104	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA368109127 rs1419357589	106	S>F		No	ClinGen gnomAD
CA4334666 rs775734926	107	S>T		No	ClinGen ExAC gnomAD
CA4334667 rs760816329	108	T>A		No	ClinGen ExAC gnomAD
CA162760368 rs868364699	109	G>D		No	ClinGen TOPMed
CA368109150 rs868364699	109	G>V		No	ClinGen TOPMed
rs773016040 CA4334669	110	K>E		No	ClinGen ExAC gnomAD
TCGA novel	110	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368109169 rs1170581524	111	E>D		No	ClinGen gnomAD
rs1401316012 CA368109190	114	K>E		No	ClinGen gnomAD
CA368109218 rs762863542	117	R>G		No	ClinGen ExAC TOPMed
rs766100371 CA4334672	117	R>Q		No	ClinGen ExAC gnomAD
rs762863542 CA4334670 COSM328721	117	R>W	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
CA368109227 rs187133761	118	H>P		No	ClinGen 1000Genomes ExAC gnomAD
CA368109230 rs1357402624	118	H>Q		No	ClinGen TOPMed gnomAD
rs187133761 CA4334673	118	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA368109242 rs754614156	120	S>C		No	ClinGen ExAC TOPMed gnomAD
CA368109241 rs754614156	120	S>G		No	ClinGen ExAC TOPMed gnomAD
rs138436598 CA368109244	120	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4334675 rs138436598	120	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs754614156 CA4334674	120	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1318033336 CA368109252	121	P>A		No	ClinGen TOPMed gnomAD
rs1318033336 CA368109253	121	P>S		No	ClinGen TOPMed gnomAD
rs1584826576 CA368109274	122	S>T		No	ClinGen Ensembl
CA368109291 rs548218812	123	S>L		No	ClinGen 1000Genomes TOPMed gnomAD
COSM398366 CA162760369 rs548218812	123	S>W	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes TOPMed gnomAD
CA162762925 rs1002397119	124	P>A		No	ClinGen TOPMed gnomAD
rs770857488 CA4334692	125	T>A		No	ClinGen ExAC gnomAD
CA4334693 rs774035523	125	T>K		No	ClinGen ExAC TOPMed gnomAD
CA162762926 rs774035523	125	T>R		No	ClinGen ExAC TOPMed gnomAD
CA368110120 rs1189350713	126	S>N		No	ClinGen gnomAD
rs1446774584 CA368110126	127	P>A		No	ClinGen TOPMed
CA368110134 rs1386447874	128	K>R		No	ClinGen TOPMed
rs368905588 CA4334694	129	F>L		No	ClinGen ESP ExAC gnomAD
CA4334695 rs767194171	129	F>Y		No	ClinGen ExAC gnomAD
CA368110157 rs1195252629	131	K>N		No	ClinGen gnomAD
CA4334696 rs752335356	134	S>L		No	ClinGen ExAC gnomAD
TCGA novel	135	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	136	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763521264 CA4334698	136	E>*		No	ClinGen ExAC TOPMed gnomAD
rs763521264 CA368110186	136	E>K		No	ClinGen ExAC TOPMed gnomAD
CA368110208 rs1355136461	139	E>Q		No	ClinGen gnomAD
rs963889531 CA162762927	143	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	143	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368110254 rs1252818146	146	Y>D		No	ClinGen TOPMed
CA4334700 rs148988868	148	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368110271 rs1249813063	149	V>I		No	ClinGen TOPMed
CA368110300 rs1227185891	153	K>Q		No	ClinGen gnomAD
TCGA novel	154	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751932807 CA4334723	156	V>I		No	ClinGen ExAC gnomAD
rs1447782919 CA368108130	159	K>T		No	ClinGen TOPMed
CA4334724 rs755269646	161	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	165	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA162767833 rs914875994	165	V>M		No	ClinGen Ensembl
rs1373969717 CA368108186	168	L>V		No	ClinGen gnomAD
rs779366057 CA162767834	169	Q>*		No	ClinGen Ensembl
CA368108193 rs1243695072	169	Q>R		No	ClinGen gnomAD
rs551102163 CA162767835	171	E>V		No	ClinGen 1000Genomes gnomAD
CA162767836 rs868158883	181	E>D		No	ClinGen Ensembl
CA368108279 rs1410417148	182	A>T		No	ClinGen gnomAD
CA4334749 rs779939026	182	A>V		No	ClinGen ExAC gnomAD
TCGA novel	184	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746876558 CA368109406	187	G>A		No	ClinGen ExAC TOPMed gnomAD
CA4334750 rs746876558	187	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1185397175 CA368109437	192	N>D		No	ClinGen gnomAD
TCGA novel	192	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334751 rs146138173	193	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA368109480 rs1437334626	198	D>E		No	ClinGen gnomAD
rs776229393 COSM1134292 CA4334752 COSM453534	198	D>N	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1235104048 CA368109494	200	I>M		No	ClinGen gnomAD
CA162776324 rs950528805	201	H>R		No	ClinGen TOPMed
TCGA novel	203	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769287160 CA4334754	205	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1455284231 CA368109533	206	L>R		No	ClinGen gnomAD
CA368109542 rs1395083598	208	L>F		No	ClinGen TOPMed gnomAD
rs972373326 CA162780257	214	H>N		No	ClinGen TOPMed
TCGA novel	214	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1372152173 CA368108568	215	T>S		No	ClinGen gnomAD
rs1169137821 CA368108666	223	K>E		No	ClinGen gnomAD
CA368108672 rs1207505110	223	K>M		No	ClinGen TOPMed
rs1411044653 CA368108682	224	H>N		No	ClinGen gnomAD
CA368108690 rs747845379	224	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs769531582 CA4334771	226	G>E		No	ClinGen ExAC gnomAD
CA368108700 rs1301086353	226	G>W		No	ClinGen gnomAD
rs777536906 CA4334772	227	G>E		No	ClinGen ExAC TOPMed gnomAD
rs773939489 CA4334775	229	H>L		No	ClinGen ExAC gnomAD
rs760122649 CA4334776	230	P>A		No	ClinGen ExAC TOPMed gnomAD
COSM3778667 COSM3778668 CA4334777 rs373874746	230	P>L	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA368108752 rs1233157690	231	D>G		No	ClinGen TOPMed gnomAD
CA368109607 rs1424639263	236	F>L		No	ClinGen TOPMed
TCGA novel	239	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA162782250 rs889029403	239	Q>R		No	ClinGen Ensembl
rs1277755061 CA368109792	242	R>*		No	ClinGen gnomAD
CA368109795 rs1260973082	242	R>Q		No	ClinGen TOPMed gnomAD
CA368109809 rs1485025266	243	G>A		No	ClinGen gnomAD
TCGA novel	244	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334795 rs150860380	245	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	246	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334796 rs775861080	249	Q>R		No	ClinGen ExAC gnomAD
CA162782254 rs758302947 COSM287481	250	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA4334798 rs769024611	250	R>H		No	ClinGen ExAC TOPMed gnomAD
rs769024611 CA368109900	250	R>L		No	ClinGen ExAC TOPMed gnomAD
CA368109944 rs762051742	254	H>P		No	ClinGen ExAC gnomAD
CA4334800 rs762051742	254	H>R		No	ClinGen ExAC gnomAD
CA368109967 rs1160616800	257	L>R		No	ClinGen gnomAD
rs1194624302 CA368110019	265	S>C		No	ClinGen TOPMed gnomAD
CA4334802 rs376270298	267	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1411190046 CA368110044	269	E>K		No	ClinGen TOPMed
CA368110076 rs1241642909	273	A>G		No	ClinGen gnomAD
rs1336650810 CA368110072	273	A>T		No	ClinGen gnomAD
rs202149959	275	F>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA4334806 rs756057096	276	G>R		No	ClinGen ExAC gnomAD
CA368110094 rs756057096 COSM3950944 COSM3950943	276	G>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA368110500 rs1194426506	278	A>T		No	ClinGen gnomAD
TCGA novel	281	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334828 rs765001934	283	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	287	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA162786294 CA4334829 rs551786255	288	Y>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC gnomAD NCI-TCGA
CA368110573 rs1307197285	289	S>A		No	ClinGen gnomAD
CA4334830 rs202143669	290	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	291	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM298616 rs144455762 CA162786295	291	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA
TCGA novel	294	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs982185188 CA162786297	295	L>S		No	ClinGen TOPMed
CA368110623 rs1294864066	296	W>*		No	ClinGen gnomAD
TCGA novel	302	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334832 rs201692399 COSM1739405 COSM1739404	308	E>Q	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs755525669 CA4334833	308	E>V		No	ClinGen ExAC gnomAD
CA368110716 rs1584164619	311	T>P		No	ClinGen Ensembl
rs537592613 CA4334836	313	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs537592613 CA4334835	313	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA162786298 rs959432374	315	M>I		No	ClinGen TOPMed gnomAD
CA4334837 rs767090072	315	M>V		No	ClinGen ExAC TOPMed gnomAD
CA162786299 rs775101573	316	W>S		No	ClinGen Ensembl
rs769725111 CA4334864	317	G>E		No	ClinGen ExAC gnomAD
CA368109648 rs1450066971	318	V>I		No	ClinGen gnomAD
CA162789538 rs754985656	319	G>V		No	ClinGen Ensembl
rs1327755208 CA368109662	320	C>Y		No	ClinGen gnomAD
rs1224142601 CA368109697	325	M>V		No	ClinGen gnomAD
CA368109711 rs1380755090	326	I>M		No	ClinGen TOPMed
rs1562856505 CA368109738	331	A>T		No	ClinGen Ensembl
CA162789539 rs1034040358	331	A>V		No	ClinGen TOPMed
TCGA novel	333	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	334	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334868 rs751195714	335	M>I		No	ClinGen ExAC TOPMed gnomAD
rs766082964 CA4334867	335	M>T		No	ClinGen ExAC gnomAD
CA162789540 rs955030004	335	M>V		No	ClinGen TOPMed
CA162789541 rs984678329	336	K>R		No	ClinGen TOPMed
COSM1452724 rs759130780 COSM1452723 CA4334869	337	D>G	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA368109789 rs759130780	337	D>V		No	ClinGen ExAC TOPMed gnomAD
rs751060584 CA162789542	338	I>F		No	ClinGen TOPMed gnomAD
CA4334870 rs767018307	339	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA368109815 rs1209507684	339	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA368109833 rs1470121677	340	D>V		No	ClinGen gnomAD
rs756600731 CA4334872	343	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1441195365 CA368109884 COSM198162	344	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs139618090 CA4334873	344	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	347	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754224017 CA4334874	347	L>P		No	ClinGen ExAC gnomAD
CA368109917 rs1304849060	347	L>V		No	ClinGen TOPMed
CA162796279 rs972174121	348	V>A		No	ClinGen TOPMed
TCGA novel	349	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368110362 rs1562881145	352	P>L		No	ClinGen Ensembl
rs780389516 CA4334898	353	N>D		No	ClinGen ExAC gnomAD
rs780389516 CA368110365	353	N>H		No	ClinGen ExAC gnomAD
CA162796280 rs145309096	353	N>S		No	ClinGen ESP TOPMed gnomAD
rs1219740375 CA368110387	356	T>P		No	ClinGen gnomAD
CA368110407 rs1260553592	358	P>L		No	ClinGen gnomAD
rs1216855494 CA368110471	368	P>T		No	ClinGen TOPMed
rs781363070 CA4334918	369	E>G		No	ClinGen ExAC TOPMed gnomAD
rs748125989 CA4334919	370	R>C		No	ClinGen ExAC gnomAD
rs778818423 CA4334921	370	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4334920 rs748125989	370	R>S		No	ClinGen ExAC gnomAD
rs1374152099 CA368111360	373	L>M		No	ClinGen TOPMed
CA4334923 rs573288226	375	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	378	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334924 rs775081722	378	N>S		No	ClinGen ExAC gnomAD
TCGA novel	378	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs34419285 CA4334925	379	L>F		No	ClinGen ExAC gnomAD
rs145058405 CA162800327	379	L>R		No	ClinGen ESP
CA368111405 rs1353929508	380	R>G		No	ClinGen gnomAD
rs1350465482 CA368111407	380	R>K		No	ClinGen TOPMed
CA162800328 rs942444813	381	Q>E		No	ClinGen TOPMed gnomAD
CA368111415 rs1485075798	381	Q>R		No	ClinGen gnomAD
CA368111424 rs1200897899	382	A>V		No	ClinGen gnomAD
rs776256901 CA4334927	383	W>C		No	ClinGen ExAC gnomAD
rs768148638 CA4334926	383	W>R		No	ClinGen ExAC gnomAD
rs1369783458	385	K>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
COSM1673273 COSM48652 CA368110771 rs1369783458 COSM1673272	385	K>N	lung breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1387033887 CA368110779	387	S>G		No	ClinGen gnomAD
CA4334950 rs149042459	388	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4334949 rs149042459	388	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA368110792 rs1305283125	389	V>M		No	ClinGen gnomAD
TCGA novel	390	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1258639898 CA368110804	390	N>K		No	ClinGen gnomAD
CA4334952 rs771292152	390	N>S		No	ClinGen ExAC gnomAD
rs867080085 CA368110805	391	H>N		No	ClinGen gnomAD
rs867080085 CA162804016	391	H>Y		No	ClinGen gnomAD
COSM1452729 rs112642464 COSM1452730 CA4334954	392	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1172848091 CA368110820	393	E>A		No	ClinGen gnomAD
CA4334956 COSM387788 rs376448497	394	D>E	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs991118689 CA162804017	398	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	399	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4334959 rs753868379	401	Q>R		No	ClinGen ExAC gnomAD
CA4334960 rs758412165	402	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1349713779 CA368110876	402	C>Y		No	ClinGen gnomAD
CA162804018 rs371326924	403	S>C		No	ClinGen ESP TOPMed gnomAD
CA368110885 rs371326924	403	S>F		No	ClinGen ESP TOPMed gnomAD
CA368110882 rs1584077863	403	S>P		No	ClinGen Ensembl
rs952608830 CA162804019	404	P>S		No	ClinGen Ensembl
CA368110895 rs1359173552	405	K>R		No	ClinGen gnomAD
CA4334962 rs751441445	406	N>D		No	ClinGen ExAC gnomAD
rs1278345449 CA368110906	407	R>G		No	ClinGen gnomAD
CA4334963 rs754712322	409	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1562909474 CA368110929	411	Q>E		No	ClinGen Ensembl
rs747804971 CA4334965	411	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs750909933 CA162804020	412	A>T		No	ClinGen Ensembl
CA368110958 rs1222497512	415	S>T		No	ClinGen gnomAD
CA4334966 rs562036988 COSM134219	416	H>Y	skin [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs368151673 CA162804022	417	E>*		No	ClinGen ESP TOPMed gnomAD
rs368151673 CA162804021	417	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs1584077963 CA368110977	418	Y>D		No	ClinGen Ensembl
rs1584077967 CA368110980	418	Y>F		No	ClinGen Ensembl
CA368110984 rs1264048227	419	F>L		No	ClinGen gnomAD
TCGA novel	420	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771509192 CA4334969	421	D>A		No	ClinGen ExAC gnomAD
rs746328505 CA4334971	421	D>E		No	ClinGen ExAC gnomAD
rs771509192 CA4334970	421	D>V		No	ClinGen ExAC gnomAD
CA368111005 rs1424766137	422	L>V		No	ClinGen gnomAD
CA4334972 rs372790579	423	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA368111015 rs1368723248	424	P>A		No	ClinGen TOPMed
rs140184613 CA162804025	425	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs546258215 COSM1154869 COSM198193 CA4334975	425	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM1092841 rs140184613 CA4334974 COSM1154868	425	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs200612683 CA4334976	426	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1283530128 CA368111027	427	W>R		No	ClinGen TOPMed gnomAD
CA368111039 rs1584078049	428	E>G		No	ClinGen Ensembl
COSM1488770 COSM453535 rs1229807116 CA368111055	431	D>N	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs773301216 COSM20678 VAR_046765 CA4334996	432	M>I	ovary an ovarian mucinous carcinoma; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ExAC TOPMed dbSNP gnomAD
rs367861451 CA4334997	433	S>A		No	ClinGen ESP ExAC gnomAD
rs1212881786 CA368111085	433	S>C		No	ClinGen gnomAD
rs886566535 CA162804611	434	S>P		No	ClinGen Ensembl
rs768328515 CA4335000	439	P>A		No	ClinGen ExAC gnomAD
rs763896589 CA4335001	440	N>K		No	ClinGen ExAC gnomAD
CA4335002 rs753437995	442	R>K		No	ClinGen ExAC gnomAD
rs1171450340 CA368111151	444	Q>K		No	ClinGen gnomAD
rs778310021 CA4335004	450	S>G		No	ClinGen ExAC TOPMed gnomAD
CA4335005 rs745362270	450	S>N		No	ClinGen ExAC gnomAD
CA4335006 rs758947105	451	M>L		No	ClinGen ExAC gnomAD
CA4335009 rs74839397	452	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4335007 rs145303395	452	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA4335011 rs748346862	453	A>D		No	ClinGen ExAC TOPMed gnomAD
CA368111210 rs1434638099	453	A>S		No	ClinGen gnomAD
rs748346862 CA4335012	453	A>V		No	ClinGen ExAC TOPMed gnomAD
rs773212152 CA4335013	454	F>I		No	ClinGen ExAC TOPMed gnomAD
CA162804613 rs957033108	457	N>K		No	ClinGen TOPMed gnomAD
CA4335014 rs763092368	457	N>S		No	ClinGen ExAC TOPMed gnomAD
CA4335015 rs772202719	458	N>D		No	ClinGen ExAC TOPMed gnomAD
rs775554751 CA4335016	458	N>S		No	ClinGen ExAC gnomAD
CA368111242 rs772202719	458	N>Y		No	ClinGen ExAC TOPMed gnomAD
CA368111260 rs1449491803	460	Y>F		No	ClinGen gnomAD
CA368111263 rs1246743783	461	G>S		No	ClinGen gnomAD
VAR_046766 CA4335019 rs35643773	463	S>R		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs761423097 CA4335020	464	L>P		No	ClinGen ExAC gnomAD
CA162804614 rs199515743	464	L>V		No	ClinGen Ensembl
TCGA novel	465	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368111288 rs1392089669	465	S>P		No	ClinGen TOPMed gnomAD
rs1403771836 CA368111298	466	N>I		No	ClinGen gnomAD
CA368111296 rs1403771836	466	N>T		No	ClinGen gnomAD
CA4335022 rs141334351	467	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368111316 rs1438684659	469	H>N		No	ClinGen gnomAD
CA4335024 rs779484753	469	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs757894840 CA4335023	469	H>R		No	ClinGen ExAC gnomAD

No associated diseases with O94921

3 regional properties for O94921

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	135 - 419	IPR000719
active_site	Serine/threonine-protein kinase, active site	252 - 264	IPR008271
binding_site	Protein kinase, ATP binding site	141 - 164	IPR017441

Functions

		Description
EC Number	2.7.11.22	Protein-serine/threonine kinases
Subcellular Localization	Cell membrane; Peripheral membrane protein Cytoplasm Nucleus	Recruited to the cell membrane by CCNY
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin binding	Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

6 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of canonical Wnt signaling pathway	Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
regulation of transcription involved in G1/S transition of mitotic cell cycle	Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q00526	CDK3	Cyclin-dependent kinase 3	Homo sapiens (Human)	PR
Q15131	CDK10	Cyclin-dependent kinase 10	Homo sapiens (Human)	PR
Q9UQ88	CDK11A	Cyclin-dependent kinase 11A	Homo sapiens (Human)	PR
Q96Q40	CDK15	Cyclin-dependent kinase 15	Homo sapiens (Human)	PR
Q00537	CDK17	Cyclin-dependent kinase 17	Homo sapiens (Human)	PR
P49336	CDK8	Cyclin-dependent kinase 8	Homo sapiens (Human)	PR
Q9BWU1	CDK19	Cyclin-dependent kinase 19	Homo sapiens (Human)	PR
P50750	CDK9	Cyclin-dependent kinase 9	Homo sapiens (Human)	PR
Q5MAI5	CDKL4	Cyclin-dependent kinase-like 4	Homo sapiens (Human)	PR
Q00532	CDKL1	Cyclin-dependent kinase-like 1	Homo sapiens (Human)	PR
Q92772	CDKL2	Cyclin-dependent kinase-like 2	Homo sapiens (Human)	PR
Q8IZL9	CDK20	Cyclin-dependent kinase 20	Homo sapiens (Human)	PR
P21127	CDK11B	Cyclin-dependent kinase 11B	Homo sapiens (Human)	PR
Q8K0D0	Cdk17	Cyclin-dependent kinase 17	Mus musculus (Mouse)	PR
O35495	Cdk14	Cyclin-dependent kinase 14	Mus musculus (Mouse)	PR
O35831	Cdk17	Cyclin-dependent kinase 17	Rattus norvegicus (Rat)	PR
Q5Z754	CDKF-1	Cyclin-dependent kinase F-1	Oryza sativa subsp japonica (Rice)	PR
Q9S713	STN7	Serine/threonine-protein kinase STN7, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
A4IIW7	cdk14	Cyclin-dependent kinase 14	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q1RLU9	cdk15	Cyclin-dependent kinase 15	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MCDLIEPQPA	EKIGKMKKLR	RTLSESFSRI	ALKKDDTTFD	EICVTKMSTR	NCQGMDSVIK
70	80	90	100	110	120
PLDTIPEDKK	VRVQRTQSTF	DPFEKPANQV	KRVHSENNAC	INFKTSSTGK	ESPKVRRHSS
130	140	150	160	170	180
PSSPTSPKFG	KADSYEKLEK	LGEGSYATVY	KGKSKVNGKL	VALKVIRLQE	EEGTPFTAIR
190	200	210	220	230	240
EASLLKGLKH	ANIVLLHDII	HTKETLTLVF	EYVHTDLCQY	MDKHPGGLHP	DNVKLFLFQL
250	260	270	280	290	300
LRGLSYIHQR	YILHRDLKPQ	NLLISDTGEL	KLADFGLARA	KSVPSHTYSN	EVVTLWYRPP
310	320	330	340	350	360
DVLLGSTEYS	TCLDMWGVGC	IFVEMIQGVA	AFPGMKDIQD	QLERIFLVLG	TPNEDTWPGV
370	380	390	400	410	420
HSLPHFKPER	FTLYSSKNLR	QAWNKLSYVN	HAEDLASKLL	QCSPKNRLSA	QAALSHEYFS
430	440	450	460
DLPPRLWELT	DMSSIFTVPN	VRLQPEAGES	MRAFGKNNSY	GKSLSNSKH