O93602

SS
Gene name
ATF2
Protein name
Cyclic AMP-dependent transcription factor ATF-2
Names
cAMP-dependent transcription factor ATF-2 , Activating transcription factor 2
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395727
EC number
Protein Class

Descriptions

ATF-2 is a cellular basic region-leucine zipper (bZIP) transcription factor that can mediate diverse transcriptional responses, including activation by the adenovirus Ela protein. ATF-2 contains an activation domain, required for transcriptional activity, but in the absence of an appropriate inducer, full-length ATF-2 is transcriptionally inactive. The ATF-2 bZIP (residues 350-415) suppresses the ATF-2 and the related Ela activation domains but not acidic- and glutamine-rich activation domains. The ATF-2 bZIP and activation domain are engaged in an inhibitory intramolecular interaction and the inducers of ATF-2 disrupt this interaction to activate transcription.

Autoinhibitory domains (AIDs)

332-397 (bZIP domain) SS

Target domain

0-91 (Activation domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O93602

Entry ID Method Resolution Chain Position Source
AF-O93602-F1 Predicted AlphaFoldDB

No variants for O93602

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O93602

No associated diseases with O93602

2 regional properties for O93602

Type Name Position InterPro Accession
domain Basic-leucine zipper domain 332 - 397 IPR004827
domain Zinc finger C2H2-type 7 - 31 IPR013087

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Mitochondrion outer membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
cAMP response element binding Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA damage response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P15408 FOSL2 Fos-related antigen 2 Homo sapiens (Human) PR
Q02930 CREB5 Cyclic AMP-responsive element-binding protein 5 Homo sapiens (Human) SS
P17544 ATF7 Cyclic AMP-dependent transcription factor ATF-7 Homo sapiens (Human) PR
P15336 ATF2 Cyclic AMP-dependent transcription factor ATF-2 Homo sapiens (Human) EV
P47930 Fosl2 Fos-related antigen 2 Mus musculus (Mouse) PR
Q8R0S1 Atf7 Cyclic AMP-dependent transcription factor ATF-7 Mus musculus (Mouse) PR
P16951 Atf2 Cyclic AMP-dependent transcription factor ATF-2 Mus musculus (Mouse) SS
Q00969 Atf2 Cyclic AMP-dependent transcription factor ATF-2 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSDDKPFLCT APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RNDSVIVADQ TPTPTRFLKN
70 80 90 100 110 120
CEEVGLFNEL ASPFENEFKK ASEDDIKKMP LDLSPLATPI IRNKIEEPSV VETTHQDSPL
130 140 150 160 170 180
PHPESTTNDE KEVSLQQTAQ PTSTIVRPAS LQVPNVLLTS SDSSVIIQQA IPSPTSSTVI
190 200 210 220 230 240
TQAPSSNRPI VPVPGPFPLL LHLPNGQTMP VAIPASITNS NVHVPAAVPL VRPVTMVPSI
250 260 270 280 290 300
PGIPGPSSPQ PVQSEAKLRL KAALTQQHPQ VTNGDTAKGH PSGLVRTQSE EPRPQSLQQP
310 320 330 340 350 360
ATSTTETPAS PAQPTQQTPN TGGRRRRAAN EDPDEKRRKF LERNRAAASR CRQKRKVWVQ
370 380 390 400 410 420
SLEKKAEDLS SLNGQLQNEV TLLRNEVAQL KQLLLAHKDC PVTAMQKKSG YHTADKDDSS
430 440 450 460 470 480
EDISVPSSPH TEAIQHSSVS TSNGVSSTSK AEAVATSVLT QLADQSSEPG LPQVGVVPPS
QAQPSGS