O89033
PR
Gene name |
Cdc6 |
Protein name |
Cell division control protein 6 homolog |
Names |
CDC6-related protein, p62(cdc6) |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:23834 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O89033
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O89033-F1 | Predicted | AlphaFoldDB |
42 variants for O89033
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs587286679 | 26 | P>T | No | EVA | |
| rs27026106 | 37 | N>K | No | EVA | |
| rs249697698 | 39 | Q>H | No | EVA | |
| rs3389195398 | 44 | T>N | No | EVA | |
| rs27026105 | 47 | V>A | No | EVA | |
| rs3389186493 | 86 | P>T | No | EVA | |
| rs245057936 | 105 | F>V | No | EVA | |
| rs3389195383 | 106 | K>N | No | EVA | |
| rs27026098 | 109 | P>T | No | EVA | |
| rs224551111 | 110 | P>Q | No | EVA | |
| rs3389193524 | 111 | K>E | No | EVA | |
| rs244564009 | 122 | R>S | No | EVA | |
| rs240565846 | 134 | A>T | No | EVA | |
| rs3389206889 | 157 | T>I | No | EVA | |
| rs3402794835 | 159 | Y>* | No | EVA | |
| rs3389193450 | 186 | N>S | No | EVA | |
| rs3389173646 | 197 | A>V | No | EVA | |
| rs3389136405 | 215 | S>R | No | EVA | |
| rs3389186444 | 221 | F>I | No | EVA | |
| rs3389169601 | 234 | N>I | No | EVA | |
| rs3389206913 | 247 | A>S | No | EVA | |
| rs3389206850 | 247 | A>V | No | EVA | |
| rs27026095 | 261 | A>S | No | EVA | |
| rs257647666 | 275 | A>V | No | EVA | |
| rs3389200038 | 278 | G>V | No | EVA | |
| rs3389136432 | 285 | L>* | No | EVA | |
| rs3389195458 | 294 | K>I | No | EVA | |
| rs3389161742 | 304 | E>Q | No | EVA | |
| rs3389214892 | 311 | S>Y | No | EVA | |
| rs3389214919 | 342 | L>I | No | EVA | |
| rs221538184 | 362 | S>N | No | EVA | |
| rs3402684020 | 397 | R>G | No | EVA | |
| rs245349813 | 418 | E>K | No | EVA | |
| rs258653810 | 419 | C>G | No | EVA | |
| rs3389136417 | 454 | N>I | No | EVA | |
| rs3389203144 | 467 | V>A | No | EVA | |
| rs3389206894 | 470 | L>S | No | EVA | |
| rs3389210412 | 484 | L>M | No | EVA | |
| rs578518235 | 486 | K>R | No | EVA | |
| rs3389214866 | 497 | K>N | No | EVA | |
| rs3389206870 | 545 | H>P | No | EVA | |
| rs27026057 | 548 | N>K | No | EVA |
No associated diseases with O89033
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intercellular bridge | A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA replication origin binding | Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic DNA replication checkpoint signaling | A signal transduction process that contributes to a mitotic DNA replication checkpoint. |
| positive regulation of chromosome segregation | Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that activates or increases the frequency, rate or extent of CDK activity. |
| positive regulation of cytokinesis | Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. |
| positive regulation of fibroblast proliferation | Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
| regulation of mitotic metaphase/anaphase transition | Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPQTRSQTQA | TIGFPKKKLS | NTLKKPNSRD | CEVKLRNVQP | VPTTPCVDVK | LLPLSPRKRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDDNLCNTPR | LSPCSPPKLG | KKENGPPRSH | TWKGCRLVFD | DEPTFKASPP | KEQDRVRQHQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IRSSSAQRSP | ESKADPEQKC | PPEKESVCIR | LFKQEGTCYQ | QAKLVLNTAV | PDRLPAREQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MGVIRNFLKE | HICGKKAGSL | YLSGAPGTGK | TACLSRILQD | FKKEVKGFKS | ILLNCMSLRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AQAVFPAIAQ | EIGREELCRP | AGKDLMRKLE | KHLTAEKGPM | IVLVLDEMDQ | LDSKGQDVLY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLFEWPWLSN | SRLVLIGIAN | TLDLTDRILP | RLEARENCKP | QLLNFPPYTR | NQIAAILQDR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSQVSKDQVL | DSAAIQFCAR | KVSAVSGDIR | KALDVCRRAI | EIVESDVRSQ | TVLKPLSECK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SPSESPVPKR | VGLAHISQVI | SEVDGNRVTL | SQENTQDSLP | LQQKILVCSL | LLLTRRLKIK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EVTLGKLYEA | YSSICRKQQV | TAVDQSECLS | LSGLLESRGL | VGLKKNKESR | LTKVSLKIEE |
| 550 | 560 | ||||
| KEIEHVLNGK | AFTGNILAAG | LP |