Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88874
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88874-F1 | Predicted | AlphaFoldDB |
No variants for O88874
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O88874 | |||||
No associated diseases with O88874
4 regional properties for O88874
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, C-terminal domain | 158 - 278 | IPR004367 |
| domain | Cyclin, N-terminal | 42 - 155 | IPR006671 |
| domain | Cyclin-like domain | 55 - 149 | IPR013763-1 |
| domain | Cyclin-like domain | 162 - 256 | IPR013763-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin K-CDK12 complex | A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. |
| cyclin K-CDK13 complex | A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. |
| cyclin/CDK positive transcription elongation factor complex | A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase activator activity | Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| negative regulation by host of viral genome replication | A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication. |
| negative regulation of stem cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. |
| phosphorylation of RNA polymerase II C-terminal domain | The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. |
| positive regulation of DNA-templated transcription, elongation | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues | Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues. |
| positive regulation of transcription elongation by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
| regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6T8E9 | CCNT1 | Cyclin-T1 | Bos taurus (Bovine) | SS |
| Q8HXN7 | CCNT1 | Cyclin-T1 | Pan troglodytes (Chimpanzee) | SS |
| O60563 | CCNT1 | Cyclin-T1 | Homo sapiens (Human) | EV |
| Q8N1B3 | CCNQ | Cyclin-Q | Homo sapiens (Human) | PR |
| O75909 | CCNK | Cyclin-K | Homo sapiens (Human) | PR |
| Q9QWV9 | Ccnt1 | Cyclin-T1 | Mus musculus (Mouse) | SS |
| Q61458 | Ccnh | Cyclin-H | Mus musculus (Mouse) | PR |
| Q62447 | Ccnc | Cyclin-C | Mus musculus (Mouse) | PR |
| Q2QQS5 | CYCT1-1 | Cyclin-T1-4 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z7H3 | CYCT1_2 | Cyclin-T1-2 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAC5 | CYCT1-3 | Cyclin-T1-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q8GYM6 | CYCT1-4 | Cyclin-T1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q503D6 | ccnq | Cyclin-Q | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKENKENSSP | SVTSANLDHT | KPCWYWDKKD | LAHTPSQLEG | LDPATEARYR | REGARFIFDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTRLGLHYDT | LATGIIYFHR | FYMFHSFKQF | PRYVTGACCL | FLAGKVEETP | KKCKDIIKTA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSLLNDVQFG | QFGDDPKEEV | MVLERILLQT | IKFDLQVEHP | YQFLLKYAKQ | LKGDKNKIQK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVQMAWTFVN | DSLCTTLSLQ | WEPEIIAVAV | MYLAGRLCKF | EIQEWTSKPM | YRRWWEQFVQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DVPVDVLEDI | CHQILDLYSQ | GKQQMPHHTP | HQLQQPPSLQ | PTPQVPQGPQ | SQPSQGSEAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QPPQKDSQQS | AQQQQQQAQQ | PKKPSPQPSP | PRQAKRAVVV | SPKEENKATE | PPPPPKIPKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EATHPPLPPA | HPPPDRKPPL | APALGEAEAT | GPVETSDLPK | VQIPPPAHPA | PVHQPPPLPH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RPPPPPPSSY | MTGMSTTSSY | MSGEGYQSLQ | SMMKTEGPSY | GALPPASFPP | PTIPPPTPGY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPPPPTYNPN | FPPPPPRLPP | THAVPPHPPP | GLGLPPASYP | PPAVPPGGQP | PVPPPIPPPG |
| 550 | |||||
| MPPVGGLGRA | AWMR |