O88746
PR
Gene name |
Tom1 |
Protein name |
Target of Myb1 membrane trafficking protein |
Names |
Target of Myb protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21968 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88746
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88746-F1 | Predicted | AlphaFoldDB |
18 variants for O88746
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388968019 | 54 | V>L | No | EVA | |
| rs3388944224 | 87 | V>E | No | EVA | |
| rs3388996584 | 151 | F>Y | No | EVA | |
| rs3388991985 | 158 | M>I | No | EVA | |
| rs3388996637 | 178 | Q>L | No | EVA | |
| rs3388964046 | 197 | P>L | No | EVA | |
| rs3388991896 | 229 | G>E | No | EVA | |
| rs3399474931 | 248 | P>H | No | EVA | |
| rs3388984793 | 260 | T>I | No | EVA | |
| rs3388944226 | 285 | L>P | No | EVA | |
| rs224321117 | 315 | E>D | No | EVA | |
| rs3388944172 | 327 | P>L | No | EVA | |
| rs3388979511 | 335 | L>I | No | EVA | |
| rs3388996615 | 378 | A>V | No | EVA | |
| rs3388984757 | 393 | D>Y | No | EVA | |
| rs3388964044 | 442 | E>K | No | EVA | |
| rs579900101 | 471 | P>S | No | EVA | |
| rs254344360 | 483 | E>D | No | EVA |
No associated diseases with O88746
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| clathrin heavy chain binding | Binding to a clathrin heavy chain. |
| myosin VI binding | Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. |
| phosphatidylinositol-5-phosphate binding | Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
| polyubiquitin modification-dependent protein binding | Binding to a protein upon poly-ubiquitination of the target protein. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome-lysosome fusion | The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| positive regulation of autophagosome maturation | Any process that activates or increases the frequency, rate or extent of autophagosome maturation. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of endosome organization | Any process that modulates the frequency, rate or extent of endosome organization. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| substrate localization to autophagosome | The localization process by which an autophagic substrate is delivered to a forming autophagosome. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NZ52 | GGA3 | ADP-ribosylation factor-binding protein GGA3 | Homo sapiens (Human) | EV |
| O75674 | TOM1L1 | TOM1-like protein 1 | Homo sapiens (Human) | SS |
| Q6ZVM7 | TOM1L2 | TOM1-like protein 2 | Homo sapiens (Human) | SS |
| Q8BMI3 | Gga3 | ADP-ribosylation factor-binding protein GGA3 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFLLGNPFS | SPVGQRIEKA | TDGSLQSEDW | ALNMEICDII | NETEEGPKDA | FRAVKKRIMG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKNFHEVMLA | LTVLETCVKN | CGHRFHVLVA | NQDFVENVLV | RTILPKNNPP | TIVHDKVLNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQSWADAFRS | SPDLTGVVAV | YEDLRRKGLE | FPMTDLDMLS | PIHTPQRTVF | NSETPSRQNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSSNTSQRGD | LSQHATPLPT | PAVLPGDSPI | TPTPEQIGKL | RSELEMVSGN | VRVMSEMLTE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVPTQVEPAD | LELLQELNRT | CRAMQQRILE | LIPRISNEQL | TEELLMINDN | LNNVFLRHER |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FERFRTGQTA | KASSEAELAT | DLIDMGPDPA | ATNNLSSQLA | GMNLGSRSVR | AGLQSLETSG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HLEDDFDMFA | LTRGSSLADQ | RKGVKYEAPQ | TTDGLAGALD | ARQQSTGAIP | ATQARIMEDI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EQWLSTDVGN | SAEEPSGVTS | EEFDKFLEER | AKAADRLPNL | ASPSAEGPPR | PSPGTAPRRK |
| 490 | |||||
| TQEKDDDMLF | AL |