O88506

PR
Gene name
Stk39 (Pask, Spak)
Protein name
STE20/SPS1-related proline-alanine-rich protein kinase
Names
Ste-20-related kinase, Pancreatic serine/threonine-protein kinase, PS/TK, PSTK1, Serine/threonine-protein kinase 39
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:54348
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

218-246 (Activation loop from InterPro)

Target domain

72-346 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O88506

Entry ID Method Resolution Chain Position Source
AF-O88506-F1 Predicted AlphaFoldDB

No variants for O88506

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O88506

No associated diseases with O88506

3 regional properties for O88506

Type Name Position InterPro Accession
domain Protein kinase domain 72 - 346 IPR000719
binding_site Protein kinase, ATP binding site 78 - 101 IPR017441
domain Serine/threonine-protein kinase OSR1/WNK, CCT domain 460 - 517 IPR024678

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Nucleus when caspase-cleaved
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

29 GO annotations of biological process

Name Definition
cellular chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
cellular hypotonic response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
cellular response to chemokine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
cellular response to potassium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
chemokine (C-X-C motif) ligand 12 signaling pathway The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
ion homeostasis Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
macrophage activation A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
maintenance of lens transparency A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.
negative regulation of creatine transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity.
negative regulation of pancreatic juice secretion Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.
negative regulation of potassium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.
negative regulation of potassium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.
negative regulation of sodium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of ion transmembrane transporter activity Any process that activates or increases the activity of an ion transporter.
positive regulation of p38MAPK cascade Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
positive regulation of potassium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of T cell chemotaxis Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of blood pressure Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
response to aldosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus.
response to dietary excess The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C0K7 STRADB STE20-related kinase adapter protein beta Homo sapiens (Human) PR
Q7RTN6 STRADA STE20-related kinase adapter protein alpha Homo sapiens (Human) PR
O95747 OXSR1 Serine/threonine-protein kinase OSR1 Homo sapiens (Human) PR
Q9UEW8 STK39 STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens (Human) PR
Q8K4T3 Stradb STE20-related kinase adapter protein beta Mus musculus (Mouse) PR
Q3UUJ4 Strada STE20-related kinase adapter protein alpha Mus musculus (Mouse) PR
Q6P9R2 Oxsr1 Serine/threonine-protein kinase OSR1 Mus musculus (Mouse) PR
Q9Z1W9 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus (Mouse) PR
Q863I2 OXSR1 Serine/threonine-protein kinase OSR1 Sus scrofa (Pig) PR
Q7TNZ6 Strada STE20-related kinase adapter protein alpha Rattus norvegicus (Rat) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
B0LT89 Stk24 Serine/threonine-protein kinase 24 Rattus norvegicus (Rat) PR
E9PTG8 Stk10 Serine/threonine-protein kinase 10 Rattus norvegicus (Rat) PR
O23304 BLUS1 Serine/threonine-protein kinase BLUS1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAEPSGSPVH VQLPQQAAPV TAAAAAPAAA TSAPAPAPAP AAPAAPAPAP AAAPAPAPAA
70 80 90 100 110 120
QAVGWPICRD AYELQEVIGS GATAVVQAAL CKPRQERVAI KRINLEKCQT SMDELLKEIQ
130 140 150 160 170 180
AMSQCSHPNV VTYYTSFVVK DELWLVMKLL SGGSMLDIIK YIVNRGEHKN GVLEEAIIAT
190 200 210 220 230 240
ILKEVLEGLD YLHRNGQIHR DLKAGNILLG EDGSVQIADF GVSAFLATGG DVTRNKVRKT
250 260 270 280 290 300
FVGTPCWMAP EVMEQVRGYD FKADMWSFGI TAIELATGAA PYHKYPPMKV LMLTLQNDPP
310 320 330 340 350 360
TLETGVEDKE MMKKYGKSFR KLLSLCLQKD PSKRPTAAEL LKCKFFQKAK NREYLIEKLL
370 380 390 400 410 420
TRTPDIAQRA KKVRRVPGSS GHLHKTEDGD WEWSDDEMDE KSEEGKAAAS QEKSRRVKEE
430 440 450 460 470 480
NPEISVNAGG IPEQIQSLSV HDSQGQPNAN EDYREGPCAV NLVLRLRNSR KELNDIRFEF
490 500 510 520 530 540
TPGRDTADGV SQELFSAGLV DGHDVVIVAA NLQKIVDDPK ALKTLTFKLA SGCDGAEIPD
550
EVKLIGFAQL SVS