O81415
SS
Gene name |
PME39 (ARATH39, At4g02300, T2H3.6) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 39 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G02300 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
222-517 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O81415
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O81415-F1 | Predicted | AlphaFoldDB |
104 variants for O81415
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10530464 | 2 | I>M | No | 1000Genomes | |
| tmp_4_1013022_G_A | 5 | H>Y | No | 1000Genomes | |
| tmp_4_1013000_T_C | 12 | K>R | No | 1000Genomes | |
| ENSVATH10530463 | 13 | H>Y | No | 1000Genomes | |
| ENSVATH02621214 | 14 | I>T | No | 1000Genomes | |
| ENSVATH06423176 | 15 | I>L | No | 1000Genomes | |
| ENSVATH10530462 | 16 | F>L | No | 1000Genomes | |
| tmp_4_1012976_G_A | 20 | S>L | No | 1000Genomes | |
| ENSVATH13881219 | 21 | L>P | No | 1000Genomes | |
| ENSVATH06423174 | 31 | V>L | No | 1000Genomes | |
| ENSVATH00454688 | 35 | Q>H | No | 1000Genomes | |
| ENSVATH06423173 | 36 | S>P | No | 1000Genomes | |
| ENSVATH10530460 | 37 | P>Q | No | 1000Genomes | |
| tmp_4_1012926_G_A | 37 | P>S | No | 1000Genomes | |
| ENSVATH02621212 | 42 | H>Y | No | 1000Genomes | |
| ENSVATH00454687 | 45 | Q>K | No | 1000Genomes | |
| tmp_4_1012877_A_G | 53 | I>T | No | 1000Genomes | |
| tmp_4_1012859_G_A | 59 | A>V | No | 1000Genomes | |
| ENSVATH00454684 | 62 | N>D | No | 1000Genomes | |
| tmp_4_1012833_C_T | 68 | V>I | No | 1000Genomes | |
| ENSVATH06423171 | 76 | S>P | No | 1000Genomes | |
| ENSVATH02621211 | 77 | D>N | No | 1000Genomes | |
| tmp_4_1012791_G_A | 82 | L>F | No | 1000Genomes | |
| ENSVATH06423170 | 83 | F>L | No | 1000Genomes | |
| tmp_4_1012739_C_G | 99 | G>A | No | 1000Genomes | |
| tmp_4_1012740_C_G | 99 | G>R | No | 1000Genomes | |
| tmp_4_1012736_A_T | 100 | L>Q | No | 1000Genomes | |
| tmp_4_1012731_C_T | 102 | D>N | No | 1000Genomes | |
| ENSVATH02621209 | 107 | D>N | No | 1000Genomes | |
| ENSVATH02621209 | 107 | D>Y | No | 1000Genomes | |
| tmp_4_1012710_C_T | 109 | E>K | No | 1000Genomes | |
| ENSVATH06423166 | 117 | S>P | No | 1000Genomes | |
| tmp_4_1012672_C_G | 121 | E>D | No | 1000Genomes | |
| tmp_4_1012627_T_A | 136 | Q>H | No | 1000Genomes | |
| ENSVATH00454681 | 141 | D>G | No | 1000Genomes | |
| tmp_4_1012611_C_A | 142 | G>C | No | 1000Genomes | |
| tmp_4_1012598_C_G | 146 | S>T | No | 1000Genomes | |
| ENSVATH10530459 | 151 | N>S | No | 1000Genomes | |
| ENSVATH10530457 | 170 | S>C | No | 1000Genomes | |
| ENSVATH00454679 | 171 | N>K | No | 1000Genomes | |
| ENSVATH06423165 | 171 | N>T | No | 1000Genomes | |
| tmp_4_1012479_T_C | 186 | K>E | No | 1000Genomes | |
| ENSVATH02621208 | 187 | K>N | No | 1000Genomes | |
| ENSVATH10530456 | 191 | K>T | No | 1000Genomes | |
| ENSVATH06423164 | 195 | V>L | No | 1000Genomes | |
| ENSVATH00454677 | 198 | E>V | No | 1000Genomes | |
| tmp_4_1012428_G_C | 203 | L>V | No | 1000Genomes | |
| ENSVATH06423163 | 205 | E>V | No | 1000Genomes | |
| tmp_4_1012398_C_T | 213 | A>T | No | 1000Genomes | |
| ENSVATH06423162 | 215 | V>L | No | 1000Genomes | |
| ENSVATH00454676 | 217 | E>V | No | 1000Genomes | |
| ENSVATH10530455 | 222 | L>R | No | 1000Genomes | |
| tmp_4_1012371_G_C | 222 | L>V | No | 1000Genomes | |
| tmp_4_1012364_A_G | 224 | V>A | No | 1000Genomes | |
| ENSVATH06423161 | 227 | D>G | No | 1000Genomes | |
| tmp_4_1012352_C_T | 228 | G>D | No | 1000Genomes | |
| tmp_4_1012347_C_G | 230 | G>R | No | 1000Genomes | |
| ENSVATH06423160 | 235 | I>T | No | 1000Genomes | |
| ENSVATH10530443 | 237 | D>N | No | 1000Genomes | |
| ENSVATH10530442 | 238 | A>V | No | 1000Genomes | |
| tmp_4_1012301_A_T | 245 | M>K | No | 1000Genomes | |
| tmp_4_1012302_T_C | 245 | M>V | No | 1000Genomes | |
| tmp_4_1011677_A_G | 251 | I>T | No | 1000Genomes | |
| tmp_4_1011670_A_T | 253 | Y>* | No | 1000Genomes | |
| ENSVATH02621184 | 259 | Y>H | No | 1000Genomes | |
| tmp_4_1011630_T_C | 267 | K>E | No | 1000Genomes | |
| ENSVATH02621183 | 270 | T>I | No | 1000Genomes | |
| ENSVATH06423152 | 275 | I>N | No | 1000Genomes | |
| tmp_4_1011593_A_C | 279 | I>S | No | 1000Genomes | |
| ENSVATH00454674 | 282 | T>A | No | 1000Genomes | |
| tmp_4_1011531_G_C | 300 | P>A | No | 1000Genomes | |
| ENSVATH00454670 | 309 | Y>F | No | 1000Genomes | |
| ENSVATH00454669 | 310 | I>V | No | 1000Genomes | |
| tmp_4_1010006_G_C | 320 | A>G | No | 1000Genomes | |
| tmp_4_1009970_C_G | 332 | S>T | No | 1000Genomes | |
| tmp_4_1009962_C_T | 335 | D>N | No | 1000Genomes | |
| tmp_4_1009952_G_A | 338 | A>V | No | 1000Genomes | |
| tmp_4_1009940_C_G | 342 | C>S | No | 1000Genomes | |
| tmp_4_1009904_T_A,G | 354 | H>L | No | 1000Genomes | |
| tmp_4_1009904_T_A,G | 354 | H>P | No | 1000Genomes | |
| ENSVATH00454667 | 354 | H>Q | No | 1000Genomes | |
| ENSVATH06423101 | 359 | F>L | No | 1000Genomes | |
| ENSVATH06423100 | 365 | I>M | No | 1000Genomes | |
| tmp_4_1009851_T_A | 372 | I>L | No | 1000Genomes | |
| ENSVATH00454664 | 417 | C>S | No | 1000Genomes | |
| ENSVATH06423098 | 423 | P>A | No | 1000Genomes | |
| ENSVATH02621091 | 428 | V>E | No | 1000Genomes | |
| ENSVATH00454662 | 433 | K>M | No | 1000Genomes | |
| ENSVATH06423097 | 438 | R>Q | No | 1000Genomes | |
| ENSVATH02621088 | 449 | I>V | No | 1000Genomes | |
| tmp_4_1009604_T_C | 454 | D>G | No | 1000Genomes | |
| tmp_4_1009605_C_T | 454 | D>N | No | 1000Genomes | |
| ENSVATH02621086 | 465 | G>W | No | 1000Genomes | |
| ENSVATH06423095 | 469 | F>L | No | 1000Genomes | |
| ENSVATH13881109 | 470 | A>S | No | 1000Genomes | |
| tmp_4_1009547_G_A | 473 | T>I | No | 1000Genomes | |
| ENSVATH00454660 | 489 | A>T | No | 1000Genomes | |
| ENSVATH06423094 | 494 | W>* | No | 1000Genomes | |
| ENSVATH10530028 | 499 | R>L | No | 1000Genomes | |
| tmp_4_1009464_C_T | 501 | E>K | No | 1000Genomes | |
| tmp_4_1009417_G_T | 516 | D>E | No | 1000Genomes | |
| ENSVATH06423093 | 529 | S>C | No | 1000Genomes | |
| ENSVATH10530027 | 529 | S>I | No | 1000Genomes | |
| ENSVATH10530027 | 529 | S>N | No | 1000Genomes |
No associated diseases with O81415
No regional properties for O81415
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O81415 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| defense response to Gram-negative bacterium | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MINNHPIREK | PKHIIFNLLS | LIFFLIFLST | VVSSQSPSYT | THKTQRLTET | KTIPELIIAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNLTILKVNL | ASSNFSDLQT | RLFPNLTHYE | RCAFEDCLGL | LDDTISDLET | AVSDLRSSSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EFNDISMLLT | NVMTYQDTCL | DGFSTSDNEN | NNDMTYELPE | NLKEIILDIS | NNLSNSLHML |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QVISRKKPSP | KSSEVDVEYP | SWLSENDQRL | LEAPVQETNY | NLSVAIDGTG | NFTTINDAVF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAPNMSETRF | IIYIKGGEYF | ENVELPKKKT | MIMFIGDGIG | KTVIKANRSR | IDGWSTFQTP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TVGVKGKGYI | AKDISFVNSA | GPAKAQAVAF | RSGSDHSAFY | RCEFDGYQDT | LYVHSAKQFY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RECDIYGTID | FIFGNAAVVF | QNSSLYARKP | NPGHKIAFTA | QSRNQSDQPT | GISILNCRIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AAPDLIPVKE | NFKAYLGRPW | RKYSRTVIIK | SFIDDLIHPA | GWLEGKKDFA | LETLYYGEYM |
| 490 | 500 | 510 | 520 | 530 | |
| NEGPGANMAK | RVTWPGFRRI | ENQTEATQFT | VGPFIDGSTW | LNSTGIPFSL | GF |