O81320
SS
Gene name |
PME38 (ARATH38, At4g00190, F6N15.23) |
Protein name |
Putative pectinesterase/pectinesterase inhibitor 38 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G00190 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
164-461 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O81320
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O81320-F1 | Predicted | AlphaFoldDB |
61 variants for O81320
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_81932_A_G | 37 | S>P | No | 1000Genomes | |
| ENSVATH06401779 | 41 | T>K | No | 1000Genomes | |
| ENSVATH10459461 | 43 | D>A | No | 1000Genomes | |
| ENSVATH06401778 | 46 | V>I | No | 1000Genomes | |
| ENSVATH02600998 | 48 | A>T | No | 1000Genomes | |
| ENSVATH02600997 | 54 | F>V | No | 1000Genomes | |
| tmp_4_81878_GAAAATA_CAAAATA,G | 55 | L>V | No | 1000Genomes | |
| tmp_4_81846_C_T | 65 | W>* | No | 1000Genomes | |
| tmp_4_81791_A_T | 84 | L>M | No | 1000Genomes | |
| tmp_4_81761_C_A | 94 | D>Y | No | 1000Genomes | |
| ENSVATH13860079 | 98 | W>C | No | 1000Genomes | |
| ENSVATH06401776 | 103 | L>F | No | 1000Genomes | |
| ENSVATH10459456 | 110 | Q>* | No | 1000Genomes | |
| ENSVATH10459442 | 142 | Q>R | No | 1000Genomes | |
| ENSVATH06401775 | 144 | G>V | No | 1000Genomes | |
| tmp_4_81481_G_A | 150 | S>L | No | 1000Genomes | |
| tmp_4_81464_T_G | 156 | T>P | No | 1000Genomes | |
| ENSVATH10459441 | 159 | I>V | No | 1000Genomes | |
| ENSVATH10459440 | 166 | V>L | No | 1000Genomes | |
| tmp_4_81431_C_T | 167 | V>M | No | 1000Genomes | |
| ENSVATH02600991 | 169 | Q>H | No | 1000Genomes | |
| ENSVATH02600990 | 170 | D>G | No | 1000Genomes | |
| ENSVATH06401774 | 182 | V>M | No | 1000Genomes | |
| ENSVATH02600989 | 189 | L>P | No | 1000Genomes | |
| ENSVATH10459438 | 192 | S>I | No | 1000Genomes | |
| ENSVATH00804106 | 199 | V>A | No | 1000Genomes | |
| tmp_4_81296_T_A | 212 | I>F | No | 1000Genomes | |
| tmp_4_81286_T_A | 215 | N>I | No | 1000Genomes | |
| tmp_4_81260_T_A | 224 | I>F | No | 1000Genomes | |
| tmp_4_81235_T_C | 232 | D>G | No | 1000Genomes | |
| ENSVATH10459435 | 250 | E>* | No | 1000Genomes | |
| ENSVATH10459423 | 259 | I>M | No | 1000Genomes | |
| tmp_4_81073_C_G | 262 | R>T | No | 1000Genomes | |
| tmp_4_80995_C_G | 288 | S>T | No | 1000Genomes | |
| tmp_4_80993_T_G | 289 | I>L | No | 1000Genomes | |
| tmp_4_80974_G_A | 295 | T>I | No | 1000Genomes | |
| tmp_4_80944_A_G | 305 | F>S | No | 1000Genomes | |
| tmp_4_80918_C_G | 314 | V>L | No | 1000Genomes | |
| tmp_4_80890_G_A | 323 | A>V | No | 1000Genomes | |
| tmp_4_80887_A_C | 324 | V>G | No | 1000Genomes | |
| tmp_4_80876_A_T | 328 | C>S | No | 1000Genomes | |
| tmp_4_80872_C_A | 329 | R>L | No | 1000Genomes | |
| ENSVATH06401768 | 340 | N>S | No | 1000Genomes | |
| tmp_4_80836_G_A | 341 | T>I | No | 1000Genomes | |
| tmp_4_80822_T_A | 346 | S>C | No | 1000Genomes | |
| tmp_4_80788_A_T | 357 | V>E | No | 1000Genomes | |
| tmp_4_80755_C_T | 368 | G>E | No | 1000Genomes | |
| tmp_4_80753_C_A | 369 | V>L | No | 1000Genomes | |
| tmp_4_80705_A_G | 385 | Y>H | No | 1000Genomes | |
| tmp_4_80674_A_T | 395 | L>H | No | 1000Genomes | |
| ENSVATH02600983 | 405 | I>V | No | 1000Genomes | |
| tmp_4_80626_G_T | 411 | T>K | No | 1000Genomes | |
| ENSVATH00804104 | 414 | S>N | No | 1000Genomes | |
| tmp_4_80606_A_G | 418 | Y>H | No | 1000Genomes | |
| ENSVATH06401766 | 424 | S>L | No | 1000Genomes | |
| ENSVATH06401766 | 424 | S>W | No | 1000Genomes | |
| tmp_4_80572_C_T | 429 | G>E | No | 1000Genomes | |
| tmp_4_80558_C_T | 434 | V>I | No | 1000Genomes | |
| tmp_4_80554_T_G | 435 | D>A | No | 1000Genomes | |
| tmp_4_80538_G_C | 440 | H>Q | No | 1000Genomes | |
| tmp_4_80539_T_C | 440 | H>R | No | 1000Genomes |
No associated diseases with O81320
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFGNEMCDE | TPHPGECKTL | LIKHKPIRST | TQFLQVSVER | TLDGAVKAKS | DTYFLEPQFG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKQAWEECMD | LYEQTIHRLN | ESVLCPKNVC | SRSDVQAWLS | TALTNLDTCQ | EEMSELGVSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSLESITIDV | INTLAINKRM | EQNGKEFGIS | KITMKTLSIG | EKVDVVVAQD | GSGDYKTIQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVNGAGERLK | GSPRYVIHVK | QGVYEEYVNV | GIKSNNIMIT | GDGIGKTIIT | GDKSKGRGFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYKSATFVAE | GDGFVGRDIT | IRNTAGPENH | QAVALRSNSD | MSVFYRCSIE | GYQDTLYVHS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GRQFFRECDI | YGTVDFIFGN | AAAVLQNCRI | FARNPPNGVN | TITAQSRFNP | NQTTGIVIHN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVVKGAPGVQ | LGGVKTYLGR | PWRSYARTVV | IGTYLDTLIE | PNGWIDWDNV | TALSTLYYGE |
| 430 | 440 | 450 | 460 | 470 | |
| YQNSGPGSGT | ENRVDWAGFH | VISDIQEARE | FTLPKFIDSA | SWLPPTKVPF | TINL |