O81301
SS
Gene name |
PME40 (ARATH40, At4g02320, T14P8.1) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 40 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G02320 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
207-504 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O81301
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O81301-F1 | Predicted | AlphaFoldDB |
109 variants for O81301
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06423494 | 3 | T>I | No | 1000Genomes | |
| ENSVATH10532522 | 5 | S>L | No | 1000Genomes | |
| ENSVATH06423493 | 5 | S>P | No | 1000Genomes | |
| tmp_4_1026084_A_T | 12 | L>* | No | 1000Genomes | |
| ENSVATH06423492 | 13 | T>S | No | 1000Genomes | |
| tmp_4_1026055_C_T | 22 | V>I | No | 1000Genomes | |
| tmp_4_1026043_G_A | 26 | H>Y | No | 1000Genomes | |
| ENSVATH06423491 | 27 | V>I | No | 1000Genomes | |
| tmp_4_1026030_C_A | 30 | R>L | No | 1000Genomes | |
| tmp_4_1026026_A_C | 31 | F>L | No | 1000Genomes | |
| tmp_4_1026025_T_C | 32 | T>A | No | 1000Genomes | |
| tmp_4_1026004_C_T | 39 | E>K | No | 1000Genomes | |
| ENSVATH06423490 | 55 | S>F | No | 1000Genomes | |
| ENSVATH02621503 | 64 | Q>* | No | 1000Genomes | |
| ENSVATH02621502 | 64 | Q>H | No | 1000Genomes | |
| ENSVATH02621503 | 64 | Q>K | No | 1000Genomes | |
| ENSVATH06423489 | 67 | G>R | No | 1000Genomes | |
| tmp_4_1025907_C_T | 71 | S>N | No | 1000Genomes | |
| ENSVATH00454759 | 75 | L>R | No | 1000Genomes | |
| ENSVATH00454758 | 77 | A>G | No | 1000Genomes | |
| tmp_4_1025884_C_T | 79 | D>N | No | 1000Genomes | |
| tmp_4_1025874_A_T | 82 | L>H | No | 1000Genomes | |
| tmp_4_1025868_A_T | 84 | L>Q | No | 1000Genomes | |
| tmp_4_1025858_G_T,A | 87 | D>E | No | 1000Genomes | |
| ENSVATH06423488 | 87 | D>H | No | 1000Genomes | |
| tmp_4_1025854_C_T | 89 | V>I | No | 1000Genomes | |
| tmp_4_1025835_G_A | 95 | A>V | No | 1000Genomes | |
| tmp_4_1025824_G_A | 99 | L>F | No | 1000Genomes | |
| tmp_4_1025821_G_A | 100 | R>* | No | 1000Genomes | |
| ENSVATH13881668 | 104 | P>R | No | 1000Genomes | |
| tmp_4_1025805_T_C | 105 | E>G | No | 1000Genomes | |
| ENSVATH02621501 | 126 | G>S | No | 1000Genomes | |
| tmp_4_1025737_C_G | 128 | A>P | No | 1000Genomes | |
| ENSVATH00454757 | 132 | N>D | No | 1000Genomes | |
| ENSVATH02621500 | 140 | D>N | No | 1000Genomes | |
| tmp_4_1025687_A_C | 144 | Y>* | No | 1000Genomes | |
| tmp_4_1025677_C_T | 148 | E>K | No | 1000Genomes | |
| ENSVATH06423485 | 149 | S>R | No | 1000Genomes | |
| ENSVATH00454756 | 152 | E>D | No | 1000Genomes | |
| ENSVATH06423483 | 157 | I>F | No | 1000Genomes | |
| ENSVATH06423481 | 165 | L>S | No | 1000Genomes | |
| tmp_4_1025613_T_C | 169 | E>G | No | 1000Genomes | |
| ENSVATH06423480 | 173 | G>R | No | 1000Genomes | |
| ENSVATH02621499 | 179 | V>L | No | 1000Genomes | |
| ENSVATH02621498 | 180 | K>E | No | 1000Genomes | |
| ENSVATH00454754 | 183 | V>G | No | 1000Genomes | |
| ENSVATH00454755 | 183 | V>I | No | 1000Genomes | |
| tmp_4_1025569_C_T | 184 | G>R | No | 1000Genomes | |
| ENSVATH06423479 | 189 | V>I | No | 1000Genomes | |
| tmp_4_1025545_T_G | 192 | S>R | No | 1000Genomes | |
| tmp_4_1025521_G_A | 200 | P>S | No | 1000Genomes | |
| ENSVATH00454753 | 201 | V>L | No | 1000Genomes | |
| tmp_4_1025499_T_G | 207 | N>T | No | 1000Genomes | |
| ENSVATH00454752 | 209 | V>A | No | 1000Genomes | |
| tmp_4_1025479_C_T | 214 | G>R | No | 1000Genomes | |
| tmp_4_1025478_C_A | 214 | G>V | No | 1000Genomes | |
| ENSVATH00454751 | 219 | T>M | No | 1000Genomes | |
| tmp_4_1025460_G_C | 220 | T>S | No | 1000Genomes | |
| tmp_4_1025427_G_A | 231 | S>L | No | 1000Genomes | |
| ENSVATH00454750 | 232 | S>G | No | 1000Genomes | |
| ENSVATH10532311 | 236 | F>V | No | 1000Genomes | |
| ENSVATH02621414 | 239 | Y>H | No | 1000Genomes | |
| ENSVATH06423426 | 244 | E>Q | No | 1000Genomes | |
| tmp_4_1023713_A_C | 249 | I>S | No | 1000Genomes | |
| ENSVATH02621413 | 252 | P>A | No | 1000Genomes | |
| tmp_4_1023696_T_C | 255 | K>E | No | 1000Genomes | |
| ENSVATH10532310 | 256 | T>K | No | 1000Genomes | |
| tmp_4_1023677_A_G | 261 | I>T | No | 1000Genomes | |
| tmp_4_1023675_C_T | 262 | G>R | No | 1000Genomes | |
| ENSVATH06423425 | 266 | G>E | No | 1000Genomes | |
| tmp_4_1023623_C_A | 279 | G>V | No | 1000Genomes | |
| tmp_4_1023597_C_T | 288 | V>I | No | 1000Genomes | |
| tmp_4_1023401_C_G | 294 | G>A | No | 1000Genomes | |
| tmp_4_1023402_C_G | 294 | G>R | No | 1000Genomes | |
| tmp_4_1023352_T_A,G | 310 | K>N | No | 1000Genomes | |
| tmp_4_1023352_T_A,G | 310 | K>N | No | 1000Genomes | |
| tmp_4_1023342_C_T | 314 | V>M | No | 1000Genomes | |
| ENSVATH02621407 | 322 | L>I | No | 1000Genomes | |
| ENSVATH06423420 | 324 | A>P | No | 1000Genomes | |
| tmp_4_1023308_T_C | 325 | Y>C | No | 1000Genomes | |
| tmp_4_1023309_A_T | 325 | Y>N | No | 1000Genomes | |
| tmp_4_1023263_T_A | 340 | H>L | No | 1000Genomes | |
| tmp_4_1023216_C_T | 356 | D>N | No | 1000Genomes | |
| tmp_4_1023207_A_G | 359 | F>L | No | 1000Genomes | |
| ENSVATH06423416 | 378 | P>L | No | 1000Genomes | |
| tmp_4_1023142_C_G | 380 | Q>H | No | 1000Genomes | |
| tmp_4_1023140_T_C | 381 | K>R | No | 1000Genomes | |
| ENSVATH06423415 | 384 | Y>C | No | 1000Genomes | |
| tmp_4_1023128_G_A | 385 | T>I | No | 1000Genomes | |
| ENSVATH06423413 | 394 | E>Q | No | 1000Genomes | |
| tmp_4_1023098_G_A | 395 | P>L | No | 1000Genomes | |
| ENSVATH06423410 | 416 | A>P | No | 1000Genomes | |
| tmp_4_1022994_A_C | 430 | S>A | No | 1000Genomes | |
| tmp_4_1022980_A_C | 434 | I>M | No | 1000Genomes | |
| tmp_4_1022975_T_G | 436 | K>T | No | 1000Genomes | |
| tmp_4_1022967_T_C | 439 | I>V | No | 1000Genomes | |
| ENSVATH02621405 | 446 | A>V | No | 1000Genomes | |
| ENSVATH02621404 | 451 | W>R | No | 1000Genomes | |
| ENSVATH10532259 | 457 | L>F | No | 1000Genomes | |
| ENSVATH06423408 | 465 | Y>* | No | 1000Genomes | |
| ENSVATH06423409 | 465 | Y>F | No | 1000Genomes | |
| ENSVATH10532258 | 467 | N>T | No | 1000Genomes | |
| tmp_4_1022849_A_G | 478 | V>A | No | 1000Genomes | |
| ENSVATH00454737 | 490 | E>D | No | 1000Genomes | |
| ENSVATH13881577 | 496 | S>C | No | 1000Genomes | |
| tmp_4_1022786_G_C | 499 | P>R | No | 1000Genomes | |
| tmp_4_1022757_A_T | 509 | S>T | No | 1000Genomes | |
| tmp_4_1022751_T_C | 511 | R>G | No | 1000Genomes | |
| ENSVATH10532256 | 513 | P>R | No | 1000Genomes |
No associated diseases with O81301
5 regional properties for O81301
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 117 | IPR000008 |
| domain | HECT domain | 516 - 870 | IPR000569 |
| domain | WW domain | 300 - 363 | IPR001202-1 |
| domain | WW domain | 405 - 437 | IPR001202-2 |
| domain | WW domain | 444 - 477 | IPR001202-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTKSKHIIL | SLTFLLLFLS | TVFSSHVTQR | FTSSDDITEL | VVTALNQTIS | NVNLSSSNFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLLQRLGSNL | SHRDLCAFDD | CLELLDDTVF | DLTTAISKLR | SHSPELHNVK | MLLSAAMTNT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTCLDGFASS | DNDENLNNND | NKTYGVAESL | KESLFNISSH | VSDSLAMLEN | IPGHIPGKVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDVGFPMWVS | GSDRNLLQDP | VDETKVNLVV | AQNGTGNYTT | IGEAISAAPN | SSETRFVIYI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KCGEYFENIE | IPREKTMIMF | IGDGIGRTVI | KANRSYADGW | TAFHSATVGV | RGSGFIAKDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SFVNYAGPEK | HQAVALRSSS | DLSAYYRCSF | ESYQDTIYVH | SHKQFYRECD | IYGTVDFIFG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DASVVFQNCS | LYARRPNPNQ | KIIYTAQGRE | NSREPTGISI | ISSRILAAPD | LIPVQANFKA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLGRPWQLYS | RTVIMKSFID | DLVDPAGWLK | WKDDFALETL | YYGEYMNEGP | GSNMTNRVQW |
| 490 | 500 | 510 | |||
| PGFKRIETVE | EASQFSVGPF | IDGNKWLNST | RIPFTLDL |