O81211

PR
Gene name
RBOHE (At1g19230, T29M8.10)
Protein name
Respiratory burst oxidase homolog protein E
Names
NADPH oxidase RBOHE, AtRBOHE
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G19230
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-200 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O81211

Entry ID Method Resolution Chain Position Source
AF-O81211-F1 Predicted AlphaFoldDB

33 variants for O81211

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00031918 32 A>S No 1000Genomes
tmp_1_6644303_G_C 39 V>L No 1000Genomes
tmp_1_6644393_G_A 69 D>N No 1000Genomes
ENSVATH04601454 112 R>S No 1000Genomes
tmp_1_6644603_C_T 139 L>F No 1000Genomes
ENSVATH04601456 143 T>M No 1000Genomes
tmp_1_6644621_G_T 145 V>L No 1000Genomes
ENSVATH11521658 201 K>N No 1000Genomes
tmp_1_6644798_G_A 204 E>K No 1000Genomes
ENSVATH04601461 228 V>L No 1000Genomes
tmp_1_6645021_A_C 254 K>T No 1000Genomes
ENSVATH13924457 374 V>A No 1000Genomes
ENSVATH01070414 403 M>I No 1000Genomes
tmp_1_6646614_G_A 408 V>I No 1000Genomes
ENSVATH11521907 413 E>V No 1000Genomes
ENSVATH01070415 415 R>K No 1000Genomes
ENSVATH04601482 421 K>E No 1000Genomes
tmp_1_6646791_T_C 467 F>L No 1000Genomes
ENSVATH01070416 509 V>A No 1000Genomes
ENSVATH04601491 546 T>I No 1000Genomes
ENSVATH13924459 558 R>K No 1000Genomes
ENSVATH04601492 561 A>T No 1000Genomes
ENSVATH04601494 575 T>S No 1000Genomes
tmp_1_6647401_A_C 608 I>L No 1000Genomes
ENSVATH04601498 662 I>M No 1000Genomes
ENSVATH04601499 694 T>I No 1000Genomes
ENSVATH04601500 704 R>G No 1000Genomes
tmp_1_6647906_G_A 719 R>H No 1000Genomes
ENSVATH13924460 725 Y>S No 1000Genomes
tmp_1_6647929_A_G 727 N>D No 1000Genomes
ENSVATH04601501 730 M>V No 1000Genomes
tmp_1_6648267_G_A 784 D>N No 1000Genomes
tmp_1_6648787_C_G 899 N>K No 1000Genomes

No associated diseases with O81211

7 regional properties for O81211

Type Name Position InterPro Accession
domain EF-hand domain 251 - 303 IPR002048
domain FAD-binding 8 629 - 745 IPR013112
domain Ferric reductase, NAD binding domain 752 - 934 IPR013121
domain Ferric reductase transmembrane component-like domain 432 - 587 IPR013130
domain NADPH oxidase Respiratory burst 161 - 271 IPR013623
domain FAD-binding domain, ferredoxin reductase-type 626 - 748 IPR017927
binding_site EF-Hand 1, calcium-binding site 281 - 293 IPR018247

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PH1 NOX5 NADPH oxidase 5 Homo sapiens (Human) EV
Q948U0 RBOHA Respiratory burst oxidase homolog protein A Solanum tuberosum (Potato) PR
Q948T9 RBOHB Respiratory burst oxidase homolog protein B Solanum tuberosum (Potato) PR
Q5ZAJ0 RBOHB Respiratory burst oxidase homolog protein B Oryza sativa subsp japonica (Rice) PR
F4I4K7 FRO3 Ferric reduction oxidase 3, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
O48538 RBOHF Respiratory burst oxidase homolog protein F Arabidopsis thaliana (Mouse-ear cress) PR
P92949 CDC5 Ferric reduction oxidase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W110 FRO4 Ferric reduction oxidase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIJ0 RBOHD Respiratory burst oxidase homolog protein D Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJD6 RBOHH Putative respiratory burst oxidase homolog protein H Arabidopsis thaliana (Mouse-ear cress) PR
Q9SUT8 RBOHI Probable respiratory burst oxidase homolog protein I Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKLSPLSFST SSSFSHADGI DDGVELISSP FAGGAMLPVF LNDLSRNSGE SGSGSSWERE
70 80 90 100 110 120
LVEVTLELDV GDDSILVCGM SEAASVDSRA RSVDLVTARL SRNLSNASTR IRQKLGKLLR
130 140 150 160 170 180
SESWKTTTSS TAGERDRDLE RQTAVTLGIL TARDKRKEDA KLQRSTSSAQ RALKGLQFIN
190 200 210 220 230 240
KTTRGNSCVC DWDCDCDQMW KKVEKRFESL SKNGLLARDD FGECVGMVDS KDFAVSVFDA
250 260 270 280 290 300
LARRRRQKLE KITKDELHDF WLQISDQSFD ARLQIFFDMA DSNEDGKITR EEIKELLMLS
310 320 330 340 350 360
ASANKLAKLK EQAEEYASLI MEELDPENFG YIELWQLETL LLQRDAYMNY SRPLSTTSGG
370 380 390 400 410 420
VSTPRRNLIR PRHVVQKCRK KLQCLILDNW QRSWVLLVWV MLMAILFVWK FLEYREKAAF
430 440 450 460 470 480
KVMGYCLTTA KGAAETLKLN MALVLLPVCR NTLTWLRSTR ARACVPFDDN INFHKIIACA
490 500 510 520 530 540
IAIGILVHAG THLACDFPRI INSSPEQFVL IASAFNGTKP TFKDLMTGAE GITGISMVIL
550 560 570 580 590 600
TTIAFTLAST HFRRNRVRLP APLDRLTGFN AFWYTHHLLV VVYIMLIVHG TFLFFADKWY
610 620 630 640 650 660
QKTTWMYISV PLVLYVAERS LRACRSKHYS VKILKVSMLP GEVLSLIMSK PPGFKYKSGQ
670 680 690 700 710 720
YIFLQCPTIS RFEWHPFSIT SAPGDDQLSV HIRTLGDWTE ELRRVLTVGK DLSTCVIGRS
730 740 750 760 770 780
KFSAYCNIDM INRPKLLVDG PYGAPAQDYR SYDVLLLIGL GIGATPFISI LKDLLNNSRD
790 800 810 820 830 840
EQTDNEFSRS DFSWNSCTSS YTTATPTSTH GGKKKAVKAH FYWVTREPGS VEWFRGVMEE
850 860 870 880 890 900
ISDMDCRGQI ELHNYLTSVY DEGDARSTLI KMVQALNHAK HGVDILSGTR VRTHFARPNW
910 920 930 940 950
KEVFSSIARK HPNSTVGVFY CGIQTVAKEL KKQAQDMSQK TTTRFEFHKE HF