O80462
PR
Gene name |
XLG1 (XLG, At2g23460, F26B6.11) |
Protein name |
Extra-large guanine nucleotide-binding protein 1 |
Names |
Extra-large GTP-binding protein 1, Extra-large G-protein 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G23460 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O80462
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O80462-F1 | Predicted | AlphaFoldDB |
57 variants for O80462
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01875242 | 45 | C>R | No | 1000Genomes | |
| ENSVATH14537888 | 64 | K>I | No | 1000Genomes | |
| ENSVATH05567309 | 65 | K>T | No | 1000Genomes | |
| ENSVATH05567310 | 68 | I>M | No | 1000Genomes | |
| tmp_2_9995987_A_G | 97 | T>A | No | 1000Genomes | |
| tmp_2_9996006_C_T | 103 | T>I | No | 1000Genomes | |
| tmp_2_9996066_G_T | 123 | G>V | No | 1000Genomes | |
| ENSVATH05567312 | 147 | V>I | No | 1000Genomes | |
| tmp_2_9996161_T_C | 155 | S>P | No | 1000Genomes | |
| tmp_2_9996219_C_A | 174 | T>N | No | 1000Genomes | |
| tmp_2_9996267_C_T | 190 | A>V | No | 1000Genomes | |
| ENSVATH05567313 | 197 | E>A | No | 1000Genomes | |
| ENSVATH05567314 | 198 | E>K | No | 1000Genomes | |
| ENSVATH05567314 | 198 | E>Q | No | 1000Genomes | |
| ENSVATH13351011 | 202 | S>T | No | 1000Genomes | |
| ENSVATH00243584 | 204 | L>Q | No | 1000Genomes | |
| tmp_2_9996330_C_T | 211 | P>L | No | 1000Genomes | |
| ENSVATH05567315 | 217 | Q>L | No | 1000Genomes | |
| ENSVATH05567316 | 244 | D>N | No | 1000Genomes | |
| ENSVATH01875246 | 249 | N>S | No | 1000Genomes | |
| tmp_2_9996520_T_A | 274 | D>E | No | 1000Genomes | |
| ENSVATH05567317 | 284 | C>S | No | 1000Genomes | |
| tmp_2_9996565_G_T | 289 | K>N | No | 1000Genomes | |
| tmp_2_9996620_G_A | 308 | E>K | No | 1000Genomes | |
| ENSVATH00243586 | 336 | S>P | No | 1000Genomes | |
| tmp_2_9996721_G_T | 341 | K>N | No | 1000Genomes | |
| ENSVATH13351014 | 378 | S>C | No | 1000Genomes | |
| ENSVATH13351025 | 419 | N>Y | No | 1000Genomes | |
| ENSVATH00243588 | 459 | A>V | No | 1000Genomes | |
| ENSVATH05567333 | 534 | M>K | No | 1000Genomes | |
| ENSVATH01875255 | 547 | L>V | No | 1000Genomes | |
| ENSVATH05567334 | 548 | A>T | No | 1000Genomes | |
| ENSVATH05567335 | 552 | T>K | No | 1000Genomes | |
| tmp_2_9997627_G_A | 558 | E>K | No | 1000Genomes | |
| ENSVATH13351029 | 560 | I>V | No | 1000Genomes | |
| ENSVATH05567339 | 566 | D>N | No | 1000Genomes | |
| ENSVATH13351031 | 572 | K>I | No | 1000Genomes | |
| ENSVATH14537892 | 581 | P>L | No | 1000Genomes | |
| tmp_2_9997887_T_A | 599 | L>H | No | 1000Genomes | |
| ENSVATH13351032 | 631 | S>N | No | 1000Genomes | |
| tmp_2_9998009_G_A | 640 | A>T | No | 1000Genomes | |
| ENSVATH00243592 | 641 | S>N | No | 1000Genomes | |
| tmp_2_9998162_G_A | 656 | E>K | No | 1000Genomes | |
| tmp_2_9998182_A_G | 662 | I>M | No | 1000Genomes | |
| ENSVATH05567347 | 697 | D>G | No | 1000Genomes | |
| ENSVATH14537896 | 731 | V>I | No | 1000Genomes | |
| tmp_2_9998587_T_A | 770 | L>H | No | 1000Genomes | |
| tmp_2_9998610_C_A | 778 | L>I | No | 1000Genomes | |
| ENSVATH13351048 | 783 | V>L | No | 1000Genomes | |
| ENSVATH13351049 | 792 | E>K | No | 1000Genomes | |
| tmp_2_9998691_C_A | 805 | R>S | No | 1000Genomes | |
| tmp_2_9998744_G_A | 822 | M>I | No | 1000Genomes | |
| ENSVATH14537899 | 843 | S>I | No | 1000Genomes | |
| tmp_2_9998829_G_A | 851 | V>I | No | 1000Genomes | |
| tmp_2_9998839_C_T | 854 | S>L | No | 1000Genomes | |
| tmp_2_9998897_G_A | 873 | M>I | No | 1000Genomes | |
| tmp_2_9998905_A_G | 876 | Y>C | No | 1000Genomes |
No associated diseases with O80462
12 regional properties for O80462
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 194 - 243 | IPR000315-1 |
| domain | B-box-type zinc finger | 273 - 314 | IPR000315-2 |
| repeat | NHL repeat | 593 - 636 | IPR001258-1 |
| repeat | NHL repeat | 640 - 683 | IPR001258-2 |
| repeat | NHL repeat | 687 - 730 | IPR001258-3 |
| repeat | NHL repeat | 734 - 777 | IPR001258-4 |
| repeat | NHL repeat | 781 - 824 | IPR001258-5 |
| repeat | NHL repeat | 828 - 868 | IPR001258-6 |
| repeat | Filamin/ABP280 repeat | 483 - 583 | IPR001298 |
| domain | Zinc finger, RING-type | 12 - 95 | IPR001841 |
| repeat | Filamin/ABP280 repeat-like | 479 - 580 | IPR017868 |
| conserved_site | Zinc finger, RING-type, conserved site | 61 - 70 | IPR017907 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| heterotrimeric G-protein complex | Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor binding | Binding to a G protein-coupled receptor. |
| G-protein beta/gamma-subunit complex binding | Binding to a complex of G-protein beta/gamma subunits. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). |
76 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P04695 | GNAT1 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P04696 | GNAT2 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P08239 | GNAO1 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P0C7Q4 | GNAT3 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P63097 | GNAI1 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P38408 | GNA14 | Guanine nucleotide-binding protein subunit alpha-14 | Bos taurus (Bovine) | PR |
| P04896 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Bos taurus (Bovine) | PR |
| P50147 | GNAI2 | Guanine nucleotide-binding protein G | Gallus gallus (Chicken) | SS |
| P50146 | GNAI1 | Guanine nucleotide-binding protein G | Gallus gallus (Chicken) | SS |
| P38400 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P63091 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P20353 | Galphai | G protein alpha i subunit | Drosophila melanogaster (Fruit fly) | SS |
| P25157 | cta | Guanine nucleotide-binding protein subunit alpha homolog | Drosophila melanogaster (Fruit fly) | SS |
| P23625 | Galphaq | G protein alpha q subunit | Drosophila melanogaster (Fruit fly) | PR |
| P16378 | Galphao | G protein alpha o subunit | Drosophila melanogaster (Fruit fly) | SS |
| A8MTJ3 | GNAT3 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P08754 | GNAI3 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P11488 | GNAT1 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P19086 | GNAZ | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P19087 | GNAT2 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P29992 | GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | Homo sapiens (Human) | SS |
| P30679 | GNA15 | Guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (Human) | SS |
| P50148 | GNAQ | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| O95837 | GNA14 | Guanine nucleotide-binding protein subunit alpha-14 | Homo sapiens (Human) | SS |
| P04899 | GNAI2 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P63096 | GNAI1 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | EV |
| Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | Homo sapiens (Human) | SS |
| Q03113 | GNA12 | Guanine nucleotide-binding protein subunit alpha-12 | Homo sapiens (Human) | SS |
| P38405 | GNAL | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| P09471 | GNAO1 | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| B2RSH2 | Gnai1 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| O70443 | Gnaz | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| P08752 | Gnai2 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| P20612 | Gnat1 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| P27600 | Gna12 | Guanine nucleotide-binding protein subunit alpha-12 | Mus musculus (Mouse) | SS |
| P27601 | Gna13 | Guanine nucleotide-binding protein subunit alpha-13 | Mus musculus (Mouse) | SS |
| P50149 | Gnat2 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| Q3V3I2 | Gnat3 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| Q9DC51 | Gnai3 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| P21279 | Gnaq | Guanine nucleotide-binding protein G(q) subunit alpha | Mus musculus (Mouse) | PR |
| P30678 | Gna15 | Guanine nucleotide-binding protein subunit alpha-15 | Mus musculus (Mouse) | PR |
| P18872 | Gnao1 | Guanine nucleotide-binding protein G | Mus musculus (Mouse) | SS |
| Q2PKF4 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Sus scrofa (Pig) | PR |
| P29797 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha | Sus scrofa (Pig) | PR |
| P93564 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Solanum tuberosum (Potato) | SS |
| P04897 | Gnai2 | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| P08753 | Gnai3 | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| P19627 | Gnaz | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| P29348 | Gnat3 | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| Q63210 | Gna12 | Guanine nucleotide-binding protein subunit alpha-12 | Rattus norvegicus (Rat) | SS |
| Q6Q7Y5 | Gna13 | Guanine nucleotide-binding protein subunit alpha-13 | Rattus norvegicus (Rat) | SS |
| P10824 | Gnai1 | Guanine nucleotide-binding protein G subunit alpha-1 | Rattus norvegicus (Rat) | EV |
| P82471 | Gnaq | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| O88302 | Gna15 | Guanine nucleotide-binding protein subunit alpha-15 | Rattus norvegicus (Rat) | SS |
| Q9JID2 | Gna11 | Guanine nucleotide-binding protein subunit alpha-11 | Rattus norvegicus (Rat) | SS |
| P38406 | Gnal | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| P59215 | Gnao1 | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| Q63803 | Gnas | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| Q0DJ33 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Oryza sativa subsp. japonica (Rice) | SS |
| P28051 | gpa-1 | Guanine nucleotide-binding protein alpha-1 subunit | Caenorhabditis elegans | SS |
| P28052 | gpa-3 | Guanine nucleotide-binding protein alpha-3 subunit | Caenorhabditis elegans | SS |
| P51875 | goa-1 | Guanine nucleotide-binding protein G | Caenorhabditis elegans | SS |
| P91907 | gpa-15 | Guanine nucleotide-binding protein alpha-15 subunit | Caenorhabditis elegans | SS |
| Q18434 | odr-3 | Guanine nucleotide-binding protein alpha-17 subunit | Caenorhabditis elegans | SS |
| Q20907 | gpa-8 | Guanine nucleotide-binding protein alpha-8 subunit | Caenorhabditis elegans | PR |
| Q21917 | gpa-7 | Guanine nucleotide-binding protein alpha-7 subunit | Caenorhabditis elegans | SS |
| Q93743 | gpa-6 | Guanine nucleotide-binding protein alpha-6 subunit | Caenorhabditis elegans | SS |
| Q9BIG4 | gpa-10 | Guanine nucleotide-binding protein alpha-10 subunit | Caenorhabditis elegans | PR |
| Q9BIG5 | gpa-4 | Guanine nucleotide-binding protein alpha-4 subunit | Caenorhabditis elegans | SS |
| Q9N2V6 | gpa-16 | Guanine nucleotide-binding protein alpha-16 subunit | Caenorhabditis elegans | SS |
| Q9XTB2 | gpa-13 | Guanine nucleotide-binding protein alpha-13 subunit | Caenorhabditis elegans | SS |
| O76584 | gpa-11 | Guanine nucleotide-binding protein alpha-11 subunit | Caenorhabditis elegans | SS |
| P49084 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Glycine max (Soybean) (Glycine hispida) | SS |
| P93163 | GPA2 | Guanine nucleotide-binding protein alpha-2 subunit | Glycine max (Soybean) (Glycine hispida) | SS |
| P18064 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P26981 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLKEDDCCL | FAEEYDGPPL | SYNIPCAVPI | NVEKIPVAAV | VSPVCISDNM | SFPVIQPILS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VESKKFLIDS | VSPTSVIANC | GSNQLELVSD | SITVSPTSVI | EHTEEEEEEE | GGDGEDCELS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSGELLLRSC | SVKESLDLNE | SSSNPLVPDW | ESNESVLSMD | YPSSRVTGDC | VSETNGDGKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPVVTFLGIA | SDDGFEEEES | CSNLRRVRVV | PVKKQPQTKG | KKGSCYRCFK | GSRFTEKEVC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVCDAKYCNS | CVLRAMGSMP | EGRKCVTCIG | FPIDESKRGS | LGKCSRMLKR | LLNDLEVKQI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MKTERFCEAN | QLPAEYVYVN | GQPLYPEELV | TLQTCSNPPK | KLKPGDYWYD | KVSGLWGKEG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EKPYQIISPH | LNVGGPISPE | ASNGNTQVFI | NGREITKVEL | RMLQLAGVQC | AGNPHFWVNE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGSYQEEGQK | NTKGYIWGKA | GTKLLCAVLS | LPVPSKSTAN | ASGEQLYSAN | SRSILDHLEH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RTLQKILLVG | NSGSGTSTIF | KQAKILYKDV | PFLEDERENI | KVIIQTNVYG | YLGMLLEGRE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RFEEEALALR | NTKQCVLENI | PADEGDAKSN | DKTVTMYSIG | PRLKAFSDWL | LKTMAAGNLG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VIFPAASREY | APLVEELWRD | AAIQATYKRR | SELGLLPSVA | SYFLERAIDV | LTPDYEPSDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DILYAEGVTS | SSGLACLDFS | FPQTASEENL | DPSDHHDSLL | RYQLIRVPSR | GLGENCKWID |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MFEDVGMVVF | VVSMSDYDQV | SEDGTNKMLL | TKKLFESIIT | HPIFENMDFL | LILNKYDLLE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EKVERVPLAR | CEWFQDFNPV | VSRHRGSNNG | NPTLGQLAFH | FMAVKFKRFY | SSLTGKKLFV |
| 850 | 860 | 870 | 880 | ||
| SSSKSLDPNS | VDSSLKLAME | ILKWSEERTN | ICMSEYSMYS | TEPSSFSN |