O77775
Gene name |
NCF2 |
Protein name |
Neutrophil cytosol factor 2 |
Names |
NCF-2, 67 kDa neutrophil oxidase factor, Neutrophil NADPH oxidase factor 2, p67-phox |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281346 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O77775
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O77775-F1 | Predicted | AlphaFoldDB |
No variants for O77775
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O77775 | |||||
No associated diseases with O77775
10 regional properties for O77775
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PB1 domain | 352 - 430 | IPR000270 |
| repeat | Tetratricopeptide repeat 1 | 71 - 99 | IPR001440 |
| domain | SH3 domain | 240 - 299 | IPR001452-1 |
| domain | SH3 domain | 458 - 517 | IPR001452-2 |
| repeat | Tetratricopeptide repeat | 37 - 70 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 71 - 104 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 121 - 154 | IPR019734-3 |
| domain | Neutrophil cytosol factor 2, PB1 domain | 351 - 430 | IPR034885 |
| domain | Neutrophil cytosol factor 2, SH3 domain | 462 - 513 | IPR034889 |
| domain | Neutrophil cytosol factor 2, SH3 domain 1 | 244 - 297 | IPR035546 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| NADPH oxidase complex | A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| superoxide-generating NADPH oxidase activator activity | Increases the activity of the enzyme superoxide-generating NADPH oxidase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| respiratory burst | A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. |
| superoxide anion generation | The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5HYK7 | SH3D19 | SH3 domain-containing protein 19 | Homo sapiens (Human) | PR |
| Q6XZF7 | DNMBP | Dynamin-binding protein | Homo sapiens (Human) | PR |
| Q86UR1 | NOXA1 | NADPH oxidase activator 1 | Homo sapiens (Human) | EV |
| P19878 | NCF2 | Neutrophil cytosol factor 2 | Homo sapiens (Human) | PR |
| Q8CJ00 | Noxa1 | NADPH oxidase activator 1 | Mus musculus (Mouse) | SS |
| O70145 | Ncf2 | Neutrophil cytosol factor 2 | Mus musculus (Mouse) | PR |
| A7E3N7 | Noxa1 | NADPH oxidase activator 1 | Rattus norvegicus (Rat) | SS |
| A7E3N2 | Ncf2 | Neutrophil cytosol factor 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLAEAISLW | NEGVLAADKK | DWKGALDAFT | GVQDPHSRIC | FNVGCIYTIL | GNLPEAEKAF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TKSINRDKHL | AVSYFQRGML | YYQMEKYDSA | IKDLKEALTQ | LRGNQLIDYK | ILGLQFKLFA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CEVLYNIAFM | YAKREEWKKA | EEHLALAVSM | KSEPRHSKID | RAMESVWKQK | LYEPVVIPVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLFRPNEKQV | AQLVKKDYLG | KATVVASVVD | QDSFSGFAPL | QPQAAEPPPR | PKTPEIFRAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EGEAHRVLFG | FVPETPEELQ | VMPGNIVFVL | KKGNDNWATV | MFNGQKGLVP | CNYLEPVELR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IHPQQQPQEE | TSLESDIPAP | PSSSAPGRPQ | LSPGQKGKEE | PKQEIKLSVP | KSYTLKVHYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YTVVMETQFR | LPYSQVRDMV | AKKLDLLPEH | TKLSYRRQDS | NELVPLSEFS | MKDAWAQVKN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YCLTLWCENT | VGDQGFPDEP | EESKKSDANN | QTTEPELKEG | SKVVALFSYE | ATQPEDLEFL |
| 490 | 500 | 510 | 520 | ||
| EGDVILVIST | VNEQWLEGEC | KGKVGIFPKA | FVEQHPTTDL | ESTPGRV |