O76240

SS
Gene name
Protein name
S-adenosylmethionine decarboxylase proenzyme
Names
AdoMetDC , SAMDC , EC 4.1.1.50 [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]
Species
Trypanosoma cruzi
KEGG Pathway
tcr:504257.30
EC number
4.1.1.50: Carboxy-lyases
Protein Class

Descriptions

Autoinhibitory domains (AIDs)

27-30 (N-terminal autoinhibitory sequence) SS

Target domain

86-370 (S-adenosylmethionine decarboxylase alpha chain, specifically, 202-247 active site helices/strands)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O76240

Entry ID Method Resolution Chain Position Source
AF-O76240-F1 Predicted AlphaFoldDB

No variants for O76240

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76240

No associated diseases with O76240

1 regional properties for O76240

Type Name Position InterPro Accession
conserved_site S-adenosylmethionine decarboxylase, conserved site 80 - 90 IPR018166

Functions

Description
EC Number 4.1.1.50 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
adenosylmethionine decarboxylase activity Catalysis of the reaction

2 GO annotations of biological process

Name Definition
spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSNKDPLSL MAMWGSVKGY DPNQGASFEG PEKRLEVIMR IIDETHSEGL HALGDEVWKG
70 80 90 100 110 120
VVGSLNAQIV SKESNEYIRS YVLTESSLFV MRDRIILITC GTTTLLNAVP FVLDAVSDVR
130 140 150 160 170 180
GEVEWVSFMH KNYSFPWEQK GPHLSMAEEF NTLRTYFPSG KPFIFGPVDS DHYFLFVYDD
190 200 210 220 230 240
VIRPCETEND TQLSMTMYGL DRTQTKHWFS DRFISTGTET AAIRKATKLD KVADDSWKLH
250 260 270 280 290 300
DLQFEPCGYS INTIRGAEYQ TIHITPEDHC SFASYETNTP AVNYSERINT VLGVFAPIRF
310 320 330 340 350 360
SVIVFIDPDS DVGRLYQKGQ NVGVEAEYYP KYELQNRTVN EFAPGYVVMK MNYARRAEVT
EKDSTDSVEE