AiPD: Autoinhibited Protein Database

O75582

Gene name	RPS6KA5 (MSK1)
Protein name	Ribosomal protein S6 kinase alpha-5
Names	S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9252
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

MSK1 is a member of p90 ribosomal S6 kinases (RSKs) containing two distinct kinase catalytic domains. MSK1 plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression.
RSKs contain two kinase domains and C-terminal autoinhibitory α helix.

Autoinhibitory domains (AIDs)

709-727 (Putative autoinhibitory α helix) SS

Target domain	429-703 (C-terminal kinase domain)
Relief mechanism	PTM
Assay

AID

709-727 (Putative autoinhibitory α helix)

Target domain

429-703 (C-terminal kinase domain)

Relief mechanism

PTM (Phosphorylation of activation loop in C-terminal kinase domain)

Assay

Accessory elements

194-218 (Activation loop from InterPro)

Target domain	49-318 (Protein kinase domain)
Relief mechanism
Assay

564-587 (Activation loop from InterPro)

Target domain	426-687 (Protein kinase domain)
Relief mechanism
Assay

References

Vermeulen L et al. (2003) "Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)", The EMBO journal, 22, 1313-24

Poteet-Smith CE et al. (1999) "Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family", The Journal of biological chemistry, 274, 22135-8

Zhao Y et al. (1995) "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation", Molecular and cellular biology, 15, 4353-63

Martinez EC et al. (2015) "RSK3: A regulator of pathological cardiac remodeling", IUBMB life, 67, 331-7

Anjum R et al. (2008) "The RSK family of kinases: emerging roles in cellular signalling", Nature reviews. Molecular cell biology, 9, 747-58

Malakhova M et al. (2008) "Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2", Nature structural & molecular biology, 15, 112-3

Li D et al. (2012) "Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1", Acta crystallographica. Section D, Biological crystallography, 68, 680-5

Li D et al. (2013) "The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis", The Journal of biological chemistry, 288, 32528-32538

Autoinhibited structure

Activated structure

9 structures for O75582

Entry ID	Method	Resolution	Chain	Position	Source
1VZO	X-ray	180 A	A	2-348	PDB
3KN5	X-ray	240 A	A/B	414-738	PDB
3KN6	X-ray	200 A	A/B	414-738	PDB
7UP4	X-ray	300 A	A/B	414-738	PDB
7UP5	X-ray	280 A	A/B	414-738	PDB
7UP6	X-ray	260 A			PDB
7UP7	X-ray	280 A			PDB
7UP8	X-ray	290 A	A/B	414-738	PDB
AF-O75582-F1	Predicted				AlphaFoldDB

464 variants for O75582

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs749741829 CA390692817	3	E>D	No	ClinGen ExAC gnomAD
rs1274552217 CA390692810	4	E>A	No	ClinGen TOPMed gnomAD
rs762845963 CA265033151	5	G>R	No	ClinGen TOPMed
CA7307445 rs372919173	8	S>G	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390692782 rs1435148220	8	S>R	No	ClinGen gnomAD
CA390692788 rs372919173	8	S>R	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7307444 rs375911233	9	G>C	No	ClinGen ESP ExAC gnomAD
CA265033150 rs1008637753	9	G>D	No	ClinGen TOPMed gnomAD
rs1483423077 CA390692777	10	G>S	No	ClinGen gnomAD
rs746185525 CA7307443	11	A>P	No	ClinGen ExAC gnomAD
rs746185525 CA390692771	11	A>T	No	ClinGen ExAC gnomAD
rs781588549 CA7307442	13	G>R	No	ClinGen ExAC gnomAD
CA7307440 rs751292340	15	S>G	No	ClinGen ExAC gnomAD
CA390692741 rs202148951	16	A>P	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7307439 rs202148951	16	A>S	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765224867 CA7307436	18	G>R	No	ClinGen ExAC TOPMed gnomAD
CA390692729 rs765224867	18	G>S	No	ClinGen ExAC TOPMed gnomAD
CA7307435 rs776541777	19	G>D	No	ClinGen ExAC TOPMed gnomAD
CA265033149 rs1029077430	19	G>S	No	ClinGen TOPMed
rs776541777 CA7307434	19	G>V	No	ClinGen ExAC TOPMed gnomAD
CA7307432 rs761932282	20	D>G	No	ClinGen ExAC TOPMed gnomAD
rs555348355 CA7307433	20	D>N	No	ClinGen 1000Genomes ExAC gnomAD
rs749352681 CA390692712	21	G>E	No	ClinGen ExAC gnomAD
rs768768064 CA7307430	21	G>R	No	ClinGen ExAC gnomAD
rs749352681 CA7307429	21	G>V	No	ClinGen ExAC gnomAD
rs1392023520 CA390692711	22	G>R	No	ClinGen gnomAD
rs1369945741 CA390692702	23	E>G	No	ClinGen gnomAD
rs1483029166 CA390692705	23	E>K	No	ClinGen TOPMed gnomAD
rs1483029166 CA390692704	23	E>Q	No	ClinGen TOPMed gnomAD
CA390692691 rs1343296599	24	Q>H	No	ClinGen TOPMed gnomAD
rs1202549406 CA390692694	24	Q>P	No	ClinGen TOPMed gnomAD
rs1202549406 CA390692693	24	Q>R	No	ClinGen TOPMed gnomAD
rs770267401 CA390692688	25	L>F	No	ClinGen ExAC gnomAD
rs770267401 CA7307427	25	L>V	No	ClinGen ExAC gnomAD
rs1426419277 CA390692677	27	T>A	No	ClinGen TOPMed gnomAD
rs1426419277 CA390692678	27	T>P	No	ClinGen TOPMed gnomAD
CA7307423 rs747349129	28	V>I	No	ClinGen ExAC gnomAD
CA390692666 rs1334733624	29	K>E	No	ClinGen gnomAD
CA390692652 rs1416021973	30	H>Q	No	ClinGen gnomAD
rs1399772704 CA390692646	31	E>V	No	ClinGen gnomAD
rs1217506851 CA390692636	33	R>Q	No	ClinGen TOPMed
rs753889864 CA7307417	34	T>A	No	ClinGen ExAC TOPMed gnomAD
rs766260545 CA390692630	34	T>I	No	ClinGen ExAC TOPMed gnomAD
CA7307416 rs766260545	34	T>S	No	ClinGen ExAC TOPMed gnomAD
rs1190194033 CA390692628	35	A>P	No	ClinGen gnomAD
rs1595445043 CA390602101	40	H>N	No	ClinGen Ensembl
rs888601559 CA264690670	40	H>R	No	ClinGen TOPMed
CA390602092 rs1389611261	41	A>D	No	ClinGen TOPMed
CA7307362 rs781028330	41	A>T	No	ClinGen ExAC gnomAD
CA390602090 rs1389611261	41	A>V	No	ClinGen TOPMed
CA390602057 rs1413278594	46	I>T	No	ClinGen gnomAD
CA7307360 rs544043188	55	L>V	No	ClinGen 1000Genomes ExAC gnomAD
CA7307338 rs777592660	59	A>G	No	ClinGen ExAC gnomAD
rs1210580531 CA390601536	60	Y>*	No	ClinGen gnomAD
CA7307333 rs151225102	67	R>C	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756086272 CA7307332	67	R>H	No	ClinGen ExAC TOPMed gnomAD
CA7307334 rs151225102	67	R>S	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1225629526 CA390601363	71	G>V	No	ClinGen gnomAD
CA264669594 rs995029576	72	H>R	No	ClinGen TOPMed gnomAD
rs750519388 CA7307331	72	H>Y	No	ClinGen ExAC TOPMed gnomAD
CA7307330 rs768094502	73	D>G	No	ClinGen ExAC gnomAD
rs1386909073 CA390601314	74	T>I	No	ClinGen TOPMed gnomAD
CA264669553 rs367694592	80	M>V	No	ClinGen ESP TOPMed
CA390601113 rs1371027093	86	A>V	No	ClinGen gnomAD
CA7307327 rs764624247	87	T>A	No	ClinGen ExAC gnomAD
rs1460273306 CA390601096	88	I>V	No	ClinGen gnomAD
rs1199820517 CA390601079	89	V>I	No	ClinGen gnomAD
rs762657053 CA7307325	94	T>I	No	ClinGen ExAC gnomAD
CA390600974 rs1309143667	97	H>R	No	ClinGen TOPMed gnomAD
rs1198719757 CA390600965	98	T>I	No	ClinGen gnomAD
rs1483677586 CA390600956	100	T>A	No	ClinGen gnomAD
CA7307324 rs774948932	100	T>I	No	ClinGen ExAC gnomAD
CA390600943 rs1339128052	102	R>*	No	ClinGen gnomAD
CA7307322 rs142061817	107	H>Y	No	ClinGen 1000Genomes ExAC gnomAD
CA390600899 rs1265768241	108	I>M	No	ClinGen TOPMed
CA390600833 rs770831665	118	H>L	No	ClinGen ExAC gnomAD
rs770831665 CA7307320	118	H>R	No	ClinGen ExAC gnomAD
rs771998704 CA7307301	133	Y>C	No	ClinGen ExAC gnomAD
rs771998704 CA7307300	133	Y>F	No	ClinGen ExAC gnomAD
CA390599000 rs1252512273	136	G>S	No	ClinGen gnomAD
CA390598991 rs1204376586	137	G>D	No	ClinGen TOPMed gnomAD
rs201222390 CA264649147	145	Q>E	No	ClinGen Ensembl
CA7307299 rs747853891	148	R>C	No	ClinGen ExAC gnomAD
CA7307298 rs778788639	148	R>H	No	ClinGen ExAC gnomAD
CA390598897 rs1595298510	149	F>L	No	ClinGen Ensembl
rs1481994077 CA390598883	150	T>A	No	ClinGen gnomAD
CA7307297 rs7143758	151	E>D	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390598867 rs1240941638	151	E>V	No	ClinGen gnomAD
CA7307296 rs746170983	152	H>R	No	ClinGen ExAC TOPMed gnomAD
rs781411551 CA7307295	153	E>A	No	ClinGen ExAC TOPMed gnomAD
CA264649138 rs1007729748	154	V>G	No	ClinGen TOPMed gnomAD
rs1284709350 CA390598804	155	Q>H	No	ClinGen gnomAD
CA7307294 rs757359077	155	Q>R	No	ClinGen ExAC TOPMed gnomAD
rs1314684959 CA390598763	158	V>I	No	ClinGen gnomAD
CA7307291 rs758967947	159	G>A	No	ClinGen ExAC gnomAD
rs1566778089 CA390598714	161	I>T	No	ClinGen Ensembl
rs1003458452 CA264649115	163	L>F	No	ClinGen Ensembl
CA7307288 rs759105458	166	E>A	No	ClinGen ExAC TOPMed gnomAD
rs1044722331 CA264649108	166	E>K	No	ClinGen TOPMed gnomAD
rs200296811 CA264649104	168	L>F	No	ClinGen ESP ExAC TOPMed gnomAD
rs200296811 CA7307287	168	L>V	No	ClinGen ESP ExAC TOPMed gnomAD
rs1268012505 CA390598110	176	R>C	No	ClinGen gnomAD
CA7307262 rs199633732	176	R>H	No	ClinGen ExAC TOPMed
rs755783181 CA7307260	178	I>T	No	ClinGen ExAC gnomAD
rs765972573 CA7307261	178	I>V	No	ClinGen ExAC TOPMed gnomAD
CA264647007 rs749909993	179	K>N	No	ClinGen ExAC gnomAD
rs200169986 CA7307258	183	I>M	No	ClinGen ESP ExAC TOPMed gnomAD
CA7307255 rs148618662	187	S>C	No	ClinGen ESP ExAC TOPMed gnomAD
CA7307254 rs528231414	188	N>D	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7307252 VAR_051634 rs34699345	190	H>R	No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
rs1353092180 CA390597925	191	V>M	No	ClinGen gnomAD
CA390597909 rs1409034173	192	V>A	No	ClinGen gnomAD
rs1409034173 CA390597908	192	V>G	No	ClinGen gnomAD
CA390597782 rs1177976289	202	F>L	No	ClinGen gnomAD
rs772251191 CA7307249	203	V>L	No	ClinGen ExAC gnomAD
CA7307247 rs779406710	205	D>E	No	ClinGen ExAC TOPMed gnomAD
CA7307248 rs77756213	205	D>G	No	ClinGen ExAC gnomAD
rs1312037829 CA390597738	206	E>G	No	ClinGen TOPMed
rs1201978063 CA390602575	207	T>S	No	ClinGen gnomAD
rs760965172 CA7307229	217	I>T	No	ClinGen ExAC gnomAD
CA7307230 rs765188423	217	I>V	No	ClinGen ExAC gnomAD
CA390602473 rs772187708	222	P>S	No	ClinGen ExAC gnomAD
CA7307227 rs772187708	222	P>T	No	ClinGen ExAC gnomAD
rs748214958 CA7307226	225	V>I	No	ClinGen ExAC gnomAD
rs993884899 CA264646642	227	G>A	No	ClinGen TOPMed gnomAD
CA390602433 rs1450041819	228	G>E	No	ClinGen gnomAD
rs144064383 CA264646638	229	D>H	No	ClinGen ESP TOPMed
rs1356606981 CA390602358	237	D>E	No	ClinGen TOPMed
CA390602360 rs1457216641	237	D>G	No	ClinGen gnomAD
CA390602331 rs1595217467	240	S>R	No	ClinGen Ensembl
CA264645801 rs1032824605	242	G>D	No	ClinGen Ensembl
rs967260755 CA264645795	243	V>I	No	ClinGen gnomAD
rs372452750 CA390602301	245	M>I	No	ClinGen ESP ExAC TOPMed gnomAD
rs372452750 CA7307203	245	M>I	No	ClinGen ESP ExAC TOPMed gnomAD
CA390602297 rs1455680711	246	Y>C	No	ClinGen gnomAD
CA390602274 rs1431416370	249	L>P	No	ClinGen gnomAD
rs1595217259 CA390602255	252	A>V	No	ClinGen Ensembl
CA390602223 rs1267374524	257	V>G	No	ClinGen gnomAD
rs746195386 CA264645787	258	D>H	No	ClinGen ExAC TOPMed gnomAD
rs746195386 CA7307201	258	D>N	No	ClinGen ExAC TOPMed gnomAD
CA7307200 rs140126863	260	E>G	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390602182 rs1251568234	263	S>F	No	ClinGen gnomAD
rs746707654 CA7307198	268	S>F	No	ClinGen ExAC gnomAD
CA264645784 rs1017996699	269	R>G	No	ClinGen Ensembl
CA264641767 rs371531566	280	Q>R	No	ClinGen ESP
CA7307172 rs747410357	286	A>T	No	ClinGen ExAC gnomAD
CA390601834 rs1281348481	286	A>V	No	ClinGen gnomAD
CA7307170 rs771878009	287	K>R	No	ClinGen ExAC gnomAD
CA7307169 rs747609197	288	D>E	No	ClinGen ExAC TOPMed gnomAD
CA390601801 rs149616968	291	Q>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs534048620 CA7307167	292	R>C	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7307166 rs200357482	292	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs996283858 CA264641739	294	L>V	No	ClinGen TOPMed gnomAD
CA390601764 rs1365990500	297	D>Y	No	ClinGen gnomAD
rs138308039 CA264641738	298	P>T	No	ClinGen ESP
rs150910355 CA7307162	307	R>H	No	ClinGen ESP ExAC TOPMed gnomAD
rs150910355 CA264641734	307	R>L	No	ClinGen ESP ExAC TOPMed gnomAD
rs370238703 CA264641731	308	D>H	No	ClinGen Ensembl
rs1411560797 CA390601681	309	A>V	No	ClinGen TOPMed
rs758673014 CA264641728	310	D>G	No	ClinGen ExAC TOPMed gnomAD
CA390601680 rs1237245826	310	D>N	No	ClinGen gnomAD
rs758673014 CA7307161	310	D>V	No	ClinGen ExAC TOPMed gnomAD
CA7307160 rs752746147	311	E>A	No	ClinGen ExAC TOPMed gnomAD
CA390601671 rs752746147	311	E>G	No	ClinGen ExAC TOPMed gnomAD
rs765370847 CA264641722	312	I>L	No	ClinGen ExAC TOPMed gnomAD
rs765370847 CA7307159	312	I>V	No	ClinGen ExAC TOPMed gnomAD
rs1360775608 CA390601659	313	K>T	No	ClinGen TOPMed
rs1407799005 CA390601648	314	E>D	No	ClinGen TOPMed
CA7307158 rs760077770	315	H>Q	No	ClinGen ExAC TOPMed gnomAD
CA264641714 rs760077770	315	H>Q	No	ClinGen ExAC TOPMed gnomAD
rs776943706 CA7307157	316	L>V	No	ClinGen ExAC gnomAD
rs754944278 CA7307139	320	K>E	No	ClinGen ExAC TOPMed gnomAD
rs997329245 CA264640401	320	K>R	No	ClinGen Ensembl
rs766743012 CA7307137	322	N>S	No	ClinGen ExAC TOPMed gnomAD
rs761309319 CA7307136	323	W>*	No	ClinGen ExAC gnomAD
CA390601551 rs1483247182	325	D>Y	No	ClinGen gnomAD
CA7307134 rs768059667	326	L>V	No	ClinGen ExAC TOPMed gnomAD
CA7307131 rs376247617	328	A>T	No	ClinGen ESP ExAC TOPMed gnomAD
CA7307130 rs762322464	328	A>V	No	ClinGen ExAC TOPMed gnomAD
rs375770844 CA264640390	329	K>R	No	ClinGen gnomAD
rs775115824 CA7307129	330	K>N	No	ClinGen ExAC gnomAD
CA7307128 rs769592023	331	V>L	No	ClinGen ExAC TOPMed
CA390601488 rs769592023	331	V>M	No	ClinGen ExAC TOPMed
rs1348316639 CA390601478	332	P>A	No	ClinGen TOPMed
rs773482291 CA7307127	333	A>T	No	ClinGen ExAC gnomAD
rs780955166 CA7307126	334	P>A	No	ClinGen ExAC TOPMed gnomAD
CA390601460 rs780955166	334	P>S	No	ClinGen ExAC TOPMed gnomAD
CA7307124 rs746809054	338	V>G	No	ClinGen ExAC gnomAD
rs909143652 CA264640377	340	R>Q	No	ClinGen TOPMed gnomAD
rs577750321 CA7307123	341	D>G	No	ClinGen 1000Genomes ExAC gnomAD
rs1208196188 CA390601373	342	E>A	No	ClinGen TOPMed
rs755247579 CA7307122	343	L>I	No	ClinGen ExAC TOPMed gnomAD
CA7307120 rs780222805	350	E>G	No	ClinGen ExAC gnomAD
CA7307118 rs557893123	353	T>I	No	ClinGen 1000Genomes ExAC gnomAD
CA7307119 rs557893123	353	T>R	No	ClinGen 1000Genomes ExAC gnomAD
CA7307116 rs762231001	355	M>V	No	ClinGen ExAC gnomAD
CA7307115 rs200895075	356	D>E	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1566717598 CA390601198	356	D>V	No	ClinGen Ensembl
rs762707763 CA7307113	362	A>T	No	ClinGen ExAC gnomAD
rs146532003 CA7307110	366	Q>R	No	ClinGen ESP ExAC TOPMed gnomAD
rs981586839 CA264640352	368	S>F	No	ClinGen Ensembl
rs1349695832 CA390601076	368	S>T	No	ClinGen gnomAD
CA7307109 rs770884768	369	E>K	No	ClinGen ExAC gnomAD
rs770884768 CA7307108	369	E>Q	No	ClinGen ExAC gnomAD
CA7307086 rs776138152	374	G>D	No	ClinGen ExAC gnomAD
CA390600724 rs1431385349	374	G>S	No	ClinGen gnomAD
CA390600715 rs1177626577	375	Y>F	No	ClinGen gnomAD
rs1236620385 CA390600693	378	V>A	No	ClinGen TOPMed gnomAD
CA390600668 rs1186275327	382	I>T	No	ClinGen gnomAD
CA7307083 rs760703708	386	R>H	No	ClinGen ExAC TOPMed gnomAD
rs1018108592 CA264639533	388	A>V	No	ClinGen TOPMed
CA7307080 rs771959307	389	A>V	No	ClinGen ExAC gnomAD
CA7307079 rs747906939	393	P>S	No	ClinGen ExAC TOPMed gnomAD
rs1308942225 CA390600589	395	Q>E	No	ClinGen gnomAD
CA264639530 rs995096349	398	M>I	No	ClinGen Ensembl
rs770164792 CA7307077	398	M>T	No	ClinGen ExAC gnomAD
rs1382996502 CA390600565	398	M>V	No	ClinGen gnomAD
rs745922176 CA7307076	402	R>C	No	ClinGen ExAC gnomAD
rs1011167649 CA264639526	402	R>H	No	ClinGen TOPMed gnomAD
rs1402330643 CA390600519	405	V>A	No	ClinGen gnomAD
CA390600523 rs1159699562	405	V>M	No	ClinGen gnomAD
rs781462520 CA7307075	406	T>P	No	ClinGen ExAC gnomAD
rs757836027 CA7307074	407	N>D	No	ClinGen ExAC TOPMed
rs747613814 CA7307073	410	R>K	No	ClinGen ExAC gnomAD
rs778160536 CA7307072	412	A>S	No	ClinGen ExAC TOPMed gnomAD
CA390600479 rs778160536	412	A>T	No	ClinGen ExAC TOPMed gnomAD
rs1274383549 CA390600474	413	M>V	No	ClinGen gnomAD
rs1261787695 CA390600460	414	M>R	No	ClinGen TOPMed
rs758848393 CA390600421	418	P>A	No	ClinGen ExAC TOPMed gnomAD
rs758848393 CA7307054	418	P>S	No	ClinGen ExAC TOPMed gnomAD
rs758848393 CA390600422	418	P>T	No	ClinGen ExAC TOPMed gnomAD
CA390600380 rs1338800427	423	Y>*	No	ClinGen gnomAD
rs141570904 CA7307053	423	Y>C	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141570904 CA7307052	423	Y>F	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7307051 rs754617697	424	D>Y	No	ClinGen ExAC gnomAD
rs1320680307 CA390600365	426	D>Y	No	ClinGen TOPMed gnomAD
CA264639390 rs1030868486	428	K>R	No	ClinGen TOPMed
rs766033940 CA7307049	429	D>A	No	ClinGen ExAC gnomAD
CA390600339 rs1595161666	429	D>E	No	ClinGen Ensembl
CA7307048 rs143530311	431	P>T	No	ClinGen ESP ExAC gnomAD
rs200091410 CA7307047	439	I>F	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7307046 rs200091410	439	I>V	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369503281 CA7307045	441	R>Q	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1406845788 CA390600253	443	C>S	No	ClinGen TOPMed gnomAD
CA390600245 rs1392660268	444	V>M	No	ClinGen gnomAD
CA7307042 rs762858981	445	H>R	No	ClinGen ExAC gnomAD
CA7307041 rs776931899	447	K>N	No	ClinGen ExAC gnomAD
rs771092000 CA7307040	448	S>C	No	ClinGen ExAC TOPMed gnomAD
CA390600217 rs771092000	448	S>R	No	ClinGen ExAC TOPMed gnomAD
CA7307039 rs760763362	449	N>S	No	ClinGen ExAC gnomAD
rs773211826 CA7307038	450	Q>P	No	ClinGen ExAC TOPMed gnomAD
rs773211826 CA390600200	450	Q>R	No	ClinGen ExAC TOPMed gnomAD
rs772598315 CA7307037	454	V>A	No	ClinGen ExAC TOPMed gnomAD
rs554880063 CA7307036	456	I>M	No	ClinGen 1000Genomes ExAC gnomAD
CA7307034 rs201610483	459	K>E	No	ClinGen ExAC TOPMed gnomAD
rs201610483 CA7307035	459	K>Q	No	ClinGen ExAC TOPMed gnomAD
CA390600110 rs1222606268	461	M>I	No	ClinGen TOPMed
CA390600116 rs1397845269	461	M>L	No	ClinGen gnomAD
rs1172474992 CA390600106	462	E>G	No	ClinGen gnomAD
rs745565405 CA7307012	462	E>K	No	ClinGen ExAC gnomAD
rs1284159698 CA390600101	463	A>T	No	ClinGen TOPMed
CA7307011 rs372449079	464	N>S	No	ClinGen ESP ExAC TOPMed gnomAD
CA7307010 rs191930267	466	Q>H	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7307009 rs751150206	467	K>N	No	ClinGen ExAC TOPMed gnomAD
CA7307008 rs777806922	469	I>V	No	ClinGen ExAC gnomAD
CA390600044 rs1461053466	471	A>V	No	ClinGen TOPMed
rs1187714869 CA390600028	474	L>F	No	ClinGen gnomAD
CA390600021 rs1443623106	475	C>Y	No	ClinGen gnomAD
rs1188456832 CA390600014	476	E>K	No	ClinGen TOPMed
CA390600004 rs1253408285	477	G>A	No	ClinGen TOPMed gnomAD
CA390600005 rs1253408285	477	G>E	No	ClinGen TOPMed gnomAD
CA264639069 rs939826341	479	P>H	No	ClinGen Ensembl
rs936571241 CA264639068	480	N>D	No	ClinGen TOPMed gnomAD
CA390599986 rs1351236661	480	N>S	No	ClinGen gnomAD
rs758462031 CA7307007	481	I>V	No	ClinGen ExAC gnomAD
CA7307005 rs148385885	485	H>N	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7307006 rs148385885	485	H>Y	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1450344063 CA390599945	486	E>G	No	ClinGen gnomAD
rs1315968352 CA390599949	486	E>K	No	ClinGen gnomAD
CA390599937 rs1174011689	487	V>A	No	ClinGen TOPMed
rs750549414 CA7307003	489	H>Y	No	ClinGen ExAC gnomAD
CA390599919 rs1296810191	490	D>H	No	ClinGen gnomAD
CA7307002 rs767783761	490	D>V	No	ClinGen ExAC gnomAD
CA7307001 rs761841279	491	Q>E	No	ClinGen ExAC
CA7307000 rs374856978	491	Q>H	No	ClinGen ESP ExAC gnomAD
rs1379356994 CA390599910	491	Q>R	No	ClinGen gnomAD
CA390599883 rs1329043053	493	H>L	No	ClinGen gnomAD
CA7306963 rs374156204	494	T>M	No	ClinGen ESP ExAC TOPMed gnomAD
CA390599855 rs1262890443	498	M>V	No	ClinGen TOPMed
CA7306961 rs771647081	501	L>V	No	ClinGen ExAC gnomAD
rs747695262 CA7306959	507	F>L	No	ClinGen ExAC gnomAD
rs778673783 CA7306958	508	E>A	No	ClinGen ExAC gnomAD
rs754963730 CA7306957	509	R>C	No	ClinGen ExAC gnomAD
rs537754207 CA7306956	509	R>H	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1198080263 CA390599726	515	H>P	No	ClinGen gnomAD
rs1256236878 CA390599727	515	H>Y	No	ClinGen gnomAD
rs1447027477 CA390599697	519	T>A	No	ClinGen TOPMed
CA7306954 rs757458685	521	A>G	No	ClinGen ExAC
CA7306953 rs200260836	522	S>G	No	ClinGen ExAC gnomAD
rs1447079397 CA390599608	532	V>I	No	ClinGen gnomAD
CA7306948 rs760132998	535	M>T	No	ClinGen ExAC gnomAD
rs765644584 CA7306949	535	M>V	No	ClinGen ExAC gnomAD
CA390599551 rs1445389914	540	V>M	No	ClinGen gnomAD
rs1178108548 CA390599544	541	V>L	No	ClinGen gnomAD
rs1424216101 CA390599520	544	D>G	No	ClinGen gnomAD
CA264634996 rs957531772	552	F>L	No	ClinGen TOPMed gnomAD
rs761566070 CA7306922	554	D>E	No	ClinGen ExAC TOPMed gnomAD
rs55911249 CA7306923 VAR_040634	554	D>N	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA390599428 rs1255803875	555	E>*	No	ClinGen TOPMed
rs1226099402 CA390599403	558	N>S	No	ClinGen gnomAD
rs773729525 CA7306921	560	E>G	No	ClinGen ExAC gnomAD
CA264634989 rs978041244	560	E>K	No	ClinGen gnomAD
CA390599390 rs978041244	560	E>Q	No	ClinGen gnomAD
CA7306920 rs768156182	561	I>T	No	ClinGen ExAC gnomAD
CA264634979 rs868072956	570	R>Q	No	ClinGen Ensembl
CA264634983 rs748183093	570	R>W	No	ClinGen gnomAD
rs1194938398 CA390599310	572	K>T	No	ClinGen TOPMed
rs762375512 CA7306919	573	P>S	No	ClinGen ExAC gnomAD
CA7306918 rs34604933 VAR_040635	574	P>L	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs745642692 CA7306916	576	N>H	No	ClinGen ExAC gnomAD
CA7306915 rs781008603	577	Q>K	No	ClinGen ExAC gnomAD
CA7306913 rs748456297	580	K>E	No	ClinGen ExAC gnomAD
rs779012780 CA7306912	585	T>S	No	ClinGen ExAC TOPMed gnomAD
rs1266818999 CA390599212	587	H>R	No	ClinGen gnomAD
CA7306911 rs755016647	589	A>S	No	ClinGen ExAC gnomAD
CA390599196 rs1333558064	589	A>V	No	ClinGen gnomAD
rs1220407517 CA390599193	590	A>T	No	ClinGen gnomAD
rs1392360459 CA390599166	594	L>*	No	ClinGen gnomAD
rs1189487598 CA390599161	595	N>Y	No	ClinGen gnomAD
rs1240440502 CA390599152	596	Q>E	No	ClinGen gnomAD
CA390599139 rs139792854	597	N>K	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7306907 rs765581206	598	G>S	No	ClinGen ExAC gnomAD
rs936278757 CA390599129	599	Y>*	No	ClinGen TOPMed
CA7306905 VAR_040636 rs55968863	599	Y>C	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs767990787 CA390599132	599	Y>H	No	ClinGen ExAC TOPMed gnomAD
rs767990787 CA7306906	599	Y>N	No	ClinGen ExAC TOPMed gnomAD
rs904683955 CA264634893	604	D>A	No	ClinGen TOPMed
rs1378758119 CA390599089	605	L>M	No	ClinGen Ensembl
CA390599076 rs1595137229	607	S>G	No	ClinGen Ensembl
rs763687878 CA390599072	607	S>I	No	ClinGen ExAC gnomAD
rs763687878 CA7306903	607	S>N	No	ClinGen ExAC gnomAD
rs762401928 CA7306902	607	S>R	No	ClinGen ExAC gnomAD
CA7306901 rs775033644	609	G>D	No	ClinGen ExAC gnomAD
CA390599056 rs1435259524	610	V>A	No	ClinGen gnomAD
CA7306899 rs759541597	610	V>I	No	ClinGen ExAC TOPMed gnomAD
rs182308463 CA7306873	613	Y>C	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1335281079 CA390598323	615	M>T	No	ClinGen gnomAD
rs573196540 CA7306872	615	M>V	No	ClinGen ExAC TOPMed gnomAD
CA390598296 rs1334842503	619	Q>R	No	ClinGen TOPMed gnomAD
CA390598283 rs1398320270	621	P>S	No	ClinGen gnomAD
CA7306871 rs781690351	624	S>Y	No	ClinGen ExAC gnomAD
CA390598243 rs1312723746	626	D>E	No	ClinGen gnomAD
rs747371219 CA7306869	627	R>*	No	ClinGen ExAC gnomAD
rs747371219 CA7306870	627	R>G	No	ClinGen ExAC gnomAD
CA7306868 rs373786141	627	R>Q	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758035959 CA7306867	630	T>M	No	ClinGen ExAC gnomAD
rs1362709766 CA390598219	631	C>R	No	ClinGen TOPMed gnomAD
CA264625848 rs376770842	632	T>I	No	ClinGen ESP TOPMed gnomAD
rs376770842 CA390598209	632	T>S	No	ClinGen ESP TOPMed gnomAD
rs778537958 CA7306865	633	S>G	No	ClinGen ExAC gnomAD
CA390598203 rs1209960135	633	S>I	No	ClinGen gnomAD
rs753307259 CA7306863	634	A>T	No	ClinGen ExAC TOPMed gnomAD
CA7306862 rs766315907	634	A>V	No	ClinGen ExAC gnomAD
rs1595097977 CA390598192	635	V>A	No	ClinGen Ensembl
CA390598196 rs1284915992	635	V>M	No	ClinGen gnomAD
rs546733309 CA7306860	637	I>T	No	ClinGen 1000Genomes ExAC gnomAD
CA390598156 rs1293188530	638	M>V	No	ClinGen gnomAD
rs761713973 CA7306858	641	I>S	No	ClinGen ExAC gnomAD
rs775814724 CA7306857	642	K>R	No	ClinGen ExAC gnomAD
rs920219205 CA264625803	644	G>R	No	ClinGen Ensembl
rs139155141 CA7306856	645	D>E	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA264625800 rs151173238	647	S>F	No	ClinGen ESP TOPMed
rs759640790 CA7306855	647	S>T	No	ClinGen ExAC TOPMed gnomAD
CA7306853 rs771466676	649	E>D	No	ClinGen ExAC gnomAD
rs961440854 CA264625793	649	E>Q	No	ClinGen TOPMed
rs747531260 CA7306852	652	A>S	No	ClinGen ExAC gnomAD
CA7306850 rs772352475	654	K>E	No	ClinGen ExAC gnomAD
rs753356455 CA390597832	659	E>D	No	ClinGen ExAC gnomAD
rs1290821786 CA390597820	660	A>V	No	ClinGen gnomAD
CA390597808 rs1236929974	661	K>I	No	ClinGen gnomAD
rs1202896948 CA390597805	661	K>N	No	ClinGen TOPMed
CA7306845 rs779496203	662	D>Y	No	ClinGen ExAC TOPMed gnomAD
CA390597781 rs1272580665	663	L>M	No	ClinGen TOPMed gnomAD
rs767594984 CA7306842	664	I>M	No	ClinGen ExAC TOPMed gnomAD
rs748949889 CA7306828	671	D>G	No	ClinGen ExAC gnomAD
CA7306826 rs755512871	672	P>L	No	ClinGen ExAC TOPMed gnomAD
CA7306825 rs745406792	674	K>E	No	ClinGen ExAC gnomAD
rs781254517 CA7306824	679	S>C	No	ClinGen ExAC gnomAD
rs201885024 CA7306822	684	N>S	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1394695194 CA390693676	688	Q>*	No	ClinGen gnomAD
rs758229532 CA7306820	689	D>G	No	ClinGen ExAC TOPMed gnomAD
CA265012739 rs533096467	692	Q>L	No	ClinGen 1000Genomes
rs564177046 CA7306816	696	N>S	No	ClinGen 1000Genomes ExAC gnomAD
rs767977575 CA7306815	697	P>A	No	ClinGen ExAC TOPMed gnomAD
CA7306814 rs544286455	697	P>L	No	ClinGen 1000Genomes ExAC gnomAD
rs1566673911 CA390693604	699	M>K	No	ClinGen Ensembl
CA265012731 rs867506498	700	T>I	No	ClinGen TOPMed gnomAD
CA390693588 rs1298075797	701	P>L	No	ClinGen TOPMed
CA7306809 rs769535940	708	G>R	No	ClinGen ExAC gnomAD
CA390693544 rs1566673830	709	A>T	No	ClinGen Ensembl
CA265012722 rs527985475	710	A>V	No	ClinGen Ensembl
CA7306807 rs780918760	711	V>L	No	ClinGen ExAC TOPMed gnomAD
rs780918760 CA7306808	711	V>M	No	ClinGen ExAC TOPMed gnomAD
rs757249503 CA7306806	714	C>R	No	ClinGen ExAC TOPMed gnomAD
rs1004150102 CA265012717	714	C>Y	No	ClinGen Ensembl
CA7306805 rs746888024	717	A>V	No	ClinGen ExAC gnomAD
CA7306804 rs777773959	718	T>A	No	ClinGen ExAC gnomAD
rs867099727 CA265012714	718	T>I	No	ClinGen Ensembl
rs1566672020 CA390693456	721	A>T	No	ClinGen Ensembl
CA390693440 rs1321813401	723	N>S	No	ClinGen gnomAD
CA7306784 rs772100058	724	K>R	No	ClinGen ExAC TOPMed gnomAD
rs1231397516 CA390693417	726	K>R	No	ClinGen TOPMed gnomAD
rs1231397516 CA390693418	726	K>T	No	ClinGen TOPMed gnomAD
CA7306783 rs747867978	728	E>K	No	ClinGen ExAC gnomAD
rs778837620 CA7306782	728	E>V	No	ClinGen ExAC gnomAD
CA265012445 rs937248322	734	N>D	No	ClinGen TOPMed gnomAD
CA390693363 rs937248322	734	N>H	No	ClinGen TOPMed gnomAD
CA390693350 rs1437406085	736	D>N	No	ClinGen gnomAD
CA7306779 rs781398254	738	A>T	No	ClinGen ExAC gnomAD
rs370587714 CA7306778	739	P>H	No	ClinGen ESP ExAC gnomAD
rs1424961195 CA390693269	747	K>R	No	ClinGen gnomAD
CA7306777 rs751709680	748	K>M	No	ClinGen ExAC gnomAD
rs933555892 CA265012438	752	S>G	No	ClinGen Ensembl
CA390693227 rs1488572636	753	T>S	No	ClinGen gnomAD
rs759980356 CA7306771	755	T>M	No	ClinGen ExAC gnomAD
rs149441965 CA7306769	756	R>C	No	ClinGen ESP ExAC TOPMed gnomAD
rs375975906 CA7306768	756	R>H	No	ClinGen ESP ExAC gnomAD
CA7306767 rs772822945	760	S>N	No	ClinGen ExAC gnomAD
rs771901541 CA7306766	766	S>Y	No	ClinGen ExAC gnomAD
CA265012425 rs748271652	767	S>A	No	ClinGen Ensembl
CA390693130 rs1566671565	768	S>C	No	ClinGen Ensembl
CA390693128 rs1566671565	768	S>F	No	ClinGen Ensembl
CA265012422 rs923582174	769	H>R	No	ClinGen Ensembl
CA7306765 rs748176348	769	H>Y	No	ClinGen ExAC gnomAD
CA7306763 rs768374038	772	G>D	No	ClinGen ExAC gnomAD
CA7306764 rs778730906	772	G>S	No	ClinGen ExAC gnomAD
CA390693072 rs1372886372	777	T>I	No	ClinGen gnomAD
rs749113650 CA7306762	778	K>E	No	ClinGen ExAC gnomAD
rs1457514878 CA390693068	778	K>R	No	ClinGen TOPMed
CA7306761 rs778900661	779	T>I	No	ClinGen ExAC TOPMed gnomAD
CA390693060 rs778900661	779	T>R	No	ClinGen ExAC TOPMed gnomAD
rs1197487303 CA390693044	782	P>H	No	ClinGen gnomAD
CA7306758 rs200115430	782	P>S	No	ClinGen ExAC gnomAD
CA7306757 rs758419560	783	S>G	No	ClinGen ExAC gnomAD
rs1391275040 CA390693035	783	S>R	No	ClinGen gnomAD
CA390693026 rs1250607600	785	P>A	No	ClinGen gnomAD
rs755066054 CA7306756	786	A>P	No	ClinGen ExAC TOPMed gnomAD
CA390693012 rs200886537	787	D>A	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1208435887 CA390693010	787	D>E	No	ClinGen TOPMed
CA7306754 rs35358985	787	D>N	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7306753 rs200886537	787	D>V	No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7306752 rs543409817	788	S>G	No	ClinGen 1000Genomes ExAC gnomAD
rs760474693 CA7306751	788	S>N	No	ClinGen ExAC
CA390693001 rs1266646054	789	N>D	No	ClinGen TOPMed
CA7306750 rs772586913	790	N>S	No	ClinGen ExAC TOPMed gnomAD
CA7306749 rs756443629	791	P>L	No	ClinGen ExAC TOPMed gnomAD
rs1303836978 CA390692979	792	E>G	No	ClinGen TOPMed gnomAD
CA7306746 rs768603375	794	L>F	No	ClinGen ExAC gnomAD
rs1324047982 CA390692963	795	F>L	No	ClinGen gnomAD
CA7306745 rs749051475	795	F>S	No	ClinGen ExAC TOPMed gnomAD
CA390692950 rs1453352381	796	Q>H	No	ClinGen gnomAD
CA7306744 rs147233692	798	S>L	No	ClinGen ESP ExAC gnomAD
CA7306741 rs777859214	802	A>G	No	ClinGen ExAC TOPMed gnomAD
CA390692913 rs1249693873	802	A>S	No	ClinGen gnomAD

No associated diseases with O75582

8 regional properties for O75582

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	49 - 318	IPR000719-1
domain	Protein kinase domain	426 - 687	IPR000719-2
domain	AGC-kinase, C-terminal	319 - 387	IPR000961
active_site	Serine/threonine-protein kinase, active site	173 - 185	IPR008271-1
active_site	Serine/threonine-protein kinase, active site	540 - 552	IPR008271-2
binding_site	Protein kinase, ATP binding site	55 - 81	IPR017441-1
binding_site	Protein kinase, ATP binding site	432 - 455	IPR017441-2
domain	Protein kinase, C-terminal	339 - 377	IPR017892

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Cytoplasm	Predominantly nuclear Exported into cytoplasm in response to glucocorticoid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

19 GO annotations of biological process

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
epidermal growth factor receptor signaling pathway	The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
histone H2A-S1 phosphorylation	OBSOLETE. The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.
histone H3-S10 phosphorylation	OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
histone H3-S28 phosphorylation	OBSOLETE. The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
histone phosphorylation	OBSOLETE. The modification of histones by addition of phosphate groups.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
interleukin-1-mediated signaling pathway	The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of cytokine production	Any process that stops, prevents, or reduces the rate of production of a cytokine.
negative regulation of transcription, DNA-templated	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of CREB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
positive regulation of histone acetylation	Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
positive regulation of histone phosphorylation	OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.
positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of transcription, DNA-templated	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

19 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P18652	RPS6KA	Ribosomal protein S6 kinase 2 alpha	Gallus gallus (Chicken)	SS
Q5F3L1	RPS6KA5	Ribosomal protein S6 kinase alpha-5	Gallus gallus (Chicken)	SS
Q96S38	RPS6KC1	Ribosomal protein S6 kinase delta-1	Homo sapiens (Human)	PR
Q15349	RPS6KA2	Ribosomal protein S6 kinase alpha-2	Homo sapiens (Human)	SS
Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	Homo sapiens (Human)	EV
Q9UK32	RPS6KA6	Ribosomal protein S6 kinase alpha-6	Homo sapiens (Human)	SS
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Homo sapiens (Human)	EV
O75676	RPS6KA4	Ribosomal protein S6 kinase alpha-4	Homo sapiens (Human)	SS
Q9UBS0	RPS6KB2	Ribosomal protein S6 kinase beta-2	Homo sapiens (Human)	PR
P23443	RPS6KB1	Ribosomal protein S6 kinase beta-1	Homo sapiens (Human)	EV SS
Q9WUT3	Rps6ka2	Ribosomal protein S6 kinase alpha-2	Mus musculus (Mouse)	SS
Q9Z2B9	Rps6ka4	Ribosomal protein S6 kinase alpha-4	Mus musculus (Mouse)	SS
P18654	Rps6ka3	Ribosomal protein S6 kinase alpha-3	Mus musculus (Mouse)	SS
Q8BLK9	Rps6kc1	Ribosomal protein S6 kinase delta-1	Mus musculus (Mouse)	PR
P18653	Rps6ka1	Ribosomal protein S6 kinase alpha-1	Mus musculus (Mouse)	SS
Q8C050	Rps6ka5	Ribosomal protein S6 kinase alpha-5	Mus musculus (Mouse)	PR
Q63531	Rps6ka1	Ribosomal protein S6 kinase alpha-1	Rattus norvegicus (Rat)	SS
Q21734	rskn-1	Putative ribosomal protein S6 kinase alpha-1	Caenorhabditis elegans	SS
Q18846	rskn-2	Putative ribosomal protein S6 kinase alpha-2	Caenorhabditis elegans	PR

10	20	30	40	50	60
MEEEGGSSGG	AAGTSADGGD	GGEQLLTVKH	ELRTANLTGH	AEKVGIENFE	LLKVLGTGAY
70	80	90	100	110	120
GKVFLVRKIS	GHDTGKLYAM	KVLKKATIVQ	KAKTTEHTRT	ERQVLEHIRQ	SPFLVTLHYA
130	140	150	160	170	180
FQTETKLHLI	LDYINGGELF	THLSQRERFT	EHEVQIYVGE	IVLALEHLHK	LGIIYRDIKL
190	200	210	220	230	240
ENILLDSNGH	VVLTDFGLSK	EFVADETERA	YSFCGTIEYM	APDIVRGGDS	GHDKAVDWWS
250	260	270	280	290	300
LGVLMYELLT	GASPFTVDGE	KNSQAEISRR	ILKSEPPYPQ	EMSALAKDLI	QRLLMKDPKK
310	320	330	340	350	360
RLGCGPRDAD	EIKEHLFFQK	INWDDLAAKK	VPAPFKPVIR	DELDVSNFAE	EFTEMDPTYS
370	380	390	400	410	420
PAALPQSSEK	LFQGYSFVAP	SILFKRNAAV	IDPLQFHMGV	ERPGVTNVAR	SAMMKDSPFY
430	440	450	460	470	480
QHYDLDLKDK	PLGEGSFSIC	RKCVHKKSNQ	AFAVKIISKR	MEANTQKEIT	ALKLCEGHPN
490	500	510	520	530	540
IVKLHEVFHD	QLHTFLVMEL	LNGGELFERI	KKKKHFSETE	ASYIMRKLVS	AVSHMHDVGV
550	560	570	580	590	600
VHRDLKPENL	LFTDENDNLE	IKIIDFGFAR	LKPPDNQPLK	TPCFTLHYAA	PELLNQNGYD
610	620	630	640	650	660
ESCDLWSLGV	ILYTMLSGQV	PFQSHDRSLT	CTSAVEIMKK	IKKGDFSFEG	EAWKNVSQEA
670	680	690	700	710	720
KDLIQGLLTV	DPNKRLKMSG	LRYNEWLQDG	SQLSSNPLMT	PDILGSSGAA	VHTCVKATFH
730	740	750	760	770	780
AFNKYKREGF	CLQNVDKAPL	AKRRKMKKTS	TSTETRSSSS	ESSHSSSSHS	HGKTTPTKTL
790	800
QPSNPADSNN	PETLFQFSDS	VA