AiPD: Autoinhibited Protein Database

O75469

Gene name	NR1I2 (PXR)
Protein name	Nuclear receptor subfamily 1 group I member 2
Names	Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8856
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-64 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

58 structures for O75469

Entry ID	Method	Resolution	Chain	Position	Source
1ILG	X-ray	252 A	A	130-434	PDB
1ILH	X-ray	276 A	A	130-434	PDB
1M13	X-ray	215 A	A	130-434	PDB
1NRL	X-ray	200 A	A/B	130-434	PDB
1SKX	X-ray	280 A	A	130-431	PDB
2O9I	X-ray	280 A	A/B	142-434	PDB
2QNV	X-ray	280 A	A	130-434	PDB
3CTB	X-ray	200 A	A/B	130-434	PDB
3HVL	X-ray	210 A	A/B	130-434	PDB
3R8D	X-ray	280 A	A	130-434	PDB
4J5W	X-ray	280 A	A/B	130-434	PDB
4J5X	X-ray	280 A	A/B	130-434	PDB
4NY9	X-ray	280 A	A	142-431	PDB
4S0S	X-ray	280 A	A/B	130-434	PDB
4S0T	X-ray	314 A	A/B	130-434	PDB
4X1F	X-ray	200 A	A	130-434	PDB
4X1G	X-ray	225 A	A	130-434	PDB
4XAO	X-ray	258 A	A	130-434	PDB
4XHD	X-ray	240 A	A	130-434	PDB
5A86	X-ray	225 A	A/B	130-432	PDB
5X0R	X-ray	267 A	A/B	130-434	PDB
6BNS	X-ray	256 A	A/B	130-434	PDB
6DUP	X-ray	230 A	A/B	130-426	PDB
6HJ2	X-ray	228 A	A	130-434	PDB
6HTY	X-ray	222 A	A/B	129-434	PDB
6NX1	X-ray	227 A	A/B	130-434	PDB
6P2B	X-ray	230 A	A/B	130-434	PDB
6S41	X-ray	270 A	A/B	138-434	PDB
6TFI	X-ray	185 A	A/B	129-434	PDB
6XP9	X-ray	227 A	A/B	130-434	PDB
7AX8	X-ray	215 A	A	130-434	PDB
7AX9	X-ray	225 A	A	130-434	PDB
7AXA	X-ray	226 A	A	130-434	PDB
7AXB	X-ray	255 A	A	130-434	PDB
7AXC	X-ray	205 A	A	130-434	PDB
7AXD	X-ray	265 A	A	130-434	PDB
7AXE	X-ray	190 A	A	130-434	PDB
7AXF	X-ray	245 A	A	130-434	PDB
7AXG	X-ray	270 A	A	130-434	PDB
7AXH	X-ray	255 A	A	130-434	PDB
7AXI	X-ray	215 A	A	130-434	PDB
7AXJ	X-ray	230 A	A	130-434	PDB
7AXK	X-ray	200 A	A	130-434	PDB
7AXL	X-ray	250 A	A	130-434	PDB
7N2A	X-ray	226 A	A	137-434	PDB
7RIO	X-ray	248 A	A	137-434	PDB
7RIU	X-ray	205 A	A	137-434	PDB
7RIV	X-ray	220 A	A	137-434	PDB
7YFK	X-ray	210 A	A/B	130-434	PDB
8CCT	X-ray	290 A	A	130-434	PDB
8CF9	X-ray	200 A	A	130-434	PDB
8CH8	X-ray	215 A	A	130-434	PDB
8E3N	X-ray	225 A	A	130-434	PDB
8EQZ	X-ray	237 A	A/B	130-434	PDB
8F5Y	X-ray	215 A	A/B	130-434	PDB
8FPE	X-ray	230 A	A	130-434	PDB
8SZV	X-ray	220 A	A	130-434	PDB
AF-O75469-F1	Predicted				AlphaFoldDB

409 variants for O75469

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1269667069 CA354055420	2	E>G		No	ClinGen TOPMed gnomAD
CA2557713 rs768372778	3	V>L		No	ClinGen ExAC gnomAD
rs1428433468 CA354055463	6	K>Q		No	ClinGen TOPMed gnomAD
rs143921735 CA2557714	8	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139729585 CA2557716	11	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2557715 rs761442741	11	H>Y		No	ClinGen ExAC gnomAD
VAR_050581 CA2557717 rs1063955	12	A>T		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA81750753 rs374088662	15	V>L		No	ClinGen Ensembl
CA81750757 rs781531379	16	H>L		No	ClinGen gnomAD
rs781531379 CA354055589	16	H>P		No	ClinGen gnomAD
CA2557718 rs201648270	17	C>R		No	ClinGen ExAC TOPMed gnomAD
CA2557719 rs766155450	17	C>W		No	ClinGen ExAC gnomAD
CA2557720 VAR_033237 rs59371185	18	E>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA354055627 rs1237061529	19	D>E		No	ClinGen gnomAD
rs1224749184 CA354055630 COSM4005233	20	T>A	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA2557721 rs758491224	20	T>K		No	ClinGen ExAC gnomAD
rs1219117720 CA354055649 COSM1036793	21	E>D	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1315404276 CA354055653	22	S>P		No	ClinGen gnomAD
CA354055671 rs1216188922	24	P>A		No	ClinGen gnomAD
rs1366147754 CA354055678	24	P>L		No	ClinGen TOPMed
VAR_012228 CA2557723 rs12721613	27	P>S	allele PXR*2 [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2557725 rs781646686	29	V>D		No	ClinGen ExAC
CA2557724 rs770086423	29	V>I		No	ClinGen ExAC gnomAD
rs756493951 CA2557727	31	A>T		No	ClinGen ExAC TOPMed gnomAD
rs561984009 CA2557729	32	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs561984009 CA354055765	32	D>V		No	ClinGen 1000Genomes ExAC gnomAD
CA2557728 rs780228223	32	D>Y		No	ClinGen ExAC gnomAD
CA2557730 rs377248798	33	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs747640055 CA2557732	34	E>D		No	ClinGen ExAC gnomAD
rs774172261 CA2557731	34	E>K		No	ClinGen ExAC gnomAD
rs375785850 CA354055813	36	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs375785850 CA2557735	36	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_012229 rs12721607 CA2557734	36	G>R	allele PXR*3 [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1047883186 CA81750853	37	G>S		No	ClinGen gnomAD
rs533429053 CA2557736	40	I>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1427230711 CA354055851	40	I>T		No	ClinGen TOPMed
rs776219511 CA2557737 COSM1418050	42	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs151248272 CA2557738	42	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs151248272 CA354055875	42	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs974968906 CA354055886	44	C>F		No	ClinGen TOPMed
CA81750872 rs974968906	44	C>Y		No	ClinGen TOPMed
rs751825488 CA2557740	45	G>E		No	ClinGen ExAC TOPMed gnomAD
rs757293919 CA2557742	46	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2557741 rs757293919	46	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA2557744 rs756514899	50	G>C		No	ClinGen ExAC gnomAD
rs890659419 CA81750892	50	G>V		No	ClinGen gnomAD
CA354055996 rs1469447639	54	N>S		No	ClinGen gnomAD
CA81750907 rs1009134763	55	V>A		No	ClinGen TOPMed
rs780646192 CA2557745	56	M>T		No	ClinGen ExAC gnomAD
rs1376552093 CA354056027	57	T>A		No	ClinGen TOPMed
rs749570207 CA2557746	58	C>R		No	ClinGen ExAC gnomAD
rs922087091 CA81750921	58	C>Y		No	ClinGen TOPMed gnomAD
CA2557749 rs747878625	59	E>D		No	ClinGen ExAC TOPMed gnomAD
CA2557748 rs778678548	59	E>G		No	ClinGen ExAC TOPMed gnomAD
rs377629240 CA2557747	59	E>K		No	ClinGen ESP ExAC gnomAD
CA81750930 rs984502020	60	G>A		No	ClinGen TOPMed
CA2557750 rs199999304	60	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1353209173 CA354056089	61	C>*		No	ClinGen TOPMed gnomAD
rs772537982 CA354056117	62	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1577281533 CA354056135	63	G>D		No	ClinGen Ensembl
rs1559788699 CA354056141	64	F>S		No	ClinGen Ensembl
CA2557752 rs370890377	65	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1316167492 CA354056147	65	F>L		No	ClinGen gnomAD
rs1559789550 CA354056561	68	A>T		No	ClinGen Ensembl
CA354056572 rs1480451898	69	M>I		No	ClinGen gnomAD
rs1559789554 CA354056568	69	M>L		No	ClinGen Ensembl
CA2557778 rs773536011	72	N>K		No	ClinGen ExAC gnomAD
rs1169152470 CA354056600	73	A>S		No	ClinGen gnomAD
CA81751988 rs979295561	73	A>V		No	ClinGen Ensembl
rs1407382756 CA354056610	74	R>Q		No	ClinGen TOPMed
CA2557780 rs754289162	76	R>K		No	ClinGen ExAC TOPMed gnomAD
CA354056696 rs1316429046	80	R>Q		No	ClinGen gnomAD
rs1384110705 CA354056689	80	R>W		No	ClinGen gnomAD
CA2557782 rs765842027	82	G>R		No	ClinGen ExAC gnomAD
COSM479262 rs1343552901 CA354056766	84	C>*	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1462533648 CA354056772	85	E>Q		No	ClinGen TOPMed gnomAD
CA2557785 rs777268672	86	I>N		No	ClinGen ExAC gnomAD
CA354056800 rs1577283480	87	T>P		No	ClinGen Ensembl
CA81752008 rs956098723	88	R>G		No	ClinGen TOPMed gnomAD
rs545818462 CA2557786	88	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA354056818 rs956098723	88	R>W		No	ClinGen TOPMed gnomAD
rs756712963 CA354056838 CA2557787	89	K>N		No	ClinGen ExAC gnomAD
rs1284820806 CA354056834	89	K>R		No	ClinGen gnomAD
rs1577283496 CA354056842	90	T>P		No	ClinGen Ensembl
CA354056857 rs150019952	91	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150019952 CA2557788	91	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA354056873 rs1022524999	92	R>L		No	ClinGen TOPMed gnomAD
rs1022524999 CA81752025	92	R>P		No	ClinGen TOPMed gnomAD
CA2557791 rs779991929	94	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA354056910 rs1455632506	95	Q>K		No	ClinGen gnomAD
rs1157083954 CA354056933	96	A>T		No	ClinGen gnomAD
CA81752040 VAR_018340 rs72551371	98	R>C		No	ClinGen UniProt Ensembl dbSNP
CA354056990 rs1305029551	99	L>P		No	ClinGen gnomAD
rs917173740 CA81752042	100	R>C		No	ClinGen TOPMed gnomAD
CA354056998 rs1386123286	100	R>H		No	ClinGen gnomAD
rs768540361 CA2557793	101	K>E		No	ClinGen ExAC gnomAD
rs1236534380 CA354057021	101	K>N		No	ClinGen gnomAD
CA2557794 rs773302670	101	K>R		No	ClinGen ExAC TOPMed gnomAD
CA354057027 rs761016051	102	C>G		No	ClinGen ExAC TOPMed gnomAD
rs761016051 CA2557795	102	C>R		No	ClinGen ExAC TOPMed gnomAD
rs749979628 CA354057114	106	G>A		No	ClinGen TOPMed gnomAD
rs749979628 CA354057113	106	G>D		No	ClinGen TOPMed gnomAD
CA2557800 rs569524145	106	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs569524145 CA81752079	106	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs749979628 CA81752086	106	G>V		No	ClinGen TOPMed gnomAD
rs200198969 CA354057130	107	M>K		No	ClinGen 1000Genomes TOPMed
rs200198969 CA2557801	107	M>R		No	ClinGen 1000Genomes TOPMed
rs1172565762 CA354057601	112	I>N		No	ClinGen TOPMed gnomAD
rs1413944791 CA354057591	112	I>V		No	ClinGen TOPMed
rs1438668845 CA354057640	113	M>I		No	ClinGen TOPMed
rs1463977583 CA354057629	113	M>T		No	ClinGen gnomAD
rs1454314508 CA354057708	115	D>A		No	ClinGen gnomAD
rs373686292 CA354057719	115	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs762110065 CA2557823	115	D>H		No	ClinGen ExAC TOPMed gnomAD
rs762110065 CA2557824	115	D>N		No	ClinGen ExAC TOPMed gnomAD
rs755621657 CA2557826	116	E>K		No	ClinGen ExAC TOPMed gnomAD
CA354057792 rs1309835132	117	A>G		No	ClinGen gnomAD
CA2557828 rs765931820	117	A>S		No	ClinGen ExAC gnomAD
rs542581336 CA2557830	118	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1239295516 CA354057811	119	E>K		No	ClinGen TOPMed
rs1205910367 CA354057866	121	R>K		No	ClinGen gnomAD
CA2557833 rs533749078	122	R>G		No	ClinGen ExAC gnomAD
rs12721608 CA2557835	122	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2557834 VAR_012230 rs12721608	122	R>Q	allele PXR*4 [UniProt]	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA2557832 rs533749078	122	R>W		No	ClinGen ExAC gnomAD
CA354057914 rs1577284506	123	A>G		No	ClinGen Ensembl
CA2557837 rs201081582	124	L>S		No	ClinGen ExAC TOPMed gnomAD
rs796992519 CA81752684	124	L>V		No	ClinGen gnomAD
rs555441030 CA2557840	127	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA354057968 rs371659081	127	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2557841 rs371659081	127	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs555441030 CA2557838	127	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs998779933 CA81752697	130	S>N		No	ClinGen TOPMed
rs772496647 CA2557842	130	S>R		No	ClinGen ExAC gnomAD
CA2557845 rs375233676	132	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2557844 rs375233676	132	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA2557843 rs772838074	132	R>W		No	ClinGen ExAC gnomAD
CA2557846 rs753350624	134	G>E		No	ClinGen ExAC gnomAD
CA354058101 rs1208628681	135	T>I		No	ClinGen TOPMed
rs1577284562 CA354058084	135	T>P		No	ClinGen Ensembl
rs201940433 CA2557847	136	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs765197913 CA2557848	137	P>T		No	ClinGen ExAC gnomAD
CA354058156 rs1206018744	139	G>*		No	ClinGen TOPMed
CA2557853 rs758263277	140	V>G		No	ClinGen ExAC gnomAD
CA2557851 rs72551372	140	V>M		No	ClinGen ESP
CA2557854 rs573567813	141	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2557855 rs751409859	142	G>W		No	ClinGen ExAC gnomAD
rs1193022204 CA354058254	146	E>K		No	ClinGen gnomAD
CA2557858 rs72551373 VAR_018341	148	R>Q		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA2557857 rs780452746	148	R>W		No	ClinGen ExAC gnomAD
rs145927431 CA2557859	149	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA354058349 rs1419412608	151	I>T		No	ClinGen gnomAD
rs1577284652 CA354058339	151	I>V		No	ClinGen Ensembl
rs1318907001 CA354058356	152	R>G		No	ClinGen TOPMed
rs375457171 CA2557860	153	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA354058373 rs375457171	153	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA81752757 rs975415207	155	M>T		No	ClinGen TOPMed
rs138795315 CA2557861	156	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs138795315 CA354058424	156	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs773499666 CA2557863	157	A>T		No	ClinGen ExAC TOPMed gnomAD
CA354058477 rs1188078946	159	M>I		No	ClinGen TOPMed
CA2557864 rs761060380	160	K>N		No	ClinGen ExAC gnomAD
rs1273540746 CA354058487	160	K>Q		No	ClinGen gnomAD
rs1224625973 CA354058506	161	T>A		No	ClinGen gnomAD
CA354058539 rs1216033567	162	F>C		No	ClinGen gnomAD
CA354058537 rs1351775615	162	F>V		No	ClinGen TOPMed gnomAD
rs72551374 CA2557866	163	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA354058578 rs1451352725	164	T>A		No	ClinGen TOPMed
rs1451352725 CA354058580	164	T>S		No	ClinGen TOPMed
CA81752776 rs756102563	165	T>A		No	ClinGen TOPMed gnomAD
CA354058610 rs1245989103	165	T>I		No	ClinGen gnomAD
CA2557868 rs764720561	168	H>Y		No	ClinGen ExAC gnomAD
rs553589290 CA2557869	170	K>N		No	ClinGen ExAC gnomAD
rs373183819 CA81752801	171	N>T		No	ClinGen ESP TOPMed gnomAD
CA81752802 rs763487661	172	F>V		No	ClinGen Ensembl
CA2557871 rs373024967	173	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2557870 rs201775074	173	R>W		No	ClinGen ExAC TOPMed gnomAD
CA354059285 rs1445960808	175	P>L		No	ClinGen gnomAD
CA354059293 rs765529027	176	G>E		No	ClinGen ExAC TOPMed gnomAD
CA2557894 rs765529027	176	G>V		No	ClinGen ExAC TOPMed gnomAD
CA2557895 rs752727322	177	V>L		No	ClinGen ExAC gnomAD
rs376112054 CA2557898	182	C>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs373870063 CA2557899	183	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs906302130 CA81753169	184	L>F		No	ClinGen Ensembl
rs746244461 CA2557901	185	P>L		No	ClinGen ExAC gnomAD
rs781353779 CA2557900	185	P>S		No	ClinGen ExAC gnomAD
rs1478478283 CA354059426	187	S>F		No	ClinGen gnomAD
CA2557903 rs769287200	190	A>T		No	ClinGen ExAC gnomAD
rs775228283 CA2557904	190	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2557905 rs748782694	192	S>L		No	ClinGen ExAC TOPMed gnomAD
CA2557906 rs748782694	192	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1404700759 CA354059477	193	R>K		No	ClinGen gnomAD
CA354059539 rs1412966426	197	A>D		No	ClinGen gnomAD
CA354059541 rs1412966426	197	A>V		No	ClinGen gnomAD
rs1333683212 CA354059593	200	S>R		No	ClinGen gnomAD
rs894661381 CA81753203	201	Q>H		No	ClinGen Ensembl
rs201940328 CA354059635	203	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2557910 rs199710321	203	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201940328 CA2557908	203	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1339723554 CA354059646	204	K>E		No	ClinGen gnomAD
CA354059668 rs1223964209	205	D>Y		No	ClinGen gnomAD
rs760541932 CA354059779	211	V>F		No	ClinGen ExAC gnomAD
rs760541932 CA2557912	211	V>I		No	ClinGen ExAC gnomAD
rs752954517 CA2557914	214	Q>*		No	ClinGen ExAC gnomAD
CA2557915 rs758467475	214	Q>L		No	ClinGen ExAC gnomAD
CA2557916 rs779954489	215	L>V		No	ClinGen ExAC TOPMed gnomAD
CA2557920 rs377500972	216	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2557921 rs377500972	216	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2557919 rs377500972	216	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2557918 rs757634172	216	R>W		No	ClinGen ExAC TOPMed gnomAD
CA81753243 CA2557923 rs749007639	217	G>R		No	ClinGen ExAC TOPMed gnomAD
COSM78194 rs749007639 CA2557924	217	G>W	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA354059873 rs147984184	218	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA2557925 rs147984184	218	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA354059870 rs147984184	218	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA354059894 rs1385921021	219	D>G		No	ClinGen gnomAD
rs538208001 CA354059888	219	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs538208001 CA2557926	219	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA354059913 rs1421642994	220	G>D		No	ClinGen gnomAD
rs1404116609 CA354059924	221	S>G		No	ClinGen TOPMed
CA81753248 rs200618563	223	W>C		No	ClinGen Ensembl
CA2557928 rs773253505	224	N>S		No	ClinGen ExAC gnomAD
CA354059988 rs1405498377	224	N>Y		No	ClinGen gnomAD
rs760358828 CA2557929	226	K>N		No	ClinGen ExAC
CA354060048 rs1329166731	227	P>S		No	ClinGen gnomAD
CA81753255 rs993502856	228	P>S		No	ClinGen Ensembl
rs370995407 CA2557933	230	D>N		No	ClinGen ESP ExAC gnomAD
CA354060116 rs1284665228	232	G>D		No	ClinGen gnomAD
rs191312162 CA2557937	233	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs77816628 CA2557938	234	K>E		No	ClinGen ExAC TOPMed gnomAD
CA354060154 rs756423102	236	I>F		No	ClinGen ExAC
CA2557940 rs756423102	236	I>V		No	ClinGen ExAC
CA354060170 rs1450296477	237	F>V		No	ClinGen gnomAD
rs754260839 CA354060248	242	H>L		No	ClinGen ExAC TOPMed gnomAD
CA81753280 rs754260839	242	H>P		No	ClinGen ExAC TOPMed gnomAD
rs754260839 CA2557943	242	H>R		No	ClinGen ExAC TOPMed gnomAD
rs754641379 CA354060258	243	M>L		No	ClinGen ExAC gnomAD
rs1490291991 CA354060263	243	M>R		No	ClinGen TOPMed
rs754641379 CA2557944	243	M>V		No	ClinGen ExAC gnomAD
rs778733994 CA2557945	244	A>G		No	ClinGen ExAC gnomAD
CA2557946 rs747592553	245	D>A		No	ClinGen ExAC gnomAD
rs574094737 CA2557947	246	M>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2557948 rs777564852	246	M>R		No	ClinGen ExAC TOPMed gnomAD
rs574094737 COSM1632745 CA354060300	246	M>V	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs141599641 CA2557950	247	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs141599641 CA2557949	247	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA354060330 rs1271748693	248	T>A		No	ClinGen TOPMed
rs776337288 CA2557951	249	Y>C		No	ClinGen ExAC gnomAD
rs759357800 CA2557952	250	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1237522486 CA354060414	252	K>N		No	ClinGen gnomAD
rs768816150 CA2557953	253	G>A		No	ClinGen ExAC TOPMed gnomAD
rs768816150 CA354060430	253	G>D		No	ClinGen ExAC TOPMed gnomAD
CA354060448 rs1222625969	254	I>M		No	ClinGen TOPMed
rs964915799 CA81753301	256	S>G		No	ClinGen Ensembl
rs774604402 CA2557954	258	A>T		No	ClinGen ExAC TOPMed gnomAD
rs761766539 CA354060553	260	V>A		No	ClinGen ExAC gnomAD
rs761766539 CA2557955	260	V>G		No	ClinGen ExAC gnomAD
CA2557957 rs750483931	261	I>T		No	ClinGen ExAC TOPMed gnomAD
CA2557959 rs146128653	263	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2557958 rs761179278	263	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA354060592 rs761179278	263	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs146128653 CA354060602	263	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA354061119 rs1559791515	266	D>V		No	ClinGen Ensembl
rs777320630 CA2557977	269	I>F		No	ClinGen ExAC gnomAD
CA354061156 rs759977935	269	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1323369621 CA354061151	269	I>N		No	ClinGen gnomAD
CA354061150 rs777320630	269	I>V		No	ClinGen ExAC gnomAD
CA2557979 rs765752068	270	E>K		No	ClinGen ExAC TOPMed gnomAD
CA354061157 rs765752068	270	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs541839505 CA2557982	271	D>A		No	ClinGen 1000Genomes ExAC gnomAD
CA2557981 rs144833620	271	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1477398226 CA354061180	272	Q>K		No	ClinGen TOPMed
rs1375485214 CA354061184	272	Q>P		No	ClinGen TOPMed
CA354061194 rs1200911701	273	I>V		No	ClinGen TOPMed
rs1456499728 CA354061224	276	L>Q		No	ClinGen gnomAD
CA2557984 rs371067095	277	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs751030739 CA2557983	277	K>T		No	ClinGen ExAC gnomAD
rs200219497 CA354061241	278	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs200219497 CA2557985	278	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs976156170 CA81753924	278	G>R		No	ClinGen TOPMed
rs1344388711 CA354061253	279	A>V		No	ClinGen TOPMed
rs779833449 CA2557988	280	A>T		No	ClinGen ExAC TOPMed gnomAD
CA354061285 rs367648421	282	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA354061292 rs1192782454	282	E>A		No	ClinGen gnomAD
rs367648421 CA2557990	282	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1444991668 CA354061305	283	L>P		No	ClinGen TOPMed
rs771205341 CA2557993	287	R>K		No	ClinGen ExAC TOPMed gnomAD
CA354061347 rs1413623058	287	R>S		No	ClinGen TOPMed
CA2557994 rs771205341	287	R>T		No	ClinGen ExAC TOPMed gnomAD
rs942238206 CA2557995	289	N>H		No	ClinGen TOPMed gnomAD
rs201179068 CA2558003	294	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201179068 CA354061422	294	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2558001 rs763780333	294	A>T		No	ClinGen ExAC TOPMed gnomAD
rs201179068 CA2558002	294	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756006781 CA2558006	295	E>D		No	ClinGen ExAC TOPMed gnomAD
CA354061423 rs749942595	295	E>K		No	ClinGen ExAC gnomAD
rs749942595 CA2558005	295	E>Q		No	ClinGen ExAC gnomAD
CA2558007 rs199860148	301	C>G		No	ClinGen 1000Genomes ExAC gnomAD
CA2558010 rs778054838	303	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2558009 rs142454025	303	R>W		No	ClinGen ESP ExAC gnomAD
rs1489369518 CA354061531	305	S>T		No	ClinGen gnomAD
rs1046989140 CA81753962	306	Y>H		No	ClinGen Ensembl
rs771289157 CA354061569	308	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1421474484 CA354061582	309	E>A		No	ClinGen gnomAD
CA2558013 rs781350413	311	T>P		No	ClinGen ExAC TOPMed gnomAD
CA2558014 rs773503796	312	A>T		No	ClinGen ExAC TOPMed gnomAD
rs774659689 CA2558036	314	G>V		No	ClinGen ExAC gnomAD
rs375142772 CA2558037	316	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA2558038 rs771690396	318	L>F		No	ClinGen ExAC gnomAD
CA354061750 rs1275367503	322	P>R		No	ClinGen TOPMed
rs1436851778 CA354061771	324	L>R		No	ClinGen gnomAD
rs1187745331 CA354061799	327	H>Y		No	ClinGen gnomAD
rs1316864493 CA354061811	328	Y>C		No	ClinGen TOPMed
rs760231204 CA2558040	328	Y>H		No	ClinGen ExAC gnomAD
CA2558042 rs762908247	329	M>R		No	ClinGen ExAC TOPMed gnomAD
CA354061859 rs765294571	332	K>M		No	ClinGen ExAC gnomAD
CA2558044 rs765294571	332	K>T		No	ClinGen ExAC gnomAD
rs943929920 CA81754068	335	L>Q		No	ClinGen Ensembl
CA354061898 rs1409620636	336	H>P		No	ClinGen gnomAD
CA2558051 rs376659976	340	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs565595512 CA354061945	340	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
CA2558050 rs565595512	340	Y>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1338435034 CA354061982	343	M>I		No	ClinGen TOPMed gnomAD
CA2558057 rs772496539	349	F>S		No	ClinGen ExAC gnomAD
rs1257515500 CA354062063	350	S>F		No	ClinGen TOPMed gnomAD
CA2558058 rs772842174	352	D>N		No	ClinGen ExAC gnomAD
rs747428529 CA2558084	353	R>C		No	ClinGen ExAC TOPMed gnomAD
rs747428529 CA354062148	353	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1737177 rs200382925 CA2558086	353	R>H	kidney central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs200382925 CA81754175	353	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747428529 CA81754170	353	R>S		No	ClinGen ExAC TOPMed gnomAD
rs776391299 CA2558087	354	P>L		No	ClinGen ExAC TOPMed gnomAD
rs147825108 CA354062178	355	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147825108 CA2558088	355	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140256022 CA81754180	356	V>G		No	ClinGen ESP gnomAD
CA354062185 rs1467387959	356	V>M		No	ClinGen gnomAD
rs1441667815 CA354062204	357	L>P		No	ClinGen gnomAD
CA2558091 rs762924091	358	Q>*		No	ClinGen ExAC gnomAD
CA2558092 rs768717426	358	Q>R		No	ClinGen ExAC gnomAD
rs773969078 CA2558093	359	H>R		No	ClinGen ExAC gnomAD
CA2558094 rs751429694	360	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2558095 rs552135134	360	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA2558096 rs780684359	361	V>M		No	ClinGen ExAC TOPMed gnomAD
rs933896594 CA81754201	362	V>A		No	ClinGen TOPMed gnomAD
CA354062281 rs1340484968	362	V>L		No	ClinGen gnomAD
CA354062278 rs1340484968	362	V>M		No	ClinGen gnomAD
CA354062299 rs1577287684	363	D>A		No	ClinGen Ensembl
rs1049623483 CA81754205	363	D>N		No	ClinGen TOPMed gnomAD
CA81754207 rs949600566	364	Q>K		No	ClinGen TOPMed gnomAD
CA354062316 rs1259023751	365	L>Q		No	ClinGen gnomAD
CA81754209 rs889604951	366	Q>P		No	ClinGen TOPMed gnomAD
CA354062361 rs1249914367	367	E>G		No	ClinGen gnomAD
CA354062355 rs1194240746	367	E>Q		No	ClinGen gnomAD
CA81754211 rs1046611926	368	Q>K		No	ClinGen Ensembl
CA81754214 rs369188703	369	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_033238 CA2558099 rs35761343	370	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA354062442 rs1218063370	372	T>S		No	ClinGen TOPMed
CA354062495 rs1559792041	375	S>F		No	ClinGen Ensembl
CA2558100 rs758865308	377	I>T		No	ClinGen ExAC TOPMed gnomAD
rs745423296 CA2558101	379	C>G		No	ClinGen ExAC TOPMed gnomAD
CA2558102 rs546792969 COSM3669068	380	N>S	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2558104 rs780700712 COSM1217779	381	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs72551375 CA2558103 VAR_018342	381	R>W		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1463370348 CA354062598	382	P>L		No	ClinGen TOPMed
CA354062624 rs1297212066	383	Q>H		No	ClinGen gnomAD
rs1402329533 CA354062640	385	A>T		No	ClinGen TOPMed gnomAD
rs745572717 CA2558105	385	A>V		No	ClinGen ExAC gnomAD
rs769584263 CA2558106	386	H>Y		No	ClinGen ExAC gnomAD
rs144612379 CA2558131	388	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA354062918 rs1434559203	388	F>L		No	ClinGen gnomAD
CA354062913 rs144612379	388	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2558134 rs772955551	390	F>L		No	ClinGen ExAC gnomAD
CA81754542 rs1046005768	392	K>R		No	ClinGen Ensembl
CA354062953 rs1222448541	394	M>V		No	ClinGen TOPMed
rs1419720009 CA354062976	396	M>I		No	ClinGen gnomAD
rs1393990160 CA354062968	396	M>V		No	ClinGen gnomAD
CA354062979 rs1159835423	397	L>F		No	ClinGen gnomAD
CA2558137 rs138909256	399	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2558138 rs201008680	401	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1443380230 CA354063004	401	R>H		No	ClinGen TOPMed gnomAD
rs1443380230 CA354063006	401	R>L		No	ClinGen TOPMed gnomAD
rs1347311088 CA354063011	402	S>N		No	ClinGen gnomAD
rs764289441 CA2558139	402	S>R		No	ClinGen ExAC gnomAD
CA2558140 VAR_018343 rs72551376	403	I>V		No	ClinGen UniProt ExAC dbSNP gnomAD
rs1315047488 COSM3845928 CA354063036	406	Q>*	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1315911114 CA354063038	406	Q>R		No	ClinGen TOPMed
CA81754554 rs750065304	407	H>D		No	ClinGen TOPMed
CA2558142 rs767940172	407	H>R		No	ClinGen ExAC gnomAD
CA354063048 rs1577288702	408	T>P		No	ClinGen Ensembl
rs138512680 CA2558144	410	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2558143 COSM479264 rs750767310	410	R>W	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1439814825 CA354063065	411	L>M		No	ClinGen gnomAD
rs753604506 CA2558146	412	L>V		No	ClinGen ExAC gnomAD
CA2558147 rs377445958	413	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2558148 rs778422709	413	R>H		No	ClinGen ExAC gnomAD
rs747645727 CA2558149	414	I>T		No	ClinGen ExAC gnomAD
rs1350862529 CA354063104	417	I>T		No	ClinGen gnomAD
rs1473385020 CA354063101	417	I>V		No	ClinGen TOPMed
CA354063119 rs1463325700	419	P>R		No	ClinGen gnomAD
rs537873676 CA2558150	422	T>M		No	ClinGen ExAC TOPMed gnomAD
CA81754570 rs200964018	423	P>L		No	ClinGen Ensembl
CA354063142 rs1559792589	423	P>S		No	ClinGen Ensembl
rs1030264620 CA81754573	425	M>V		No	ClinGen Ensembl
CA2558153 rs56162473	426	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2558154 rs568300037	427	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2558156 rs370394566	430	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2558157 rs375281175	431	I>F		No	ClinGen ESP ExAC gnomAD
rs1211554084 CA354063208	433	G>D		No	ClinGen TOPMed gnomAD
rs547650613 CA2558161	434	S>G		No	ClinGen 1000Genomes ExAC gnomAD

No associated diseases with O75469

9 regional properties for O75469

Type	Name	Position	InterPro Accession
domain	SH3 domain	228 - 297	IPR001452
domain	PDZ domain	129 - 208	IPR001478
domain	L27 domain	1 - 110	IPR004172
domain	Guanylate kinase-like domain	351 - 538	IPR008144
domain	Guanylate kinase/L-type calcium channel beta subunit	350 - 541	IPR008145
domain	L27 domain, C-terminal	1 - 53	IPR014775-1
domain	L27 domain, C-terminal	58 - 108	IPR014775-2
conserved_site	Guanylate kinase, conserved site	386 - 403	IPR020590
domain	MPP6, SH3 domain	232 - 292	IPR035603

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
intermediate filament cytoskeleton	Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

8 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
nuclear receptor activity	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
nuclear receptor binding	Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
zinc ion binding	Binding to a zinc ion (Zn).

12 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
xenobiotic catabolic process	The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic transport	The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

29 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9TTR7	NR2F2	COUP transcription factor 2	Bos taurus (Bovine)	PR
O18971	PPARG	Peroxisome proliferator-activated receptor gamma	Bos taurus (Bovine)	PR
Q90733	NR2F2	COUP transcription factor 2	Gallus gallus (Chicken)	PR
P68306	THRB	Thyroid hormone receptor beta	Gallus gallus (Chicken)	PR
A7X8B3	PGR	Progesterone receptor	Pan troglodytes (Chimpanzee)	SS
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Homo sapiens (Human)	PR
P06401	PGR	Progesterone receptor	Homo sapiens (Human)	EV
P10589	NR2F1	COUP transcription factor 1	Homo sapiens (Human)	PR
P24468	NR2F2	COUP transcription factor 2	Homo sapiens (Human)	PR
P49116	NR2C2	Nuclear receptor subfamily 2 group C member 2	Homo sapiens (Human)	PR
P37231	PPARG	Peroxisome proliferator-activated receptor gamma	Homo sapiens (Human)	PR
Q14995	NR1D2	Nuclear receptor subfamily 1 group D member 2	Homo sapiens (Human)	PR
P35396	Ppard	Peroxisome proliferator-activated receptor delta	Mus musculus (Mouse)	PR
P43136	Nr2f6	Nuclear receptor subfamily 2 group F member 6	Mus musculus (Mouse)	PR
P43135	Nr2f2	COUP transcription factor 2	Mus musculus (Mouse)	PR
Q00175	Pgr	Progesterone receptor	Mus musculus (Mouse)	SS
Q9Z0Y9	Nr1h3	Oxysterols receptor LXR-alpha	Mus musculus (Mouse)	PR
O62807	PPARG	Peroxisome proliferator-activated receptor gamma	Sus scrofa (Pig)	PR
O09018	Nr2f2	COUP transcription factor 2	Rattus norvegicus (Rat)	PR
Q63449	Pgr	Progesterone receptor	Rattus norvegicus (Rat)	SS
Q8SQ01	NR1I2	Nuclear receptor subfamily 1 group I member 2	Macaca mulatta (Rhesus macaque)	PR
O45460	nhr-54	Nuclear hormone receptor family member nhr-54	Caenorhabditis elegans	PR
Q20765	nhr-7	Nuclear hormone receptor family member nhr-7	Caenorhabditis elegans	PR
Q21006	nhr-34	Nuclear hormone receptor family member nhr-34	Caenorhabditis elegans	PR
O17928	nhr-52	Nuclear hormone receptor family member nhr-52	Caenorhabditis elegans	PR
Q21878	nhr-1	Nuclear hormone receptor family member nhr-1	Caenorhabditis elegans	PR
O18141	nhr-79	Nuclear hormone receptor family member nhr-79	Caenorhabditis elegans	PR
G5EFF5	daf-12	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	PR
Q6PH18	nr2f1b	Nuclear receptor subfamily 2 group F member 1-B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEVRPKESWN	HADFVHCEDT	ESVPGKPSVN	ADEEVGGPQI	CRVCGDKATG	YHFNVMTCEG
70	80	90	100	110	120
CKGFFRRAMK	RNARLRCPFR	KGACEITRKT	RRQCQACRLR	KCLESGMKKE	MIMSDEAVEE
130	140	150	160	170	180
RRALIKRKKS	ERTGTQPLGV	QGLTEEQRMM	IRELMDAQMK	TFDTTFSHFK	NFRLPGVLSS
190	200	210	220	230	240
GCELPESLQA	PSREEAAKWS	QVRKDLCSLK	VSLQLRGEDG	SVWNYKPPAD	SGGKEIFSLL
250	260	270	280	290	300
PHMADMSTYM	FKGIISFAKV	ISYFRDLPIE	DQISLLKGAA	FELCQLRFNT	VFNAETGTWE
310	320	330	340	350	360
CGRLSYCLED	TAGGFQQLLL	EPMLKFHYML	KKLQLHEEEY	VLMQAISLFS	PDRPGVLQHR
370	380	390	400	410	420
VVDQLQEQFA	ITLKSYIECN	RPQPAHRFLF	LKIMAMLTEL	RSINAQHTQR	LLRIQDIHPF
430
ATPLMQELFG	ITGS