AiPD: Autoinhibited Protein Database

O75122

Gene name	CLASP2 (KIAA0627)
Protein name	CLIP-associating protein 2
Names	Cytoplasmic linker-associated protein 2, Protein Orbit homolog 2, hOrbit2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23122
EC number
Protein Class	CLASP (PTHR21567)

Descriptions

CLASPs, major microtubule-stabilizing factors in interphase and mitosis, prevent microtubule from switching form growth to shortening by stabilizing growing microtubule ends, and thus suppress microtubule catastrophes. CLASP2a consists of three TOG-like domains (termed TOG1, 2, and 3) and a C-terminal domain, CLIP-interacting domain (CLIP-ID) responsible for interaction with CLIP-170 and other partners. CLASP2a TOG2 is necessary and sufficient for catastrophe inhibition. The inhibition function is suppressed by the C-terminal domain CLIP-ID while the TOG1 domain or the CLIP-ID partner binding to CLIP-ID can release the autoinhibition.

Autoinhibitory domains (AIDs)

Target domain	647-885 (TOG2 domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Structural analysis

AID

1177-1286 (C-terminal domain CLIP-ID)

Target domain

647-885 (TOG2 domain)

Relief mechanism

Partner binding (TOG1 domain or CLIP-ID partner binding)

Assay

Deletion assay, Structural analysis

Accessory elements

No accessory elements

References

Aher A et al. (2018) "CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain", Developmental cell, 46, 40-58.e8

Autoinhibited structure

Activated structure

3 structures for O75122

Entry ID	Method	Resolution	Chain	Position	Source
3WOY	X-ray	210 A	A	60-310	PDB
5NR4	X-ray	120 A	A/B	1111-1275	PDB
AF-O75122-F1	Predicted				AlphaFoldDB

679 variants for O75122

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA2303154 rs757571044	3	M>V		No	ClinGen ExAC gnomAD
CA352304172 rs1241673891	5	D>E		No	ClinGen gnomAD
rs1207470392 CA352030581	6	D>V		No	ClinGen TOPMed
CA2303126 rs371694459	9	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs867247245 CA72754865	11	D>Y		No	ClinGen Ensembl
CA352030536 rs1379398655	12	E>G		No	ClinGen gnomAD
CA352030527 rs1465420591	13	E>D		No	ClinGen TOPMed gnomAD
CA2303125 rs765153363	13	E>Q		No	ClinGen ExAC gnomAD
CA2303124 rs368155880	15	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs776443036 CA2303123	16	D>G		No	ClinGen ExAC gnomAD
CA352030514 rs1174788989	16	D>Y		No	ClinGen gnomAD
rs1452107033 CA352030482	20	P>L		No	ClinGen gnomAD
rs749923775 CA72754841	23	A>G		No	ClinGen Ensembl
rs368159421 CA72754836	24	A>S		No	ClinGen TOPMed gnomAD
rs368159421 CA352030463	24	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2303120 rs374632684	24	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs771193783 CA2303119	26	A>T		No	ClinGen ExAC gnomAD
CA352030443 rs1455403549	27	F>C		No	ClinGen TOPMed
rs1575197140 CA352030433	28	K>N		No	ClinGen Ensembl
rs1272453710 CA352030436	28	K>R		No	ClinGen gnomAD
rs1345643464 CA352030431	29	V>L		No	ClinGen gnomAD
CA72754785 rs959577768	32	P>L		No	ClinGen Ensembl
rs1431754285 CA352030401	34	T>P		No	ClinGen Ensembl
CA2303118 rs749536394	36	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1316940201 CA352030371	38	P>L		No	ClinGen TOPMed
CA352030370 rs1310222949	39	A>P		No	ClinGen gnomAD
CA72754743 rs978086763	41	S>N		No	ClinGen TOPMed
rs748487007 CA2303115	43	R>K		No	ClinGen ExAC gnomAD
rs1318270540 CA352030330	44	K>N		No	ClinGen TOPMed
rs781615494 CA2303114	51	P>S		No	ClinGen ExAC gnomAD
rs566010531 CA2303112	52	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs755478813 CA2303113	52	K>T		No	ClinGen ExAC gnomAD
rs1559464799 CA352029120	55	G>D		No	ClinGen Ensembl
CA2303090 rs745354490	56	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1342975907 CA352029097	57	S>Y		No	ClinGen gnomAD
CA72744524 rs964314164	61	G>S		No	ClinGen TOPMed
COSM4915616 COSM4915614 rs1174055064 COSM4915615 CA352029043	62	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1405620358 CA352029033	62	A>V		No	ClinGen gnomAD
CA352029007 rs1162536220	65	V>I		No	ClinGen gnomAD
CA2303088 rs756907900	68	D>G		No	ClinGen ExAC gnomAD
CA72744517 rs914492550	71	I>M		No	ClinGen gnomAD
rs1192920835 CA352028824	78	P>R		No	ClinGen gnomAD
rs753628605 CA2303087	80	I>L		No	ClinGen ExAC gnomAD
rs1248556708 CA352028792	81	Q>R		No	ClinGen gnomAD
rs749004043 CA2303063	82	I>V		No	ClinGen ExAC gnomAD
rs976613437 CA72740283	84	S>C		No	ClinGen Ensembl
rs1305930247 CA352027852	89	E>K		No	ClinGen gnomAD
CA352027839 rs1415483360	90	E>V		No	ClinGen TOPMed
CA72740268 rs546215585	91	T>R		No	ClinGen 1000Genomes
rs755952130 CA2303061	95	I>V		No	ClinGen ExAC gnomAD
rs1577400562 CA352027716	107	D>Y		No	ClinGen Ensembl
rs754887404 CA2303058	110	A>T		No	ClinGen ExAC gnomAD
CA2303056 rs79585335	111	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA352027637 rs1456850477	112	A>V		No	ClinGen gnomAD
rs1393129626 CA352026141	122	A>T		No	ClinGen TOPMed
CA2303040 rs769327926	122	A>V		No	ClinGen ExAC gnomAD
rs747984696 CA2303039	124	A>T		No	ClinGen ExAC gnomAD
rs1460264982 CA352026062	126	Q>R		No	ClinGen gnomAD
rs559091295 CA2303037	127	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA352025934 rs1341557805	129	C>G		No	ClinGen TOPMed
CA352025747 rs1428561036	134	L>S		No	ClinGen gnomAD
CA2303033 rs753854739	141	L>F		No	ClinGen ExAC gnomAD
rs1230429564 CA352025520	143	L>F		No	ClinGen TOPMed gnomAD
CA2303032 rs764414007	143	L>H		No	ClinGen ExAC gnomAD
CA72736736 rs901622387	145	A>T		No	ClinGen TOPMed
CA352025321 rs1259879101	152	V>A		No	ClinGen gnomAD
rs752922489 CA2303030	161	A>V		No	ClinGen ExAC gnomAD
CA352024533 rs1391254967	162	H>N		No	ClinGen gnomAD
CA352024438 rs1325737427	165	T>A		No	ClinGen gnomAD
CA2303011 rs767793432	166	V>L		No	ClinGen ExAC gnomAD
rs865951508 CA72734903	168	G>*		No	ClinGen Ensembl
rs1181603301 CA352024403	168	G>A		No	ClinGen TOPMed
CA352024393 rs1559410901	169	N>Y		No	ClinGen Ensembl
rs763390842 CA352024288	175	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2303007 rs763390842	175	A>T		No	ClinGen ExAC TOPMed gnomAD
CA72734856 rs868790455	177	A>V		No	ClinGen Ensembl
rs1381860069 CA352024199	180	P>H		No	ClinGen gnomAD
CA72734849 rs963434755	182	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs370502005 CA2303002	186	V>I		No	ClinGen ESP ExAC gnomAD
CA72734818 rs868656871	187	P>T		No	ClinGen Ensembl
rs1360504420 CA352024064	188	N>S		No	ClinGen TOPMed
rs1279735854 CA352023949	195	T>A		No	ClinGen gnomAD
CA72734816 rs1012467186	196	S>C		No	ClinGen TOPMed gnomAD
rs1232293745 CA352023891	197	G>A		No	ClinGen gnomAD
rs1301996216 CA352023834	199	A>V		No	ClinGen TOPMed
rs1056110549 CA72734804	200	A>V		No	ClinGen TOPMed
rs377648606 CA72734787	201	I>V		No	ClinGen ESP gnomAD
CA352023723 rs1334394669	204	I>V		No	ClinGen TOPMed gnomAD
CA352023696 rs1315388584	205	I>V		No	ClinGen gnomAD
rs1375457974 CA352023674	206	R>Q		No	ClinGen gnomAD
rs1397144928 CA352023677	206	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA352021456 rs1164787405	208	T>S		No	ClinGen gnomAD
CA72729274 rs765604762	209	H>R		No	ClinGen Ensembl
CA72729268 rs944770084	214	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA72729260 rs930840568	217	I>V		No	ClinGen gnomAD
rs774491582 CA2302977	218	T>A		No	ClinGen ExAC TOPMed gnomAD
rs755067579 CA2302973	228	V>M		No	ClinGen ExAC gnomAD
CA2302948 rs746275758	231	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2302947 rs779268624	233	F>L		No	ClinGen ExAC gnomAD
rs1174447608 CA352020438	234	E>K		No	ClinGen gnomAD
rs1220044146 CA352020417	235	F>V		No	ClinGen TOPMed gnomAD
CA72727734 rs909528559	237	D>G		No	ClinGen Ensembl
CA352020373 rs1374798663	237	D>Y		No	ClinGen TOPMed
rs778196993 CA352020324	238	L>F		No	ClinGen ExAC gnomAD
CA2302943 rs558837241	242	E>K		No	ClinGen ExAC TOPMed gnomAD
rs752250877 CA2302942	245	T>S		No	ClinGen ExAC gnomAD
CA352020100 rs1559363216	249	E>K		No	ClinGen Ensembl
CA2302925 rs756614560	251	H>Y		No	ClinGen ExAC gnomAD
CA2302922 rs751268788	252	A>G		No	ClinGen ExAC TOPMed gnomAD
rs780778763 CA2302923	252	A>S		No	ClinGen ExAC TOPMed gnomAD
rs780778763 CA2302924	252	A>T		No	ClinGen ExAC TOPMed gnomAD
rs751268788 CA2302921	252	A>V		No	ClinGen ExAC TOPMed gnomAD
rs370720523 CA2302918	254	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs765132307 CA2302917	259	I>V		No	ClinGen ExAC gnomAD
rs374242633 CA2302916	263	I>V		No	ClinGen ESP ExAC gnomAD
COSM1154137 rs1196556763 CA352019011 COSM1043773	264	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed
rs776390048 CA2302915	267	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1013537237 CA72726982	268	A>S		No	ClinGen TOPMed gnomAD
rs1013537237 CA72726984	268	A>T		No	ClinGen TOPMed gnomAD
rs759558003 CA2302913	269	E>K		No	ClinGen ExAC gnomAD
rs1360404789 CA352018917	270	A>G		No	ClinGen gnomAD
CA352018890 rs1176230654	272	V>L		No	ClinGen gnomAD
CA2302911 rs771142357	274	A>T		No	ClinGen ExAC gnomAD
CA352018733 rs1467079440	279	M>I		No	ClinGen gnomAD
rs1560279806 CA352018746	279	M>V		No	ClinGen Ensembl
rs1253065344 CA352018715	280	G>A		No	ClinGen TOPMed gnomAD
CA352018717 rs1253065344	280	G>D		No	ClinGen TOPMed gnomAD
rs1577103889 CA352018695	282	R>G		No	ClinGen Ensembl
rs1217868995 CA352018675	283	N>D		No	ClinGen TOPMed
rs1577103806 CA916867108	284	H>LT*		No	ClinGen Ensembl
rs1265933589 CA352018638	284	H>Q		No	ClinGen TOPMed
rs763927614 CA2302894	285	F>L		No	ClinGen ExAC gnomAD
rs774386519 CA2302892	286	P>A		No	ClinGen ExAC gnomAD
CA352018605 rs1236795116	286	P>L		No	ClinGen gnomAD
rs774386519 CA72726703	286	P>S		No	ClinGen ExAC gnomAD
rs766638013 CA2302891	287	G>C		No	ClinGen ExAC gnomAD
rs1325661085 CA352018597	287	G>D		No	ClinGen gnomAD
CA352018574 rs1439250810	288	E>D		No	ClinGen gnomAD
CA352018560 rs1487631325	289	A>V		No	ClinGen TOPMed
CA352018527 rs1190379219	291	T>I		No	ClinGen TOPMed
rs1560279155 CA352018471	295	S>F		No	ClinGen Ensembl
CA72726686 rs928793982	296	L>V		No	ClinGen Ensembl
CA2302887 rs372430834	299	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2302885 rs769254869	305	Q>K		No	ClinGen ExAC gnomAD
CA352018317 rs1192760819	306	T>I		No	ClinGen gnomAD
rs1431274484 CA352018307	307	Y>C		No	ClinGen gnomAD
rs1252535258 CA352018249	309	K>N		No	ClinGen gnomAD
CA2302882 rs757938141	311	S>F		No	ClinGen ExAC TOPMed gnomAD
rs778369057 CA2302880	312	G>D		No	ClinGen ExAC gnomAD
CA2302878 rs753573345	313	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1232523497 CA352018165	314	V>I		No	ClinGen gnomAD
CA2302877 rs777731757	318	P>L		No	ClinGen ExAC TOPMed gnomAD
CA352017963 rs1577102244	326	S>G		No	ClinGen Ensembl
rs1305633067 CA352017887	330	S>G		No	ClinGen gnomAD
rs778696774 CA2302862	333	R>H		No	ClinGen ExAC gnomAD
rs1331423082 CA352017491	339	W>C		No	ClinGen TOPMed
CA72725517 rs989750283	341	T>A		No	ClinGen TOPMed gnomAD
rs1167067440 CA352017473	341	T>I		No	ClinGen gnomAD
rs867903898 CA72725513	342	A>E		No	ClinGen Ensembl
rs770462470 CA2302861	343	N>S		No	ClinGen ExAC gnomAD
CA72725506 rs1020032312	346	T>A		No	ClinGen TOPMed gnomAD
rs1185619871 CA352017366	347	V>M		No	ClinGen gnomAD
rs1448951033 CA352017342	348	A>T		No	ClinGen gnomAD
CA72725502 rs867062218	348	A>V		No	ClinGen Ensembl
CA352017294 rs1262763880	349	G>E		No	ClinGen gnomAD
rs749160482 CA2302860	350	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs371576065 CA2302843	353	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2302842 rs748925105	354	G>D		No	ClinGen ExAC TOPMed gnomAD
rs566311938 CA2302840	355	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA352016018 rs1321549919	358	A>V		No	ClinGen gnomAD
rs979158877 CA72724947	359	S>G		No	ClinGen gnomAD
rs979158877 CA352016015	359	S>R		No	ClinGen gnomAD
rs1313375624 CA352016012	359	S>T		No	ClinGen gnomAD
rs1397326377 CA352015991	362	P>L		No	ClinGen gnomAD
CA2302839 rs747926848	363	G>A		No	ClinGen ExAC gnomAD
rs117166070 CA2302838	364	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302837 rs754847355	365	L>V		No	ClinGen ExAC gnomAD
rs1454149289 CA352015967	366	Q>H		No	ClinGen TOPMed gnomAD
COSM1201267 COSM1201266 CA2302833 rs754123905	369	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1007994485 CA72724915	371	D>V		No	ClinGen Ensembl
rs764395392 CA2302832	373	D>G		No	ClinGen ExAC gnomAD
CA352015812 rs1234708793	382	A>V		No	ClinGen gnomAD
CA2302828 rs759987017	383	H>Y		No	ClinGen ExAC gnomAD
rs1577059518 CA352015788	384	H>R		No	ClinGen Ensembl
CA352015780 rs1444305120	385	A>T		No	ClinGen gnomAD
rs200748001 CA352015721	390	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs200748001 CA2302827	390	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs199696785 CA2302825	391	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1377483421 CA352015698	392	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2302823 rs776348001	393	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2302821 rs371555607	394	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2302822 rs371555607	394	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA72724863 rs943890442	394	R>H		No	ClinGen TOPMed gnomAD
CA352015672 rs371555607	394	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA352015659 rs1470802152	395	L>V		No	ClinGen gnomAD
CA352015646 rs1276741959	396	G>R		No	ClinGen TOPMed
rs768458478 CA2302820	397	A>T		No	ClinGen ExAC gnomAD
rs779980704 CA2302818	398	G>C		No	ClinGen ExAC TOPMed gnomAD
CA2302819 rs779980704	398	G>S		No	ClinGen ExAC TOPMed gnomAD
CA2302817 rs757335504	399	A>D		No	ClinGen ExAC gnomAD
rs1481809464 CA352015611	399	A>T		No	ClinGen gnomAD
CA352015596 rs1311330073	400	L>V		No	ClinGen gnomAD
CA352015552 rs1225316008	403	G>D		No	ClinGen gnomAD
rs376410378 CA2302816	405	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1736243 COSM1736241 CA2302815 COSM1736242 rs778183956	406	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
CA2302813 rs752922345	408	L>R		No	ClinGen ExAC gnomAD
CA352012538 rs1247062204	410	D>V		No	ClinGen TOPMed
CA72720330 rs868651277	417	G>*		No	ClinGen Ensembl
CA352011444 rs1397285719	419	A>P		No	ClinGen TOPMed gnomAD
CA352011446 rs1397285719	419	A>T		No	ClinGen TOPMed gnomAD
rs1477986645 CA352011427	420	S>C		No	ClinGen TOPMed gnomAD
rs1164952127 CA352011389	424	R>Q		No	ClinGen TOPMed gnomAD
rs774491937 CA2302711	424	R>W		No	ClinGen ExAC gnomAD
rs1259573321 CA352011374	427	A>T		No	ClinGen TOPMed
rs925310510 CA72717060	427	A>V		No	ClinGen TOPMed
CA2302709 rs201388522	430	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA72717035 rs900282191	432	P>L		No	ClinGen TOPMed
rs1449892152 CA352011342	432	P>S		No	ClinGen gnomAD
rs748326148 CA72717012	435	G>D		No	ClinGen Ensembl
COSM4116983 rs773840527 COSM4116984 CA2302708 COSM4116982	436	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA72716984 rs923179774	438	N>Y		No	ClinGen TOPMed
rs770174015 CA352011301	439	A>S		No	ClinGen ExAC TOPMed gnomAD
rs770174015 CA2302707	439	A>T		No	ClinGen ExAC TOPMed gnomAD
rs747713025 CA2302706	440	K>R		No	ClinGen ExAC gnomAD
CA352011271 rs780874039	443	S>C		No	ClinGen ExAC TOPMed gnomAD
CA2302705 rs780874039	443	S>F		No	ClinGen ExAC TOPMed gnomAD
rs768212793 CA2302704	447	S>R		No	ClinGen ExAC gnomAD
CA72716965 rs572553856	447	S>T		No	ClinGen 1000Genomes
COSM2984527 CA2302703 rs554149266 COSM3823695 COSM2984528	448	R>Q	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs779555760 CA2302702	449	T>R		No	ClinGen ExAC gnomAD
CA352011230 rs1398293357	450	K>I		No	ClinGen TOPMed
CA72716925 rs758276495 CA2302701	451	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1047647670 CA72716931	451	M>L		No	ClinGen Ensembl
rs1201399275 CA352011224	451	M>T		No	ClinGen TOPMed gnomAD
CA352011186 rs778958119	457	P>A		No	ClinGen ExAC gnomAD
rs778958119 CA2302699	457	P>S		No	ClinGen ExAC gnomAD
CA2302677 rs751564793	460	R>Q		No	ClinGen ExAC gnomAD
rs755117690 CA2302678	460	R>W		No	ClinGen ExAC gnomAD
rs763108253 CA2302675	470	T>I		No	ClinGen ExAC gnomAD
CA2302674 rs750621692	471	T>A		No	ClinGen ExAC TOPMed gnomAD
CA352028182 COSM4116979 rs1576785703 COSM4116980 COSM4116981	472	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic Ensembl
CA352028152 rs1456729794	477	S>C		No	ClinGen TOPMed gnomAD
CA352028151 rs1382903949	477	S>N		No	ClinGen gnomAD
rs762251812 CA2302672	478	S>P		No	ClinGen ExAC gnomAD
CA352028141 rs1374021174	479	G>S		No	ClinGen TOPMed
CA2302671 rs777340686	480	V>I		No	ClinGen ExAC gnomAD
CA2302670 rs767546200	484	L>M		No	ClinGen ExAC gnomAD
rs938232578 CA72723105	486	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA352028066 rs1281517976	491	Q>*		No	ClinGen gnomAD
rs770770692 CA2302664	492	K>Q		No	ClinGen ExAC gnomAD
CA2302663 rs749078873	492	K>T		No	ClinGen ExAC gnomAD
COSM3774938 COSM3774937 COSM3774936 CA352028054 rs777731869	493	R>G	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2302661 rs756027315	495	K>N		No	ClinGen ExAC gnomAD
CA352028017 rs1429946321	498	R>P		No	ClinGen TOPMed gnomAD
rs780032238 CA2302659	498	R>W		No	ClinGen ExAC TOPMed gnomAD
CA352027999 rs1560158913	501	G>S		No	ClinGen Ensembl
CA2302658 rs758442813	502	C>G		No	ClinGen ExAC TOPMed gnomAD
CA2302657 rs750666804	506	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2302656 rs765548402	507	S>N		No	ClinGen ExAC gnomAD
rs757733632 CA2302655	507	S>R		No	ClinGen ExAC gnomAD
CA352027943 rs1391171236	509	S>C		No	ClinGen TOPMed gnomAD
rs931437554 CA72723051	513	V>G		No	ClinGen Ensembl
rs374516433 CA2302613	514	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA352027443 rs1322814619	516	S>N		No	ClinGen gnomAD
rs776469505 CA2302612	518	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2302611 rs776469505	518	R>L		No	ClinGen ExAC TOPMed gnomAD
rs768612053 CA2302609	521	R>*		No	ClinGen ExAC gnomAD
rs572837521 CA72721738	521	R>L		No	ClinGen Ensembl
CA72721735 rs899577497	524	V>A		No	ClinGen TOPMed
CA352027257 rs1431125084	530	R>W		No	ClinGen gnomAD
rs746871079 CA2302608	531	E>K		No	ClinGen ExAC gnomAD
CA352027235 rs1419554254	532	A>T		No	ClinGen gnomAD
CA352027181 rs1369924707	534	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
COSM5069051 CA352027184 rs1404612941	534	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA352027053 rs1173607941	539	D>E		No	ClinGen gnomAD
rs779165122 CA2302607	540	T>A		No	ClinGen ExAC gnomAD
rs779165122 CA352027048	540	T>P		No	ClinGen ExAC gnomAD
rs749533648 CA2302605	544	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs749533648 CA352026991	544	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2302604 rs778128977	544	R>H		No	ClinGen ExAC gnomAD
CA2302602 rs753074704	545	S>P		No	ClinGen ExAC TOPMed gnomAD
CA352026951 rs1460799052	547	Q>H		No	ClinGen gnomAD
rs1454257914 CA352026946	548	P>H		No	ClinGen TOPMed
CA352026939 rs1210625315	549	L>F		No	ClinGen gnomAD
CA2302600 rs755535036	549	L>H		No	ClinGen ExAC gnomAD
CA352026928 rs530462971	550	A>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA72721713 rs530462971	550	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
CA352026036 rs1170328627	550	A>V		No	ClinGen gnomAD
CA2302580 rs780531961	553	H>R		No	ClinGen ExAC gnomAD
rs1421275106 CA352026000	553	H>Y		No	ClinGen TOPMed
rs757941650 CA2302579	554	H>Y		No	ClinGen ExAC gnomAD
CA2302578 rs749908038	556	R>K		No	ClinGen ExAC TOPMed gnomAD
CA352025912 rs1222047263	557	S>*		No	ClinGen gnomAD
CA352025916 rs1247463802	557	S>P		No	ClinGen gnomAD
CA352025901 rs1277192034	558	T>I		No	ClinGen gnomAD
CA2302577 rs764598812	560	A>T		No	ClinGen ExAC TOPMed gnomAD
rs756965077 CA2302575	561	L>F		No	ClinGen ExAC gnomAD
CA352025814 rs558277186	562	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302573 rs763963352	562	Y>C		No	ClinGen ExAC gnomAD
rs775636718 CA2302571	563	A>T		No	ClinGen ExAC TOPMed gnomAD
rs767531678 CA2302570	564	P>L		No	ClinGen ExAC gnomAD
rs767531678 CA72719693	564	P>R		No	ClinGen ExAC gnomAD
CA2302568 rs773366139	565	E>K		No	ClinGen ExAC TOPMed gnomAD
CA352025750 rs769725395	566	V>L		No	ClinGen ExAC TOPMed gnomAD
rs769725395 CA2302567	566	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2302565 rs776663409	567	Y>C		No	ClinGen ExAC gnomAD
CA2302549 rs761789213	572	P>R		No	ClinGen ExAC gnomAD
CA2302547 rs768840323	575	G>E		No	ClinGen ExAC gnomAD
rs992834931 CA72719376	576	I>M		No	ClinGen Ensembl
rs917342028 CA72719382	576	I>T		No	ClinGen Ensembl
rs1436126681 CA352025262	578	Q>R		No	ClinGen gnomAD
CA2302545 rs775860244	579	S>P		No	ClinGen ExAC
rs772354706 CA352025202	581	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772354706 CA2302544	581	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs746397949 CA2302543	582	L>P		No	ClinGen ExAC TOPMed gnomAD
rs770540550 CA2302541	583	S>L		No	ClinGen ExAC TOPMed gnomAD
CA352025093 rs1336038451	588	A>T		No	ClinGen gnomAD
rs781141777 CA2302535	590	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs373710625 CA72719290	594	T>A		No	ClinGen ESP TOPMed gnomAD
rs1362320183 CA352025023	595	G>V		No	ClinGen gnomAD
rs1445640111 CA352025013	597	D>G		No	ClinGen gnomAD
CA2302533 rs751576709	597	D>H		No	ClinGen ExAC gnomAD
rs1243026672 CA352025008	598	V>M		No	ClinGen gnomAD
rs1459542277 CA352024984	601	A>V		No	ClinGen gnomAD
CA72719277 rs75005449	603	A>G		No	ClinGen Ensembl
rs761998947 CA2302531	603	A>T		No	ClinGen ExAC gnomAD
rs753881504 CA352024967	604	D>G		No	ClinGen ExAC gnomAD
CA2302530 rs753881504	604	D>V		No	ClinGen ExAC gnomAD
CA352024964 rs1281211293	605	A>T		No	ClinGen TOPMed gnomAD
rs755187415 CA2302488	609	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA352024627 rs1322924892	611	R>G		No	ClinGen gnomAD
CA2302487 rs760251835	611	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs556081832 CA2302485	614	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA352024592 rs1479861584	614	Y>H		No	ClinGen TOPMed
rs762357764 CA2302482	617	Y>C		No	ClinGen ExAC gnomAD
rs1337994914 CA352024524	619	M>L		No	ClinGen gnomAD
rs1452642721 CA352024521	619	M>R		No	ClinGen gnomAD
rs776307662 CA352024495	620	H>L		No	ClinGen ExAC gnomAD
rs1173411820 CA352024493	620	H>Q		No	ClinGen gnomAD
rs776307662 CA2302481	620	H>R		No	ClinGen ExAC gnomAD
CA2302479 rs746652162	625	A>T		No	ClinGen ExAC gnomAD
CA2302478 rs775193571	629	A>V		No	ClinGen ExAC gnomAD
rs1576615755 CA352024320	633	C>Y		No	ClinGen Ensembl
rs1460863047 CA352024293	636	R>C		No	ClinGen gnomAD
CA2302476 rs184615866	636	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302475 rs778871201	637	S>T		No	ClinGen ExAC gnomAD
CA2302474 rs757208245	637	S>Y		No	ClinGen ExAC gnomAD
rs938089501 CA72717869	638	Y>C		No	ClinGen TOPMed gnomAD
rs749185193 CA2302473	641	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1362042788 CA352024251	641	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA352024248 rs1316274783	642	N>H		No	ClinGen gnomAD
COSM3592538 COSM3592539 COSM3592540 CA2302471 rs755029277	649	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1432340688 CA352024148	650	R>T		No	ClinGen gnomAD
rs1307113994 CA352024140	651	Q>E		No	ClinGen TOPMed
rs751789762 CA2302470	652	T>M		No	ClinGen ExAC TOPMed gnomAD
CA352024050 rs1386850200	659	L>F		No	ClinGen gnomAD
CA352024040 rs1443899300	660	N>D		No	ClinGen gnomAD
rs982286211 CA72717848	660	N>S		No	ClinGen Ensembl
rs998187639 CA72717836	661	R>K		No	ClinGen TOPMed
rs1215309981 CA352024016	661	R>S		No	ClinGen TOPMed
CA2302466 rs765653655	663	A>T		No	ClinGen ExAC gnomAD
rs1486252830 CA352023987	664	S>C		No	ClinGen gnomAD
CA352023982 rs1560097535	664	S>T		No	ClinGen Ensembl
rs762410958 CA2302465	666	N>S		No	ClinGen ExAC gnomAD
rs763568275 CA2302463	668	S>A		No	ClinGen ExAC gnomAD
rs760226798 CA2302462	675	L>V		No	ClinGen ExAC gnomAD
CA2302461 rs775043156	680	L>F		No	ClinGen ExAC TOPMed gnomAD
CA352023689 rs1269998869	682	K>R		No	ClinGen TOPMed
CA2302460 rs771732253	684	Q>*		No	ClinGen ExAC
CA352023636 rs368363195	684	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA352023630 rs1362065184	685	R>K		No	ClinGen gnomAD
rs1431723388 CA352022907	690	V>A		No	ClinGen gnomAD
CA352022898 rs1295126239	691	E>*		No	ClinGen TOPMed
CA352022900 rs1295126239	691	E>Q		No	ClinGen TOPMed
CA72716539 rs75825648	693	K>*		No	ClinGen Ensembl
rs1038012014 CA72716515	694	R>K		No	ClinGen Ensembl
rs1232692530 CA352022793	694	R>S		No	ClinGen TOPMed
CA72716508 rs867184637	702	M>V		No	ClinGen Ensembl
rs774761519 CA2302411 CA2302410	714	M>L		No	ClinGen ExAC gnomAD
CA72711260 rs915933392	714	M>T		No	ClinGen Ensembl
CA2302408 rs749430986	717	E>D		No	ClinGen ExAC gnomAD
rs1464677548 CA352020737	718	T>S		No	ClinGen gnomAD
CA352020667 rs1439469049	723	I>M		No	ClinGen gnomAD
CA2302404 rs781663448	723	I>V		No	ClinGen ExAC gnomAD
CA2302403 rs754525665	724	Q>E		No	ClinGen ExAC gnomAD
rs528292583 CA2302402	724	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs758104918 CA2302400	725	V>I		No	ClinGen ExAC gnomAD
CA72711235 rs948461159	726	H>Y		No	ClinGen TOPMed gnomAD
CA2302397 rs761505252	728	D>G		No	ClinGen ExAC gnomAD
CA2302399 rs144079580	728	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302398 rs144079580	728	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1487260841 CA352020604	729	D>Y		No	ClinGen TOPMed
rs764098967 CA2302395	734	L>V		No	ClinGen ExAC gnomAD
CA352020447 rs1338213373	738	L>Q		No	ClinGen gnomAD
rs77805662 CA72711180	744	K>N		No	ClinGen Ensembl
CA72711160 rs77213021	745	M>I		No	ClinGen gnomAD
CA72711172 rs76701586	745	M>K		No	ClinGen ESP TOPMed gnomAD
CA72711164 rs76701586	745	M>T		No	ClinGen ESP TOPMed gnomAD
rs373215296 CA2302392 COSM5006144 COSM5006146 COSM5006145	747	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ESP ExAC NCI-TCGA gnomAD
CA2302391 rs770848847	751	G>A		No	ClinGen ExAC TOPMed gnomAD
CA2302389 rs773294266	753	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1456431952 CA352020034	760	A>G		No	ClinGen gnomAD
rs938773650 CA72711143	763	V>I		No	ClinGen Ensembl
CA72710359 rs898026717	766	E>V		No	ClinGen TOPMed
CA352019881 rs1334855480	767	S>Y		No	ClinGen TOPMed
rs375735857 CA2302370	769	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs780398129 CA2302366	775	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1055374428 CA72710344	776	I>V		No	ClinGen TOPMed gnomAD
CA2302365 rs771682974	779	R>T		No	ClinGen ExAC gnomAD
CA352019638 rs1404752760	781	T>A		No	ClinGen gnomAD
rs778430865 CA2302363	786	Q>R		No	ClinGen ExAC gnomAD
CA2302362 rs756866089	789	S>N		No	ClinGen ExAC gnomAD
rs753502235 CA2302361	790	L>S		No	ClinGen ExAC gnomAD
rs765250670 CA2302336	795	A>V		No	ClinGen ExAC gnomAD
CA352017735 rs1443466410	796	I>V		No	ClinGen TOPMed
rs544056188 CA72705624	800	I>M		No	ClinGen Ensembl
rs374578698 CA72705626	800	I>T		No	ClinGen ESP TOPMed
rs368913164 CA2302335	800	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA352017652 rs1158044444	808	D>N		No	ClinGen TOPMed
CA72705618 rs1010617258	811	D>G		No	ClinGen TOPMed
CA352017591 rs1403101210	815	S>A		No	ClinGen gnomAD
rs1302501097 CA352017574	816	S>R		No	ClinGen gnomAD
rs764290497 CA2302333	819	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA72705609 rs935002973	819	R>H		No	ClinGen TOPMed
CA72705602 rs935002973	819	R>L		No	ClinGen TOPMed
rs1576316570 CA352017521	821	A>V		No	ClinGen Ensembl
rs1008099635 CA72705564	824	R>Q		No	ClinGen TOPMed
rs889596999 CA72705562	829	T>S		No	ClinGen TOPMed gnomAD
rs1279696199 CA352017399	831	E>K		No	ClinGen TOPMed
rs775724211 CA2302331	838	R>Q		No	ClinGen ExAC gnomAD
rs759914127 CA2302310	842	Q>R		No	ClinGen ExAC gnomAD
CA2302309 rs774785600	843	S>L		No	ClinGen ExAC TOPMed gnomAD
rs770355634 CA72702248	845	L>Q		No	ClinGen gnomAD
rs769385672 CA2302305	847	S>*		No	ClinGen ExAC gnomAD
rs769385672 CA2302306	847	S>L		No	ClinGen ExAC gnomAD
rs763493957 CA2302307	847	S>T		No	ClinGen ExAC gnomAD
CA2302302 rs200353593	850	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA352015759 rs1576217378	851	L>H		No	ClinGen Ensembl
rs1412577805 CA352015749	852	N>S		No	ClinGen TOPMed gnomAD
CA72702221 rs370718492	856	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA352015699 rs1424610640	856	F>L		No	ClinGen TOPMed
rs779769335 CA2302300	858	M>V		No	ClinGen ExAC gnomAD
rs1387826003 CA352015631	861	G>E		No	ClinGen gnomAD
CA2302298 rs745767300	869	D>N		No	ClinGen ExAC gnomAD
rs776709778 CA72702159	870	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs776709778 CA352015519	870	G>V		No	ClinGen TOPMed gnomAD
CA352015514 rs1455960117	871	A>T		No	ClinGen gnomAD
CA352015483 rs1425258753	873	K>N		No	ClinGen TOPMed gnomAD
CA352015486 rs1286605175	873	K>R		No	ClinGen TOPMed
CA2302297 rs777854408	874	L>R		No	ClinGen ExAC gnomAD
CA352015455 rs1477330434	875	L>I		No	ClinGen gnomAD
CA2302296 rs756197761	876	H>R		No	ClinGen ExAC gnomAD
rs1396226812 CA352015391	878	H>Y		No	ClinGen TOPMed
CA352015353 rs1338439175	880	R>*		No	ClinGen TOPMed
CA2302295 rs550618048	880	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302294 rs781471511	882	T>A		No	ClinGen ExAC gnomAD
CA352015317 rs755355195	882	T>I		No	ClinGen ExAC TOPMed gnomAD
rs755355195 CA2302293	882	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2302292 rs751984268	883	G>S		No	ClinGen ExAC gnomAD
rs949057256 CA72702134	884	N>D		No	ClinGen TOPMed gnomAD
CA2302291 rs539122583	884	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1273512073 CA352015108	890	M>L		No	ClinGen TOPMed gnomAD
CA352015104 rs1453184299	890	M>T		No	ClinGen TOPMed
rs1242912252 CA352015055	892	S>T		No	ClinGen gnomAD
rs1309299486 CA352015036	893	P>L		No	ClinGen gnomAD
CA2302277 rs748245697	893	P>S		No	ClinGen ExAC gnomAD
CA2302276 rs781072953	894	L>F		No	ClinGen ExAC gnomAD
CA2302275 rs187113660	895	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1576197224 CA352015004	896	R>S		No	ClinGen Ensembl
rs1245092464 CA352014971	898	T>I		No	ClinGen TOPMed
CA352014977 rs1335798047	898	T>S		No	ClinGen gnomAD
rs1414736606 CA352014964	899	P>R		No	ClinGen gnomAD
CA72701641 rs940696009	899	P>S		No	ClinGen Ensembl
COSM3408607 CA352014955 COSM3408608 COSM3408606 rs1350668772	900	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA2302274 rs777152959	900	R>L		No	ClinGen ExAC TOPMed gnomAD
rs777152959 CA2302273	900	R>P		No	ClinGen ExAC TOPMed gnomAD
rs777152959 CA72701638	900	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1284463344 CA352014951	901	S>P		No	ClinGen TOPMed gnomAD
CA352014952 rs1284463344	901	S>T		No	ClinGen TOPMed gnomAD
rs1483699101 CA352014912	902	P>Q		No	ClinGen TOPMed
CA352014935 rs1260424501	902	P>S		No	ClinGen TOPMed
rs758808715 CA2302272	906	S>P		No	ClinGen ExAC gnomAD
CA2302271 rs751003564	907	S>G		No	ClinGen ExAC gnomAD
rs765764765 CA2302270	907	S>N		No	ClinGen ExAC gnomAD
rs1206015278 CA352014799	908	P>L		No	ClinGen TOPMed
rs753395553 CA2302268	910	T>S		No	ClinGen ExAC gnomAD
CA352014657 rs1248291582	914	N>S		No	ClinGen TOPMed gnomAD
rs771894699 CA2302264	917	Q>R		No	ClinGen ExAC gnomAD
rs759323024 CA2302263	921	S>P		No	ClinGen ExAC gnomAD
CA2302241 rs768196398	924	A>S		No	ClinGen ExAC TOPMed gnomAD
CA352013743 rs768196398	924	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1268746231 CA352013673	928	D>N		No	ClinGen TOPMed
rs1340880942 CA352013648	929	T>I		No	ClinGen gnomAD
rs369566274 CA2302240	932	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1340472046 CA352013616	932	M>V		No	ClinGen TOPMed
CA72699246 rs868261938	933	N>S		No	ClinGen Ensembl
CA2302239 rs775657093	934	S>T		No	ClinGen ExAC gnomAD
CA2302237 rs746050621	938	Y>C		No	ClinGen ExAC gnomAD
rs1242332188 CA352013366	945	T>A		No	ClinGen gnomAD
CA352013250 rs1336387642	953	F>L		No	ClinGen TOPMed
COSM5934724 rs1017768054 COSM5934725 COSM5934723 CA72699225	954	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA2302234 rs376323807	954	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs778138302 CA2302233	956	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1260827989 CA352013199	957	E>G		No	ClinGen TOPMed
CA2302232 rs755679336	957	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1221576500 CA352013175	959	M>V		No	ClinGen gnomAD
CA352013134 rs1450551177	960	N>S		No	ClinGen gnomAD
rs752216479 CA2302231	965	R>G		No	ClinGen ExAC gnomAD
CA352013042 rs1318217362	966	D>N		No	ClinGen gnomAD
rs766946802 CA2302230	968	K>I		No	ClinGen ExAC TOPMed gnomAD
rs1037357574 CA72699214	969	K>T		No	ClinGen Ensembl
CA352012947 rs1185608512	970	D>Y		No	ClinGen Ensembl
rs751122925 CA2302228	971	D>N		No	ClinGen ExAC gnomAD
rs773262799 CA2302225	972	G>D		No	ClinGen ExAC gnomAD
rs762622458 CA2302226	972	G>S		No	ClinGen ExAC gnomAD
rs201682138 CA2302223	973	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA2302209 rs371559460	977	G>D		No	ClinGen ESP ExAC gnomAD
rs1364872511 CA352012230	979	P>L		No	ClinGen gnomAD
CA72697181 rs931145377	979	P>S		No	ClinGen Ensembl
rs1576047396 CA916866828	980	G>E		No	ClinGen Ensembl
rs894342619 CA72697179	981	M>I		No	ClinGen Ensembl
CA352012198 rs1467825911	982	S>T		No	ClinGen gnomAD
rs758268206 CA2302208	983	D>H		No	ClinGen ExAC gnomAD
rs1165991085 CA352012163	985	R>G		No	ClinGen TOPMed
rs1576047054 CA352012161	985	R>K		No	ClinGen Ensembl
rs765088254 CA2302206	986	A>G		No	ClinGen ExAC gnomAD
rs750193897 CA2302207	986	A>T		No	ClinGen ExAC gnomAD
rs753808173 CA2302204	987	G>R		No	ClinGen ExAC gnomAD
rs990493314 CA72697133	989	D>N		No	ClinGen TOPMed
CA72697126 rs938636647	991	T>N		No	ClinGen Ensembl
rs200647324 CA72697119	993	S>P		No	ClinGen Ensembl
CA352012089 rs1425300548	996	T>I		No	ClinGen TOPMed
rs1249278679 CA352012084	997	A>G		No	ClinGen gnomAD
rs1439791528 CA352012088	997	A>T		No	ClinGen TOPMed gnomAD
rs767746519 CA2302203	998	L>F		No	ClinGen ExAC TOPMed gnomAD
CA72697114 rs376656899	999	D>Y		No	ClinGen Ensembl
rs1256342894 CA352012049	1002	A>V		No	ClinGen gnomAD
rs1386219298 CA352012047	1003	S>P		No	ClinGen TOPMed
CA2302201 rs774692902	1005	L>P		No	ClinGen ExAC gnomAD
CA2302200 rs771073324	1006	H>R		No	ClinGen ExAC gnomAD
CA72697104 rs928560904	1006	H>Y		No	ClinGen Ensembl
rs200273295 CA2302199	1008	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA352012006 rs1328469760	1009	P>H		No	ClinGen TOPMed
CA2302198 rs773597901	1009	P>T		No	ClinGen ExAC gnomAD
rs1419848041 CA352011997	1011	H>Y		No	ClinGen gnomAD
CA2302197 rs537339494	1012	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA352011981 rs1397974088	1013	S>F		No	ClinGen gnomAD
rs370607793 CA2302195	1014	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1413328554 CA352011973	1015	R>C		No	ClinGen gnomAD
rs746484508 CA2302193	1015	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750046209 CA2302190	1016	S>F		No	ClinGen ExAC gnomAD
rs201766506 CA2302191	1016	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs778905362 CA2302189	1017	R>Q		No	ClinGen ExAC
rs570365071 CA2302188	1019	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA352011935 rs1576045224	1021	P>L		No	ClinGen Ensembl
rs375078809 CA2302187	1022	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1256456184 CA352011910	1023	N>T		No	ClinGen gnomAD
CA352011894 COSM1645861 rs1576045087 COSM1137016	1024	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic Ensembl
rs1190074905 CA352011885	1025	S>T		No	ClinGen TOPMed
rs764115456 CA2302186	1026	D>G		No	ClinGen ExAC gnomAD
rs748204669 CA352011854	1027	S>G		No	ClinGen gnomAD
rs760605050 CA2302185	1027	S>N		No	ClinGen ExAC TOPMed gnomAD
rs748204669 CA72696976	1027	S>R		No	ClinGen gnomAD
CA72696922 rs751593894	1028	I>M		No	ClinGen ExAC TOPMed gnomAD
CA352011827 rs1444956816	1029	S>R		No	ClinGen TOPMed
CA72696894 rs998347063	1032	N>H		No	ClinGen TOPMed
rs778888055 CA72696890	1033	K>R		No	ClinGen gnomAD
CA352011726 rs1312298151	1036	L>F		No	ClinGen gnomAD
rs1363598492 CA352011679	1039	A>V		No	ClinGen TOPMed
CA2302178 rs777178306	1045	A>V		No	ClinGen ExAC TOPMed gnomAD
CA352011537 rs1202025769	1047	Q>R		No	ClinGen TOPMed gnomAD
CA2302177 rs769053975	1049	P>S		No	ClinGen ExAC gnomAD
rs908164925 CA72711435	1054	L>P		No	ClinGen Ensembl
CA72711428 rs930768824	1056	H>R		No	ClinGen TOPMed
rs1233635039 CA352029066	1070	H>Y		No	ClinGen TOPMed
rs1575743793 CA352029030	1072	E>Q		No	ClinGen Ensembl
CA352029023 rs1274983986	1072	E>V		No	ClinGen TOPMed
rs1559820490 CA352029013	1073	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA2302158 rs560504448	1073	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302155 rs771551971	1076	E>G		No	ClinGen ExAC gnomAD
rs745358591 CA2302154	1078	K>E		No	ClinGen ExAC TOPMed gnomAD
CA2302153 rs548789620	1080	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA2302152 rs183373873	1082	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2302151 rs748907521	1084	L>F		No	ClinGen ExAC gnomAD
CA72711334 rs966520046	1085	M>I		No	ClinGen Ensembl
rs777450082 CA2302150	1085	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1370971265 CA352028787	1089	Q>R		No	ClinGen gnomAD
rs748075075 CA2302148	1093	F>C		No	ClinGen ExAC TOPMed gnomAD
rs748075075 CA352028750	1093	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1461362862 CA352028721	1097	D>A		No	ClinGen TOPMed
rs1010819205 CA72711318	1097	D>N		No	ClinGen TOPMed
rs758462310 CA2302146	1100	F>L		No	ClinGen ExAC gnomAD
CA2302145 rs750512970	1103	I>T		No	ClinGen ExAC TOPMed gnomAD
CA352028664 rs1383368994	1105	L>F		No	ClinGen TOPMed
rs200758119 CA2302143	1110	T>M		No	ClinGen ExAC TOPMed gnomAD
CA352028572 rs1239462320	1117	T>A		No	ClinGen gnomAD
rs769544334 CA2302130	1118	I>V		No	ClinGen ExAC gnomAD
CA352028553 rs1485542441	1120	A>T		No	ClinGen gnomAD
CA352028541 rs1219396742	1122	A>T		No	ClinGen TOPMed gnomAD
CA352028520 rs1274073871	1125	V>L		No	ClinGen TOPMed
CA352028511 rs1354550338	1126	L>S		No	ClinGen TOPMed gnomAD
rs746905410 CA2302126	1132	H>R		No	ClinGen ExAC gnomAD
CA352028457 rs1463788477	1134	P>S		No	ClinGen gnomAD
CA352028428 rs1233582638	1138	K>R		No	ClinGen gnomAD
rs1026798841 CA72710901	1139	N>S		No	ClinGen gnomAD
rs561251841 CA2302124	1140	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA72710900 rs995043967	1140	Y>N		No	ClinGen Ensembl
CA352028410 rs1401742026	1141	A>T		No	ClinGen gnomAD
rs1345737125 CA352028405	1141	A>V		No	ClinGen gnomAD
CA2302121 rs756233257	1153	K>E		No	ClinGen ExAC gnomAD
CA352028283 rs1575730994	1155	P>S		No	ClinGen Ensembl
rs1006079166 CA72708313	1164	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA352026540 rs1443901787	1166	A>T		No	ClinGen TOPMed gnomAD
rs1193639018 CA352026530	1166	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs781723103 CA2302100	1167	A>T		No	ClinGen ExAC gnomAD
CA72708296 rs531815234	1167	A>V		No	ClinGen 1000Genomes
CA352026473 rs1480783733	1169	V>A		No	ClinGen gnomAD
rs766979627 CA2302097	1170	L>W		No	ClinGen ExAC gnomAD
CA352026449 rs1313819585	1171	A>V		No	ClinGen TOPMed gnomAD
CA352026430 rs1575662982	1172	T>I		No	ClinGen Ensembl
CA352026425 rs1280977436	1173	S>P		No	ClinGen gnomAD
CA352026410 rs377235240	1174	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs749950134 CA2302095	1174	I>S		No	ClinGen ExAC TOPMed gnomAD
CA2302096 rs377235240	1174	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs906936375 CA72708267	1176	P>S		No	ClinGen TOPMed
CA352026393 rs906936375	1176	P>T		No	ClinGen TOPMed
rs1392160914 CA352026359	1180	I>M		No	ClinGen gnomAD
CA352026355 rs1372903789	1181	K>T		No	ClinGen gnomAD
rs1296773047 CA352026343	1182	V>L		No	ClinGen gnomAD
rs1450641539 CA352026290	1184	C>S		No	ClinGen TOPMed gnomAD
rs564748894 CA2302094	1186	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA2302092 rs776118648	1189	T>S		No	ClinGen ExAC gnomAD
CA352026155 rs1392697482	1190	A>T		No	ClinGen gnomAD
rs953040113 COSM4931304 COSM4931303 CA72708210	1191	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs572141479 CA2302090	1194	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA352026010 rs1406793687	1195	N>I		No	ClinGen gnomAD
CA2302089 rs775211679	1195	N>K		No	ClinGen ExAC gnomAD
CA352025792 rs1258051710	1201	M>I		No	ClinGen gnomAD
CA352025729 rs1409347463	1204	K>E		No	ClinGen gnomAD
rs560162561 CA2302087	1204	K>I		No	ClinGen 1000Genomes ExAC
rs773366100 CA2302086	1206	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2302084 rs748441736	1208	R>S		No	ClinGen ExAC gnomAD
rs374687770 CA2302083	1211	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2302082 rs755451718	1213	T>I		No	ClinGen ExAC gnomAD
CA352025297 rs1289975062	1220	E>G		No	ClinGen TOPMed
rs1413421350 CA352025141	1224	G>D		No	ClinGen gnomAD
CA72703320 rs960256852	1230	D>V		No	ClinGen TOPMed
rs777225350 CA2302055	1235	S>G		No	ClinGen ExAC gnomAD
CA2302054 rs755787230	1236	V>I		No	ClinGen ExAC gnomAD
rs1376498494 CA352022823	1239	A>T		No	ClinGen gnomAD
CA352022806 rs1179018551	1240	C>S		No	ClinGen TOPMed
rs1478148861 CA352022589	1246	A>T		No	ClinGen TOPMed
CA352022546 rs1371204354	1247	V>F		No	ClinGen gnomAD
CA2302051 rs759245006	1248	H>Y		No	ClinGen ExAC gnomAD
CA2302050 rs200365117	1249	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA352022499 rs200365117	1249	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2302047 rs369552604	1250	V>A		No	ClinGen ESP ExAC gnomAD
rs1168304019 CA352022489	1250	V>I		No	ClinGen gnomAD
rs1371269369 CA352022460	1251	I>V		No	ClinGen gnomAD
rs1308592631 CA352022421	1252	G>R		No	ClinGen TOPMed
CA2302046 rs768804970	1253	D>N		No	ClinGen ExAC gnomAD
rs1454751305 CA352022355	1254	E>K		No	ClinGen gnomAD
CA2302044 rs775853317	1257	P>Q		No	ClinGen ExAC gnomAD
rs772549060 CA2302043	1258	H>Y		No	ClinGen ExAC gnomAD
rs1389801514 CA352022284	1259	L>I		No	ClinGen TOPMed
CA352022275 rs1306348881	1260	S>G		No	ClinGen TOPMed
CA2302018 rs780686778	1267	M>I		No	ClinGen ExAC gnomAD
CA352021059 rs1415275245	1267	M>V		No	ClinGen TOPMed gnomAD
rs754614136 CA2302017	1275	K>R		No	ClinGen ExAC gnomAD
rs1385836021 CA352020795	1277	A>S		No	ClinGen gnomAD
rs746620473 CA2302016	1281	S>P		No	ClinGen ExAC gnomAD
rs758234415 CA352020720	1282	G>A		No	ClinGen ExAC TOPMed gnomAD
rs758234415 CA2302014	1282	G>E		No	ClinGen ExAC TOPMed gnomAD
rs779760245 CA2302015	1282	G>R		No	ClinGen ExAC gnomAD
CA72701636 rs902138980	1283	G>E		No	ClinGen TOPMed
rs765282276 CA2302012	1284	A>P		No	ClinGen ExAC TOPMed gnomAD
rs372110144 CA72701631	1286	P>R		No	ClinGen ESP TOPMed gnomAD
rs1380611073 CA352020655	1288	T>A		No	ClinGen TOPMed
CA352020536 rs1421459814	1295	S>L		No	ClinGen TOPMed

No associated diseases with O75122

No regional properties for O75122

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O75122

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Golgi apparatus Golgi apparatus, trans-Golgi network Cell membrane Cell projection, ruffle membrane	Localizes to microtubule plus ends (PubMed:15631994) Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514) In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella Localizes to the cell cortex and this requires ERC1 and PHLDB2 (PubMed:16824950) The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane
PANTHER Family	PTHR21567	CLASP
PANTHER Subfamily	PTHR21567:SF30	CLIP-ASSOCIATING PROTEIN 2
PANTHER Protein Class	non-motor microtubule binding protein
PANTHER Pathway Category	No pathway information available

18 GO annotations of cellular component

Name	Definition
axonal growth cone	The migrating motile tip of a growing nerve cell axon.
basal cortex	The region that lies just beneath the plasma membrane on the basal edge of a cell.
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell leading edge	The area of a motile cell closest to the direction of movement.
cortical microtubule plus-end	The plus-end of a cortical microtubule.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic microtubule	Any microtubule in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
kinetochore microtubule	Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.
spindle microtubule	Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

5 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
dystroglycan binding	Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule plus-end binding	Binding to the plus end of a microtubule.
protein tyrosine kinase binding	Binding to protein tyrosine kinase.

29 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle localization	The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.
establishment or maintenance of cell polarity	Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
exit from mitosis	The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
microtubule anchoring	Any process in which a microtubule is maintained in a specific location in a cell.
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
microtubule nucleation	The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
microtubule organizing center organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
mitotic spindle assembly	Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
negative regulation of focal adhesion assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
negative regulation of microtubule depolymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
negative regulation of stress fiber assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
negative regulation of wound healing, spreading of epidermal cells	Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells.
platelet-derived growth factor receptor-beta signaling pathway	The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
positive regulation of basement membrane assembly involved in embryonic body morphogenesis	Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.
positive regulation of epithelial cell migration	Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
positive regulation of exocytosis	Any process that activates or increases the frequency, rate or extent of exocytosis.
positive regulation of extracellular matrix disassembly	Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
regulation of actin cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of axon extension	Any process that modulates the rate, direction or extent of axon extension.
regulation of epithelial to mesenchymal transition	Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
regulation of gastrulation	Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
regulation of microtubule polymerization	Any process that modulates the frequency, rate or extent of microtubule polymerization.
regulation of microtubule polymerization or depolymerization	Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.
regulation of microtubule-based process	Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.
vesicle targeting	The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38198	STU1	Protein STU1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9NBD7	chb	CLIP-associating protein	Drosophila melanogaster (Fruit fly)	SS
Q7Z460	CLASP1	CLIP-associating protein 1	Homo sapiens (Human)	SS
Q80TV8	Clasp1	CLIP-associating protein 1	Mus musculus (Mouse)	SS
Q8BRT1	Clasp2	CLIP-associating protein 2	Mus musculus (Mouse)	SS
Q99JD4	Clasp2	CLIP-associating protein 2	Rattus norvegicus (Rat)	SS
Q6NYW6	clasp2	CLIP-associating protein 2	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MAMGDDKSFD	DEESVDGNRP	SSAASAFKVP	APKTSGNPAN	SARKPGSAGG	PKVGGASKEG
70	80	90	100	110	120
GAGAVDEDDF	IKAFTDVPSI	QIYSSRELEE	TLNKIREILS	DDKHDWDQRA	NALKKIRSLL
130	140	150	160	170	180
VAGAAQYDCF	FQHLRLLDGA	LKLSAKDLRS	QVVREACITV	AHLSTVLGNK	FDHGAEAIVP
190	200	210	220	230	240
TLFNLVPNSA	KVMATSGCAA	IRFIIRHTHV	PRLIPLITSN	CTSKSVPVRR	RSFEFLDLLL
250	260	270	280	290	300
QEWQTHSLER	HAAVLVETIK	KGIHDADAEA	RVEARKTYMG	LRNHFPGEAE	TLYNSLEPSY
310	320	330	340	350	360
QKSLQTYLKS	SGSVASLPQS	DRSSSSSQES	LNRPFSSKWS	TANPSTVAGR	VSAGSSKASS
370	380	390	400	410	420
LPGSLQRSRS	DIDVNAAAGA	KAHHAAGQSV	RSGRLGAGAL	NAGSYASLED	TSDKLDGTAS
430	440	450	460	470	480
EDGRVRAKLS	APLAGMGNAK	ADSRGRSRTK	MVSQSQPGSR	SGSPGRVLTT	TALSTVSSGV
490	500	510	520	530	540
QRVLVNSASA	QKRSKIPRSQ	GCSREASPSR	LSVARSSRIP	RPSVSQGCSR	EASRESSRDT
550	560	570	580	590	600
SPVRSFQPLA	SRHHSRSTGA	LYAPEVYGAS	GPGYGISQSS	RLSSSVSAMR	VLNTGSDVEE
610	620	630	640	650	660
AVADALKKPA	RRRYESYGMH	SDDDANSDAS	SACSERSYSS	RNGSIPTYMR	QTEDVAEVLN
670	680	690	700	710	720
RCASSNWSER	KEGLLGLQNL	LKNQRTLSRV	ELKRLCEIFT	RMFADPHGKR	VFSMFLETLV
730	740	750	760	770	780
DFIQVHKDDL	QDWLFVLLTQ	LLKKMGADLL	GSVQAKVQKA	LDVTRESFPN	DLQFNILMRF
790	800	810	820	830	840
TVDQTQTPSL	KVKVAILKYI	ETLAKQMDPG	DFINSSETRL	AVSRVITWTT	EPKSSDVRKA
850	860	870	880	890	900
AQSVLISLFE	LNTPEFTMLL	GALPKTFQDG	ATKLLHNHLR	NTGNGTQSSM	GSPLTRPTPR
910	920	930	940	950	960
SPANWSSPLT	SPTNTSQNTL	SPSAFDYDTE	NMNSEDIYSS	LRGVTEAIQN	FSFRSQEDMN
970	980	990	1000	1010	1020
EPLKRDSKKD	DGDSMCGGPG	MSDPRAGGDA	TDSSQTALDN	KASLLHSMPT	HSSPRSRDYN
1030	1040	1050	1060	1070	1080
PYNYSDSISP	FNKSALKEAM	FDDDADQFPD	DLSLDHSDLV	AELLKELSNH	NERVEERKIA
1090	1100	1110	1120	1130	1140
LYELMKLTQE	ESFSVWDEHF	KTILLLLLET	LGDKEPTIRA	LALKVLREIL	RHQPARFKNY
1150	1160	1170	1180	1190	1200
AELTVMKTLE	AHKDPHKEVV	RSAEEAASVL	ATSISPEQCI	KVLCPIIQTA	DYPINLAAIK
1210	1220	1230	1240	1250	1260
MQTKVIERVS	KETLNLLLPE	IMPGLIQGYD	NSESSVRKAC	VFCLVAVHAV	IGDELKPHLS
1270	1280	1290
QLTGSKMKLL	NLYIKRAQTG	SGGADPTTDV	SGQS