AiPD: Autoinhibited Protein Database

O75116

Gene name	ROCK2 (KIAA0619)
Protein name	Rho-associated protein kinase 2
Names	EC 2.7.11.1 , Rho kinase 2 , Rho-associated, coiled-coil-containing protein kinase 2 , Rho-associated, coiled-coil-containing protein kinase II , ROCK-II , p164 ROCK-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9475
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Rho kinases (ROCKs) are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. ROCK2 contains an N-terminal kinase domain, Rho-binding domain (RBD), and PH domain. RBD and PH domains interact with the catalytic kinase domain for autoinhibition. Rho binding to RBD relieves the autoinhibition.

Autoinhibitory domains (AIDs)

971-1047 (RBD domain) SS

Target domain	107-392 (Catalytic kinase domain)
Relief mechanism	Partner binding
Assay

AID

971-1047 (RBD domain)

Target domain

107-392 (Catalytic kinase domain)

Relief mechanism

Partner binding (Binding of Rho to RBD domain)

Assay

1150-1349 (PH domain) SS

Target domain	107-392 (Catalytic kinase domain)
Relief mechanism	Partner binding
Assay

AID

1150-1349 (PH domain)

Target domain

107-392 (Catalytic kinase domain)

Relief mechanism

Partner binding (Binding of Rho to RBD domain)

Assay

Accessory elements

231-255 (Activation loop from InterPro)

Target domain	39-417 (Protein kinase domain)
Relief mechanism
Assay

References

Riento K et al. (2003) "Rocks: multifunctional kinases in cell behaviour", Nature reviews. Molecular cell biology, 4, 446-56

Amano M et al. (1999) "The COOH terminus of Rho-kinase negatively regulates rho-kinase activity", The Journal of biological chemistry, 274, 32418-24

Chen XQ et al. (2002) "Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies", The Journal of biological chemistry, 277, 12680-8

Leung T et al. (1996) "The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton", Molecular and cellular biology, 16, 5313-27

Autoinhibited structure

Activated structure

12 structures for O75116

Entry ID	Method	Resolution	Chain	Position	Source
4L6Q	X-ray	279 A	A/B	19-417	PDB
4WOT	X-ray	293 A	A/B/C/D	22-417	PDB
5U7Q	X-ray	315 A	A/B/C/D	23-417	PDB
5U7R	X-ray	333 A	A/B/C/D	23-417	PDB
6ED6	X-ray	286 A	A/B	27-417	PDB
6P5M	X-ray	265 A	A/B/C/D	18-417	PDB
6P5P	X-ray	330 A	A/B/C/D	18-417	PDB
7JNT	X-ray	221 A	A/B/C/D/E/F/G/H	19-417	PDB
7JOV	X-ray	259 A	A/B/C/D/E/F/G/H	23-417	PDB
7P6N	X-ray	300 A	A/B/C/D/E/F/G/H	19-417	PDB
8GDS	X-ray	271 A	A/B/C/D	22-417	PDB
AF-O75116-F1	Predicted				AlphaFoldDB

956 variants for O75116

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2148066424 RCV001376020	527	R>*	Non-immune hydrops fetalis [ClinVar]	Yes	ClinVar Ensembl dbSNP
rs1383664600 RCV001376019	1044	R>*	Variant assessed as Somatic; HIGH impact. Non-immune hydrops fetalis [NCI-TCGA, ClinVar]	Yes	ClinVar NCI-TCGA dbSNP gnomAD
rs2148286382	3	R>Q		No	Ensembl
rs1003618482	3	R>W		No	TOPMed gnomAD
rs780887014	4	P>A		No	ExAC gnomAD
rs754636827	4	P>L		No	ExAC gnomAD
rs780887014	4	P>S		No	ExAC gnomAD
rs1292233613	5	P>L		No	gnomAD
rs1292233613	5	P>Q		No	gnomAD
rs867931783	6	P>L		No	1000Genomes TOPMed gnomAD
rs1558411299	7	T>R		No	Ensembl
rs758361484	8	G>E		No	ExAC gnomAD
rs1330384935	10	M>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs750399227	10	M>V		No	ExAC gnomAD
rs1279317759	11	P>L		No	gnomAD
rs764201136	11	P>S		No	ExAC gnomAD
rs752775547	13	A>D		No	1000Genomes ExAC TOPMed gnomAD
rs971557331	13	A>P		No	TOPMed
rs971557331	13	A>S		No	TOPMed
rs752775547	13	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs1011980585	14	P>S		No	TOPMed gnomAD
rs199617335	15	E>D		No	gnomAD
TCGA novel	15	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1325038763	15	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs759714742	16	T>I		No	ExAC TOPMed gnomAD
rs759714742	16	T>N		No	ExAC TOPMed gnomAD
rs759714742	16	T>S		No	ExAC TOPMed gnomAD
rs1156659639	17	A>T		No	gnomAD
rs371946291	17	A>V		No	ESP ExAC gnomAD
rs763387507	18	P>L		No	ExAC TOPMed gnomAD
TCGA novel	18	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773708028	19	G>R		No	ExAC TOPMed gnomAD
rs773708028	19	G>W		No	ExAC TOPMed gnomAD
rs547017422	20	D>E		No	Ensembl
rs776046926	20	D>N		No	ExAC gnomAD
rs776046926	20	D>Y		No	ExAC gnomAD
rs199520770	21	G>R		No	ExAC TOPMed gnomAD
rs199520770	21	G>W		No	ExAC TOPMed gnomAD
rs779937083	23	G>A		No	ExAC TOPMed gnomAD
rs779937083	23	G>D		No	ExAC TOPMed gnomAD
rs1446627904	24	A>G		No	TOPMed gnomAD
rs1446627904	24	A>V		No	TOPMed gnomAD
rs745722011	26	R>H		No	ExAC TOPMed gnomAD
rs745722011	26	R>L		No	ExAC TOPMed gnomAD
rs1465760381	26	R>S		No	gnomAD
rs778979009	27	Q>R		No	ExAC TOPMed gnomAD
rs1669199467	28	R>M		No	gnomAD
rs902469624	29	K>R		No	TOPMed gnomAD
rs1342345132	30	L>V		No	gnomAD
rs1669199180	31	E>K		No	Ensembl
rs1276091293	32	A>P		No	gnomAD
rs1233582144	34	I>M		No	TOPMed gnomAD
rs1408931331	34	I>T		No	TOPMed gnomAD
rs1393707937	34	I>V		No	Ensembl
rs201281924	35	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1318331779	35	R>Q		No	gnomAD
rs1036134868	37	P>S		No	Ensembl
rs767520743	38	R>C		No	ExAC TOPMed gnomAD
rs767520743	38	R>G		No	ExAC TOPMed gnomAD
rs755174294	39	S>C		No	ExAC TOPMed gnomAD
TCGA novel	40	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs766658319	40	P>S		No	ExAC TOPMed gnomAD
rs766658319	40	P>T		No	ExAC TOPMed gnomAD
rs199867337	41	I>V		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM6087351 COSM6087352	43	V>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1005718 COSM1005716 rs866098413	48	D>G	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs1667242850	49	G>A		No	TOPMed gnomAD
rs1558361922	51	N>S		No	Ensembl
rs1010385393	60	P>R		No	Ensembl
rs960307190	62	L>V		No	TOPMed gnomAD
COSM4084332 COSM4084333	63	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1035914716	66	K>E		No	Ensembl
COSM1398886 COSM1398887	67	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764727812	68	I>V		No	ExAC gnomAD
COSM1005713 COSM1005715	69	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM418607 COSM418606	71	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs760088893	73	N>H		No	ExAC TOPMed gnomAD
rs1408278647	73	N>S		No	TOPMed gnomAD
rs1001716337	74	R>T		No	Ensembl
rs1667241842	75	Y>H		No	TOPMed gnomAD
rs1460362071	78	I>T		No	TOPMed gnomAD
rs1667202246	79	V>A		No	gnomAD
rs368014961	80	K>E		No	ESP ExAC TOPMed gnomAD
rs1667202022	81	K>I		No	TOPMed
TCGA novel	82	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	82	I>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1667201608	84	G>D		No	TOPMed
rs1667201693	84	G>S		No	TOPMed
rs1456155299	85	L>Q		No	gnomAD
rs575795682	92	Y>F		No	1000Genomes ExAC gnomAD
rs1419079002	93	D>H		No	gnomAD
rs1423847374	94	V>A		No	gnomAD
rs1189154739	95	V>I		No	TOPMed gnomAD
rs1667200322	101	G>V		No	TOPMed
COSM714684 COSM714683	107	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1667199989	107	Q>K		No	Ensembl
rs1254543995	107	Q>R		No	TOPMed gnomAD
rs1191034888	110	R>C		No	TOPMed gnomAD
rs1434029280	110	R>H		No	TOPMed gnomAD
rs1434029280	110	R>P		No	TOPMed gnomAD
rs1665762249	112	K>R		No	Ensembl
rs148591129	113	A>P		No	1000Genomes ExAC gnomAD
rs148591129	113	A>S		No	1000Genomes ExAC gnomAD
rs148591129	113	A>T		No	1000Genomes ExAC gnomAD
COSM1185833 rs564194657 COSM1185832	115	Q>H	lung [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1482875648	115	Q>L		No	gnomAD
rs774529136	116	K>T		No	ExAC gnomAD
rs749545036	117	V>F		No	ExAC
COSM4401699 COSM4401700	121	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1297052243	129	I>M		No	gnomAD
rs1226451739	135	A>V		No	gnomAD
RCV000933226 rs201939803	136	F>C		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs201939803	136	F>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1398873 rs755738345 COSM1398872	138	W>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
COSM3040212 COSM3040211	138	W>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1665759885	139	E>G		No	Ensembl
COSM5103320 COSM5103319	140	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs748584485	142	D>G		No	ExAC gnomAD
TCGA novel	146	F>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs755583790	147	A>S		No	ExAC TOPMed gnomAD
rs755583790	147	A>T		No	ExAC TOPMed gnomAD
rs376820323	148	N>S		No	ESP TOPMed gnomAD
rs750996051	149	S>N		No	ExAC TOPMed gnomAD
rs1193595808	154	Q>R		No	gnomAD
rs1665187363	156	F>L		No	Ensembl
rs1553303519	157	Y>C		No	Ensembl
TCGA novel	157	Y>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1665187117	157	Y>N		No	TOPMed
COSM4397462 COSM4397463	160	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	161	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs749959332	163	R>K		No	ExAC gnomAD
rs962837972	167	M>V		No	TOPMed
rs1016039350	168	V>I		No	TOPMed gnomAD
rs1234494799	169	M>L		No	gnomAD
COSM1005642 COSM1005640	170	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	170	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1337182372	172	M>I		No	gnomAD
rs199740035	172	M>L		No	ExAC TOPMed gnomAD
rs868859632	174	G>V		No	Ensembl
rs1390131866	179	N>I		No	TOPMed gnomAD
rs756942050	180	L>F		No	ExAC TOPMed gnomAD
rs753588993	182	S>N		No	ExAC gnomAD
rs1170615120	183	N>S		No	TOPMed
rs1282382142	186	V>A		No	Ensembl
COSM1005637 COSM1005639	188	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	190	W>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1388365886	191	A>T		No	gnomAD
rs1295036583	192	K>E		No	gnomAD
COSM1631252 COSM1631253 rs763895660	192	K>R	liver [Cosmic]	No	cosmic curated ExAC gnomAD
TCGA novel	193	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1665184052	198	V>I		No	Ensembl
rs1363941468	201	A>S		No	TOPMed gnomAD
rs375900030	202	L>V		No	ESP gnomAD
COSM4932371 COSM4932370	203	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1665183400	203	D>V		No	Ensembl
rs1665183069	205	I>V		No	TOPMed
rs1665182657	208	M>I		No	TOPMed
rs752680185	209	G>D		No	ExAC TOPMed gnomAD
TCGA novel	214	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1464860959	217	P>A		No	gnomAD
TCGA novel	225	H>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs372642453	225	H>Q		No	ESP ExAC TOPMed gnomAD
rs1266723148	225	H>Y		No	TOPMed gnomAD
COSM5175713 COSM5175714	226	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	233	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	238	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1385868238	240	D>G		No	gnomAD
rs1665180586	240	D>H		No	TOPMed
rs368133500	242	T>I		No	ESP ExAC TOPMed gnomAD
rs1664851883	242	T>YVSGSFRA*		No	Ensembl
rs1664851776	244	M>I		No	TOPMed
rs1333622304	246	H>R		No	TOPMed gnomAD
rs765422651	248	D>G		No	ExAC gnomAD
rs762061673	250	A>T		No	ExAC gnomAD
rs2148086670	251	V>A		No	1000Genomes
rs776989339	251	V>I		No	ExAC TOPMed gnomAD
COSM3565405 COSM3565404	255	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	255	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3425121 COSM3425122	255	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1287684 COSM1287685	257	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664850997	257	I>M		No	Ensembl
TCGA novel	258	S>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM6153658 COSM6153659	258	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs187905137	262	L>M		No	1000Genomes ExAC gnomAD
rs1664850583	266	G>R		No	gnomAD
rs761077451	266	G>V		No	ExAC gnomAD
rs775757018	267	G>D		No	ExAC TOPMed gnomAD
rs775757018	267	G>V		No	ExAC TOPMed gnomAD
rs772589940	269	G>S		No	ExAC TOPMed gnomAD
rs1664849839	270	F>Y		No	gnomAD
rs1211220471	271	Y>C		No	gnomAD
rs1281824632	271	Y>H		No	gnomAD
rs1272250445	273	R>*		No	gnomAD
rs773789965	273	R>P		No	ExAC TOPMed gnomAD
rs773789965	273	R>Q		No	ExAC TOPMed gnomAD
COSM3797858 COSM3797859	279	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1429688570	280	V>L		No	TOPMed
rs910042982	289	V>M		No	Ensembl
rs1664745478	291	D>E		No	TOPMed
TCGA novel	293	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767786101	296	A>V		No	ExAC gnomAD
rs1664744881	297	D>E		No	gnomAD
rs370278900	304	S>G		No	ESP ExAC TOPMed gnomAD
TCGA novel	305	K>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs922190084	307	M>V		No	TOPMed gnomAD
rs1443199981	308	D>N		No	gnomAD
rs771483620	310	K>N		No	ExAC TOPMed gnomAD
TCGA novel	312	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs559020986	312	S>T		No	1000Genomes ExAC TOPMed gnomAD
rs1572267045	314	C>Y		No	TOPMed
rs1664743708	315	F>C		No	gnomAD
rs1463494030	315	F>L		No	TOPMed gnomAD
rs367600731	316	P>S		No	ESP ExAC TOPMed gnomAD
rs1471943360	318	D>G		No	gnomAD
rs1403307948	318	D>Y		No	gnomAD
rs201316858	323	K>E		No	ESP ExAC TOPMed gnomAD
rs754726374	323	K>I		No	ExAC TOPMed gnomAD
rs1211549993	323	K>N		No	gnomAD
rs754726374	323	K>R		No	ExAC TOPMed gnomAD
rs1409454002	324	H>Q		No	gnomAD
rs746861128	324	H>R		No	ExAC TOPMed gnomAD
rs961835571	326	K>E		No	gnomAD
TCGA novel	327	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1664741879	327	N>S		No	gnomAD
rs1208017685	328	L>F		No	gnomAD
rs753927042	330	C>S		No	ExAC gnomAD
rs1367110997	330	C>Y		No	gnomAD
rs764103419	331	A>V		No	ExAC TOPMed gnomAD
COSM3565396 COSM3565395	336	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1269243338	338	V>A		No	TOPMed gnomAD
rs1257372019	339	R>*		No	TOPMed
COSM1398848 COSM1398847 rs1664658999	339	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs1171441372	341	G>A		No	gnomAD
rs763387619	342	R>T		No	ExAC gnomAD
rs1664658405	344	G>E		No	TOPMed
TCGA novel	346	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1664658268	346	E>A		No	TOPMed
TCGA novel	347	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs977827342	347	E>D		No	TOPMed
rs1199987707	349	R>S		No	TOPMed gnomAD
rs1395511221	350	Q>*		No	gnomAD
rs765702766	350	Q>P		No	ExAC TOPMed gnomAD
rs765702766	350	Q>R		No	ExAC TOPMed gnomAD
rs1426693555 COSM3565393 COSM3565394	352	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1049773415	352	P>T		No	Ensembl
rs1191463083	358	Q>R		No	TOPMed
rs765831941	362	D>G		No	ExAC gnomAD
rs1187197699	364	I>V		No	gnomAD
rs369959149	367	T>M		No	ESP ExAC TOPMed gnomAD
rs200150539	369	A>G		No	ExAC TOPMed gnomAD
rs200150539	369	A>V		No	ExAC TOPMed gnomAD
rs753237427	370	P>T		No	ExAC
rs763708164	372	V>G		No	ExAC
rs2148075672	372	V>I		No	Ensembl
rs760337689	373	P>T		No	ExAC
rs1664630506	376	S>N		No	Ensembl
rs1572263130	376	S>R		No	Ensembl
rs1572263126	377	S>R		No	Ensembl
rs775276884	379	I>V		No	ExAC gnomAD
rs1664630005	381	S>N		No	TOPMed
rs1664629779	385	D>G		No	TOPMed
rs1664629451	386	D>G		No	Ensembl
rs759226246	386	D>N		No	ExAC gnomAD
rs377480951	387	I>L		No	1000Genomes ExAC TOPMed gnomAD
rs1252221792	387	I>M		No	TOPMed gnomAD
rs377480951	387	I>V		No	1000Genomes ExAC TOPMed gnomAD
rs770727992	389	D>N		No	ExAC gnomAD
TCGA novel	390	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs776629994	392	G>E		No	ExAC gnomAD
rs1333267871	392	G>R		No	TOPMed gnomAD
rs776629994	392	G>V		No	ExAC gnomAD
rs1234517810	393	D>V		No	gnomAD
rs1355710783	394	V>A		No	gnomAD
rs999968637	396	T>I		No	TOPMed gnomAD
rs999968637	396	T>N		No	TOPMed gnomAD
rs999968637	396	T>S		No	TOPMed gnomAD
rs1156504196	398	P>S		No	TOPMed
rs1419492371	399	I>M		No	TOPMed gnomAD
rs375372605	399	I>V		No	ESP ExAC TOPMed gnomAD
rs2148075530	400	P>L		No	Ensembl
rs2148075538	400	P>S		No	Ensembl
TCGA novel	407	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1664627695	407	Q>H		No	gnomAD
rs1029575797	416	Y>C		No	Ensembl
rs758688551	416	Y>H		No	ExAC gnomAD
rs779355928	417	R>T		No	ExAC TOPMed gnomAD
TCGA novel	419	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1664626555	419	N>Y		No	Ensembl
rs757646214	420	L>I		No	ExAC TOPMed gnomAD
rs965392252	424	D>E		No	TOPMed gnomAD
rs972787975	424	D>N		No	Ensembl
rs189516597	425	S>F		No	1000Genomes ESP ExAC gnomAD
rs1664529183	426	P>S		No	TOPMed gnomAD
rs1441578233	428	C>G		No	gnomAD
VAR_041062 RCV000454422 CA1530417 rs2230774	431	T>N		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2230774	431	T>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2148071780	432	D>Y		No	Ensembl
rs1664528247	433	S>A		No	TOPMed gnomAD
rs780773039	433	S>C		No	ExAC TOPMed gnomAD
rs780773039	433	S>F		No	ExAC TOPMed gnomAD
rs371977002	434	I>M		No	ESP ExAC TOPMed gnomAD
rs199983938	434	I>V		No	1000Genomes ExAC gnomAD
rs954340164	435	Q>L		No	Ensembl
rs766009922	438	K>R		No	ExAC TOPMed gnomAD
rs1032991211	439	N>D		No	TOPMed gnomAD
rs2148071710	439	N>K		No	Ensembl
rs762787575	439	N>T		No	ExAC gnomAD
rs1170192181	441	E>D		No	gnomAD
rs1664462610	445	I>T		No	Ensembl
rs756019279	446	Q>E		No	ExAC TOPMed gnomAD
rs752579341	448	K>R		No	ExAC gnomAD
rs1267902916	449	L>P		No	gnomAD
rs1664461766	455	H>N		No	Ensembl
rs758533507	455	H>R		No	ExAC TOPMed gnomAD
rs765515929	457	S>N		No	ExAC TOPMed gnomAD
rs1558300337	460	M>L		No	Ensembl
rs1468508347	460	M>T		No	TOPMed
rs1558300308	461	Q>P		No	Ensembl
rs761964777	462	A>V		No	ExAC gnomAD
rs776997959	469	K>T		No	ExAC gnomAD
rs751625329	470	C>Y		No	TOPMed gnomAD
rs764371898	471	K>R		No	ExAC gnomAD
TCGA novel	474	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1013023821 COSM4084282 COSM4084283	476	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1572255463	476	R>H		No	Ensembl
rs1358847863	478	E>G		No	gnomAD
rs764432475	479	K>R		No	ExAC TOPMed gnomAD
TCGA novel	480	T>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1398838 COSM1398837	481	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1325988 COSM1325987	484	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs959441048	485	E>Q		No	TOPMed gnomAD
COSM4818166 COSM4818165	486	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664400681	488	I>V		No	TOPMed
rs1221439194	491	R>Q		No	TOPMed
rs1293985451	492	K>E		No	TOPMed
rs747913278	492	K>R		No	ExAC TOPMed gnomAD
rs1307412206	493	S>N		No	TOPMed
rs1167146496	494	V>A		No	TOPMed gnomAD
rs1392405999	494	V>M		No	gnomAD
rs768660182	496	S>*		No	ExAC gnomAD
rs1260038775	497	A>V		No	Ensembl
rs1664399022	501	L>S		No	gnomAD
rs963509272	504	E>Q		No	Ensembl
rs1467487602	508	L>R		No	gnomAD
rs1489303995	509	Q>R		No	Ensembl
rs1015004425	510	H>R		No	gnomAD
rs1184726494	510	H>Y		No	TOPMed
rs1211038248	511	K>R		No	gnomAD
rs1356629612	513	A>T		No	TOPMed gnomAD
rs955100356	514	E>D		No	Ensembl
rs753011445	514	E>G		No	ExAC TOPMed gnomAD
rs767881289	515	Y>H		No	ExAC TOPMed gnomAD
rs1414992810	517	R>K		No	TOPMed
rs1664396287	522	E>D		No	Ensembl
rs766961740	523	A>E		No	ExAC gnomAD
rs762340837	525	K>R		No	ExAC gnomAD
TCGA novel	526	K>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772811025	527	R>Q		No	ExAC gnomAD
rs1664395696	529	L>F		No	TOPMed gnomAD
COSM1564855 COSM1564856	529	L>W	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs190769228	531	N>H		No	1000Genomes ExAC gnomAD
TCGA novel	532	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	534	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	535	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1664390567	539	Q>R		No	TOPMed gnomAD
COSM3971519 COSM3971518	540	L>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel rs764811315	542	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ExAC TOPMed
rs764811315	542	D>Y		No	ExAC TOPMed
TCGA novel	546	R>E	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1558298272	546	R>G		No	Ensembl
rs1558298263	546	R>K		No	TOPMed gnomAD
TCGA novel	546	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1195694008	548	Q>E		No	TOPMed gnomAD
rs760511802	549	N>H		No	ExAC gnomAD
rs745831464	551	Q>E		No	ExAC TOPMed gnomAD
rs773097695	552	I>V		No	ExAC gnomAD
rs1209703176	553	S>C		No	gnomAD
rs769858786	553	S>P		No	ExAC gnomAD
rs1664388396	557	V>L		No	Ensembl
rs1664388396	557	V>M		No	Ensembl
rs1280448114	561	Q>R		No	gnomAD
rs1341955192	565	D>G		No	Ensembl
rs1664379265	567	T>I		No	gnomAD
rs1664379265	567	T>N		No	gnomAD
TCGA novel	568	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1027383462	568	N>S		No	TOPMed gnomAD
rs760350090	569	A>T		No	Ensembl
rs1466584300	572	R>*		No	gnomAD
rs747260728	572	R>L		No	1000Genomes ExAC TOPMed gnomAD
rs747260728 COSM3836622 COSM3836621	572	R>Q	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1664378068	573	T>A		No	gnomAD
TCGA novel	575	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs766080162	575	S>F		No	Ensembl
rs1403246942	576	D>G		No	gnomAD
rs1664377683	577	T>A		No	TOPMed gnomAD
rs1664377683	577	T>S		No	TOPMed gnomAD
rs993262145	578	A>S		No	TOPMed
rs1415434255	578	A>V		No	TOPMed gnomAD
COSM3565382 COSM3565381	579	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs377618955	580	R>G		No	ExAC TOPMed gnomAD
rs753346725	580	R>L		No	ExAC gnomAD
rs753346725	580	R>Q		No	ExAC gnomAD
rs377618955	580	R>W		No	ExAC TOPMed gnomAD
COSM1481864 COSM1481863	581	L>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664376627	581	L>V		No	TOPMed
rs755655484	583	K>E		No	ExAC gnomAD
rs1252482300	584	T>I		No	TOPMed gnomAD
rs1252482300	584	T>S		No	TOPMed gnomAD
rs1664375718	585	Q>R		No	Ensembl
rs752389673	586	A>T		No	ExAC gnomAD
rs767132059	593	Q>E		No	ExAC gnomAD
rs751343885	599	N>S		No	ExAC TOPMed gnomAD
RCV002246826 VAR_041063 rs35768389	601	D>V		No	ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD
rs768721907	604	D>N		No	ExAC TOPMed gnomAD
rs1664373842	607	C>R		No	Ensembl
rs1323848258	608	L>M		No	TOPMed gnomAD
rs1664373538	609	L>P		No	gnomAD
rs1323669309	610	E>G		No	TOPMed gnomAD
rs1369918538	611	T>I		No	TOPMed gnomAD
COSM1325990 COSM1325989	612	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664372711	613	K>R		No	TOPMed
rs1664372427	614	L>F		No	Ensembl
rs1664372316	615	K>*		No	Ensembl
rs1160193624	616	L>F		No	gnomAD
rs1160193624	616	L>I		No	gnomAD
rs1394467244	617	E>D		No	gnomAD
COSM3797854 COSM3797855	617	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664371749	618	K>R		No	TOPMed
rs1664371630	620	F>L		No	Ensembl
rs935995814	621	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1189394965	621	I>T		No	TOPMed gnomAD
rs746201358	622	N>S		No	ExAC TOPMed gnomAD
rs907932374	627	L>V		No	Ensembl
rs778490468	629	S>C		No	ExAC TOPMed gnomAD
rs913697140	634	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM1481861 COSM1481862	637	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs755636674	638	S>T		No	ExAC gnomAD
rs780864829	640	I>L		No	ExAC gnomAD
rs1429627024	640	I>M		No	gnomAD
rs754610202	640	I>R		No	ExAC TOPMed gnomAD
rs1664369347	641	I>T		No	Ensembl
rs1167456096	643	D>N		No	TOPMed
rs2148065209	645	Q>E		No	Ensembl
COSM1005622 COSM1005624	646	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664356681	648	I>L		No	TOPMed
rs1664356552	649	C>R		No	TOPMed
rs754592808	649	C>Y		No	ExAC gnomAD
rs1169636481	650	G>D		No	gnomAD
rs746661835	653	E>K		No	ExAC gnomAD
rs1664355593	655	L>*		No	Ensembl
rs1474975134	658	G>C		No	gnomAD
rs1474975134	658	G>S		No	gnomAD
rs765183859	660	I>M		No	ExAC gnomAD
rs750261875	660	I>V		No	ExAC TOPMed gnomAD
rs1664354505	661	L>F		No	TOPMed gnomAD
rs376938631	661	L>I		No	ESP TOPMed
rs200475392	663	A>T		No	ESP ExAC TOPMed gnomAD
rs767495736	663	A>V		No	ExAC gnomAD
rs1664353723	664	K>N		No	TOPMed
TCGA novel	664	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1165643377	665	V>L		No	TOPMed gnomAD
rs774700263	667	L>Q		No	ExAC TOPMed gnomAD
rs774700263	667	L>R		No	ExAC TOPMed gnomAD
rs766756146	669	K>R		No	ExAC gnomAD
rs1664352542	673	Q>L		No	TOPMed gnomAD
rs770278980	674	E>G		No	ExAC gnomAD
TCGA novel	675	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs376177845	675	R>T		No	ESP TOPMed
rs748608634	676	F>Y		No	ExAC TOPMed gnomAD
rs1572252589	678	D>N		No	Ensembl
rs2148064494	679	L>F		No	Ensembl
rs1664351272	679	L>V		No	TOPMed
COSM5755800 COSM5755801	682	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1398834 COSM1398835	684	S>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1156982814	685	N>S		No	TOPMed gnomAD
rs763282423	686	M>T		No	ExAC gnomAD
rs766667964	686	M>V		No	ExAC TOPMed gnomAD
rs1381539409	687	E>D		No	gnomAD
rs750735443	687	E>K		No	ExAC gnomAD
rs1193556899	688	I>R		No	gnomAD
rs927365196	690	M>K		No	TOPMed gnomAD
rs927365196	690	M>T		No	TOPMed gnomAD
rs2148060306	691	T>I		No	Ensembl
COSM1398832 COSM1398833	695	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765515362	697	I>T		No	ExAC TOPMed gnomAD
rs984336860	698	Q>H		No	TOPMed gnomAD
rs762297001	700	S>G		No	ExAC gnomAD
rs1664256390	705	E>A		No	TOPMed
rs1664256274	706	A>G		No	Ensembl
rs939345819	708	H>R		No	TOPMed gnomAD
COSM1005618 COSM1005620 rs1460278753	709	K>E	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs776984846	710	A>T		No	ExAC gnomAD
rs1664255554	712	K>E		No	TOPMed
COSM263418 COSM263419	712	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664255311	713	A>S		No	Ensembl
rs1309972292	713	A>V		No	gnomAD
COSM4427926 rs869312716 COSM4427927 CA358642 RCV000209925	714	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ClinVar Ensembl NCI-TCGA dbSNP
TCGA novel	714	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778059351	716	A>T		No	Ensembl
rs760140608	716	A>V		No	ExAC
rs1664254033	717	D>G		No	Ensembl
rs1262884931	719	N>S		No	TOPMed gnomAD
rs771651568	720	K>N		No	ExAC gnomAD
rs1460310600 RCV000997028	722	Y>C		No	ClinVar TOPMed dbSNP gnomAD
rs1664253706	722	Y>N		No	Ensembl
rs1421981372	726	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1446917935	728	A>T		No	TOPMed
rs749156202	729	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs749156202	729	K>T		No	ExAC TOPMed gnomAD
TCGA novel	732	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1664252625	733	M>V		No	Ensembl
rs371591492	734	K>R		No	ESP ExAC TOPMed gnomAD
rs757526335	736	M>V		No	ExAC gnomAD
rs1374986506	737	E>K		No	TOPMed gnomAD
rs1446636508	738	K>E		No	gnomAD
rs754097125	739	K>Q		No	ExAC gnomAD
rs1167834471	740	L>F		No	gnomAD
rs764443687	741	L>W		No	ExAC gnomAD
rs1162283464	746	L>S		No	gnomAD
rs1021044760	747	K>E		No	TOPMed gnomAD
rs1664130869	748	Q>H		No	TOPMed gnomAD
rs188469889	750	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs201820613	751	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1457229425	753	L>V		No	gnomAD
TCGA novel	758	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs372509570	758	E>K		No	ESP ExAC gnomAD
rs1458257852	759	K>N		No	gnomAD
rs1381420833	760	R>K		No	TOPMed gnomAD
rs2148054960	761	C>Y		No	1000Genomes
rs765898223	763	L>V		No	ExAC TOPMed gnomAD
COSM4084264 COSM4084263	766	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664129413	768	L>V		No	TOPMed
rs762679348	769	K>I		No	ExAC TOPMed gnomAD
rs762679348	769	K>R		No	ExAC TOPMed gnomAD
rs773066505	770	Q>E		No	ExAC TOPMed gnomAD
rs769698930	770	Q>L		No	ExAC TOPMed gnomAD
rs769698930	770	Q>R		No	ExAC TOPMed gnomAD
rs1664128684	773	Q>R		No	Ensembl
rs748007730	774	K>E		No	ExAC gnomAD
rs368271329	777	E>D		No	ESP ExAC TOPMed gnomAD
COSM4929746 COSM4929745	777	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs927981383	778	L>F		No	Ensembl
COSM5168942 COSM5168941	778	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664127917	780	K>E		No	TOPMed
rs1664127803	780	K>R		No	TOPMed gnomAD
rs374045267	782	K>E		No	ESP ExAC TOPMed gnomAD
rs374045267	782	K>Q		No	ESP ExAC TOPMed gnomAD
rs757357913	783	D>E		No	ExAC TOPMed gnomAD
rs1403190291	784	V>M		No	gnomAD
rs1163908364	787	E>D		No	TOPMed gnomAD
rs528187081	787	E>G		No	1000Genomes ExAC TOPMed gnomAD
rs1664127103	787	E>K		No	TOPMed
rs778025113	788	D>G		No	ExAC gnomAD
rs777936902	789	V>I		No	ExAC gnomAD
rs1350122458	790	R>G		No	TOPMed gnomAD
rs948111787	793	T>A		No	Ensembl
rs368029536	793	T>I		No	ESP ExAC gnomAD
rs368029536	793	T>R		No	ESP ExAC gnomAD
COSM1305566 COSM1305565	796	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664109213	796	I>T		No	Ensembl
COSM475785 COSM475786	797	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664109101	797	E>Q		No	TOPMed
COSM475784 COSM475783	797	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1664108860	798	Q>E		No	TOPMed
rs1312051404	798	Q>H		No	gnomAD
rs781549565	801	Q>R		No	ExAC TOPMed gnomAD
rs370068257	803	R>C		No	ExAC TOPMed gnomAD
rs942166194	803	R>H		No	gnomAD
rs2148054183	805	L>F		No	Ensembl
rs1488092249	808	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1338172145	815	Q>E		No	gnomAD
rs757896375	817	V>F		No	ExAC gnomAD
rs757896375	817	V>I		No	ExAC gnomAD
rs2148054121	820	L>I		No	Ensembl
rs1664106792	820	L>R		No	Ensembl
TCGA novel	820	L>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1167646183	821	K>N		No	TOPMed gnomAD
rs753624880	821	K>Q		No	ExAC gnomAD
rs760442417	822	M>K		No	ExAC gnomAD
TCGA novel	822	M>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs760442417	822	M>T		No	ExAC gnomAD
rs763949139	822	M>V		No	ExAC gnomAD
rs1476943025	825	K>R		No	gnomAD
COSM3425118 COSM3425119	830	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs771940265	830	E>D		No	ExAC TOPMed gnomAD
TCGA novel	831	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1236300627	831	N>Y		No	gnomAD
rs762979588	832	N>D		No	ExAC TOPMed gnomAD
rs1325128410	833	H>Y		No	gnomAD
rs2148054042	835	M>I		No	Ensembl
rs1664104589	835	M>L		No	TOPMed
rs1664104589	835	M>V		No	TOPMed
rs373352683	837	M>L		No	ESP TOPMed gnomAD
rs373352683	837	M>V		No	ESP TOPMed gnomAD
rs1217670473	839	M>I		No	gnomAD
rs769946012	842	E>Q		No	ExAC gnomAD
rs1382640563	842	E>V		No	TOPMed gnomAD
rs748373019	845	N>S		No	ExAC TOPMed gnomAD
TCGA novel	846	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1664103255	846	A>T		No	gnomAD
rs1301069849	846	A>V		No	gnomAD
rs1664103010	847	E>D		No	TOPMed
rs781327430	849	R>Q		No	ExAC TOPMed gnomAD
COSM255843 COSM255844 rs1348532929	852	R>C	central_nervous_system [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1348532929	852	R>G		No	TOPMed gnomAD
rs761931112	852	R>H		No	ExAC TOPMed gnomAD
TCGA novel	852	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1348532929	852	R>S		No	TOPMed gnomAD
rs1663873309	854	D>N		No	Ensembl
COSM99112 rs1663873189 COSM1196945	854	D>V	lung stomach [Cosmic]	No	cosmic curated TOPMed
rs1663872805	859	M>I		No	Ensembl
rs1380297455	859	M>V		No	gnomAD
rs768794358	862	L>R		No	ExAC gnomAD
rs1437334168	864	D>Y		No	gnomAD
rs1404966994	866	L>V		No	TOPMed
COSM263416 COSM263417 rs1196050559	867	E>K	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1263474499	869	E>Q		No	gnomAD
rs201566611	870	Q>L		No	TOPMed
rs201566611	870	Q>R		No	TOPMed
rs1663871459	871	Y>C		No	TOPMed gnomAD
rs1329386221	877	K>E		No	gnomAD
rs1228513348	878	T>I		No	Ensembl
rs1663845860	880	V>I		No	TOPMed
rs200468857	881	R>K		No	ExAC TOPMed gnomAD
rs200468857	881	R>T		No	ExAC TOPMed gnomAD
rs964529068	881	R>W		No	Ensembl
rs1010947270	883	L>F		No	Ensembl
rs771593782	884	K>T		No	ExAC gnomAD
rs1222515906	885	E>A		No	TOPMed gnomAD
TCGA novel	886	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1384438344	887	C>F		No	gnomAD
rs375269209	887	C>R		No	ESP ExAC TOPMed gnomAD
COSM1005601 COSM1005603	890	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663843946	891	T>I		No	TOPMed
rs777160284	893	L>V		No	ExAC gnomAD
rs1030991062	894	G>A		No	TOPMed gnomAD
rs1030991062	894	G>D		No	TOPMed gnomAD
rs1030991062	894	G>V		No	TOPMed gnomAD
rs1375404614	895	K>E		No	gnomAD
COSM1398823 COSM1398824	896	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1262208183	897	L>S		No	gnomAD
rs1191167022	898	Q>P		No	gnomAD
rs868786728	899	Q>R		No	gnomAD
rs1302549614	900	K>N		No	TOPMed gnomAD
rs1202724853	901	K>E		No	TOPMed gnomAD
rs780879734	905	Q>E		No	ExAC
rs1572234752 COSM459671 COSM459670	907	E>K	cervix Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1007946658	908	R>L		No	TOPMed gnomAD
rs1007946658	908	R>Q		No	TOPMed gnomAD
rs1663835527	917	I>N		No	TOPMed
rs1663835387	918	T>A		No	TOPMed
rs1047372976	922	A>G		No	Ensembl
rs780783659	923	D>G		No	ExAC gnomAD
rs747734227	923	D>H		No	ExAC TOPMed gnomAD
rs933002470	927	L>M		No	TOPMed gnomAD
rs746750103	928	A>V		No	ExAC gnomAD
rs1663834219	929	R>C		No	TOPMed
rs1216521636	929	R>H		No	TOPMed gnomAD
rs779832331	931	I>V		No	ExAC TOPMed gnomAD
rs1363188043	932	A>D		No	Ensembl
rs1663833777	932	A>S		No	Ensembl
rs1363188043	932	A>V		No	Ensembl
TCGA novel	933	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1283929166	934	E>Q		No	gnomAD
rs1243257279	940	E>K		No	gnomAD
TCGA novel	941	K>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1385540412	945	M>L		No	TOPMed gnomAD
rs1385540412	945	M>V		No	TOPMed gnomAD
rs778962436	947	E>D		No	ExAC gnomAD
rs923187286 COSM297076 COSM297075	949	E>D	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs1398894342	950	I>L		No	TOPMed gnomAD
COSM5984440 COSM5984441	950	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663832164	950	I>N		No	TOPMed
rs1398894342	950	I>V		No	TOPMed gnomAD
rs1419770335	951	K>E		No	Ensembl
rs1326472465	953	M>L		No	gnomAD
rs1380168482	953	M>T		No	TOPMed gnomAD
rs753685005	955	A>D		No	gnomAD
rs1396954585	957	H>N		No	TOPMed gnomAD
rs1396954585	957	H>Y		No	TOPMed gnomAD
rs1572234348	959	Q>R		No	Ensembl
rs1663830807	960	E>D		No	gnomAD
RCV000709859 rs1558285391	960	E>Q		No	ClinVar Ensembl dbSNP
rs752852649	962	T>K		No	ExAC TOPMed gnomAD
rs752852649	962	T>M		No	ExAC TOPMed gnomAD
rs752852649	962	T>R		No	ExAC TOPMed gnomAD
rs1277347871	966	A>G		No	TOPMed gnomAD
rs1663829692	967	T>A		No	Ensembl
rs202027620	967	T>I		No	1000Genomes ExAC TOPMed gnomAD
rs1387079391	968	I>V		No	gnomAD
rs914402873	969	A>D		No	TOPMed
rs1184101548	969	A>T		No	gnomAD
TCGA novel	970	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs768232919	972	E>G		No	ExAC gnomAD
rs1195128763	973	E>D		No	TOPMed gnomAD
rs1423756088	974	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1470546786	976	R>S		No	gnomAD
COSM1005594 COSM1005596	978	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201098449 COSM3565358 COSM3565359	979	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs201098449	979	T>S		No	ExAC gnomAD
rs1663734677	980	S>N		No	Ensembl
rs1663734677	980	S>T		No	Ensembl
rs1663734387	982	V>F		No	Ensembl
rs1273601241	984	N>S		No	TOPMed
rs771745893	984	N>Y		No	ExAC gnomAD
TCGA novel	987	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1663733167	989	K>R		No	Ensembl
COSM263415 COSM263414	991	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	993	N>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1292908739	993	N>S		No	gnomAD
rs371229171	994	N>D		No	ESP ExAC gnomAD
TCGA novel	994	N>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs371229171	994	N>Y		No	ESP ExAC gnomAD
rs1663731937	995	K>Q		No	TOPMed
rs1352070438	997	K>N		No	gnomAD
rs1663731670	1000	Q>E		No	TOPMed gnomAD
COSM1005593 COSM1005591	1000	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1002	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1325175849	1003	L>R		No	gnomAD
COSM3836612 COSM3836613	1004	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1294174587	1005	R>G		No	TOPMed gnomAD
TCGA novel	1010	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs770703754	1010	E>K		No	ExAC TOPMed gnomAD
TCGA novel	1010	E>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs372763637	1013	A>T		No	ESP ExAC TOPMed gnomAD
rs369183934	1013	A>V		No	ESP ExAC TOPMed gnomAD
rs1572230823	1014	A>V		No	Ensembl
rs1431335544	1015	A>S		No	TOPMed gnomAD
rs1431335544	1015	A>T		No	TOPMed gnomAD
rs201466826	1016	I>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1429357124	1016	I>V		No	Ensembl
rs747125111	1017	K>E		No	ExAC gnomAD
rs780090672	1018	A>T		No	ExAC TOPMed gnomAD
rs1430323167	1022	K>R		No	gnomAD
rs2148039459	1023	Q>R		No	Ensembl
rs1242005227	1032	T>A		No	gnomAD
rs1289562093	1034	A>V		No	gnomAD
TCGA novel	1036	N>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1039	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs371560170	1041	I>T		No	ESP gnomAD
TCGA novel	1046	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1663691391	1047	P>R		No	TOPMed
rs367991548	1048	V>I		No	ESP ExAC TOPMed gnomAD
rs367991548	1048	V>L		No	ESP ExAC TOPMed gnomAD
rs1389906156	1049	K>T		No	gnomAD
rs1663690913	1050	R>C		No	Ensembl
rs761639386	1050	R>H		No	ExAC TOPMed gnomAD
rs766176402	1051	G>D		No	ExAC gnomAD
rs1166043025	1056	V>M		No	gnomAD
rs1663689932	1057	R>W		No	TOPMed gnomAD
TCGA novel	1059	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1416784787 COSM277096 COSM277095	1062	E>D	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1663689054	1063	N>T		No	TOPMed
rs542366653	1067	H>R		No	TOPMed gnomAD
TCGA novel rs1663688316	1072	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1439267406 COSM3723415 COSM3723416	1074	R>C	upper_aerodigestive_tract [Cosmic]	No	cosmic curated TOPMed
rs1663687806	1074	R>H		No	TOPMed
COSM3836610 COSM3836611	1076	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772167443	1077	L>M		No	ExAC gnomAD
rs34945852 VAR_057110	1083	K>M		No	UniProt Ensembl dbSNP
rs2148038023	1084	Y>C		No	1000Genomes
rs376988314 COSM4850793 COSM4850792	1085	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
TCGA novel	1087	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1005590 COSM1005588	1088	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1398817 COSM1398818	1090	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs371742171	1091	M>V		No	ESP ExAC gnomAD
COSM1005587 COSM1005585	1093	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1326185996	1099	S>C		No	TOPMed gnomAD
COSM1005584 rs1316869717 COSM1005582	1100	Q>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed gnomAD
rs751063624	1101	I>V		No	ExAC gnomAD
rs867914323 COSM1005579 COSM1005581	1102	R>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs766071383	1102	R>L		No	ExAC gnomAD
rs766071383	1102	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1048040636	1108	T>A		No	TOPMed gnomAD
TCGA novel	1114	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs765108740	1120	R>Q		No	ExAC TOPMed gnomAD
rs867731618	1120	R>W		No	Ensembl
rs531693023	1122	Q>L		No	ExAC TOPMed gnomAD
rs759608106	1124	Q>R		No	ExAC gnomAD
rs759845445	1127	H>P		No	ExAC TOPMed gnomAD
rs759845445	1127	H>R		No	ExAC TOPMed gnomAD
rs1203184488	1127	H>Y		No	gnomAD
TCGA novel rs1663675117	1131	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs930986389	1132	S>N		No	Ensembl
rs535318717	1133	S>A		No	1000Genomes ExAC TOPMed gnomAD
rs1204491860	1133	S>Y		No	gnomAD
rs1260360741	1134	S>I		No	TOPMed
rs781695369	1135	I>T		No	ExAC gnomAD
rs1230284027	1135	I>V		No	gnomAD
rs1279619968	1137	S>G		No	gnomAD
rs755463270	1137	S>N		No	ExAC TOPMed gnomAD
rs369090525	1142	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs912389077	1145	D>G		No	gnomAD
rs912389077	1145	D>V		No	gnomAD
rs200853375	1147	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3565356 COSM3565357	1149	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663576460	1150	E>G		No	gnomAD
rs867412495	1151	S>L		No	Ensembl
COSM1005576 COSM1005578	1152	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs898495782	1153	L>*		No	Ensembl
rs1663575415	1157	L>F		No	TOPMed
rs1663575064	1161	V>I		No	TOPMed
rs1163971067	1162	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	1162	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs866932722	1170	W>L		No	Ensembl
rs769131010	1171	V>G		No	ExAC TOPMed gnomAD
rs1231438319	1171	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1335366531	1172	K>R		No	Ensembl
rs762981787	1174	Y>C		No	ExAC gnomAD
COSM263413 COSM263412	1183	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1490933675	1183	L>I		No	TOPMed gnomAD
COSM441004 COSM441003	1187	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs761936331	1190	D>H		No	ExAC gnomAD
COSM1005575 COSM1005573	1192	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
VAR_041064	1194	S>P	a metastatic melanoma sample; somatic mutation [UniProt]	No	UniProt
rs1051085519	1195	N>S		No	TOPMed gnomAD
TCGA novel	1197	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1225126910	1197	Y>C		No	gnomAD
rs1281437156	1197	Y>H		No	gnomAD
rs1329498175	1199	V>I		No	gnomAD
rs55839233	1202	I>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1663540553	1203	D>H		No	gnomAD
rs753975729	1205	L>V		No	ExAC gnomAD
rs1663525144	1206	F>C		No	Ensembl
TCGA novel	1207	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs764405852	1209	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs995767688	1209	R>Q		No	TOPMed gnomAD
rs369537192	1210	P>S		No	ESP ExAC gnomAD
rs778488016	1217	Y>*		No	Ensembl
rs1663523299	1221	A>G		No	Ensembl
rs1663523158	1223	E>G		No	Ensembl
COSM1305561 COSM1305562	1226	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel rs1181374829	1228	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1289495577	1232	Y>N		No	gnomAD
rs2148030971	1233	A>G		No	Ensembl
rs1247131322	1234	N>K		No	gnomAD
rs1322385537	1239	K>R		No	gnomAD
rs267598835	1240	K>Q		No	Ensembl
rs866465002	1240	K>R		No	Ensembl
rs1558277937 RCV000754891	1242	Q>*		No	ClinVar Ensembl dbSNP
COSM1005561 COSM1005559	1243	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1306593128	1245	P>L		No	gnomAD
rs1222242642	1246	V>A		No	gnomAD
rs766991543	1249	V>A		No	TOPMed gnomAD
rs760978628	1250	G>R		No	ExAC gnomAD
rs2148030906	1255	Y>C		No	1000Genomes
rs753030793	1256	I>V		No	ExAC TOPMed gnomAD
rs552881592	1257	C>G		No	1000Genomes ExAC gnomAD
rs1209477310	1258	H>L		No	TOPMed gnomAD
rs760031303	1258	H>Y		No	ExAC gnomAD
rs1647896792	1259	K>E		No	TOPMed
COSM1398809 COSM1398808	1259	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1368498336	1262	E>Q		No	gnomAD
rs1663471424	1263	F>S		No	Ensembl
rs1416879926	1265	P>S		No	TOPMed gnomAD
COSM1005558 rs772794414 COSM1005556	1267	L>F	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1558277806	1271	P>L		No	Ensembl
COSM3565346 COSM3565345	1271	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747795771	1272	T>A		No	ExAC gnomAD
rs747795771	1272	T>P		No	ExAC gnomAD
rs1211516018	1273	N>D		No	gnomAD
rs376050005	1278	M>V		No	ESP ExAC TOPMed gnomAD
rs989861341	1280	P>A		No	Ensembl
TCGA novel	1282	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1572222394	1284	M>I		No	Ensembl
rs1213934825	1285	F>S		No	gnomAD
rs1572222366	1293	C>S		No	Ensembl
rs527957824	1294	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs527957824	1294	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs1344004974 COSM5042713 COSM5042714	1294	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs201228597	1295	R>C		No	TOPMed
TCGA novel	1295	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2148030695	1295	R>H		No	Ensembl
rs201228597	1295	R>S		No	TOPMed
COSM1005553 COSM1005551	1300	C>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1363186030	1305	M>I		No	TOPMed
TCGA novel	1305	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs779803586	1307	K>R		No	ExAC TOPMed gnomAD
COSM3039741 COSM3039742	1308	K>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663465678	1308	K>T		No	gnomAD
COSM4722383 COSM4722382	1309	E>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663464909	1312	I>T		No	Ensembl
rs1572222260	1314	P>R		No	TOPMed
COSM459673 rs1663464740 COSM459672	1314	P>S	cervix Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1303070421	1315	C>R		No	TOPMed gnomAD
TCGA novel	1317	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773775703	1318	Y>C		No	ExAC TOPMed gnomAD
rs773775703	1318	Y>F		No	ExAC TOPMed gnomAD
rs1366678124	1319	Y>C		No	gnomAD
rs764703058	1321	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs761352733	1323	T>A		No	ExAC gnomAD
rs775328443	1323	T>M		No	ExAC TOPMed gnomAD
COSM3039734 COSM3039733	1325	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1016022786	1326	N>Y		No	Ensembl
rs1466357038	1327	L>M		No	gnomAD
COSM4084251 COSM4084250	1327	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663457643	1331	A>T		No	Ensembl
rs1663457510	1333	S>C		No	TOPMed gnomAD
rs960536932	1334	T>A		No	TOPMed
COSM6153678 COSM6153677	1337	Q>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663457221	1337	Q>R		No	gnomAD
rs1248648087	1339	K>N		No	gnomAD
rs201801097	1339	K>Q		No	ESP ExAC TOPMed gnomAD
rs771825593	1341	V>I		No	ExAC TOPMed gnomAD
rs1460194351	1342	S>I		No	TOPMed gnomAD
rs1460194351	1342	S>N		No	TOPMed gnomAD
COSM4133005 COSM4133004 rs745801053	1343	R>Q	thyroid [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
COSM3425114 COSM3425113	1343	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1047418299	1345	V>E		No	Ensembl
rs374395637	1345	V>M		No	ESP ExAC TOPMed gnomAD
TCGA novel	1347	K>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1663455495	1348	I>T		No	Ensembl
rs748271839	1349	P>A		No	ExAC TOPMed gnomAD
COSM4084249 COSM4084248	1349	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs748271839	1349	P>S		No	ExAC TOPMed gnomAD
COSM1398807 COSM1398806	1351	K>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1663454822	1352	P>S		No	TOPMed
rs1572221848	1353	P>A		No	Ensembl
rs968013894	1353	P>L		No	TOPMed
rs1572221848	1353	P>S		No	Ensembl
COSM1398804 COSM1398805	1353	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751806275	1354	A>P		No	ExAC TOPMed gnomAD
rs751806275	1354	A>S		No	ExAC TOPMed gnomAD
rs766761794	1354	A>V		No	ExAC gnomAD
COSM3565341 COSM3565342	1357	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3723417 COSM3723418 rs1558277230	1360	R>*	upper_aerodigestive_tract [Cosmic]	No	cosmic curated Ensembl
rs758748287	1360	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM3960992 COSM3960991	1361	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1266713911	1362	S>P		No	TOPMed gnomAD
rs750898507	1363	P>L		No	ExAC gnomAD
rs1166645564	1363	P>S		No	gnomAD
rs1390697544 COSM441000 COSM441001	1364	R>T	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs770509824	1366	S>*		No	Ensembl
rs1322913055	1367	M>T		No	gnomAD
rs200825805	1367	M>V		No	ExAC TOPMed gnomAD
rs761262690	1369	I>M		No	ExAC TOPMed gnomAD
rs1663451993	1369	I>V		No	TOPMed
rs2148030075	1370	Q>R		No	Ensembl
rs1663451532	1372	N>D		No	Ensembl
rs1426209431	1372	N>K		No	TOPMed
TCGA novel	1372	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs760366234	1374	S>C		No	ExAC gnomAD
rs1663451050	1374	S>P		No	TOPMed
rs1663450720	1375	I>F		No	Ensembl
rs1663450720	1375	I>V		No	Ensembl
rs1483703733	1377	R>Q		No	gnomAD
rs1207941601	1377	R>W		No	TOPMed gnomAD
COSM2157014 COSM2157015	1379	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1224122 rs374630605 COSM1224121	1380	R>Q	large_intestine [Cosmic]	No	cosmic curated ESP ExAC gnomAD
rs745564499	1381	Q>*		No	ExAC TOPMed gnomAD
rs1663449638	1381	Q>R		No	Ensembl
rs1285619301	1383	A>T		No	gnomAD
rs771017362	1384	P>S		No	ExAC gnomAD
rs1319487607	1385	N>D		No	gnomAD
rs1663448844	1385	N>S		No	Ensembl
rs1306014561	1387	P>L		No	TOPMed gnomAD

No associated diseases with O75116

10 regional properties for O75116

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	92 - 354	IPR000719
domain	AGC-kinase, C-terminal	357 - 425	IPR000961
domain	Pleckstrin homology domain	1150 - 1351	IPR001849
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	1260 - 1315	IPR002219
active_site	Serine/threonine-protein kinase, active site	210 - 222	IPR008271
domain	HR1 rho-binding domain	497 - 573	IPR011072
domain	ROCK, Rho binding domain	978 - 1047	IPR015008
binding_site	Protein kinase, ATP binding site	98 - 121	IPR017441
domain	Rho-associated protein kinase 2, catalytic domain	39 - 417	IPR029878
domain	Rho-associated protein kinase 2, HR1 domain	505 - 571	IPR037311

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cell membrane ; Peripheral membrane protein Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	Cytoplasmic, and associated with actin microfilaments and the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

12 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
endopeptidase activator activity	Binds to and increases the activity of an endopeptidase.
metal ion binding	Binding to a metal ion.
protease binding	Binding to a protease or a peptidase.
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions
Rho-dependent protein serine/threonine kinase activity	Rho GTPase-dependent catalysis of the reaction
RNA binding	Binding to an RNA molecule or a portion thereof.
small GTPase binding	Binding to a small monomeric GTPase.
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex.
tau protein binding	Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
tau-protein kinase activity	Catalysis of the reaction

56 GO annotations of biological process

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actomyosin structure organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
aortic valve morphogenesis	The process in which the structure of the aortic valve is generated and organized.
blood vessel diameter maintenance	Any process that modulates the diameter of blood vessels.
canonical NF-kappaB signal transduction	The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
cellular response to acetylcholine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
cellular response to testosterone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
centrosome duplication	The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
embryonic morphogenesis	The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
epithelial to mesenchymal transition	A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
mitotic cytokinesis	A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
modulation by host of viral process	A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected.
mRNA destabilization	Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of bicellular tight junction assembly	Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly.
negative regulation of biomineral tissue development	Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of myosin-light-chain-phosphatase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
negative regulation of nitric oxide biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
negative regulation of protein localization to lysosome	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.
positive regulation of amyloid precursor protein catabolic process	Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.
positive regulation of amyloid-beta formation	Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
positive regulation of cardiac muscle hypertrophy	Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of centrosome duplication	Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
positive regulation of connective tissue growth factor production	Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.
positive regulation of connective tissue replacement	Any process that activates or increases the frequency, rate or extent of connective tissue replacement.
positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of fibroblast growth factor production	Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of protein localization to early endosome	Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of stress fiber assembly	Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of actin cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of angiotensin-activated signaling pathway	Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway.
regulation of cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
regulation of cell junction assembly	Any process that modulates the frequency, rate or extent of cell junction assembly.
regulation of cell motility	Any process that modulates the frequency, rate or extent of cell motility.
regulation of cellular response to hypoxia	Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
regulation of circadian rhythm	Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of establishment of cell polarity	Any process that modulates the frequency, rate or extent of establishment of cell polarity.
regulation of establishment of endothelial barrier	Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.
regulation of focal adhesion assembly	Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
regulation of keratinocyte differentiation	Any process that modulates the frequency, rate or extent of keratinocyte differentiation.
regulation of nervous system process	Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
regulation of stress fiber assembly	Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
response to angiotensin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
response to ischemia	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
response to transforming growth factor beta	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
Rho protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
rhythmic process	Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q28021	ROCK2	Rho-associated protein kinase 2	Bos taurus (Bovine)	SS
Q9W1B0	gek	Serine/threonine-protein kinase Genghis Khan	Drosophila melanogaster (Fruit fly)	SS
Q13464	ROCK1	Rho-associated protein kinase 1	Homo sapiens (Human)	SS
Q9Y5S2	CDC42BPB	Serine/threonine-protein kinase MRCK beta	Homo sapiens (Human)	SS
Q5VT25	CDC42BPA	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (Human)	EV
Q3UU96	Cdc42bpa	Serine/threonine-protein kinase MRCK alpha	Mus musculus (Mouse)	SS
P70335	Rock1	Rho-associated protein kinase 1	Mus musculus (Mouse)	SS
Q80UW5	Cdc42bpg	Serine/threonine-protein kinase MRCK gamma	Mus musculus (Mouse)	PR
Q7TT50	Cdc42bpb	Serine/threonine-protein kinase MRCK beta	Mus musculus (Mouse)	SS
P70336	Rock2	Rho-associated protein kinase 2	Mus musculus (Mouse)	SS
M3TYT0	ROCK2	Rho-associated protein kinase 2	Sus scrofa (Pig)	SS
O54874	Cdc42bpa	Serine/threonine-protein kinase MRCK alpha	Rattus norvegicus (Rat)	SS
Q63644	Rock1	Rho-associated protein kinase 1	Rattus norvegicus (Rat)	SS
Q7TT49	Cdc42bpb	Serine/threonine-protein kinase MRCK beta	Rattus norvegicus (Rat)	SS
Q62868	Rock2	Rho-associated protein kinase 2	Rattus norvegicus (Rat)	EV

10	20	30	40	50	60
MSRPPPTGKM	PGAPETAPGD	GAGASRQRKL	EALIRDPRSP	INVESLLDGL	NSLVLDLDFP
70	80	90	100	110	120
ALRKNKNIDN	FLNRYEKIVK	KIRGLQMKAE	DYDVVKVIGR	GAFGEVQLVR	HKASQKVYAM
130	140	150	160	170	180
KLLSKFEMIK	RSDSAFFWEE	RDIMAFANSP	WVVQLFYAFQ	DDRYLYMVME	YMPGGDLVNL
190	200	210	220	230	240
MSNYDVPEKW	AKFYTAEVVL	ALDAIHSMGL	IHRDVKPDNM	LLDKHGHLKL	ADFGTCMKMD
250	260	270	280	290	300
ETGMVHCDTA	VGTPDYISPE	VLKSQGGDGF	YGRECDWWSV	GVFLYEMLVG	DTPFYADSLV
310	320	330	340	350	360
GTYSKIMDHK	NSLCFPEDAE	ISKHAKNLIC	AFLTDREVRL	GRNGVEEIRQ	HPFFKNDQWH
370	380	390	400	410	420
WDNIRETAAP	VVPELSSDID	SSNFDDIEDD	KGDVETFPIP	KAFVGNQLPF	IGFTYYRENL
430	440	450	460	470	480
LLSDSPSCRE	TDSIQSRKNE	ESQEIQKKLY	TLEEHLSNEM	QAKEELEQKC	KSVNTRLEKT
490	500	510	520	530	540
AKELEEEITL	RKSVESALRQ	LEREKALLQH	KNAEYQRKAD	HEADKKRNLE	NDVNSLKDQL
550	560	570	580	590	600
EDLKKRNQNS	QISTEKVNQL	QRQLDETNAL	LRTESDTAAR	LRKTQAESSK	QIQQLESNNR
610	620	630	640	650	660
DLQDKNCLLE	TAKLKLEKEF	INLQSALESE	RRDRTHGSEI	INDLQGRICG	LEEDLKNGKI
670	680	690	700	710	720
LLAKVELEKR	QLQERFTDLE	KEKSNMEIDM	TYQLKVIQQS	LEQEEAEHKA	TKARLADKNK
730	740	750	760	770	780
IYESIEEAKS	EAMKEMEKKL	LEERTLKQKV	ENLLLEAEKR	CSLLDCDLKQ	SQQKINELLK
790	800	810	820	830	840
QKDVLNEDVR	NLTLKIEQET	QKRCLTQNDL	KMQTQQVNTL	KMSEKQLKQE	NNHLMEMKMN
850	860	870	880	890	900
LEKQNAELRK	ERQDADGQMK	ELQDQLEAEQ	YFSTLYKTQV	RELKEECEEK	TKLGKELQQK
910	920	930	940	950	960
KQELQDERDS	LAAQLEITLT	KADSEQLARS	IAEEQYSDLE	KEKIMKELEI	KEMMARHKQE
970	980	990	1000	1010	1020
LTEKDATIAS	LEETNRTLTS	DVANLANEKE	ELNNKLKDVQ	EQLSRLKDEE	ISAAAIKAQF
1030	1040	1050	1060	1070	1080
EKQLLTERTL	KTQAVNKLAE	IMNRKEPVKR	GNDTDVRRKE	KENRKLHMEL	KSEREKLTQQ
1090	1100	1110	1120	1130	1140
MIKYQKELNE	MQAQIAEESQ	IRIELQMTLD	SKDSDIEQLR	SQLQALHIGL	DSSSIGSGPG
1150	1160	1170	1180	1190	1200
DAEADDGFPE	SRLEGWLSLP	VRNNTKKFGW	VKKYVIVSSK	KILFYDSEQD	KEQSNPYMVL
1210	1220	1230	1240	1250	1260
DIDKLFHVRP	VTQTDVYRAD	AKEIPRIFQI	LYANEGESKK	EQEFPVEPVG	EKSNYICHKG
1270	1280	1290	1300	1310	1320
HEFIPTLYHF	PTNCEACMKP	LWHMFKPPPA	LECRRCHIKC	HKDHMDKKEE	IIAPCKVYYD
1330	1340	1350	1360	1370	1380
ISTAKNLLLL	ANSTEEQQKW	VSRLVKKIPK	KPPAPDPFAR	SSPRTSMKIQ	QNQSIRRPSR

QLAPNKPS