AiPD: Autoinhibited Protein Database

O75037

Gene name	KIF21B (KIAA0449)
Protein name	Kinesin-like protein KIF21B
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23046
EC number
Protein Class	CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED (PTHR47969)

Descriptions

KIF21B, a microtubule(MT)-plus-end directed kinesin-4 motor protein, is mainly expressed in spleen, testes and central nervous tissues, particularly enriched in neurons and contains an N-terminal motor domain followed by several coiled coils and a C-terminal WD40 domain. Within neurons, KIF21B promotes intracellular transport through its N-terminal processive motor activity and influences MT dynamics through distinct MT binding domains. KIF21B positively regulates MTs dynamicity in dendrites by favoring MT growth and catastrophes and also acts as a MT pausing factor by accumulating at the MT-plus ends. These KIF21B functions can be modulated through an autoinhibitory interaction between the N-terminal motor domain and an internal regulatory coiled-coil region (rCC). Mutations within the coiled-coil region are associated with autoinhibitory release, which leads to failure of the fine-tuning of KIF21B activity, resulting in defects in proper neuronal migration and axonal growth.

Autoinhibitory domains (AIDs)

Target domain	6-378 (Kinesin motor domain)
Relief mechanism
Assay	Deletion assay, Mutagenesis experiment

AID

929-1010 (Regulatory coiled-coil domain)

Target domain

6-378 (Kinesin motor domain)

Relief mechanism

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Asselin L et al. (2020) "Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity", Nature communications, 11, 2441

Autoinhibited structure

Activated structure

1 structures for O75037

Entry ID	Method	Resolution	Chain	Position	Source
AF-O75037-F1	Predicted				AlphaFoldDB

1294 variants for O75037

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA204299 rs750865418 RCV000190240 RCV001836749	742	E>K	Long QT syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs796052152 RCV000190139 CA204080	1201	R>W	Variant assessed as Somatic; MODERATE impact. Long QT syndrome [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar NCI-TCGA dbSNP gnomAD
rs1029285127 CA35975356	2	A>D		No	ClinGen gnomAD
CA1321776 rs750359794	3	G>V		No	ClinGen ExAC gnomAD
CA344123735 rs1451627271	5	G>E		No	ClinGen TOPMed gnomAD
CA35975353 rs996349208	6	D>H		No	ClinGen gnomAD
rs1558035079 CA344123712	6	D>V		No	ClinGen Ensembl
rs996349208 CA344123727	6	D>Y		No	ClinGen gnomAD
rs1177171694 CA344123671	8	C>S		No	ClinGen TOPMed
rs781118204 CA344123635 CA1321775	10	K>N		No	ClinGen ExAC gnomAD
CA1321773 rs752880116	13	V>A		No	ClinGen ExAC TOPMed gnomAD
CA344123586 rs1455388304	13	V>I		No	ClinGen gnomAD
CA344123544 rs1485658917	14	R>K		No	ClinGen gnomAD
CA344120886 rs1481800612	16	R>Q		No	ClinGen TOPMed
rs147750916 CA35972478	19	L>P		No	ClinGen ESP
rs1368561142 CA344120798	20	S>L		No	ClinGen gnomAD
rs554431322 CA1321753	20	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1172863230 CA344120700	23	K>N		No	ClinGen gnomAD
rs923595555 CA35972472	25	E>G		No	ClinGen TOPMed
CA344120655 rs1422263786	25	E>K		No	ClinGen TOPMed gnomAD
CA344120649 rs1422263786	25	E>Q		No	ClinGen TOPMed gnomAD
rs754140661 CA1321752	26	G>V		No	ClinGen ExAC gnomAD
TCGA novel	27	C>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs766637667 CA1321751	28	H>D		No	ClinGen ExAC gnomAD
rs200017982 CA1321750	29	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344120554 rs1352288891	31	T>P		No	ClinGen gnomAD
rs758985738 CA35972438	32	S>F		No	ClinGen TOPMed gnomAD
rs1558025851 CA344120503	34	T>I		No	ClinGen Ensembl
CA1321747 rs565712809	35	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1321748 rs565712809	35	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	36	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1320588	38	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1242227998 CA344120433	38	P>T		No	ClinGen gnomAD
rs1293380136 CA344120331	44	K>R		No	ClinGen gnomAD
rs762383604 CA1321744	47	A>V		No	ClinGen ExAC gnomAD
rs1348581247 CA344120210	49	T>I		No	ClinGen gnomAD
rs1348581247 CA344120207	49	T>N		No	ClinGen gnomAD
rs764651949 CA35972420	51	D>E		No	ClinGen TOPMed gnomAD
CA344120086 rs1165774872	55	D>E		No	ClinGen gnomAD
rs376966681 CA344120092	55	D>H		No	ClinGen ESP ExAC gnomAD
CA1321740 rs376966681	55	D>N		No	ClinGen ESP ExAC gnomAD
CA344120040 rs1339896138	58	T>S		No	ClinGen TOPMed
rs1362104291 CA344120036	59	W>R		No	ClinGen gnomAD
COSM1127191 COSM4876650	62	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321738 rs746986910	63	I>M		No	ClinGen ExAC TOPMed gnomAD
CA35972400 rs912118630	64	Y>*		No	ClinGen TOPMed gnomAD
rs755110188 CA1321736	66	T>I		No	ClinGen ExAC TOPMed gnomAD
rs374878271 CA1321735	68	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321734 rs780281131	69	S>R		No	ClinGen ExAC gnomAD
rs750591931 CA1321733	72	I>M		No	ClinGen ExAC gnomAD
rs781638599 CA1321731	73	E>K		No	ClinGen ExAC gnomAD
rs757523921 CA1321730	74	G>A		No	ClinGen ExAC gnomAD
rs1239756217 CA344119856	75	C>G		No	ClinGen gnomAD
CA35972369 rs375409133	76	F>C		No	ClinGen ESP TOPMed gnomAD
rs371235927 CA1321728	77	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1321727 rs763437965	78	G>V		No	ClinGen ExAC gnomAD
rs764621053 CA1321725	79	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	80	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1158062077 CA344119741	81	A>G		No	ClinGen gnomAD
CA1321724 rs759281080	82	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	83	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	83	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1454078531 CA344119682	87	G>R		No	ClinGen gnomAD
COSM6123694 COSM6123695	88	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1225831423 CA344119050 COSM902052 COSM4866431	89	T>M	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
TCGA novel	90	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	91	A>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA1321694 rs747201044 COSM240404	92	G>R	prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs372348797 CA1321692	94	T>S		No	ClinGen ESP ExAC
COSM3481382 COSM4904044	97	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765944215 CA1321690	97	M>V		No	ClinGen ExAC gnomAD
rs754527351 CA1321689	99	T>A		No	ClinGen ExAC gnomAD
rs1175939787 CA344118762	99	T>I		No	ClinGen gnomAD
TCGA novel	100	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1337763 COSM4784171	103	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs753342023 CA1321688	105	T>A		No	ClinGen ExAC gnomAD
rs150551633 CA1321687	105	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs140589352 CA1321685	106	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1321683 rs761636522	107	E>D		No	ClinGen ExAC gnomAD
CA35971942 rs890787236	109	E>G		No	ClinGen TOPMed
COSM4026863 COSM4026864	109	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1485965385 CA344118321	113	I>V		No	ClinGen gnomAD
CA1321682 rs369827699	114	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA1321681 rs369827699	114	P>Q		No	ClinGen ESP ExAC gnomAD
CA344118267 rs1306746485	115	R>K		No	ClinGen gnomAD
CA35971929 rs374795746	116	A>T		No	ClinGen ESP gnomAD
rs922165535 CA35971923	118	A>G		No	ClinGen TOPMed
rs770974908 COSM3803423 CA1321678 COSM209457	118	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine prostate breast [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773381121 CA1321676	120	L>F		No	ClinGen ExAC gnomAD
COSM902050 COSM4871096	120	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344118088 rs1172107154	122	G>R		No	ClinGen TOPMed
rs1315405620 CA344118058	123	G>D		No	ClinGen gnomAD
rs779319005 CA1321674	125	A>G		No	ClinGen ExAC TOPMed gnomAD
CA1321673 rs779319005	125	A>V		No	ClinGen ExAC TOPMed gnomAD
CA344117998 rs749783399	126	E>K		No	ClinGen ExAC gnomAD
rs749783399 CA1321671	126	E>Q		No	ClinGen ExAC gnomAD
COSM3746718 CA1321670 rs745970550	127	R>C	liver Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
CA1321669 rs142552201	127	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321668 rs371216148	128	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs767222970 CA1321667	128	K>R		No	ClinGen ExAC gnomAD
rs756959465 CA1321666	129	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1321665 rs751378411	129	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM6123697 COSM6123696	130	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs368134803 COSM1255821 CA1321663	130	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA1321664 rs763920274	130	R>W		No	ClinGen ExAC gnomAD
CA1321662 rs141541631	131	A>T		No	ClinGen ESP ExAC gnomAD
CA344117833 rs1310662037	132	Q>H		No	ClinGen TOPMed
CA1321661 rs142277557	132	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1017818410 CA35971819	134	Q>K		No	ClinGen Ensembl
CA1321659 rs773434079	135	G>D		No	ClinGen ExAC gnomAD
CA1321660 rs538789987	135	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs371110975 CA1321657	136	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1391879484 CA344117699	137	A>V		No	ClinGen gnomAD
rs1461619167 CA344117690	138	G>E		No	ClinGen TOPMed gnomAD
rs1324852358 CA344117691	138	G>R		No	ClinGen gnomAD
CA1321656 rs774615602	140	E>A		No	ClinGen ExAC gnomAD
TCGA novel	140	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA344117559 rs1558024896	141	F>L		No	ClinGen Ensembl
rs372026817 CA1321655	144	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321653 rs368704611	145	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA35971762 rs896277805	145	A>V		No	ClinGen gnomAD
COSM3481381 COSM4893488	149	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA35969226 rs905642139	150	L>P		No	ClinGen TOPMed
CA35969222 rs57838980	152	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs202167673 CA35969224	152	N>S		No	ClinGen Ensembl
rs948674050 CA35969203	154	E>D		No	ClinGen Ensembl
rs1299490919 CA344116110	154	E>G		No	ClinGen gnomAD
TCGA novel	156	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA344116030 rs1571956668	157	D>A		No	ClinGen Ensembl
rs1370253259 CA344115956	160	D>Y		No	ClinGen TOPMed
COSM902049 COSM4872636	161	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs780898657 COSM3728141 CA1321632	162	T>N	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1571956640 CA344115920	162	T>P		No	ClinGen Ensembl
rs1174051997 CA344115881	163	R>C		No	ClinGen gnomAD
CA1321631 rs574223570	163	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1174051997 COSM1500503 CA344115887 COSM6123699 COSM6123698	163	R>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA Cosmic NCI-TCGA gnomAD
rs746670892 CA1321630	164	D>A		No	ClinGen ExAC TOPMed gnomAD
rs777415452 CA1321629	165	P>S		No	ClinGen ExAC TOPMed gnomAD
rs777415452 CA344115828	165	P>T		No	ClinGen ExAC TOPMed gnomAD
rs752543544 CA1321627	167	T>I		No	ClinGen ExAC gnomAD
CA344115761 rs1571956574	167	T>P		No	ClinGen Ensembl
CA1321626 rs778672911	168	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1321625 rs754943866	168	R>H		No	ClinGen ExAC TOPMed gnomAD
rs754943866 CA344115732	168	R>L		No	ClinGen ExAC TOPMed gnomAD
rs753749629 CA1321624	170	R>C		No	ClinGen ExAC
CA1321623 rs201113105	170	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201113105 CA344115678	170	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344115670 rs1282935526	171	R>K		No	ClinGen TOPMed gnomAD
rs1212089147 CA344115660	172	S>P		No	ClinGen gnomAD
CA35969105 rs868128266	178	E>K		No	ClinGen gnomAD
rs751746820 CA1321621	179	D>A		No	ClinGen ExAC TOPMed gnomAD
CA1321619 rs763083427	179	D>E		No	ClinGen ExAC TOPMed gnomAD
CA344115494 rs751746820	179	D>G		No	ClinGen ExAC TOPMed gnomAD
rs776039428 CA344115458	180	A>S		No	ClinGen ExAC TOPMed gnomAD
rs776039428 CA1321618	180	A>T		No	ClinGen ExAC TOPMed gnomAD
rs139624974 CA1321617	181	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA344115386 rs1313449503	182	G>S		No	ClinGen TOPMed gnomAD
rs777236820 CA1321615	183	G>D		No	ClinGen ExAC gnomAD
rs1462024814 CA344115260	186	T>S		No	ClinGen TOPMed
CA344115246 rs1295545154	187	T>I		No	ClinGen TOPMed
rs771821901 CA1321611	189	V>I		No	ClinGen ExAC TOPMed gnomAD
rs771821901 CA344115223	189	V>L		No	ClinGen ExAC TOPMed gnomAD
rs747765335 CA344115169	190	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1321610 rs747765335	190	T>N		No	ClinGen ExAC TOPMed gnomAD
rs778836144 CA35969060	191	S>C		No	ClinGen TOPMed
CA35969056 rs778836144	191	S>F		No	ClinGen TOPMed
CA1321609 COSM4905610 COSM3481378 rs778724409	192	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
CA1321608 rs754732012 COSM4026860 COSM4026859	192	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
TCGA novel	194	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1326854066 CA344115071	194	I>M		No	ClinGen Ensembl
rs1426068839 CA344115019	195	H>Q		No	ClinGen gnomAD
CA1321607 rs141640757	195	H>Y		No	ClinGen ESP ExAC
rs987054249 CA35969035	196	S>P		No	ClinGen Ensembl
CA344114954 rs954474230	198	E>D		No	ClinGen TOPMed gnomAD
rs1246329410 CA344114945	199	E>K		No	ClinGen TOPMed
CA344114824 rs1480284054	200	L>M		No	ClinGen gnomAD
TCGA novel	201	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747818334 CA344114720	203	C>G		No	ClinGen ExAC TOPMed gnomAD
CA1321592 rs747818334	203	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1467750198 CA344114667	205	K>N		No	ClinGen gnomAD
rs375811791 CA35968912	206	Q>*		No	ClinGen ESP TOPMed
CA344114650 rs1571956158	206	Q>R		No	ClinGen Ensembl
CA1321590 rs768455687	208	A>T		No	ClinGen ExAC gnomAD
TCGA novel	208	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA344114571 rs1260036392	210	S>Y		No	ClinGen gnomAD
rs1378904806 CA344114554 COSM4781928 COSM3400186	211	R>C	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs756118030 CA1321588	211	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1321587 rs756118030	211	R>L		No	ClinGen ExAC TOPMed gnomAD
CA344114506 rs1370448336	214	A>D		No	ClinGen gnomAD
rs1438986304 CA344114509	214	A>T		No	ClinGen gnomAD
TCGA novel	215	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1321586 rs745771628	217	Q>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	217	Q>H	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs777932365 CA1321585	219	N>S		No	ClinGen ExAC gnomAD
CA1321583 rs147387128	220	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA344114249 rs1420827272	224	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344114245 rs1382624794	224	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM6123700 COSM6123701	224	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4906208 COSM3481377	225	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321582 rs765495506	225	S>P		No	ClinGen ExAC gnomAD
rs200374473 CA344114191	226	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM4026857 COSM4026858 rs1200416395 CA344114190	227	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA344114181 rs1444824304	227	A>V		No	ClinGen gnomAD
rs1438761868 CA344114148	229	F>S		No	ClinGen Ensembl
CA1321580 rs754294777	231	I>V		No	ClinGen ExAC gnomAD
CA1321579 rs139587088	232	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755531305 CA1321578	236	M>R		No	ClinGen ExAC gnomAD
CA1321577 rs773539819	237	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1321576 rs767082564	237	R>H		No	ClinGen ExAC TOPMed gnomAD
CA344114014 COSM400944 rs767082564	237	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs773539819 CA344114027	237	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1321575 rs761258584	239	C>R		No	ClinGen ExAC gnomAD
rs201594775 CA1321573	240	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1317720189 CA344113913	241	Q>R		No	ClinGen gnomAD
TCGA novel	243	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1321570 rs151270657	243	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1321569 rs201624271	244	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1336478996 CA344113017	245	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1321552 rs759901677	248	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1571955379 CA344112944	249	V>G		No	ClinGen Ensembl
CA1321550 rs769636295	249	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1284855658 CA344112890	251	G>E		No	ClinGen TOPMed
CA344112809 rs924771118	254	D>A		No	ClinGen gnomAD
CA35968448 rs924771118	254	D>G		No	ClinGen gnomAD
COSM3864069 COSM3864068	254	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776472486 CA1321547	255	G>S		No	ClinGen ExAC gnomAD
CA1321546 rs143968787	256	T>I		No	ClinGen ESP ExAC gnomAD
rs1199476738 CA344112679	257	P>L		No	ClinGen gnomAD
rs746912144 CA1321545	257	P>S		No	ClinGen ExAC TOPMed gnomAD
rs746912144 CA344112708	257	P>T		No	ClinGen ExAC TOPMed gnomAD
rs971598271 CA35968426	258	P>A		No	ClinGen gnomAD
rs779179528 CA1321544	258	P>L		No	ClinGen ExAC TOPMed gnomAD
rs971598271 CA344112676	258	P>T		No	ClinGen gnomAD
rs141814113 CA1321543	259	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1473248 COSM4813857	259	S>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344112625 rs1485307904	260	S>G		No	ClinGen TOPMed
CA1321540 rs756349092	261	E>D		No	ClinGen ExAC gnomAD
rs750824129 CA1321539	262	Y>H		No	ClinGen ExAC gnomAD
rs1156271004 CA344112494	263	E>A		No	ClinGen gnomAD
CA1321538 rs781508741	265	L>F		No	ClinGen ExAC gnomAD
COSM4897412 COSM3481376	275	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM424990 COSM4813336	277	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344112076 rs1167009890	279	R>Q		No	ClinGen TOPMed
COSM4026856 COSM1337762	279	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344112034 rs1163495836	282	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM4399199 COSM4399198	282	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321533 rs752406293	287	G>D		No	ClinGen ExAC TOPMed gnomAD
rs530526185 CA1321532	288	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA35968395 rs916957778	288	E>K		No	ClinGen TOPMed gnomAD
CA344111851 rs766937251	289	R>L		No	ClinGen ExAC gnomAD
CA1321531 rs766937251	289	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA344111853 rs1459259252	289	R>W		No	ClinGen gnomAD
CA344111833 rs1571955102	290	A>G		No	ClinGen Ensembl
COSM3481375 COSM4905756	295	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321528 rs760706406	295	S>Y		No	ClinGen ExAC
CA1321527 rs761122837	298	C>G		No	ClinGen ExAC TOPMed gnomAD
COSM4937018 COSM4937019	303	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	304	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1188810723 CA344111237	306	V>M		No	ClinGen gnomAD
rs148716604 CA1321481	308	S>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1321479 rs182269799	309	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1183938960 CA344111166	309	A>V		No	ClinGen gnomAD
CA344111160 rs1239527134	310	L>S		No	ClinGen gnomAD
TCGA novel	311	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1321478 rs773498487	312	D>N		No	ClinGen ExAC gnomAD
TCGA novel	313	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1321477 rs368047749	314	S>I		No	ClinGen ESP ExAC gnomAD
CA344110986 rs1314921136	317	V>A		No	ClinGen gnomAD
rs148683091 CA1321475	320	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1333495477 CA344110888	321	P>L		No	ClinGen gnomAD
CA344110855 rs1482276187	322	Y>F		No	ClinGen TOPMed
CA344110818 rs1385194867	323	R>K		No	ClinGen gnomAD
rs1182142756 CA344110672	327	L>V		No	ClinGen TOPMed
CA35968024 rs866691072	329	R>L		No	ClinGen gnomAD
CA344110599 rs866691072	329	R>Q		No	ClinGen gnomAD
rs1044443554 CA35968031	329	R>W		No	ClinGen TOPMed
CA1321473 rs748862435	330	L>I		No	ClinGen ExAC gnomAD
rs948708465 CA35968015	332	Q>*		No	ClinGen TOPMed gnomAD
rs948708465 CA344110529	332	Q>K		No	ClinGen TOPMed gnomAD
TCGA novel	334	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs778434242 COSM1290084	337	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
COSM5832456 rs778434242 COSM5832455	338	N>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
COSM4867684 COSM902046	340	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4891810 COSM3481374 rs1262345783 CA344110130	341	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA344110113 rs1217191306	342	I>T		No	ClinGen gnomAD
CA344110044 rs528121290	344	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM902045 CA1321457 rs774564420 COSM4228990	345	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA344110013 rs1344563832	346	C>R		No	ClinGen gnomAD
CA344109841 rs1338472230	351	D>V		No	ClinGen gnomAD
COSM4874819 COSM902044	351	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344109830 rs1320150740	352	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1321454 rs779737040	352	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344109545 rs1362848044	361	L>F		No	ClinGen gnomAD
CA35967746 rs767565146	362	K>R		No	ClinGen Ensembl
CA1321451 rs780840244	365	N>S		No	ClinGen ExAC gnomAD
rs1402440194 CA344109391	366	R>Q		No	ClinGen gnomAD
COSM4860574 COSM678219 rs1250955515 CA344109395	366	R>W	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
CA344109371 rs1173856202	367	A>D		No	ClinGen gnomAD
CA344109354 rs1476570625	368	R>C		No	ClinGen gnomAD
rs756847786 CA1321450	368	R>H		No	ClinGen ExAC TOPMed gnomAD
CA344109221 rs1160783075	372	N>D		No	ClinGen TOPMed
COSM71340	373	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344109151 rs1194314570	374	V>L		No	ClinGen gnomAD
CA344109147 rs1194314570	374	V>M		No	ClinGen gnomAD
rs1571953395 CA344109051	377	N>T		No	ClinGen Ensembl
CA1321448 rs777397981	378	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1186553752 CA344108933	380	K>N		No	ClinGen gnomAD
CA344108911 rs1404410053	381	T>I		No	ClinGen TOPMed
rs758378325 CA1321447	381	T>P		No	ClinGen ExAC gnomAD
rs376452020 CA1321446	382	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs766476616 CA1321445	384	Q>*		No	ClinGen ExAC gnomAD
CA1321443 rs750620669	384	Q>H		No	ClinGen ExAC gnomAD
rs756116786 CA1321444	384	Q>R		No	ClinGen ExAC gnomAD
rs767835185 CA1321442	385	I>M		No	ClinGen ExAC gnomAD
rs761934289 CA1321441	386	S>T		No	ClinGen ExAC TOPMed gnomAD
COSM4873294 COSM902043	387	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1341401396 CA344108670	389	R>Q		No	ClinGen gnomAD
CA1321440 rs774829992	389	R>W		No	ClinGen ExAC TOPMed gnomAD
rs763589449 CA1321438	392	I>S		No	ClinGen ExAC TOPMed gnomAD
CA1321439 rs764507630	392	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1467167007 CA344108587	394	R>Q		No	ClinGen TOPMed gnomAD
rs769442976 CA1321436	394	R>W		No	ClinGen ExAC TOPMed gnomAD
CA344108536 rs1162544488	397	M>V		No	ClinGen gnomAD
CA344108450 rs1473016933	399	L>V		No	ClinGen gnomAD
CA344108409 rs1323330319	400	M>I		No	ClinGen TOPMed
COSM4228987 COSM2211769 rs371524692	404	A>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1558019653 CA344108286	404	A>T		No	ClinGen Ensembl
rs746619358 CA1321432	404	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs920356156 CA35966931	405	G>D		No	ClinGen TOPMed gnomAD
CA1321395 rs765914389	407	R>*		No	ClinGen ExAC gnomAD
CA1321394 rs373690387	407	R>Q		No	ClinGen ESP ExAC gnomAD
rs772695028 CA1321393	411	E>G		No	ClinGen ExAC TOPMed gnomAD
CA1321391 rs142774440	412	D>N		No	ClinGen ESP ExAC TOPMed
TCGA novel	413	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA344106763 rs1339999376	414	A>T		No	ClinGen TOPMed
CA1321389 rs768297694	416	G>S		No	ClinGen ExAC gnomAD
CA344106652 rs1571951529	418	S>N		No	ClinGen Ensembl
rs772692795 CA1321388	421	F>L		No	ClinGen ExAC TOPMed gnomAD
CA35966878 rs140412174	422	R>*		No	ClinGen ESP
rs771634893 CA35966874	422	R>P		No	ClinGen ExAC TOPMed gnomAD
rs771634893 CA1321387	422	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	423	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747155865 CA1321385	426	M>V		No	ClinGen ExAC gnomAD
CA1321383 rs758745163	428	Q>E		No	ClinGen ExAC gnomAD
rs563360685 CA344106283	429	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344106172 rs1357614372	435	R>Q		No	ClinGen gnomAD
CA1321380 rs755226578	435	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA1321378 rs199512300	437	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs937853917 CA35966834	437	R>W		No	ClinGen Ensembl
rs1571951378 CA344106108	438	V>G		No	ClinGen Ensembl
rs1241827924 CA344106132	438	V>M		No	ClinGen TOPMed
rs1476058834 CA344106082	439	K>T		No	ClinGen TOPMed
CA1321377 rs766852362	440	A>T		No	ClinGen ExAC gnomAD
rs1431469227 CA344106000 CA344106004	441	M>I		No	ClinGen gnomAD
CA344105953 rs1192135354	442	Q>L		No	ClinGen gnomAD
TCGA novel	445	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1321375 COSM1738494 rs200299912	445	I>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA344105857 rs1170147175	445	I>N		No	ClinGen TOPMed
rs1188630831 CA344105814	446	D>G		No	ClinGen gnomAD
CA35966798 rs866076396	446	D>N		No	ClinGen TOPMed gnomAD
CA1321373 rs761485852	449	N>K		No	ClinGen ExAC TOPMed gnomAD
rs773928737 CA1321372	451	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773928737 CA344105601	451	R>G		No	ClinGen ExAC TOPMed gnomAD
rs953396132 COSM5004691 COSM5004692 CA35966783	451	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
CA1321371 rs369897745	452	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	454	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA1321370 rs149557382	454	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM3864067 COSM3864066 rs963601591 CA35966734	456	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1378112265 CA344105518	456	M>T		No	ClinGen gnomAD
CA1321368 rs769663553	456	M>V		No	ClinGen ExAC gnomAD
CA1321366 rs773445211	457	S>I		No	ClinGen ExAC TOPMed gnomAD
CA1321367 rs773445211	457	S>N		No	ClinGen ExAC TOPMed gnomAD
CA344105497 rs1408476064	458	Q>E		No	ClinGen gnomAD
rs1264383785 CA344105493	458	Q>R		No	ClinGen TOPMed
rs772235540 CA1321365	461	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA344105411 rs1326653726	464	L>V		No	ClinGen TOPMed
CA344105385 rs1173110225	465	A>D		No	ClinGen gnomAD
COSM6123703 COSM6123702	465	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1167145203 CA344105397	465	A>T		No	ClinGen TOPMed gnomAD
CA344105364 rs1284086179	467	A>T		No	ClinGen TOPMed
rs756451256 CA1321361	468	G>S		No	ClinGen ExAC TOPMed gnomAD
CA344104547 rs758012354	469	D>N		No	ClinGen ExAC TOPMed gnomAD
CA1321335 COSM4143151 rs758012354 COSM4143150	469	D>Y	thyroid [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1321334 rs372391603	471	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1304885231 CA344104489	473	A>V		No	ClinGen TOPMed
rs765125044 CA1321333	474	I>V		No	ClinGen ExAC gnomAD
rs778478640 CA1321332	476	A>S		No	ClinGen ExAC gnomAD
rs778478640 CA35965579	476	A>T		No	ClinGen ExAC gnomAD
CA1321331 rs776549894	476	A>V		No	ClinGen ExAC TOPMed gnomAD
rs774342632 CA1321328	478	I>S		No	ClinGen ExAC gnomAD
rs1282908635 CA344104448	478	I>V		No	ClinGen TOPMed
CA1321327 rs768730594	479	Q>R		No	ClinGen ExAC
CA1321326 rs763091394	480	N>D		No	ClinGen ExAC TOPMed gnomAD
CA344104431 rs763091394	480	N>H		No	ClinGen ExAC TOPMed gnomAD
rs376885029 CA1321325	480	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321323 rs781508849	483	R>L		No	ClinGen ExAC gnomAD
rs781508849 CA1321322	483	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1333881054 CA344104355	484	E>D		No	ClinGen gnomAD
COSM133989	486	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344104303 rs1196100059	488	L>Q		No	ClinGen gnomAD
TCGA novel	489	R>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	489	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1177946556 CA344104089	494	E>K		No	ClinGen gnomAD
CA35965313 rs145642006	497	A>V		No	ClinGen ESP TOPMed gnomAD
COSM1285780	498	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1175085100 CA344103938	499	N>S		No	ClinGen TOPMed
CA344103929 COSM2211759 COSM4228976 rs1168380341	500	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
CA1321292 rs750173633	501	S>A		No	ClinGen ExAC gnomAD
CA1321290 rs761625663	501	S>F		No	ClinGen ExAC TOPMed gnomAD
CA1321291 rs761625663	501	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs752827586 CA1321289	502	L>R		No	ClinGen ExAC TOPMed gnomAD
CA1321288 rs765256319	504	R>C		No	ClinGen ExAC TOPMed gnomAD
CA344103822 rs1243878342	504	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA344103830 rs1243878342	504	R>L		No	ClinGen TOPMed gnomAD
TCGA novel	505	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1205610406 CA344103809	505	S>N		No	ClinGen gnomAD
CA344103771 rs1558017022	508	R>Q		No	ClinGen Ensembl
CA35965268 rs1053127686	508	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA35965267 rs764127649	510	S>L		No	ClinGen gnomAD
CA1321285 rs766663215	511	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1321284 rs761156956	512	R>G		No	ClinGen ExAC
COSM3481368 COSM4891823	512	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344103627 CA35965262 rs906732901	513	S>R		No	ClinGen TOPMed gnomAD
COSM3481367 COSM4905488	514	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344103616 rs1332518372	514	P>S		No	ClinGen Ensembl
CA344103583 rs1338251233	516	S>T		No	ClinGen TOPMed gnomAD
CA344103546 rs1443968197	517	L>R		No	ClinGen gnomAD
COSM6060591 COSM6060592	517	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1558016958 COSM531893 COSM6060594 CA344103524 COSM6060593	519	A>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA Cosmic Ensembl NCI-TCGA
CA1321283 rs773441238	520	S>F		No	ClinGen ExAC gnomAD
CA1321281 rs748641857	521	P>L		No	ClinGen ExAC TOPMed gnomAD
rs772671705 CA1321282	521	P>S		No	ClinGen ExAC gnomAD
COSM6123705 rs774020793 COSM1500506 CA1321280 COSM6123704	522	A>T	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
COSM4813696 COSM424988 CA35965243 rs866365757	523	A>T	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA1321277 rs779815267	523	A>V		No	ClinGen ExAC TOPMed gnomAD
CA344103457 rs1380566315	524	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs903755696 CA35965236	524	P>S		No	ClinGen TOPMed
rs1456511036 CA344103450	525	A>T		No	ClinGen gnomAD
CA344103435 rs1245146287	525	A>V		No	ClinGen TOPMed
rs1232308155 CA344103400	526	F>C		No	ClinGen gnomAD
rs745715373 CA1321275	527	G>E		No	ClinGen ExAC gnomAD
rs1440043506 CA344103397 CA344103395	527	G>R		No	ClinGen gnomAD
TCGA novel	528	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA1321274 rs780827690	528	G>V		No	ClinGen ExAC gnomAD
rs757244028 CA1321273	529	S>T		No	ClinGen ExAC gnomAD
CA344103342 rs1316737348	530	P>H		No	ClinGen gnomAD
TCGA novel	530	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA344103312 rs1237426941	531	A>V		No	ClinGen gnomAD
rs1279620644 CA344103303	532	S>N		No	ClinGen TOPMed gnomAD
rs1279620644 CA344103300	532	S>T		No	ClinGen TOPMed gnomAD
CA344103285 rs1444354136	533	S>C		No	ClinGen gnomAD
CA1321271 rs371947852	536	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321272 rs371947852	536	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1425088757 CA344103210	537	A>S		No	ClinGen gnomAD
CA344103194 rs1165706574	538	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344103159 rs1571948119	540	V>G		No	ClinGen Ensembl
CA1321266 rs760774571	542	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1471463401 CA344103139	542	R>H		No	ClinGen TOPMed gnomAD
CA344103132 rs1471463401	542	R>L		No	ClinGen TOPMed gnomAD
CA35965182 rs929639316	543	R>S		No	ClinGen TOPMed
rs1245509885 CA344103126	543	R>T		No	ClinGen gnomAD
CA344103046 rs1490617938	547	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM4026855 COSM4026854	549	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321264 rs767724966	550	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1321265 rs767724966	550	R>P		No	ClinGen ExAC TOPMed gnomAD
rs767724966 CA344103008	550	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344103010 COSM1639676 rs1294401570	550	R>W	stomach [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1225001720 CA344102974	552	K>N		No	ClinGen TOPMed gnomAD
rs975078674 CA35965167	554	K>E		No	ClinGen TOPMed
rs1571947957 CA344102911	556	V>G		No	ClinGen Ensembl
rs1284730184 CA344102926	556	V>I		No	ClinGen TOPMed
CA344102879 rs1347239507	558	Q>H		No	ClinGen gnomAD
COSM4026853 rs748876558 COSM4026852 CA1321259	559	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
CA1321260 rs762774383	559	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1321258 COSM3481365 rs774832342 COSM4899390	560	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1160049458 CA344102852	561	K>R		No	ClinGen gnomAD
CA344102725 rs1226526071	562	S>R		No	ClinGen TOPMed gnomAD
CA344102708 rs1198209870	563	P>L		No	ClinGen TOPMed
CA1321237 rs760922988	564	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs776092158 CA1321236	565	K>N		No	ClinGen ExAC gnomAD
CA344102668 rs1297441204	565	K>R		No	ClinGen gnomAD
CA1321235 rs770560122	567	A>V		No	ClinGen ExAC gnomAD
rs746870457 CA1321234	572	A>E		No	ClinGen ExAC gnomAD
COSM1473247 COSM4813837	572	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344102470 rs746870457	572	A>V		No	ClinGen ExAC gnomAD
RCV000522620 rs1553240713	573	K>missing		No	ClinVar dbSNP
CA35964643 rs865942025	575	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs998012701 CA35964641	576	Q>H		No	ClinGen TOPMed gnomAD
rs1255388970 CA344102302	578	N>K		No	ClinGen TOPMed
CA35964621 rs773684942	579	S>N		No	ClinGen gnomAD
rs1023850106 COSM902041 CA35964605 COSM4863321	580	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
CA35964601 rs553956181	582	T>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA344102223 rs553956181	582	T>R		No	ClinGen 1000Genomes TOPMed gnomAD
CA344102143 rs1421729264	586	E>K		No	ClinGen TOPMed gnomAD
CA344102140 rs1421729264	586	E>Q		No	ClinGen TOPMed gnomAD
CA1321229 rs151003945	587	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs151003945 CA1321230	587	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321226 rs757523345	589	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1336287498 CA344102076	589	E>K		No	ClinGen TOPMed
CA344101928 rs1480060106	593	E>K		No	ClinGen gnomAD
rs758635507 COSM4026848 COSM4026849 CA1321205	594	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs758635507 CA1321206	594	R>G		No	ClinGen ExAC gnomAD
CA1321203 rs373134245	594	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1321204 COSM4877355 COSM4877354 rs373134245	594	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
CA344101886 rs755476544	595	D>E		No	ClinGen ExAC gnomAD
rs753390486 CA1321201	596	E>A		No	ClinGen ExAC gnomAD
COSM1255820 rs892966441 COSM4894611 CA35964200	596	E>K	Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs892966441 CA35964202	596	E>Q		No	ClinGen TOPMed gnomAD
rs1053323751 CA35964193	597	S>G		No	ClinGen TOPMed gnomAD
rs574138491 CA1321200	599	C>W		No	ClinGen 1000Genomes ExAC gnomAD
rs554311091 CA1321199	600	E>G		No	ClinGen 1000Genomes ExAC
CA1321198 rs772782924	601	E>G		No	ClinGen ExAC
CA1321197 rs767312769	602	E>G		No	ClinGen ExAC
COSM4399001 COSM3481363	602	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM6123708 COSM6123709	603	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344101700 rs1222279062	603	E>Q		No	ClinGen gnomAD
CA1321196 rs761570467	604	G>R		No	ClinGen ExAC TOPMed gnomAD
rs774166442 COSM4026847 COSM4026846 CA1321195	605	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
CA1321194 rs147761216	605	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA344101632 rs771070541	606	E>D		No	ClinGen ExAC gnomAD
CA1321192 rs200764096	606	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1321193 rs200764096	606	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA1321190 rs747249886	607	D>N		No	ClinGen ExAC gnomAD
CA1321189 rs778202622	607	D>V		No	ClinGen ExAC TOPMed gnomAD
rs868484306 COSM4531770 CA35964150 COSM3481362	608	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic Ensembl NCI-TCGA
rs779310643 CA1321186	612	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs779310643 CA1321187	612	S>W		No	ClinGen ExAC TOPMed gnomAD
COSM902040 CA35964091 rs377169350 COSM4873165	616	E>D	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic ClinGen cosmic curated Ensembl
rs1474311296 CA344101378	618	L>M		No	ClinGen gnomAD
CA344101362 rs1192827651	619	V>A		No	ClinGen gnomAD
rs140372625 CA1321184	619	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs755560786 CA1321182	620	D>G		No	ClinGen ExAC gnomAD
rs767140551 CA1321181	622	D>H		No	ClinGen ExAC TOPMed gnomAD
rs767140551 CA1321180	622	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs761504727 CA1321179	624	D>E		No	ClinGen ExAC TOPMed gnomAD
CA344101275 rs1558015501	624	D>N		No	ClinGen Ensembl
rs1264325176 CA344101259	625	P>A		No	ClinGen gnomAD
CA35964086 COSM3481361 rs866579901 COSM4904107	625	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic Ensembl NCI-TCGA
CA1321177 rs763912127	626	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1321175 rs775513951	627	E>D		No	ClinGen ExAC TOPMed gnomAD
COSM4893614 COSM3481360	627	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA35964051 rs185829318	628	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747157519 CA1321173	629	E>K		No	ClinGen ExAC TOPMed gnomAD
rs747157519 CA344101169	629	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1359670989 CA344148861	631	N>D		No	ClinGen gnomAD
CA35998341 rs1051364011	631	N>S		No	ClinGen gnomAD
CA344148817 rs1168729002	632	F>S		No	ClinGen TOPMed gnomAD
CA1321146 rs780574108	632	F>V		No	ClinGen ExAC gnomAD
rs756736149 COSM4228955 CA1321145 COSM2211738	634	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA344148711 rs921471066	637	A>S		No	ClinGen TOPMed
CA35998321 rs921471066	637	A>T		No	ClinGen TOPMed
rs752592969 CA1321141	637	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1321139 rs759573082	638	D>N		No	ClinGen ExAC TOPMed gnomAD
CA344148645 rs1399036374	639	L>V		No	ClinGen gnomAD
CA344148607 rs1159720557	640	T>I		No	ClinGen gnomAD
rs767504399 CA1321137	640	T>S		No	ClinGen ExAC gnomAD
CA1321136 rs762009457	641	C>F		No	ClinGen ExAC gnomAD
CA344148597 rs1571944156	641	C>R		No	ClinGen Ensembl
COSM3864064 COSM3864063 rs267598289 CA35998276	644	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA gnomAD
rs1191326083 CA344148468	645	I>S		No	ClinGen TOPMed
COSM6123711 COSM6123710	649	L>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344148265 rs1478514074	649	L>V		No	ClinGen gnomAD
rs768598383 CA35998275	650	I>F		No	ClinGen Ensembl
COSM3789317 COSM3789316	650	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM424987 COSM4812816	650	I>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs186282104 CA35998241	651	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186282104 CA1321134	651	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM3481358 COSM4891889	652	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs775864023 CA1321132	652	E>Q		No	ClinGen ExAC gnomAD
CA344148011 rs1248412746	656	S>T		No	ClinGen TOPMed gnomAD
CA344147942 rs1321292382	657	Q>H		No	ClinGen gnomAD
rs145622369 CA1321130	658	R>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA35998236 rs971057642	658	R>W		No	ClinGen Ensembl
rs1369385489 CA344147887	659	R>L		No	ClinGen gnomAD
COSM382643 COSM4865506 rs780140610 CA35998227	659	R>W	lung Variant assessed as Somatic; MODERATE impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs777255666 CA1321129	660	L>V		No	ClinGen ExAC gnomAD
CA1321128 rs771341010	662	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1427696752 CA344147540	667	Y>C		No	ClinGen gnomAD
rs1480971608 CA344147567	667	Y>H		No	ClinGen gnomAD
CA35998207 rs991396176	668	E>Q		No	ClinGen Ensembl
rs1184472653 CA344147460	669	E>G		No	ClinGen gnomAD
rs754759688 CA1321122	673	L>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1295678 COSM4812031	675	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344147097 rs1210316283	679	R>*		No	ClinGen TOPMed
CA1321120 rs766404118	679	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs878964458 CA35998163	680	D>G		No	ClinGen Ensembl
CA35998159 rs1027526288	682	Q>R		No	ClinGen TOPMed
CA344146984 rs755974731	684	E>*		No	ClinGen ExAC gnomAD
CA344146969 rs1486812123	684	E>A		No	ClinGen TOPMed
rs755974731 CA1321119	684	E>Q		No	ClinGen ExAC gnomAD
CA1321118 rs751709530	685	R>C		No	ClinGen ExAC gnomAD
CA1321117 COSM1337758 rs764120600 COSM4786043	685	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
CA344146917 rs1361491079	686	D>N		No	ClinGen TOPMed gnomAD
rs1437383996 CA344146884	687	R>S		No	ClinGen gnomAD
rs765434108 CA1321114	689	L>Q		No	ClinGen ExAC gnomAD
COSM6123712 COSM6123713	695	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321078 rs757157117	695	M>T		No	ClinGen ExAC gnomAD
CA1321079 rs200201631	695	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	702	K>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA344145317 rs1413960102	704	N>K		No	ClinGen gnomAD
CA344145294 rs1490112238	705	K>N		No	ClinGen gnomAD
CA344145313 rs1571940583	705	K>Q		No	ClinGen Ensembl
rs752825828 CA1321076	705	K>R		No	ClinGen ExAC gnomAD
CA344145161 rs1319152353	708	A>V		No	ClinGen TOPMed
rs778918438 CA1321075	709	D>G		No	ClinGen ExAC
rs543715577 CA1321073	712	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA1321072 rs766776053	713	R>K		No	ClinGen ExAC gnomAD
CA344144904 rs921788932	715	R>G		No	ClinGen TOPMed gnomAD
CA1321071 rs529917183	715	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs921788932 CA35997024	715	R>W		No	ClinGen TOPMed gnomAD
rs1345199231 CA344144698	719	R>L		No	ClinGen TOPMed gnomAD
rs1345199231 CA344144700	719	R>Q		No	ClinGen TOPMed gnomAD
COSM4865654 COSM902038	719	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	720	D>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM282235 rs541186299 CA35996979	726	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA gnomAD
rs1457276556 CA344144390	728	Q>*		No	ClinGen gnomAD
TCGA novel	728	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1377982256 CA344144137	732	A>D		No	ClinGen gnomAD
CA1321064 rs777561377	732	A>S		No	ClinGen ExAC TOPMed gnomAD
rs777561377 CA1321063	732	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1321060 rs770880854	733	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs780946794 CA1321061	733	R>W		No	ClinGen ExAC gnomAD
rs1465364740 CA344144041	735	L>P		No	ClinGen gnomAD
CA344143940 rs1240133411	739	S>L		No	ClinGen TOPMed gnomAD
CA1321057 rs200885893 COSM1639675	740	R>C	stomach [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA344143917 rs753937959 COSM1581109	740	R>H	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1321056 rs753937959	740	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1321054 rs750865418	742	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs767943202 CA1321053	743	R>K		No	ClinGen ExAC gnomAD
rs1294351881 CA344143839	743	R>S		No	ClinGen gnomAD
rs754739842 CA35996950	744	E>K		No	ClinGen TOPMed
CA344143724 rs1435209966	748	L>Q		No	ClinGen gnomAD
rs1334687647 CA344143704	749	Q>R		No	ClinGen gnomAD
rs762441448 CA1321052	751	E>K		No	ClinGen ExAC TOPMed gnomAD
rs752055582 CA1321051	753	A>T		No	ClinGen ExAC gnomAD
CA35996927 rs911900092	756	K>R		No	ClinGen TOPMed gnomAD
rs764649455 CA1321050	758	A>T		No	ClinGen ExAC gnomAD
rs1251525474 CA344141638	760	V>L		No	ClinGen gnomAD
COSM6123716 COSM6123717	766	M>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321031 rs764551376	766	M>T		No	ClinGen ExAC gnomAD
CA344141482 rs1343815266	766	M>V		No	ClinGen gnomAD
COSM1581108 CA1321030 rs184368767	767	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
COSM4874451 CA344141443 rs1356366486 COSM902037	767	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA344141402 rs1442559720	768	E>V		No	ClinGen TOPMed gnomAD
CA1321029 rs752174472	772	R>Q		No	ClinGen ExAC gnomAD
CA344141331 rs1439917989	772	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1321027 rs150040803	773	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs564603169 CA1321028	773	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA344141265 rs756418278	774	R>L		No	ClinGen ExAC TOPMed gnomAD
rs756418278 CA1321025	774	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs146403487 CA1321026	774	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1216482497 CA344141252	775	L>V		No	ClinGen gnomAD
rs760527078 CA1321024	776	V>E		No	ClinGen ExAC gnomAD
rs1571934234 CA344141202	777	E>G		No	ClinGen Ensembl
rs1165457029 CA344141185 COSM369539	778	T>I	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA1321023 rs773026448	779	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1411736888 CA344141097	781	N>D		No	ClinGen gnomAD
rs959484745 CA35994190	781	N>K		No	ClinGen TOPMed gnomAD
rs1266346444 CA344141048	782	R>Q		No	ClinGen TOPMed gnomAD
rs771950376 CA1321022	782	R>W		No	ClinGen ExAC gnomAD
TCGA novel	783	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA35994174 rs775462491	785	A>S		No	ClinGen ExAC TOPMed gnomAD
rs775462491 CA1321020	785	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1321019 rs138837432	785	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1288858664 CA344140844	788	K>E		No	ClinGen gnomAD
CA344140749 rs1343341204	790	E>G		No	ClinGen gnomAD
rs781628536 CA1321017	792	R>Q		No	ClinGen ExAC gnomAD
rs1301601094 CA344140697	792	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs747380037 CA344140660	793	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1321015 rs747380037	793	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344140642 rs1388574815	795	E>K		No	ClinGen gnomAD
COSM1337756 COSM4785905	795	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1321000 rs759729192	797	Q>H		No	ClinGen ExAC gnomAD
CA344140319 rs1182437794	797	Q>R		No	ClinGen TOPMed
rs1248086878 CA344140283	799	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs776829182 CA1320999	799	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344140271 rs1459904151	800	A>P		No	ClinGen gnomAD
rs1042677151 CA35993860	802	E>*		No	ClinGen TOPMed
CA35993857 rs944245731	802	E>V		No	ClinGen TOPMed
COSM4868066 COSM902036	804	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1210588721 CA344140163	804	Q>R		No	ClinGen gnomAD
CA344140087 COSM4785696 COSM1337755 rs1364620614	806	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA1320995 rs541811989	806	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1320993 rs779467952	809	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1571933045 CA344139870	811	V>G		No	ClinGen Ensembl
CA1320992 rs367929176	811	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs528414543 COSM531897 COSM6060595 COSM6060596 CA1320991	813	R>K	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA gnomAD
CA1320990 rs779492718	816	T>S		No	ClinGen ExAC gnomAD
CA344139636 rs1361252121	817	Q>E		No	ClinGen gnomAD
COSM3481355 COSM4906138	818	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344139327 rs1558008810	819	V>A		No	ClinGen Ensembl
rs758411092 CA1320964	819	V>I		No	ClinGen ExAC gnomAD
TCGA novel	821	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	823	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1320963 rs752619880	824	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1320962 COSM3481353 rs765068592 COSM4905880	824	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA344139010 rs1421643436	828	P>T		No	ClinGen TOPMed
rs1477521082 CA344138948	829	M>V		No	ClinGen TOPMed
CA1320961 rs760879983	831	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs561504096 CA1320960	832	R>G		No	ClinGen ExAC gnomAD
rs368586806 CA1320958	832	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs561504096 CA344138803	832	R>W		No	ClinGen ExAC gnomAD
rs866613972 CA35993571	835	G>E		No	ClinGen Ensembl
CA1320954 rs776035656	836	R>C		No	ClinGen ExAC gnomAD
CA1320952 COSM458319 rs141871941	836	R>H	cervix [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs141871941 CA344138665	836	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1320953 rs141871941	836	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1320951 rs780518567	837	A>T		No	ClinGen ExAC gnomAD
rs866186108 CA35993557	838	G>E		No	ClinGen Ensembl
rs746591322 CA1320949	839	L>P		No	ClinGen ExAC TOPMed gnomAD
CA344138583 rs1558008671	840	K>R		No	ClinGen Ensembl
rs1489474129 CA344138573	841	P>A		No	ClinGen TOPMed gnomAD
CA1320948 rs138915096	842	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA344138513 rs1558008653	843	M>I		No	ClinGen Ensembl
rs141958232 CA1320947	843	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM4925773 COSM4925774	845	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752531935 CA1320945	850	V>M		No	ClinGen ExAC gnomAD
CA1320944 rs149878626	851	S>L		No	ClinGen ESP ExAC gnomAD
CA1320942 rs750541983	853	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1388013409 CA344138224	854	T>I		No	ClinGen gnomAD
rs1001416397 CA35993521	855	T>A		No	ClinGen TOPMed
TCGA novel	857	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	858	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA35993514 rs767458974	860	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1320940 rs762029270	862	G>E		No	ClinGen ExAC
CA344138035 rs1319872125	863	A>S		No	ClinGen gnomAD
rs142914751 CA1320939	864	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320937 rs201161747	864	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1320938 rs201161747	864	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1320936 rs775695479	865	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1479866453 CA344137989	866	V>F		No	ClinGen gnomAD
CA1320933 rs776206215	870	V>M		No	ClinGen ExAC gnomAD
CA1320931 rs540134751	871	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1465720206 CA344137871	871	R>H		No	ClinGen TOPMed gnomAD
TCGA novel	873	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs146392643 CA1320930	875	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1320929 rs371230464	875	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs371230464 CA344137750	875	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3803417 COSM3803418	877	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320925 rs753653884	879	H>R		No	ClinGen ExAC gnomAD
rs754976164 CA1320926	879	H>Y		No	ClinGen ExAC gnomAD
rs528339942 CA35993361	880	F>I		No	ClinGen gnomAD
CA1320924 rs200776260	881	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1367298121 CA344137514	881	L>S		No	ClinGen gnomAD
CA344137476 rs1395247207	883	D>G		No	ClinGen gnomAD
COSM4897325 COSM3481351	885	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs757387167 CA1320923	886	A>T		No	ClinGen ExAC gnomAD
rs201355461 CA1320922	886	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA1320920 rs763113039	887	P>S		No	ClinGen ExAC gnomAD
CA344137311 rs1450100213	889	V>A		No	ClinGen gnomAD
rs753135682 CA1320919	890	N>S		No	ClinGen ExAC gnomAD
rs760098433 CA1320917	892	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1212624082 CA344137171	893	R>C		No	ClinGen gnomAD
COSM902035 COSM4873798 CA1320915 rs771556735	893	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed
rs771556735 CA344137136	893	R>L		No	ClinGen ExAC TOPMed
CA1320914 COSM3481350 rs760298858 COSM4897441	896	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
COSM6060597 COSM6060598	896	R>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320913 rs772829037	896	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344136131 rs1466376454	897	K>N		No	ClinGen TOPMed gnomAD
TCGA novel	897	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs950116813 CA35993127	901	K>E		No	ClinGen TOPMed
TCGA novel	902	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1320896 rs767045421	904	A>T		No	ClinGen ExAC gnomAD
CA1320895 rs572746581	905	S>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs370606334 CA1320894	905	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA344135785 rs1356391242	906	Q>R		No	ClinGen gnomAD
CA1320893 rs377123925	911	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs761541411 CA1320892	911	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1167651753 CA344135547	912	A>T		No	ClinGen gnomAD
rs1471855756 CA344135504	913	R>K		No	ClinGen gnomAD
CA344135483 rs1411677647	914	L>V		No	ClinGen gnomAD
COSM1728911 rs1182517364 CA344135368	916	W>R	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1320890 COSM678220 rs768350530 COSM4862080	921	R>*	lung Variant assessed as Somatic; HIGH impact. [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1320889 rs373199147	921	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320888 rs779775292	922	R>Q		No	ClinGen ExAC gnomAD
rs1275046152 CA344134983	924	I>T		No	ClinGen TOPMed gnomAD
CA344134967 rs1235478663	925	D>H		No	ClinGen TOPMed
CA344134966 rs1235478663	925	D>N		No	ClinGen TOPMed
CA1320886 rs141159592	927	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344134795 rs1571930941	928	M>L		No	ClinGen Ensembl
CA344134710 rs1225216899	931	M>V		No	ClinGen gnomAD
rs1273238832 CA344134648	933	I>T		No	ClinGen gnomAD
rs142794607 CA1320883	933	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320882 rs373553632	935	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1411227503 CA344134473	938	A>T		No	ClinGen TOPMed
CA344134455 rs1388419064	938	A>V		No	ClinGen gnomAD
rs1160415808 CA344134396	940	M>V		No	ClinGen gnomAD
rs1422639545 CA344134310	942	R>Q		No	ClinGen gnomAD
rs754180658 COSM4948713 COSM1337754 CA1320879	942	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1478102580 CA344134242	945	K>E		No	ClinGen gnomAD
TCGA novel	947	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1447281807 CA344133910	951	F>I		No	ClinGen gnomAD
rs993415497 CA35992835	954	Q>*		No	ClinGen gnomAD
CA344133789 rs1385837659	956	A>V		No	ClinGen TOPMed
rs145500432 CA1320857	958	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA344133742 COSM337635 rs1296992330	958	R>W	lung large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1302664638 CA344133691	959	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	959	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1320856 rs763592461	961	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1320854 rs368046254	961	R>Q		No	ClinGen ESP ExAC gnomAD
rs763592461 CA1320855	961	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1370626580 CA344133590	962	E>D		No	ClinGen gnomAD
rs201937333 CA1320851	963	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1320852 rs764862669 COSM4026843 COSM4026842	963	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs770793249 CA1320849	965	Q>E		No	ClinGen ExAC gnomAD
rs768726346 CA1320846	969	P>L		No	ClinGen ExAC gnomAD
rs774303993 CA1320847	969	P>S		No	ClinGen ExAC gnomAD
CA1320844 rs780491834	970	E>K		No	ClinGen ExAC gnomAD
CA344133364 rs1206665889	971	E>D		No	ClinGen TOPMed gnomAD
CA35992749 rs867382583	972	E>K		No	ClinGen Ensembl
CA1320842 rs746284805	984	V>G		No	ClinGen ExAC gnomAD
rs1558007732 CA344132760	986	A>E		No	ClinGen Ensembl
rs774113322 CA35992727	987	A>G		No	ClinGen Ensembl
RCV000845074 rs1571930248	988	N>missing		No	ClinVar dbSNP
CA1320840 rs757708029	989	I>M		No	ClinGen ExAC TOPMed gnomAD
CA344132656 rs1357752151	989	I>V		No	ClinGen gnomAD
CA35992713 rs921706449	991	Y>S		No	ClinGen TOPMed
CA344132584 rs1408817244	993	N>H		No	ClinGen TOPMed gnomAD
rs1558007686 CA344132578	993	N>S		No	ClinGen Ensembl
rs370076018 CA344132558	994	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA35992710 rs973528778	995	G>S		No	ClinGen TOPMed gnomAD
rs757968603 CA1320837	996	I>V		No	ClinGen ExAC gnomAD
rs375029523 CA1320836	997	T>I		No	ClinGen ESP ExAC gnomAD
CA344132406 rs1180339606	999	C>W		No	ClinGen gnomAD
rs1385735832 CA344132269	1003	I>V		No	ClinGen Ensembl
rs983020699 CA35992676	1004	V>L		No	ClinGen TOPMed gnomAD
COSM209454 CA344132231 rs983020699	1004	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA344132052 rs1487506175	1010	K>R		No	ClinGen gnomAD
CA344131773 rs1290902105	1012	E>D		No	ClinGen TOPMed gnomAD
CA1320801 rs778411234	1012	E>K		No	ClinGen ExAC gnomAD
CA1320800 rs754544393	1014	D>H		No	ClinGen ExAC gnomAD
CA344131691 rs1558007480	1016	T>A		No	ClinGen Ensembl
COSM4863216 COSM678221	1017	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344131620 rs1416098796	1018	T>K		No	ClinGen TOPMed
rs748747363 CA1320799	1019	S>C		No	ClinGen ExAC gnomAD
rs755700539 CA1320797	1020	V>M		No	ClinGen ExAC gnomAD
CA344131559 rs1193097230	1023	S>G		No	ClinGen gnomAD
CA35992520 rs777644350	1031	R>C		No	ClinGen gnomAD
COSM312340 rs767382537 CA1320795	1031	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM6060599 COSM6060600	1031	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320792 rs764123257	1035	D>E		No	ClinGen ExAC gnomAD
rs751602599 CA1320793	1035	D>G		No	ClinGen ExAC gnomAD
rs759700369 CA1320791	1036	N>D		No	ClinGen ExAC
CA344131102 rs1252298688	1037	F>C		No	ClinGen TOPMed
TCGA novel	1040	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1041	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs766642944 CA1320789	1043	D>E		No	ClinGen ExAC gnomAD
CA344130896 rs1341882397	1044	K>R		No	ClinGen TOPMed
rs763331252	1045	G>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
CA1320765 rs774676250	1045	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1337593414 CA344130518	1047	Q>*		No	ClinGen gnomAD
CA35991769 rs1043347356	1048	V>M		No	ClinGen TOPMed
CA344130455 rs1440773202	1049	A>T		No	ClinGen gnomAD
CA1320762 rs775071133	1053	A>V		No	ClinGen ExAC gnomAD
TCGA novel	1054	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1320759 COSM4816305 rs781031353 COSM424984	1056	R>Q	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs745376488 CA1320760	1056	R>W		No	ClinGen ExAC TOPMed gnomAD
CA344130276 rs1467137241	1057	L>M		No	ClinGen TOPMed
rs913689255 CA35991747	1060	G>S		No	ClinGen gnomAD
CA344130218 rs1192977516	1061	R>*		No	ClinGen TOPMed gnomAD
rs770684134 CA1320758	1061	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1320757 rs746818505	1062	L>M		No	ClinGen ExAC TOPMed gnomAD
rs746818505 CA344130214	1062	L>V		No	ClinGen ExAC TOPMed gnomAD
CA344130168 rs1298851998	1063	R>S		No	ClinGen TOPMed
CA1320756 rs777667718	1065	T>M		No	ClinGen ExAC TOPMed gnomAD
CA344130124 rs777667718	1065	T>R		No	ClinGen ExAC TOPMed gnomAD
COSM424983 COSM4813654	1065	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320753 rs778899125	1067	M>T		No	ClinGen ExAC gnomAD
rs752516012 CA1320754	1067	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1235525526 CA344130053	1069	G>V		No	ClinGen TOPMed
rs1233599767 CA344130040	1070	S>F		No	ClinGen TOPMed gnomAD
rs750475944 CA1320751	1071	S>P		No	ClinGen ExAC TOPMed gnomAD
rs750475944 CA344130038	1071	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1328439999 CA344129974	1073	N>S		No	ClinGen gnomAD
CA1320748 rs751952433	1079	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1422573344 CA344129797	1079	A>V		No	ClinGen gnomAD
rs1286188382 CA344129795	1080	L>V		No	ClinGen gnomAD
rs764300358 CA1320747	1081	R>C		No	ClinGen ExAC TOPMed gnomAD
rs763531100 CA35991663	1081	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1320746 rs763531100	1081	R>P		No	ClinGen ExAC TOPMed gnomAD
rs770301614 CA1320744	1086	A>V		No	ClinGen ExAC gnomAD
CA1320743 rs759165397	1087	H>N		No	ClinGen ExAC TOPMed gnomAD
CA344129578 rs1571927710	1087	H>P		No	ClinGen Ensembl
rs776231896 CA1320742	1087	H>Q		No	ClinGen ExAC gnomAD
rs759165397 CA344129584	1087	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA344129540 rs1278393159	1089	E>K		No	ClinGen gnomAD
rs1306348134 CA344129472	1091	Q>H		No	ClinGen TOPMed gnomAD
rs1213306130 CA344129469	1092	A>T		No	ClinGen TOPMed gnomAD
CA35991584 rs1006440488	1094	I>M		No	ClinGen Ensembl
CA344129311 rs1439158523	1096	N>D		No	ClinGen TOPMed
CA1320739 rs777721305	1097	V>A		No	ClinGen ExAC
rs1293239166 CA344129138	1099	Q>R		No	ClinGen TOPMed
CA344128113 rs1381530001	1101	N>D		No	ClinGen TOPMed
CA1320711 CA344128042 rs200143132	1103	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344128038 rs777904600	1104	A>S		No	ClinGen ExAC TOPMed gnomAD
rs777904600 CA1320709	1104	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758596457 CA1320708	1104	A>V		No	ClinGen ExAC gnomAD
rs994062130 CA35991379	1106	T>K		No	ClinGen Ensembl
TCGA novel	1107	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1207170531 CA344127952	1107	D>Y		No	ClinGen TOPMed
CA344127825 rs1278958174	1111	S>*		No	ClinGen gnomAD
COSM4869795 COSM902033	1113	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344127732 rs1207213444	1114	S>P		No	ClinGen gnomAD
rs966273606 CA35991376	1115	E>D		No	ClinGen TOPMed gnomAD
rs1441334053 CA344127668	1116	G>D		No	ClinGen TOPMed
CA1320706 rs765567729	1117	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1366039030 CA344127622	1117	S>I		No	ClinGen TOPMed gnomAD
CA344127653 rs765567729	1117	S>R		No	ClinGen ExAC TOPMed gnomAD
CA344127381 rs1308558587	1118	F>L		No	ClinGen gnomAD
rs1427316782 CA344127368	1119	S>F		No	ClinGen TOPMed
rs748341444 CA1320689	1120	Q>H		No	ClinGen ExAC gnomAD
rs1231379900 CA344127360	1120	Q>P		No	ClinGen gnomAD
rs778986480 CA1320688	1123	T>I		No	ClinGen ExAC TOPMed gnomAD
rs868404550 CA35991207	1124	M>I		No	ClinGen Ensembl
CA1320686 rs754226401	1126	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1382480222 CA344127213	1126	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1320687 rs754226401	1126	G>V		No	ClinGen ExAC TOPMed gnomAD
rs79014613 CA1320685	1127	S>P		No	ClinGen ExAC gnomAD
rs200705792 CA1320684	1128	T>P		No	ClinGen ExAC gnomAD
rs992008787 CA35991176	1132	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA344126981 rs1395080041	1135	F>L		No	ClinGen gnomAD
rs1194793180 CA344126958	1136	K>R		No	ClinGen gnomAD
rs1223363768 CA344126785	1137	S>N		No	ClinGen TOPMed
rs1571924866 CA344126753	1139	P>S		No	ClinGen Ensembl
rs1558005047 CA344126663	1145	M>R		No	ClinGen Ensembl
CA344126633 rs1185314463	1148	V>M		No	ClinGen gnomAD
COSM902032 COSM4873668	1149	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344126605 rs1571924801	1152	C>G		No	ClinGen Ensembl
TCGA novel	1154	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA344126594 rs1337381744	1154	G>S		No	ClinGen gnomAD
rs1471048187 CA344126589	1154	G>V		No	ClinGen TOPMed
COSM2211696 COSM4335025	1156	P>H	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320664 rs781538004	1156	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA1320663 rs781538004	1156	P>R		No	ClinGen ExAC TOPMed gnomAD
CA344126570 rs1425192581	1158	D>G		No	ClinGen TOPMed
COSM77965 rs1313587578 CA344126532	1161	T>N	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA344126522 rs1368142854	1162	K>R		No	ClinGen TOPMed
CA344126493 rs1408906090	1165	T>A		No	ClinGen TOPMed
COSM1337749 COSM4782896	1169	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320659 COSM4764335 COSM4764336 rs762552831	1172	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs374324357 CA1320658	1174	I>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs867123470 CA35990285	1176	E>K		No	ClinGen Ensembl
CA344126355 rs144609175	1177	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM138268 rs759234752 CA1320656	1178	G>R	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs566220899 CA1320655	1178	G>V		No	ClinGen 1000Genomes ExAC gnomAD
rs764977449 CA35990243	1179	V>A		No	ClinGen gnomAD
CA1320654 rs770740316	1179	V>M		No	ClinGen ExAC gnomAD
rs774526461 CA1320652	1183	V>I		No	ClinGen ExAC gnomAD
CA1320653 rs774526461	1183	V>L		No	ClinGen ExAC gnomAD
rs769034251 CA1320651	1184	R>*		No	ClinGen ExAC gnomAD
rs371053876 CA1320650	1184	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs376964063 CA1320648	1189	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs746216671 CA344126176	1189	R>P		No	ClinGen ExAC gnomAD
rs746216671 CA1320647	1189	R>Q		No	ClinGen ExAC gnomAD
rs376964063 CA1320649 COSM209453 COSM4782911	1189	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs757654586 CA1320645	1191	R>G		No	ClinGen ExAC gnomAD
rs746551783 CA1320644	1192	V>I		No	ClinGen ExAC gnomAD
CA1320643 COSM1212411 rs759136145	1193	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA35990174 rs759136145	1193	S>W		No	ClinGen ExAC TOPMed gnomAD
rs983748414 CA35990158 COSM1743637	1194	R>C	biliary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs375407145 CA1320640	1194	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320638 COSM2211694 COSM4026841 rs201349051	1196	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA35990114 rs751938642	1199	P>L		No	ClinGen Ensembl
CA1320636 rs766365113	1200	T>I		No	ClinGen ExAC gnomAD
rs371066665 CA1320634	1201	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371066665 CA1320633	1201	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs763115699 CA1320632	1202	G>D		No	ClinGen ExAC gnomAD
CA344125992 rs1459053056	1203	S>C		No	ClinGen gnomAD
TCGA novel	1205	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA1320618 COSM3481346 rs756134028 COSM4891891	1210	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs750448381 CA344125666	1214	T>A		No	ClinGen ExAC gnomAD
CA1320616 rs369653840 COSM1212413	1214	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs750448381 CA1320617	1214	T>P		No	ClinGen ExAC gnomAD
CA1320614 rs775691918	1216	P>L		No	ClinGen ExAC TOPMed gnomAD
CA1320611 rs777063474	1218	T>M		No	ClinGen ExAC TOPMed gnomAD
CA1320612 rs777063474	1218	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1558004513 CA344125499	1221	K>M		No	ClinGen Ensembl
CA1320610 rs375526424	1223	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320608 rs773747249	1224	D>N		No	ClinGen ExAC gnomAD
CA344125390 rs147866695	1225	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA344125386 rs747677870	1225	R>P		No	ClinGen ExAC gnomAD
CA1320606 rs747677870	1225	R>Q		No	ClinGen ExAC gnomAD
rs778248419 CA1320605	1226	G>R		No	ClinGen ExAC gnomAD
COSM4859164 COSM678222	1227	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1184563513 CA344125341	1229	I>V		No	ClinGen gnomAD
COSM3789314 COSM3789315 CA344124746 rs1558003032	1233	D>N	urinary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
COSM1134797	1233	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4895450 COSM4895451	1235	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs748830296 CA1320585	1235	G>R		No	ClinGen ExAC gnomAD
CA1320584 rs779616811	1236	F>L		No	ClinGen ExAC TOPMed gnomAD
rs769551612 CA1320583	1237	T>I		No	ClinGen ExAC gnomAD
rs973986051 CA35988898	1238	P>L		No	ClinGen TOPMed gnomAD
CA1320582 rs745682971	1238	P>T		No	ClinGen ExAC gnomAD
TCGA novel	1241	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1292286726 CA344124581	1244	T>I		No	ClinGen gnomAD
CA1320580 rs757271782	1245	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781065888 CA1320581	1245	R>W		No	ClinGen ExAC TOPMed gnomAD
COSM1320589	1246	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751505502 CA1320579	1247	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM4867613 rs777757543 CA1320578 COSM902030	1247	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA344124554 rs777757543	1247	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1320577 rs755052725	1250	R>C		No	ClinGen ExAC gnomAD
CA1320576 rs766609365	1250	R>H		No	ClinGen ExAC gnomAD
CA1320575 rs766609365	1250	R>L		No	ClinGen ExAC gnomAD
rs1264811878 CA344124493	1251	N>H		No	ClinGen TOPMed
CA1320573 rs750792575	1251	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1253	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1558002936 CA344124397	1254	S>F		No	ClinGen Ensembl
CA1320571 rs762225525	1255	R>C		No	ClinGen ExAC TOPMed gnomAD
rs200381288 CA35988886	1258	S>G		No	ClinGen TOPMed
CA344124209 rs1175518505	1263	G>E		No	ClinGen gnomAD
CA344124216 rs1174458087	1263	G>R		No	ClinGen TOPMed
rs974494179 CA35988878	1264	S>T		No	ClinGen Ensembl
CA1320569 rs144598197	1265	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs775094351 CA344124155	1266	L>P		No	ClinGen ExAC gnomAD
CA1320567 rs775094351	1266	L>Q		No	ClinGen ExAC gnomAD
CA1320566 rs368095400	1267	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA344124108 rs1300308340	1268	K>R		No	ClinGen TOPMed
CA344123814 rs1330747785	1270	D>E		No	ClinGen TOPMed
rs1353784897 CA344123765	1272	S>G		No	ClinGen gnomAD
CA344123720 rs1231955110	1273	D>N		No	ClinGen gnomAD
rs868017782 CA35987686	1275	S>F		No	ClinGen Ensembl
rs1370112877 CA344123632	1276	L>S		No	ClinGen gnomAD
rs1301750014 CA344123596	1277	S>L		No	ClinGen TOPMed gnomAD
rs1282586376 CA344123569	1279	V>F		No	ClinGen TOPMed
rs1571914879 CA344122733	1285	S>A		No	ClinGen Ensembl
CA35983931 rs868507612	1285	S>F		No	ClinGen TOPMed
CA35983936 rs868507612	1285	S>Y		No	ClinGen TOPMed
rs756253893 CA1320535	1286	P>L		No	ClinGen ExAC gnomAD
COSM4228897 COSM3481344	1286	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1185243158 CA344122619	1288	G>A		No	ClinGen TOPMed gnomAD
rs544069907 CA1320533	1290	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751902877 CA1320531	1291	K>R		No	ClinGen ExAC TOPMed gnomAD
rs200030709 CA344122549	1292	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs991066872 CA344122548	1292	G>D		No	ClinGen TOPMed
rs200030709 CA35983918	1292	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200030709 CA1320530	1292	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs991066872 CA35983913	1292	G>V		No	ClinGen TOPMed
rs758674671 CA1320529	1294	R>Q		No	ClinGen ExAC gnomAD
rs1218953359 CA344122513	1294	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs753318546 CA1320528	1295	T>A		No	ClinGen ExAC gnomAD
CA1320527 rs765805058	1295	T>M		No	ClinGen ExAC TOPMed gnomAD
CA344122359 rs1233363392	1300	C>Y		No	ClinGen gnomAD
CA344122301 CA1320525 rs776232070	1303	M>L		No	ClinGen ExAC gnomAD
CA344122300 rs776232070	1303	M>V		No	ClinGen ExAC gnomAD
COSM5002229 CA1320523 rs760306875 COSM5002228	1305	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA1320521 rs145377208	1308	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs145377208 CA1320522	1308	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA344122097 rs1162315652	1311	I>V		No	ClinGen gnomAD
rs1168092956 CA344122066	1312	L>F		No	ClinGen TOPMed
COSM1320590	1316	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1368569214 CA344121952	1317	T>I		No	ClinGen TOPMed gnomAD
CA344121926 rs1417252859	1318	D>E		No	ClinGen gnomAD
rs541919266 CA35983842	1318	D>H		No	ClinGen 1000Genomes gnomAD
rs541919266 CA344121936	1318	D>N		No	ClinGen 1000Genomes gnomAD
CA1320518 rs768562446	1321	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1212027245 CA344121779	1322	F>C		No	ClinGen gnomAD
rs781295347 CA1320515	1324	G>A		No	ClinGen ExAC TOPMed gnomAD
rs748553881 CA1320492	1328	R>G		No	ClinGen ExAC gnomAD
rs762285465 CA1320491	1328	R>Q		No	ClinGen ExAC gnomAD
rs755554770 CA344121012	1331	K>M		No	ClinGen ExAC TOPMed gnomAD
rs755554770 CA1320490	1331	K>R		No	ClinGen ExAC TOPMed gnomAD
CA344121008 rs1247555499	1332	M>L		No	ClinGen gnomAD
CA344120964 rs1170544715	1334	N>K		No	ClinGen TOPMed
CA35982840 rs936708082	1336	V>I		No	ClinGen TOPMed
rs148995617 CA1320488	1337	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320489 rs148995617	1337	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1262593839 CA344120882	1339	Q>R		No	ClinGen gnomAD
rs749879726 CA1320486	1341	I>L		No	ClinGen ExAC gnomAD
CA344120832 rs761419541	1342	A>S		No	ClinGen ExAC TOPMed gnomAD
CA1320484 COSM209451 rs761419541	1342	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs751363063 CA1320483	1343	A>T		No	ClinGen ExAC gnomAD
rs763821874 CA1320482	1345	K>R		No	ClinGen ExAC gnomAD
COSM4897419 COSM3481341	1346	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344120748 rs1571912837	1347	H>P		No	ClinGen Ensembl
rs74962326 CA1320481	1348	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1230284212 CA344120734	1348	P>T		No	ClinGen TOPMed
COSM902029 COSM4875865	1355	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320478 rs760827160	1356	Y>S		No	ClinGen ExAC
rs773124377 CA1320477	1357	C>G		No	ClinGen ExAC gnomAD
CA1320476 rs772428493	1357	C>S		No	ClinGen ExAC gnomAD
CA344120533 rs1557998794	1358	S>T		No	ClinGen Ensembl
rs1414879600 CA344120496	1359	H>Q		No	ClinGen gnomAD
CA1320475 rs748320919	1359	H>R		No	ClinGen ExAC gnomAD
rs1050958860 CA35982780	1359	H>Y		No	ClinGen Ensembl
rs150759147 CA1320474	1360	S>L		No	ClinGen ESP ExAC gnomAD
COSM3481340 COSM4897243	1365	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1194551347 CA344120416	1366	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1039174810 CA35982771	1367	S>F		No	ClinGen Ensembl
CA344120404 rs1489310156	1367	S>P		No	ClinGen gnomAD
CA1320471 rs780660329	1370	Y>C		No	ClinGen ExAC gnomAD
CA1320470 rs756531232	1371	I>V		No	ClinGen ExAC gnomAD
rs1208140343 CA344120312	1372	K>E		No	ClinGen TOPMed
rs745419043 CA1320469	1373	V>M		No	ClinGen ExAC gnomAD
CA344120244 rs1448603030	1376	I>V		No	ClinGen TOPMed
CA1320467 rs756919658	1377	R>Q		No	ClinGen ExAC gnomAD
rs1217111451 CA344120229	1377	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA35982717 rs936730509	1380	A>V		No	ClinGen TOPMed gnomAD
rs1376322516 CA344120130	1384	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM4899319 rs148681629 CA1320465 COSM3481339	1384	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	1385	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs758234153 CA1320464	1386	L>V		No	ClinGen ExAC TOPMed gnomAD
CA1320463 rs752381283	1387	T>M		No	ClinGen ExAC TOPMed gnomAD
rs764882363 CA1320445	1388	S>F		No	ClinGen ExAC TOPMed gnomAD
rs749063098 CA1320444 COSM4026838 COSM4026837	1389	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA344119402 rs1180832159	1390	G>A		No	ClinGen gnomAD
CA35981117 rs866081298	1390	G>S		No	ClinGen Ensembl
CA1320442 rs149261347	1393	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA344119236 rs1268549977	1395	G>E		No	ClinGen TOPMed gnomAD
TCGA novel	1400	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs762033039 CA35981111	1400	A>S		No	ClinGen ExAC TOPMed gnomAD
rs762033039 COSM902027 CA1320441	1400	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1320437 rs564491313	1404	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1320436 rs770118841	1404	R>H		No	ClinGen ExAC TOPMed gnomAD
CA344118915 rs1384804072	1407	T>I		No	ClinGen gnomAD
CA344118854 rs1197387543	1409	A>V		No	ClinGen TOPMed gnomAD
CA35981065 rs1041368136	1411	G>S		No	ClinGen TOPMed
CA344118815 rs1293151975	1412	E>K		No	ClinGen gnomAD
rs777168074 CA1320434	1413	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs771373697 CA1320433	1414	Q>H		No	ClinGen ExAC gnomAD
rs746551404 CA1320432	1415	I>L		No	ClinGen ExAC gnomAD
rs771767165 CA1320430	1419	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs747812926 CA1320429	1420	L>V		No	ClinGen ExAC gnomAD
COSM678223 COSM4860076	1421	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344118466 rs1325857808	1421	S>R		No	ClinGen TOPMed
COSM902026 rs1191391325 COSM4870803 CA344118426	1423	S>L	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs753664651 CA1320426	1424	G>A		No	ClinGen ExAC gnomAD
CA1320425 rs780164811	1427	L>P		No	ClinGen ExAC gnomAD
CA1320423 rs375949029	1429	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1320421 rs763078617	1430	A>D		No	ClinGen ExAC gnomAD
rs1442856195 CA344118276	1430	A>T		No	ClinGen TOPMed gnomAD
CA1320420 rs752932959	1431	S>L		No	ClinGen ExAC TOPMed gnomAD
CA35980956 rs752932959	1431	S>W		No	ClinGen ExAC TOPMed gnomAD
COSM678224 COSM4859730	1433	N>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM678225 COSM4858961	1434	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320418 rs759837389	1435	V>I		No	ClinGen ExAC gnomAD
rs1361814429 CA344118032	1436	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1320417 COSM1733782 rs776939102	1436	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM4925975 COSM4925974	1436	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1361814429 CA344118036	1436	R>S		No	ClinGen gnomAD
rs771428814 CA1320416	1440	L>P		No	ClinGen ExAC gnomAD
CA344117806 rs1571909690	1442	R>K		No	ClinGen Ensembl
CA344117590 rs1397752528	1444	Q>H		No	ClinGen gnomAD
CA344117558 rs1169474713	1445	P>L		No	ClinGen gnomAD
CA344117556 rs1236053103	1446	V>I		No	ClinGen TOPMed
rs773631554 CA1320398	1447	G>C		No	ClinGen ExAC TOPMed gnomAD
CA1320397 rs773631554	1447	G>S		No	ClinGen ExAC TOPMed gnomAD
rs773873351 CA1320394	1453	I>V		No	ClinGen ExAC gnomAD
rs1571909149 CA344117327	1454	G>A		No	ClinGen Ensembl
CA35980495 rs1009930903	1454	G>S		No	ClinGen TOPMed gnomAD
rs1557996390 CA344117309	1455	P>L		No	ClinGen Ensembl
rs748894977 CA1320392	1455	P>S		No	ClinGen ExAC TOPMed gnomAD
rs775270816 CA1320391	1456	V>A		No	ClinGen ExAC TOPMed gnomAD
rs371235023 CA1320390	1460	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs781009610 CA1320388	1462	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1314058805 CA344117117	1463	Q>P		No	ClinGen gnomAD
rs748178950 CA1320386	1464	T>A		No	ClinGen ExAC gnomAD
rs146916477 CA1320385	1464	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1320383 rs754124617	1465	A>V		No	ClinGen ExAC gnomAD
rs142799216 CA1320380	1471	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs142799216 CA1320379	1471	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs762317273 CA1320378	1472	V>A		No	ClinGen ExAC gnomAD
rs1293823031 CA344116829	1474	G>A		No	ClinGen TOPMed
rs1437697718 CA344116790	1476	K>E		No	ClinGen gnomAD
CA344116805 rs1437697718	1476	K>Q		No	ClinGen gnomAD
CA35980464 rs141421404 COSM109764	1478	H>Q	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs773748276 CA1320377	1479	Y>F		No	ClinGen ExAC gnomAD
rs1178947844 CA344116685	1479	Y>H		No	ClinGen gnomAD
CA35980450 rs1049734021	1480	V>G		No	ClinGen Ensembl
CA344116669 rs1208206673	1480	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs752179066 CA1320357	1482	M>L		No	ClinGen ExAC gnomAD
rs1395543426 CA344116047	1483	F>I		No	ClinGen gnomAD
CA1320356 rs149715193	1483	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320354 rs146030020	1484	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs146030020 CA344116005	1484	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1176156309 CA344115974	1485	L>V		No	ClinGen gnomAD
rs1557995324 CA344115924	1486	G>V		No	ClinGen Ensembl
rs1477823118 CA344115918 COSM902024	1487	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA1320352 rs139422310	1488	C>G		No	ClinGen ESP ExAC gnomAD
CA1320351 rs776131067	1489	V>A		No	ClinGen ExAC gnomAD
CA1320349 rs200890486	1490	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs141163764 CA1320347	1492	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320345 rs143966011	1493	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557995254 CA344115801	1493	I>V		No	ClinGen Ensembl
CA1320342 rs746160875	1494	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1571907320 CA344115747	1495	P>A		No	ClinGen Ensembl
rs757683666 CA1320340	1497	H>R		No	ClinGen ExAC gnomAD
CA1320341 rs781269346	1497	H>Y		No	ClinGen ExAC gnomAD
CA344115681 rs1157596378	1498	N>D		No	ClinGen gnomAD
CA35979607 rs751851213	1499	F>L		No	ClinGen ExAC TOPMed gnomAD
CA1320338 rs778450016	1500	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM161975 COSM4810040	1502	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1503	H>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1407167199 CA344115537	1504	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs144049379 CA1320333	1505	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1320332 rs765924369	1508	E>K		No	ClinGen ExAC TOPMed gnomAD
rs61740481 CA35979548	1509	C>Y		No	ClinGen Ensembl
rs772951580 CA1320330	1511	A>T		No	ClinGen ExAC TOPMed gnomAD
CA35979539 rs372866126	1513	Q>P		No	ClinGen Ensembl
rs1462022672 CA344115321	1515	D>N		No	ClinGen gnomAD
CA1320329 rs772002911	1516	I>S		No	ClinGen ExAC gnomAD
rs769986420 CA344115155	1522	R>*		No	ClinGen ExAC gnomAD
rs1258132353 CA344115127 COSM4391731 COSM397085	1522	R>Q	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
CA1320325 rs745908641	1524	N>D		No	ClinGen ExAC gnomAD
rs1283497407 CA344115068	1525	G>V		No	ClinGen gnomAD
rs1487169305 CA344115021	1527	K>R		No	ClinGen gnomAD
CA1320323 rs771014296	1528	K>Q		No	ClinGen ExAC gnomAD
TCGA novel	1529	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1384759001 CA344114864	1530	D>G		No	ClinGen gnomAD
CA35979519 rs897984816	1530	D>N		No	ClinGen TOPMed
rs1328997473 CA344114804	1532	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344114777 rs1220838226	1533	Q>R		No	ClinGen TOPMed
rs1399760782 CA344114725	1534	Q>H		No	ClinGen gnomAD
TCGA novel	1535	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA35979146 rs893498810	1542	N>S		No	ClinGen TOPMed
rs779375010 CA1320298	1543	A>T		No	ClinGen ExAC TOPMed gnomAD
rs755638591 CA1320297 COSM4026834 COSM4026833	1543	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
CA1320295 rs767128477	1544	H>N		No	ClinGen ExAC gnomAD
CA344114303 rs1308815118	1546	D>N		No	ClinGen gnomAD
rs150039989 CA344114208	1549	C>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371234338 CA1320292	1550	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs924713622 COSM3481336 CA35979091 COSM4904080	1550	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed
CA344114126 rs1571906045	1554	I>L		No	ClinGen Ensembl
CA344114111 rs1405613213	1555	P>A		No	ClinGen gnomAD
CA1320291 rs367842661	1555	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs374243060 CA1320287	1557	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320288 rs374243060	1557	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1320286 rs772370328	1557	R>H		No	ClinGen ExAC TOPMed gnomAD
rs774513349 CA1320284	1561	L>F		No	ClinGen ExAC gnomAD
rs769220889 CA1320283	1561	L>P		No	ClinGen ExAC
COSM1337746 COSM4786294	1563	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA1320279 rs745363004	1563	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1261001548 CA344113942	1563	A>V		No	ClinGen gnomAD
rs1215834067 CA344113914	1565	R>C		No	ClinGen TOPMed gnomAD
rs757902142 CA35979017	1566	A>T		No	ClinGen TOPMed
rs1252446264 CA344113880	1566	A>V		No	ClinGen TOPMed
CA1320275 rs757273186	1567	G>S		No	ClinGen ExAC gnomAD
CA10868625 rs1282875178	1569	I>L		No	ClinGen TOPMed gnomAD
rs916406565 CA35978988	1570	K>T		No	ClinGen Ensembl
CA1320273 rs758204948	1571	V>A		No	ClinGen ExAC gnomAD
COSM4893624 COSM3481335	1572	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1572	W>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1486124253 CA344113745	1572	W>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs752614135 CA1320272	1574	V>M		No	ClinGen ExAC TOPMed gnomAD
rs760858891 CA344113614	1575	D>E		No	ClinGen ExAC gnomAD
rs1386241819 CA344113633	1575	D>N		No	ClinGen gnomAD
TCGA novel	1579	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM902021 rs1176678168 CA344113502 COSM3864058	1581	G>S	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1448590601 CA344113438	1583	I>V		No	ClinGen gnomAD
COSM1337745 COSM4784978	1585	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
CA344113345 rs1464303269	1586	H>Y		No	ClinGen TOPMed
rs1263742406 CA344113308	1587	D>E		No	ClinGen gnomAD
CA1320266 rs774619563	1587	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1209517597 CA344113291	1588	S>N		No	ClinGen gnomAD
rs1571905747 CA344113261	1589	P>T		No	ClinGen Ensembl
CA916380277 rs1571905729	1589	P>TF*		No	ClinGen Ensembl
rs1482786468 CA344113218	1591	N>S		No	ClinGen gnomAD
rs962324507 CA35978950	1592	A>S		No	ClinGen gnomAD
rs1325849166 CA344113184	1593	I>T		No	ClinGen gnomAD
COSM4897217 COSM3481334	1593	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs770240852 CA1320262	1596	N>S		No	ClinGen ExAC gnomAD
CA35978910 rs1015224828	1597	A>D		No	ClinGen TOPMed
CA35978908 rs1015224828	1597	A>V		No	ClinGen TOPMed
rs563987924 CA1320261	1598	K>M		No	ClinGen 1000Genomes ExAC gnomAD
CA1320260 rs139376570	1599	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1320259 rs770410636	1600	I>T		No	ClinGen ExAC gnomAD
rs1382524552 CA344113085	1601	F>L		No	ClinGen gnomAD
rs1382330101 COSM5595868 COSM5595869 CA344112984	1604	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed
CA344111965 rs1557993602	1606	D>G		No	ClinGen Ensembl
rs763238254 CA1320244	1608	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1320245 rs764362831	1608	R>W		No	ClinGen ExAC gnomAD
rs561876803 CA1320243	1609	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759983236 CA1320241	1610	K>M		No	ClinGen ExAC gnomAD
rs770498620 CA1320239	1612	W>C		No	ClinGen ExAC gnomAD
CA344111651 rs746518366	1614	Y>*		No	ClinGen ExAC TOPMed gnomAD
COSM4784566 COSM1285781 CA1320237 rs200570033	1615	V>I	Variant assessed as Somatic; MODERATE impact. large_intestine autonomic_ganglia [NCI-TCGA, Cosmic]	No	ClinGen NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1320235 rs201292196	1616	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA344111565 rs1398968198	1619	T>A		No	ClinGen TOPMed
CA1320234 rs559417656	1620	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA35978388 rs559417656	1620	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA344111501 rs1345917478	1621	C>W		No	ClinGen TOPMed
rs778803239 CA1320233	1624	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1320232 rs754798616	1624	R>H		No	ClinGen ExAC gnomAD
rs780134125 CA1320230	1625	R>*		No	ClinGen ExAC TOPMed gnomAD
CA344111447 rs780134125	1625	R>G		No	ClinGen ExAC TOPMed gnomAD
rs865830055 CA35978328	1625	R>Q		No	ClinGen TOPMed gnomAD
CA35978318 rs765324456	1627	L>P		No	ClinGen Ensembl
rs1239326742 CA344111399	1629	I>M		No	ClinGen gnomAD
rs757337335 COSM6123724 COSM1212410 CA1320229	1632	R>H	lung Variant assessed as Somatic; MODERATE impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs757337335 CA344111371	1632	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM4696028 CA344111367 COSM4696029 rs1222919024	1633	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Cosmic NCI-TCGA TOPMed
CA344111355 rs1571904406	1634	T>P		No	ClinGen Ensembl
rs1403795353 CA344111340	1635	T>A		No	ClinGen gnomAD
rs1403795353 CA344111336	1635	T>P		No	ClinGen gnomAD

No associated diseases with O75037

No regional properties for O75037

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O75037

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cell projection, dendrite Cell projection, growth cone Cell projection, axon Cytoplasmic vesicle
PANTHER Family	PTHR47969	CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED
PANTHER Subfamily	PTHR47969:SF28	KINESIN-LIKE PROTEIN KIF21B ISOFORM X1
PANTHER Protein Class	cytoskeletal protein microtubule binding motor protein microtubule or microtubule-binding cytoskeletal protein
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
kinesin complex	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

1 GO annotations of biological process

Name	Definition
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O95239	KIF4A	Chromosome-associated kinesin KIF4A	Homo sapiens (Human)	SS
Q2VIQ3	KIF4B	Chromosome-associated kinesin KIF4B	Homo sapiens (Human)	SS
P33176	KIF5B	Kinesin-1 heavy chain	Homo sapiens (Human)	EV
O60282	KIF5C	Kinesin heavy chain isoform 5C	Homo sapiens (Human)	EV
Q12840	KIF5A	Kinesin heavy chain isoform 5A	Homo sapiens (Human)	EV
Q2M1P5	KIF7	Kinesin-like protein KIF7	Homo sapiens (Human)	EV
Q86VH2	KIF27	Kinesin-like protein KIF27	Homo sapiens (Human)	SS
Q7Z4S6	KIF21A	Kinesin-like protein KIF21A	Homo sapiens (Human)	EV
Q9P2E2	KIF17	Kinesin-like protein KIF17	Homo sapiens (Human)	EV
O00139	KIF2A	Kinesin-like protein KIF2A	Homo sapiens (Human)	PR
Q9NQT8	KIF13B	Kinesin-like protein KIF13B	Homo sapiens (Human)	EV
Q9H1H9	KIF13A	Kinesin-like protein KIF13A	Homo sapiens (Human)	SS
O43896	KIF1C	Kinesin-like protein KIF1C	Homo sapiens (Human)	SS
Q7M6Z4	Kif27	Kinesin-like protein KIF27	Mus musculus (Mouse)	SS
B7ZNG0	Kif7	Kinesin-like protein KIF7	Mus musculus (Mouse)	SS
Q9QXL2	Kif21a	Kinesin-like protein KIF21A	Mus musculus (Mouse)	EV SS
Q9QXL1	Kif21b	Kinesin-like protein KIF21B	Mus musculus (Mouse)	SS
Q7M6Z5	Kif27	Kinesin-like protein KIF27	Rattus norvegicus (Rat)	SS
F1M5N7	Kif21b	Kinesin-like protein KIF21B	Rattus norvegicus (Rat)	SS
Q58G59	kif7	Kinesin-like protein kif7	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MAGQGDCCVK	VAVRIRPQLS	KEKIEGCHIC	TSVTPGEPQV	LLGKDKAFTY	DFVFDLDTWQ
70	80	90	100	110	120
EQIYSTCVSK	LIEGCFEGYN	ATVLAYGQTG	AGKTYTMGTG	FDMATSEEEQ	GIIPRAIAHL
130	140	150	160	170	180
FGGIAERKRR	AQEQGVAGPE	FKVSAQFLEL	YNEEILDLFD	STRDPDTRHR	RSNIKIHEDA
190	200	210	220	230	240
NGGIYTTGVT	SRLIHSQEEL	IQCLKQGALS	RTTASTQMNV	QSSRSHAIFT	IHLCQMRMCT
250	260	270	280	290	300
QPDLVNEAVT	GLPDGTPPSS	EYETLTAKFH	FVDLAGSERL	KRTGATGERA	KEGISINCGL
310	320	330	340	350	360
LALGNVISAL	GDQSKKVVHV	PYRDSKLTRL	LQDSLGGNSQ	TIMIACVSPS	DRDFMETLNT
370	380	390	400	410	420
LKYANRARNI	KNKVVVNQDK	TSQQISALRA	EIARLQMELM	EYKAGKRVIG	EDGAEGYSDL
430	440	450	460	470	480
FRENAMLQKE	NGALRLRVKA	MQEAIDAINN	RVTQLMSQEA	NLLLAKAGDG	NEAIGALIQN
490	500	510	520	530	540
YIREIEELRT	KLLESEAMNE	SLRRSLSRAS	ARSPYSLGAS	PAAPAFGGSP	ASSMEDASEV
550	560	570	580	590	600
IRRAKQDLER	LKKKEVRQRR	KSPEKEAFKK	RAKLQQENSE	ETDENEAEEE	EEERDESGCE
610	620	630	640	650	660
EEEGREDEDE	DSGSEESLVD	SDSDPEEKEV	NFQADLADLT	CEIEIKQKLI	DELENSQRRL
670	680	690	700	710	720
QTLKHQYEEK	LILLQNKIRD	TQLERDRVLQ	NLSTMECYTE	EKANKIKADY	EKRLREMNRD
730	740	750	760	770	780
LQKLQAAQKE	HARLLKNQSR	YERELKKLQA	EVAEMKKAKV	ALMKQMREEQ	QRRRLVETKR
790	800	810	820	830	840
NREIAQLKKE	QRRQEFQIRA	LESQKRQQEM	VLRRKTQEVS	ALRRLAKPMS	ERVAGRAGLK
850	860	870	880	890	900
PPMLDSGAEV	SASTTSSEAE	SGARSVSSIV	RQWNRKINHF	LGDHPAPTVN	GTRPARKKFQ
910	920	930	940	950	960
KKGASQSFSK	AARLKWQSLE	RRIIDIVMQR	MTIVNLEADM	ERLIKKREEL	FLLQEALRRK
970	980	990	1000	1010	1020
RERLQAESPE	EEKGLQELAE	EIEVLAANID	YINDGITDCQ	ATIVQLEETK	EELDSTDTSV
1030	1040	1050	1060	1070	1080
VISSCSLAEA	RLLLDNFLKA	SIDKGLQVAQ	KEAQIRLLEG	RLRQTDMAGS	SQNHLLLDAL
1090	1100	1110	1120	1130	1140
REKAEAHPEL	QALIYNVQQE	NGYASTDEEI	SEFSEGSFSQ	SFTMKGSTSH	DDFKFKSEPK
1150	1160	1170	1180	1190	1200
LSAQMKAVSA	ECLGPPLDIS	TKNITKSLAS	LVEIKEDGVG	FSVRDPYYRD	RVSRTVSLPT
1210	1220	1230	1240	1250	1260
RGSTFPRQSR	ATETSPLTRR	KSYDRGQPIR	STDVGFTPPS	SPPTRPRNDR	NVFSRLTSNQ
1270	1280	1290	1300	1310	1320
SQGSALDKSD	DSDSSLSEVL	RGIISPVGGA	KGARTAPLQC	VSMAEGHTKP	ILCLDATDEL
1330	1340	1350	1360	1370	1380
LFTGSKDRSC	KMWNLVTGQE	IAALKGHPNN	VVSIKYCSHS	GLVFSVSTSY	IKVWDIRDSA
1390	1400	1410	1420	1430	1440
KCIRTLTSSG	QVISGDACAA	TSTRAITSAQ	GEHQINQIAL	SPSGTMLYAA	SGNAVRIWEL
1450	1460	1470	1480	1490	1500
SRFQPVGKLT	GHIGPVMCLT	VTQTASQHDL	VVTGSKDHYV	KMFELGECVT	GTIGPTHNFE
1510	1520	1530	1540	1550	1560
PPHYDGIECL	AIQGDILFSG	SRDNGIKKWD	LDQQELIQQI	PNAHKDWVCA	LAFIPGRPML
1570	1580	1590	1600	1610	1620
LSACRAGVIK	VWNVDNFTPI	GEIKGHDSPI	NAICTNAKHI	FTASSDCRVK	LWNYVPGLTP
1630
CLPRRVLAIK	GRATTLP