O73878
SS
Gene name |
ephb4b (rtk8) |
Protein name |
Ephrin type-B receptor 4b |
Names |
EC 2.7.10.1 , Eph receptor B4b , Eph-like receptor tyrosine kinase rtk8 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:30691 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
613-876 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
755-783 (Activation loop from InterPro)
Target domain |
613-897 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for O73878
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O73878-F1 | Predicted | AlphaFoldDB |
No variants for O73878
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O73878 | |||||
No associated diseases with O73878
10 regional properties for O73878
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 613 - 897 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 25 - 204 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 613 - 872 | IPR001245 |
| domain | Sterile alpha motif domain | 903 - 970 | IPR001660 |
| domain | Fibronectin type III | 326 - 434 | IPR003961-1 |
| domain | Fibronectin type III | 436 - 529 | IPR003961-2 |
| active_site | Tyrosine-protein kinase, active site | 734 - 746 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 619 - 645 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 613 - 872 | IPR020635 |
| domain | Ephrin receptor, transmembrane domain | 542 - 610 | IPR027936 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Kupffer's vesicle development | The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| somitogenesis | The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
59 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| E7F3X9 | ddr1 | receptor protein-tyrosine kinase | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9YI66 | tyro3 | Tyrosine-protein kinase receptor TYRO3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRVCWIMAL | SWFWMVSTGL | VSAEEEVLMN | TKLETSDLRW | TIYPSGDPEW | EEMSGLDEEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSVRTFQVCP | MDSSVSHWLR | TRFIPRHGAS | QVYVEIRFTM | MECSAMPASF | RTCKETFNLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YYQSDEDTAS | ATHPAWMENP | YSKVDTVAAD | FLLRRGGERK | SNVKTVRVGP | LSKKGFYLAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QTQGACMALL | SVRVFFKKCP | AVSRAFSSFP | ETLPHSLVQQ | AEGVCVDNSA | PTGQSTAPPT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MFCGEDGQWV | GPPSSTCACK | PGYEPVDSDR | CRACGLGQYK | ASVGGSLCRV | CPDNSNTHFA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GSSLCVCRPG | YHRATSDLPD | SACTKPPSAP | RSIIYQINDT | VVTLEWSEPL | DRGGRSDLSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVECMHCRGS | LCVQCADSIT | YRPGQMGVPG | RRVIIRGLLP | HTTYTFTVLA | QNGVSAVSHT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SPASSSVNIT | TSRDVAVPVS | GIRRIKASES | SVSISWTVPP | QTQHSIQDYQ | LRYSLKGQDD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GWQYVSSRSS | SVVLNDLSRA | SQYQVQVRAR | TAAGYGHFSS | AVSISTLPDD | EESPSRLMLT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GVLVAIGLLI | LIAVVIVAVF | CFRRSTRRRD | PDPDKSGQFL | MGQGIKVYID | PFTYEDPNEA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VREFAKEIDV | SFVKIEEVIG | AGEFGEVCRG | RLKVPGKKEN | YVAIKTLKGG | YTDKQRRDFL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SEASIMGQFQ | HPNIIHLEGV | ITASCPVMIL | TEYMENGALD | SFLRLNDGQF | TPIQLVGMLR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GIASGMKYLS | EMSFVHRDLA | ARNILVNSNL | VCKVSDFGLS | RFLTENSSDP | TYTSSLGGKI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PIRWTAPEAI | AFRKFTSASD | VWSYGIVMWE | VMSFGERPYW | DMSNQDVINA | IEQDYRLPPP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PECPASLHQL | MLDCWQKERS | SRPRFCAIVS | ALDRLIRNPA | SLKITGRIPD | GPSHPLLDQR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| APPPLSHCSS | VADWLRAIKM | ERYEDAFMQA | GFTAIQHITH | ISTEDLLRIG | VTLAGHQKKI |
| 970 | |||||
| LSSVQTLRIH | GGSLRY |