O73592

PR
Gene name
Protein name
Homeobox protein MIXL1
Names
Homeodomain protein MIX, cMIX, MIX1 homeobox-like protein 1, Mix.1 homeobox-like protein
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395838
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O73592

Entry ID Method Resolution Chain Position Source
AF-O73592-F1 Predicted AlphaFoldDB

No variants for O73592

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O73592

No associated diseases with O73592

2 regional properties for O73592

Type Name Position InterPro Accession
domain Homeobox domain 56 - 120 IPR001356
conserved_site Homeobox, conserved site 91 - 114 IPR017970

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

2 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91994 otx1b Homeobox protein OTX1 B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAALRFGPPP AELPAVPPSC PPGRWLCGTA GGSGGGPGAA PAPLASLPPA AEGAPSAQRR
70 80 90 100 110 120
KRTSFTAAQL ETLELVFQDT MYPDIYLRER LADATQIPES RIQVWFQNRR AKSRRQRGPP
130 140 150 160 170 180
RPGAPAPPPP PPQRSPCGAA PLLRAREEHR EWPPRAAGPP GSALRPHGGS GGAPAGPYPP
190 200
RPAFPLPAGG GFSELGTEWE ENAIGAFRAL