O70511
EV
Gene name |
Ank3 |
Protein name |
Ankyrin-3 |
Names |
ANK-3 , Ankyrin-G |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:361833 |
EC number |
|
Protein Class |
ANKYRIN REPEAT-CONTAINING (PTHR24123) |
Descriptions
Ankyrins are a widely expressed scaffold protein family, which mainly function to link great varieties of functionally related but structurally diverse integral membrane proteins. Autoinhibition in Ankyrin-2 and Ankyrin-3 is facilitated by the combinatorial and quasi-independent bindings of multiple disordered segments located in the linker and tail regions. These segments interact with the membrane binding domain's ANK repeats, adopting a head-to-tail conformation that inhibits the binding to membrane proteins.
Autoinhibitory domains (AIDs)
Target domain |
38-837 (Membrane binding domain) |
Relief mechanism |
Partner binding |
Assay |
Mutagenesis experiment |
Target domain |
38-837 (Membrane binding domain) |
Relief mechanism |
Partner binding |
Assay |
Mutagenesis experiment |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
7 structures for O70511
No variants for O70511
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O70511 | |||||
No associated diseases with O70511
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24123 | ANKYRIN REPEAT-CONTAINING |
| PANTHER Subfamily | PTHR24123:SF49 | ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B |
| PANTHER Protein Class | scaffold/adaptor protein | |
| PANTHER Pathway Category | No pathway information available | |
26 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| axon cytoplasm | Any cytoplasm that is part of a axon. |
| axon initial segment | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| costamere | Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| node of Ranvier | An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| paranode region of axon | An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| sarcoplasmic reticulum | A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. |
| spectrin-associated cytoskeleton | The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
| T-tubule | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| phosphorylation-dependent protein binding | Binding to a protein upon phosphorylation of the target protein. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| spectrin binding | Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
38 GO annotations of biological process
| Name | Definition |
|---|---|
| anterograde axonal transport | The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. |
| axon development | The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation). |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| cellular response to magnesium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. |
| clustering of voltage-gated sodium channels | The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization. |
| establishment of protein localization | The directed movement of a protein to a specific location. |
| establishment or maintenance of microtubule cytoskeleton polarity | Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. |
| Golgi to plasma membrane protein transport | The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. |
| magnesium ion homeostasis | Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. |
| maintenance of protein location in cell | Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. |
| maintenance of protein location in plasma membrane | Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere. |
| membrane assembly | The aggregation, arrangement and bonding together of a set of components to form a membrane. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| negative regulation of delayed rectifier potassium channel activity | Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity. |
| negative regulation of endocytosis | Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. |
| neuromuscular junction development | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. |
| neuronal action potential | An action potential that occurs in a neuron. |
| plasma membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. |
| positive regulation of cation channel activity | Any process that activates or increases the frequency, rate or extent of cation channel activity. |
| positive regulation of cell communication by electrical coupling | Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of homotypic cell-cell adhesion | Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion. |
| positive regulation of membrane depolarization during cardiac muscle cell action potential | Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential. |
| positive regulation of membrane potential | Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| positive regulation of non-canonical NF-kappaB signal transduction | Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. |
| positive regulation of protein targeting to membrane | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| positive regulation of sodium ion import across plasma membrane | Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane. |
| positive regulation of sodium ion transmembrane transporter activity | Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. |
| positive regulation of sodium ion transport | Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein localization to axon | A process in which a protein is transported to or maintained in a location within an axon. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of potassium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of protein targeting | Any process that modulates the frequency, rate or extent of protein targeting. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to immobilization stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1N6G5 | HACE1 | E3 ubiquitin-protein ligase HACE1 | Bos taurus (Bovine) | SS |
| E1C656 | HACE1 | E3 ubiquitin-protein ligase HACE1 | Gallus gallus (Chicken) | SS |
| Q8IYU2 | HACE1 | E3 ubiquitin-protein ligase HACE1 | Homo sapiens (Human) | EV |
| P16157 | ANK1 | Ankyrin-1 | Homo sapiens (Human) | EV |
| Q01484 | ANK2 | Ankyrin-2 | Homo sapiens (Human) | EV |
| Q12955 | ANK3 | Ankyrin-3 | Homo sapiens (Human) | SS |
| Q3U0D9 | Hace1 | E3 ubiquitin-protein ligase HACE1 | Mus musculus (Mouse) | SS |
| Q8C8R3 | Ank2 | Ankyrin-2 | Mus musculus (Mouse) | SS |
| Q02357 | Ank1 | Ankyrin-1 | Mus musculus (Mouse) | SS |
| D3ZBM7 | Hace1 | E3 ubiquitin-protein ligase HACE1 | Rattus norvegicus (Rat) | SS |
| Q28BK1 | hace1 | E3 ubiquitin-protein ligase HACE1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| F8W2M1 | hace1 | E3 ubiquitin-protein ligase HACE1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHAASQLKK | NRDLEINAEE | ETEKKKKHRK | RSRDRKKKSD | ANASYLRAAR | AGHLEKALDY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IKNGVDVNIC | NQNGLNALHL | ASKEGHVEVV | SELLQREANV | DAATKKGNTA | LHIASLAGQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVVKVLVTNG | ANVNAQSQNG | FTPLYMAAQE | NHLEVVRFLL | DNGASQSLAT | EDGFTPLAVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQQGHDQVVS | LLLENDTKGK | VRLPALHIAA | RKDDTKAAAL | LLQNDTNADI | ESKMVVNRAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESGFTPLHIA | AHYGNINVAT | LLLNRAAAVD | FTARNDITPL | HVASKRGNAN | MVKLLLDRGA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KIDAKTRDGL | TPLHCGARSG | HEQVVEMLLD | RAAPILSKTK | NGLSPLHMAT | QGDHLNCVQL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLQHNVPVDD | VTNDYLTALH | VAAHCGHYKV | AKVLLDKKAN | PNAKALNGFT | PLHIACKKNR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IRVMELLLKH | GASIQAVTES | GLTPIHVAAF | MGHVNIVSQL | MHHGASPNTT | NVRGETALHM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AARSGQAEVV | RYLVQDGAQV | EAKAKDDQTP | LHISARLGKA | DIVQQLLQQG | ASPNAATTSG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YTPLHLSARE | GHEDVAAFLL | DHGASLSITT | KKGFTPLHVA | AKYGKLEVAS | LLLQKSASPD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AAGKSGLTPL | HVAAHYDNQK | VALLLLDQGA | SPHAAAKNGY | TPLHIAAKKN | QMDIATSLLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YGADANAVTR | QGIASVHLAA | QEGHVDMVSL | LLSRNANVNL | SNKSGLTPLH | LAAQEDRVNV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AEVLVNQGAH | VDAQTKMGYT | PLHVGCHYGN | IKIVNFLLQH | SAKVNAKTKN | GYTPLHQAAQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QGHTHIINVL | LQNNASPNEL | TVNGNTALAI | ARRLGYISVV | DTLKVVTEEI | MTTTTITEKH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KMNVPETMNE | VLDMSDDEVG | KASAPEKLSD | GEYISDGEEG | EDAITGDTDK | YLGPQDLKEL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GDDSLPAEGY | VGFSLGARSA | SLRSFSSDRS | YTLNRSSYAR | DSMMIEELLV | PSKEQHLPFT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| REFDSDSLRH | YSWAADTLDN | VNLVSSPVHS | GFLVSFMVDA | RGGSMRGSRH | HGMRIIIPPR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KCTAPTRITC | RLVKRHKLAN | PPPMVEGEGL | ASRLVEMGPA | GAQFLGPVIV | EIPHFGSMRG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KERELIVLRS | ENGETWKEHQ | FDSKNEDLSE | LLNGMDEELD | SPEELGTKRI | CRIITKDFPQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YFAVVSRIKQ | ESNQIGPEGG | ILSSTTVPLV | QASFPEGALT | KRIRVGLQAQ | PVPEETVKKI |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LGNKATFSPI | VTVEPRRRKF | HKPITMTIPV | PPPSGEGVSN | GYKGDTTPSL | RLLCSITGGT |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| SPAQWEDITG | TTPLTFIKDC | VSFTTNVSAR | FWLADCHQVL | ETVGLASQLY | RELICVPYMA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KFVVFAKTND | PVESSLRCFC | MTDDRVDKTL | EQQENFEEVA | RSKDIEVLEG | KPIYVDCYGN |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LAPLTKGGQQ | LVFNFYSFKE | NRLPFSIKVR | DTSQEPCGRL | SFLKEPKTTK | GLPQTAVCNL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| NITLPAHKKA | EKADRRQSFT | SLALRKRYSY | LTEPSMKTVE | RSSGTARSLP | TTYSHKPFFS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| TRPYQSWTTT | PITVPGPAKS | GSLSSSPSNT | PSASPLKSIW | SVSTPSPIKS | TLGASTTSSV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| KSISDVASPI | RSFRTISSPI | RTVASPSPYN | TQVASGTLGR | VPTITEATPI | KGVAPNSTLS |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| SRTSPVTTAG | SLLEKSSITM | TPPASPKANI | TMYSSSLPFK | SIITSAAPLI | SSPLKSVVSP |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| TKSAADVIST | AKAAMASTLS | SPLKQMSGHA | EVALVNGSVS | PLKYPSSSAL | INGCKATATL |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| QDKISTATNA | VSSVVSAAPD | TVEKALSTTT | AMPFSPLRSY | VSAAAPSAFQ | SLRAPSASAL |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| YNSLGPSVGV | TTSSVTSSII | TVPVYSVGNV | LAEPALKKLP | DSNSLTKSAA | ALLSPIKTLT |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| TETRPQPHFN | RTSSPVKSSL | FLASSALKPS | VPSSLSSSQE | ILKDVAEMKE | DLMRMTAILQ |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| TDVPEEKPFQ | TDLPREGRID | DEEPFKIVEK | VKEDLVKVSE | ILKKDVCVES | KGPPKSPKSD |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| KGHSPEDDWT | EFSSEEIREA | RQAAASHAPS | LPERVHGKAN | LTRVIDYLTN | DIGSSSLTNL |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| KYKFEEAKKE | GEERQKRILK | PAMALQEHKL | KMPPASMRPS | TSEKELCKMA | DSFFGTDAIL |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| ESPDDFSQHD | QDKSPLSDSG | FETRSEKTPS | APQSAESTGP | KPLFHEVPIP | PVITETRTEV |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| VHVIRSYEPS | TGEIPQSQPE | DPVSPKPPPT | FMELEPKPTA | LSIKEKVKAF | QMKASSEEED |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| HSRVLSKGMR | VKEETHITTT | TRMVYHSPPG | SECASERIEE | TMSVHDIMKA | FQSGRDPSKE |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| LAGLFEHKSA | MSPDVAKSAA | ETSAQHAEKD | NQMKPKLERI | IEVHIEKGPQ | SPCERTDIRM |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| AIVADHLGLS | WTELARELNF | SVDEINQIRV | ENPNSLISQS | FMLLKKWVTR | DGKNATTDAL |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| TSVLTKINRI | DIVTLLEGPI | FDYGNISGTR | SFADENNVFH | DPVDGWQNET | PSGSLESPAQ |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| ARRITGGLLD | RLDDSSDQVR | DPITSYLTGE | AGKFEANGNH | AEVIPEAKAK | AYFPESQNDI |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| GKQSIKENLK | PKTHGCGRAE | EPVSPLTAYQ | KSLEETSKLV | IEDAPKPCVP | VGMKKMTRTP |
| 2590 | 2600 | 2610 | 2620 | ||
| ADGKARLNLQ | EEEGSARSEP | KQGEGYKVKT | KKEIRNVEKK | AH |