O65554

PR
Gene name
CIPK6 (PKS4, SIP3, SnRK3.14)
Protein name
CBL-interacting serine/threonine-protein kinase 6
Names
SNF1-related kinase 3.14, SOS2-like protein kinase PKS4, SOS3-interacting protein 3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G30960
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

328-408 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O65554

Entry ID Method Resolution Chain Position Source
AF-O65554-F1 Predicted AlphaFoldDB

11 variants for O65554

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12327092 10 G>A No 1000Genomes
ENSVATH06805649 46 T>S No 1000Genomes
ENSVATH00546003 172 E>D No 1000Genomes
ENSVATH12327094 172 E>V No 1000Genomes
ENSVATH02946104 196 L>M No 1000Genomes
tmp_4_15068225_C_A 276 P>T No 1000Genomes
tmp_4_15068255_A_G 286 R>G No 1000Genomes
tmp_4_15068265_C_G 289 P>R No 1000Genomes
ENSVATH06805655 289 P>S No 1000Genomes
ENSVATH14318374 307 K>R No 1000Genomes
tmp_4_15068646_C_T 416 T>M No 1000Genomes

No associated diseases with O65554

3 regional properties for O65554

Type Name Position InterPro Accession
domain Ras-like guanine nucleotide exchange factor, N-terminal 34 - 164 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 196 - 447 IPR001895
conserved_site Ras guanine-nucleotide exchange factor, conserved site 364 - 394 IPR019804

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Endoplasmic reticulum
  • Targeted to the cell membrane when interacting with CBL4 and ATK2
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name Definition
basipetal auxin transport The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root.
hyperosmotic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
protein phosphorylation The process of introducing a phosphate group on to a protein.
response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

70 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q02066 Abscisic acid-inducible protein kinase Triticum aestivum (Wheat) PR
Q5GLH2 TRIB2 Tribbles homolog 2 Bos taurus (Bovine) SS
Q0VCE3 TRIB3 Tribbles homolog 3 Bos taurus (Bovine) SS
Q3SZW1 TSSK1B Testis-specific serine/threonine-protein kinase 1 Bos taurus (Bovine) PR
O61661 grp Serine/threonine-protein kinase grp Drosophila melanogaster (Fruit fly) SS
Q92519 TRIB2 Tribbles homolog 2 Homo sapiens (Human) SS
Q96RU7 TRIB3 Tribbles homolog 3 Homo sapiens (Human) PR
Q14680 MELK Maternal embryonic leucine zipper kinase Homo sapiens (Human) EV
Q96RU8 TRIB1 Tribbles homolog 1 Homo sapiens (Human) EV
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens (Human) EV
Q96RG2 PASK PAS domain-containing serine/threonine-protein kinase Homo sapiens (Human) EV
P54646 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens (Human) EV
Q9BXA7 TSSK1B Testis-specific serine/threonine-protein kinase 1 Homo sapiens (Human) PR
O60285 NUAK1 NUAK family SNF1-like kinase 1 Homo sapiens (Human) PR
Q9NRH2 SNRK SNF-related serine/threonine-protein kinase Homo sapiens (Human) SS
P57059 SIK1 Serine/threonine-protein kinase SIK1 Homo sapiens (Human) PR
Q15831 STK11 Serine/threonine-protein kinase STK11 Homo sapiens (Human) PR
Q96RR4 CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens (Human) PR
Q8K4K3 Trib2 Tribbles homolog 2 Mus musculus (Mouse) SS
Q8BRK8 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Mus musculus (Mouse) SS
Q61241 Tssk1b Testis-specific serine/threonine-protein kinase 1 Mus musculus (Mouse) PR
Q8K4K2 Trib3 Tribbles homolog 3 Mus musculus (Mouse) SS
Q61846 Melk Maternal embryonic leucine zipper kinase Mus musculus (Mouse) PR
O54863 Tssk2 Testis-specific serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q5EG47 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus (Mouse) SS
Q8K4K4 Trib1 Tribbles homolog 1 Mus musculus (Mouse) SS
Q641K5 Nuak1 NUAK family SNF1-like kinase 1 Mus musculus (Mouse) PR
Q8C078 Camkk2 Calcium/calmodulin-dependent protein kinase kinase 2 Mus musculus (Mouse) PR
Q28948 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Sus scrofa (Pig) SS
Q9WTQ6 Trib3 Tribbles homolog 3 Rattus norvegicus (Rat) SS
Q09137 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Rattus norvegicus (Rat) EV
P54645 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus (Rat) EV
Q5QNM6 CIPK13 Putative CBL-interacting protein kinase 13 Oryza sativa subsp japonica (Rice) PR
Q5JLQ9 CIPK30 CBL-interacting protein kinase 30 Oryza sativa subsp japonica (Rice) PR
Q5N942 SAPK4 Serine/threonine-protein kinase SAPK4 Oryza sativa subsp japonica (Rice) PR
Q852Q0 OSK3 Serine/threonine protein kinase OSK3 Oryza sativa subsp. japonica (Rice) SS
Q75LR7 SAPK1 Serine/threonine-protein kinase SAPK1 Oryza sativa subsp japonica (Rice) PR
Q75H77 SAPK10 Serine/threonine-protein kinase SAPK10 Oryza sativa subsp japonica (Rice) PR
Q7Y0B9 SAPK8 Serine/threonine-protein kinase SAPK8 Oryza sativa subsp japonica (Rice) PR
Q7XQP4 SAPK7 Serine/threonine-protein kinase SAPK7 Oryza sativa subsp japonica (Rice) PR
Q852Q2 OSK1 Serine/threonine protein kinase OSK1 Oryza sativa subsp. japonica (Rice) SS
Q6ZLP5 CIPK23 CBL-interacting protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q0D4J7 SAPK2 Serine/threonine-protein kinase SAPK2 Oryza sativa subsp japonica (Rice) PR
Q8LIG4 CIPK3 CBL-interacting protein kinase 3 Oryza sativa subsp japonica (Rice) PR
Q852Q1 OSK4 Serine/threonine protein kinase OSK4 Oryza sativa subsp. japonica (Rice) SS
Q6ERS4 CIPK16 CBL-interacting protein kinase 16 Oryza sativa subsp japonica (Rice) PR
P0C5D6 SAPK3 Serine/threonine-protein kinase SAPK3 Oryza sativa subsp japonica (Rice) PR
Q2RAX3 CIPK33 CBL-interacting protein kinase 33 Oryza sativa subsp japonica (Rice) PR
Q75V57 SAPK9 Serine/threonine-protein kinase SAPK9 Oryza sativa subsp japonica (Rice) PR
Q21017 kin-29 Serine/threonine-protein kinase kin-29 Caenorhabditis elegans SS
P45894 aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Caenorhabditis elegans SS
Q95ZQ4 aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans SS
P43291 SRK2A Serine/threonine-protein kinase SRK2A Arabidopsis thaliana (Mouse-ear cress) PR
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
P92958 KIN11 SNF1-related protein kinase catalytic subunit alpha KIN11 Arabidopsis thaliana (Mouse-ear cress) PR
Q39192 SRK2D Serine/threonine-protein kinase SRK2D Arabidopsis thaliana (Mouse-ear cress) PR
Q940H6 SRK2E Serine/threonine-protein kinase SRK2E Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLZ3 KIN12 SNF1-related protein kinase catalytic subunit alpha KIN12 Arabidopsis thaliana (Mouse-ear cress) SS
Q39193 SRK2I Serine/threonine-protein kinase SRK2I Arabidopsis thaliana (Mouse-ear cress) PR
Q9C958 SRK2B Serine/threonine-protein kinase SRK2B Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9E9 SRK2C Serine/threonine-protein kinase SRK2C Arabidopsis thaliana (Mouse-ear cress) PR
O22971 CIPK13 CBL-interacting serine/threonine-protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
O64812 SRK2J Serine/threonine-protein kinase SRK2J Arabidopsis thaliana (Mouse-ear cress) PR
P43292 SRK2G Serine/threonine-protein kinase SRK2G Arabidopsis thaliana (Mouse-ear cress) PR
Q93VD3 CIPK23 CBL-interacting serine/threonine-protein kinase 23 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CG0 CIPK21 CBL-interacting serine/threonine-protein kinase 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFP9 SRK2H Serine/threonine-protein kinase SRK2H Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJ54 CIPK20 CBL-interacting serine/threonine-protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDI3 CIPK24 CBL-interacting serine/threonine-protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q2V452 CIPK3 CBL-interacting serine/threonine-protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MVGAKPVENG SDGGSSTGLL HGRYELGRLL GHGTFAKVYH ARNIQTGKSV AMKVVGKEKV
70 80 90 100 110 120
VKVGMVDQIK REISVMRMVK HPNIVELHEV MASKSKIYFA MELVRGGELF AKVAKGRLRE
130 140 150 160 170 180
DVARVYFQQL ISAVDFCHSR GVYHRDLKPE NLLLDEEGNL KVTDFGLSAF TEHLKQDGLL
190 200 210 220 230 240
HTTCGTPAYV APEVILKKGY DGAKADLWSC GVILFVLLAG YLPFQDDNLV NMYRKIYRGD
250 260 270 280 290 300
FKCPGWLSSD ARRLVTKLLD PNPNTRITIE KVMDSPWFKK QATRSRNEPV AATITTTEED
310 320 330 340 350 360
VDFLVHKSKE ETETLNAFHI IALSEGFDLS PLFEEKKKEE KREMRFATSR PASSVISSLE
370 380 390 400 410 420
EAARVGNKFD VRKSESRVRI EGKQNGRKGK LAVEAEIFAV APSFVVVEVK KDHGDTLEYN
430 440
NFCSTALRPA LKDIFWTSTP A