O65312
PR
Gene name |
MEA (EMB173, FIS1, MEDEA, SDG5, SET5) |
Protein name |
Histone-lysine N-methyltransferase MEDEA |
Names |
Maternal embryogenesis control protein, Protein EMBRYO DEFECTIVE 173, Protein FERTILIZATION-INDEPENDENT SEED 1, Protein SET DOMAIN GROUP 5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G02580 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O65312
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O65312-F1 | Predicted | AlphaFoldDB |
68 variants for O65312
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04508740 | 22 | E>Q | No | 1000Genomes | |
| tmp_1_545036_G_A | 25 | E>K | No | 1000Genomes | |
| ENSVATH04508741 | 28 | R>K | No | 1000Genomes | |
| ENSVATH01006018 | 42 | P>S | No | 1000Genomes | |
| ENSVATH04508753 | 64 | D>G | No | 1000Genomes | |
| ENSVATH00002874 | 80 | L>F | No | 1000Genomes | |
| tmp_1_545786_C_A | 85 | A>D | No | 1000Genomes | |
| ENSVATH00002876 | 108 | E>D | No | 1000Genomes | |
| tmp_1_545870_T_C | 113 | L>S | No | 1000Genomes | |
| tmp_1_545951_T_C | 140 | V>A | No | 1000Genomes | |
| tmp_1_545950_G_T | 140 | V>F | No | 1000Genomes | |
| ENSVATH04508755 | 163 | L>S | No | 1000Genomes | |
| tmp_1_546129_G_A | 167 | A>T | No | 1000Genomes | |
| tmp_1_546176_T_G | 182 | D>E | No | 1000Genomes | |
| ENSVATH10487478 | 196 | D>N | No | 1000Genomes | |
| ENSVATH04508757 | 201 | I>L | No | 1000Genomes | |
| ENSVATH00002879 | 205 | G>E | No | 1000Genomes | |
| ENSVATH00002881 | 216 | R>Q | No | 1000Genomes | |
| ENSVATH04508759 | 218 | A>T | No | 1000Genomes | |
| ENSVATH00002882 | 241 | N>S | No | 1000Genomes | |
| tmp_1_546546_G_A | 243 | G>E | No | 1000Genomes | |
| ENSVATH04508766 | 245 | A>V | No | 1000Genomes | |
| ENSVATH00002883 | 257 | T>S | No | 1000Genomes | |
| ENSVATH10487479 | 259 | A>S | No | 1000Genomes | |
| tmp_1_546739_C_A | 278 | H>N | No | 1000Genomes | |
| ENSVATH01006025 | 278 | H>Q | No | 1000Genomes | |
| ENSVATH13849745 | 279 | M>V | No | 1000Genomes | |
| ENSVATH04508768 | 281 | E>D | No | 1000Genomes | |
| tmp_1_546757_G_A | 284 | E>K | No | 1000Genomes | |
| ENSVATH04508769 | 285 | P>A | No | 1000Genomes | |
| ENSVATH04508771 | 292 | D>G | No | 1000Genomes | |
| tmp_1_546891_G_T | 296 | L>F | No | 1000Genomes | |
| tmp_1_546892_T_C | 297 | F>L | No | 1000Genomes | |
| ENSVATH00002884 | 299 | D>N | No | 1000Genomes | |
| ENSVATH10487481 | 315 | S>T | No | 1000Genomes | |
| ENSVATH04508773 | 321 | H>N | No | 1000Genomes | |
| tmp_1_547109_C_T | 341 | T>I | No | 1000Genomes | |
| ENSVATH13849746 | 342 | M>I | No | 1000Genomes | |
| tmp_1_547116_G_T | 343 | W>C | No | 1000Genomes | |
| tmp_1_547170_C_G | 361 | N>K | No | 1000Genomes | |
| tmp_1_547271_T_C | 370 | L>P | No | 1000Genomes | |
| tmp_1_547274_G_C,A | 371 | R>P | No | 1000Genomes | |
| tmp_1_547274_G_C,A | 371 | R>Q | No | 1000Genomes | |
| ENSVATH00002886 | 384 | R>G | No | 1000Genomes | |
| tmp_1_547342_G_A | 394 | D>N | No | 1000Genomes | |
| tmp_1_547360_C_G | 400 | Q>E | No | 1000Genomes | |
| ENSVATH01006032 | 405 | V>G | No | 1000Genomes | |
| tmp_1_547568_G_A | 440 | E>K | No | 1000Genomes | |
| ENSVATH13849749 | 451 | T>I | No | 1000Genomes | |
| ENSVATH01006034 | 465 | H>Q | No | 1000Genomes | |
| ENSVATH04508787 | 489 | A>S | No | 1000Genomes | |
| ENSVATH04508787 | 489 | A>T | No | 1000Genomes | |
| tmp_1_547794_A_G | 490 | I>V | No | 1000Genomes | |
| ENSVATH04508788 | 508 | D>N | No | 1000Genomes | |
| tmp_1_548037_C_A | 541 | Q>K | No | 1000Genomes | |
| ENSVATH04508792 | 542 | T>I | No | 1000Genomes | |
| ENSVATH04508792 | 542 | T>S | No | 1000Genomes | |
| tmp_1_548045_T_A | 543 | N>K | No | 1000Genomes | |
| tmp_1_548312_A_C | 562 | D>A | No | 1000Genomes | |
| ENSVATH04508797 | 566 | K>R | No | 1000Genomes | |
| tmp_1_548381_A_T | 585 | E>V | No | 1000Genomes | |
| ENSVATH04508800 | 589 | I>V | No | 1000Genomes | |
| tmp_1_548406_T_G | 593 | I>M | No | 1000Genomes | |
| tmp_1_548583_G_A | 624 | R>K | No | 1000Genomes | |
| ENSVATH13849753 | 643 | F>L | No | 1000Genomes | |
| ENSVATH10487915 | 652 | E>K | No | 1000Genomes | |
| tmp_1_548967_G_T | 681 | R>S | No | 1000Genomes | |
| ENSVATH04508813 | 686 | R>C | No | 1000Genomes |
No associated diseases with O65312
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PcG protein complex | A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone methyltransferase activity (H3-K27 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| histone H3-K27 trimethylation | The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of endosperm development | Any process that modulates the frequency, rate or extent of endosperm development. |
| regulation of gene expression by genomic imprinting | An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles. |
| response to absence of light | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. |
| seed morphogenesis | The process in which the anatomical structures of the seed are generated and organized. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7E2Z2 | EZH1 | Histone-lysine N-methyltransferase EZH1 | Bos taurus (Bovine) | SS |
| P42124 | E(z) | Histone-lysine N-methyltransferase E | Drosophila melanogaster (Fruit fly) | SS |
| Q92800 | EZH1 | Histone-lysine N-methyltransferase EZH1 | Homo sapiens (Human) | SS |
| Q15910 | EZH2 | Histone-lysine N-methyltransferase EZH2 | Homo sapiens (Human) | EV |
| P70351 | Ezh1 | Histone-lysine N-methyltransferase EZH1 | Mus musculus (Mouse) | SS |
| Q61188 | Ezh2 | Histone-lysine N-methyltransferase EZH2 | Mus musculus (Mouse) | SS |
| Q28D84 | ezh2 | Histone-lysine N-methyltransferase EZH2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q08BS4 | ezh2 | Histone-lysine N-methyltransferase EZH2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEKENHEDDG | EGLPPELNQI | KEQIEKERFL | HIKRKFELRY | IPSVATHASH | HQSFDLNQPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AEDDNGGDNK | SLLSRMQNPL | RHFSASSDYN | SYEDQGYVLD | EDQDYALEED | VPLFLDEDVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLPSVKLPIV | EKLPRSITWV | FTKSSQLMAE | SDSVIGKRQI | YYLNGEALEL | SSEEDEEDEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDEEEIKKEK | CEFSEDVDRF | IWTVGQDYGL | DDLVVRRALA | KYLEVDVSDI | LERYNELKLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NDGTAGEASD | LTSKTITTAF | QDFADRRHCR | RCMIFDCHMH | EKYEPESRSS | EDKSSLFEDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DRQPCSEHCY | LKVRSVTEAD | HVMDNDNSIS | NKIVVSDPNN | TMWTPVEKDL | YLKGIEIFGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NSCDVALNIL | RGLKTCLEIY | NYMREQDQCT | MSLDLNKTTQ | RHNQVTKKVS | RKSSRSVRKK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SRLRKYARYP | PALKKTTSGE | AKFYKHYTPC | TCKSKCGQQC | PCLTHENCCE | KYCGCSKDCN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NRFGGCNCAI | GQCTNRQCPC | FAANRECDPD | LCRSCPLSCG | DGTLGETPVQ | IQCKNMQFLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTNKKILIGK | SDVHGWGAFT | WDSLKKNEYL | GEYTGELITH | DEANERGRIE | DRIGSSYLFT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LNDQLEIDAR | RKGNEFKFLN | HSARPNCYAK | LMIVRGDQRI | GLFAERAIEE | GEELFFDYCY |
| 670 | 680 | ||||
| GPEHADWSRG | REPRKTGASK | RSKEARPAR |