O64973
PR
Gene name |
RPS5 (At1g12220, T28K15.5) |
Protein name |
Disease resistance protein RPS5 |
Names |
Resistance to Pseudomonas syringae protein 5, pNd3/pNd10 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G12220 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O64973
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64973-F1 | Predicted | AlphaFoldDB |
49 variants for O64973
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00019377 | 12 | D>G | Following inoculation of two leaves per plant with 0.1 ml of 10 -8 cfu/ml bacteria in 10 mm mgso4 buffer using a blunt-tipped syringe. leaf collapse was scored at 20 hrs and again at 24 hrs after inoculation [20c and 12 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH00019378 | 53 | V>A | No | 1000Genomes | |
| ENSVATH00019380 | 87 | N>D | No | 1000Genomes | |
| ENSVATH04563420 | 117 | G>E | No | 1000Genomes | |
| ENSVATH00019381 | 143 | T>I | No | 1000Genomes | |
| tmp_1_4145569_G_T | 187 | V>L | No | 1000Genomes | |
| tmp_1_4145584_C_A | 192 | L>I | No | 1000Genomes | |
| ENSVATH00019384 | 202 | K>R | No | 1000Genomes | |
| tmp_1_4145693_T_G | 228 | I>R | No | 1000Genomes | |
| ENSVATH11043394 | 230 | E>K | No | 1000Genomes | |
| ENSVATH04563424 | 278 | V>F | No | 1000Genomes | |
| ENSVATH11043455 | 282 | S>N | No | 1000Genomes | |
| tmp_1_4145891_G_T | 294 | R>L | No | 1000Genomes | |
| tmp_1_4145911_C_T | 301 | R>C | No | 1000Genomes | |
| ENSVATH01040390 | 359 | G>C | No | 1000Genomes | |
| tmp_1_4146097_G_A | 363 | A>T | No | 1000Genomes | |
| tmp_1_4146346_G_A | 446 | E>K | No | 1000Genomes | |
| ENSVATH00019388 | 448 | N>Y | No | 1000Genomes | |
| ENSVATH04563427 | 455 | I>L | No | 1000Genomes | |
| ENSVATH11043457 | 472 | K>R | No | 1000Genomes | |
| tmp_1_4146433_G_A | 475 | V>M | No | 1000Genomes | |
| tmp_1_4146496_A_G | 496 | K>E | No | 1000Genomes | |
| ENSVATH01040392 | 502 | R>G | No | 1000Genomes | |
| ENSVATH00019390 | 508 | R>C | No | 1000Genomes | |
| tmp_1_4146533_G_A | 508 | R>H | No | 1000Genomes | |
| tmp_1_4146616_C_T | 536 | H>Y | No | 1000Genomes | |
| ENSVATH00019393 | 585 | E>K | No | 1000Genomes | |
| tmp_1_4146905_T_A | 632 | L>* | No | 1000Genomes | |
| tmp_1_4147064_A_T | 685 | E>V | No | 1000Genomes | |
| tmp_1_4147086_T_G | 692 | F>L | No | 1000Genomes | |
| ENSVATH11043463 | 695 | L>H | No | 1000Genomes | |
| tmp_1_4147102_G_A | 698 | E>K | No | 1000Genomes | |
| tmp_1_4147121_C_G | 704 | T>S | No | 1000Genomes | |
| ENSVATH01040395 | 785 | I>L | No | 1000Genomes | |
| tmp_1_4147387_C_G | 793 | H>D | No | 1000Genomes | |
| tmp_1_4147457_G_A | 816 | R>K | No | 1000Genomes | |
| ENSVATH00019396 | 825 | P>S | No | 1000Genomes | |
| ENSVATH04563429 | 831 | H>R | No | 1000Genomes | |
| ENSVATH11043464 | 832 | V>A | No | 1000Genomes | |
| tmp_1_4147582_T_C | 858 | Y>H | No | 1000Genomes | |
| tmp_1_4147588_G_C | 860 | E>Q | No | 1000Genomes | |
| ENSVATH04563430 | 865 | E>K | No | 1000Genomes | |
| ENSVATH04563430 | 865 | E>Q | No | 1000Genomes | |
| ENSVATH11043535 | 870 | E>K | No | 1000Genomes | |
| tmp_1_4147625_A_G | 872 | Q>R | No | 1000Genomes | |
| tmp_1_4147627_G_A | 873 | A>T | No | 1000Genomes | |
| ENSVATH04563431 | 887 | R>K | No | 1000Genomes | |
| ENSVATH11043540 | 890 | T>S | No | 1000Genomes | |
| ENSVATH11043541 | 890 | T>Y | No | 1000Genomes |
No associated diseases with O64973
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ADP binding | Binding to ADP, adenosine 5'-diphosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell death | Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| plant-type hypersensitive response | The rapid, localized death of plant cells in response to invasion by a pathogen. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1MHT9 | NLRC4 | NLR family CARD domain-containing protein 4 | Bos taurus (Bovine) | SS |
| O14727 | APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens (Human) | EV |
| Q9NPP4 | NLRC4 | NLR family CARD domain-containing protein 4 | Homo sapiens (Human) | SS |
| Q3UP24 | Nlrc4 | NLR family CARD domain-containing protein 4 | Mus musculus (Mouse) | EV |
| F1M649 | Nlrc4 | NLR family CARD domain-containing protein 4 | Rattus norvegicus (Rat) | SS |
| O22727 | At1g61190 | Probable disease resistance protein At1g61190 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64790 | At1g61300 | Probable disease resistance protein At1g61300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0C8S1 | RPP8L2 | Probable disease resistance RPP8-like protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P60838 | SUMM2 | Disease resistance protein SUMM2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38834 | RPP13L4 | Disease resistance RPP13-like protein 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39214 | RPM1 | Disease resistance protein RPM1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W3K3 | At1g58400 | Putative disease resistance protein At1g58400 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C646 | RXW24L | Probable disease resistance protein RXW24L | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJB5 | RPP8L3 | Disease resistance RPP8-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRR4 | RPPL1 | Putative disease resistance RPP13-like protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9T048 | At4g27190 | Disease resistance protein At4g27190 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIF0 | At1g59780 | Putative disease resistance protein At1g59780 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64789 | At1g61310 | Probable disease resistance protein At1g61310 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q940K0 | UNI | Disease resistance protein UNI | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9I9H8 | apaf1 | Apoptotic protease-activating factor 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGCFSVSLP | CDQVVSQFSQ | LLCVRGSYIH | NLSKNLASLQ | KAMRMLKARQ | YDVIRRLETE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFTGRQQRLS | QVQVWLTSVL | IIQNQFNDLL | RSNEVELQRL | CLCGFCSKDL | KLSYRYGKRV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMMLKEVESL | SSQGFFDVVS | EATPFADVDE | IPFQPTIVGQ | EIMLEKAWNR | LMEDGSGILG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYGMGGVGKT | TLLTKINNKF | SKIDDRFDVV | IWVVVSRSST | VRKIQRDIAE | KVGLGGMEWS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EKNDNQIAVD | IHNVLRRRKF | VLLLDDIWEK | VNLKAVGVPY | PSKDNGCKVA | FTTRSRDVCG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RMGVDDPMEV | SCLQPEESWD | LFQMKVGKNT | LGSHPDIPGL | ARKVARKCRG | LPLALNVIGE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AMACKRTVHE | WCHAIDVLTS | SAIDFSGMED | EILHVLKYSY | DNLNGELMKS | CFLYCSLFPE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DYLIDKEGLV | DYWISEGFIN | EKEGRERNIN | QGYEIIGTLV | RACLLLEEER | NKSNVKMHDV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VREMALWISS | DLGKQKEKCI | VRAGVGLREV | PKVKDWNTVR | KISLMNNEIE | EIFDSHECAA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTTLFLQKND | VVKISAEFFR | CMPHLVVLDL | SENQSLNELP | EEISELASLR | YFNLSYTCIH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLPVGLWTLK | KLIHLNLEHM | SSLGSILGIS | NLWNLRTLGL | RDSRLLLDMS | LVKELQLLEH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LEVITLDISS | SLVAEPLLCS | QRLVECIKEV | DFKYLKEESV | RVLTLPTMGN | LRKLGIKRCG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MREIKIERTT | SSSSRNKSPT | TPCFSNLSRV | FIAKCHGLKD | LTWLLFAPNL | TFLEVGFSKE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VEDIISEEKA | EEHSATIVPF | RKLETLHLFE | LRGLKRIYAK | ALHFPCLKVI | HVEKCEKLRK |
| 850 | 860 | 870 | 880 | ||
| LPLDSKSGIA | GEELVIYYGE | REWIERVEWE | DQATQLRFLP | SSRWRWRET |