O64812

PR
Gene name
SRK2J (OSKL10, SNRK2.9, At2g23030, F21P24.9)
Protein name
Serine/threonine-protein kinase SRK2J
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G23030
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

256-339 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O64812

Entry ID Method Resolution Chain Position Source
AF-O64812-F1 Predicted AlphaFoldDB

32 variants for O64812

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_9806555_A_T 17 L>M No 1000Genomes
ENSVATH14535732 18 A>T No 1000Genomes
ENSVATH05562367 28 E>K No 1000Genomes
ENSVATH14535726 53 R>I No 1000Genomes
ENSVATH13341714 61 V>I No 1000Genomes
tmp_2_9804364_C_T 207 R>H No 1000Genomes
tmp_2_9804258_T_G 215 K>T No 1000Genomes
ENSVATH13341644 231 E>V No 1000Genomes
tmp_2_9804204_C_G 233 C>S No 1000Genomes
ENSVATH05562327 239 R>C No 1000Genomes
tmp_2_9804178_C_T 242 V>I No 1000Genomes
tmp_2_9804175_C_G 243 A>P No 1000Genomes
tmp_2_9804174_G_A 243 A>V No 1000Genomes
ENSVATH05562326 246 L>S No 1000Genomes
tmp_2_9804163_G_A 247 H>Y No 1000Genomes
ENSVATH05562321 277 Y>N No 1000Genomes
tmp_2_9803938_T_A 279 R>W No 1000Genomes
ENSVATH14535708 284 I>F No 1000Genomes
ENSVATH05562320 286 F>S No 1000Genomes
ENSVATH05562319 290 R>S No 1000Genomes
tmp_2_9803901_A_T 291 V>E No 1000Genomes
tmp_2_9803899_C_T 292 E>K No 1000Genomes
ENSVATH13341642 299 G>S No 1000Genomes
tmp_2_9803854_G_A 307 L>F No 1000Genomes
ENSVATH00243056 308 S>F No 1000Genomes
tmp_2_9803848_G_A 309 R>C No 1000Genomes
tmp_2_9803844_G_A 310 P>L No 1000Genomes
ENSVATH00243055 310 P>S No 1000Genomes
ENSVATH00243054 313 S>L No 1000Genomes
tmp_2_9803829_C_T 315 G>E No 1000Genomes
tmp_2_9803826_G_A 316 S>L No 1000Genomes
ENSVATH05562317 320 D>N No 1000Genomes

No associated diseases with O64812

3 regional properties for O64812

Type Name Position InterPro Accession
conserved_site 14-3-3 protein, conserved site 44 - 54 IPR023409-1
conserved_site 14-3-3 protein, conserved site 216 - 235 IPR023409-2
domain 14-3-3 domain 4 - 247 IPR023410

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

63 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q02066 Abscisic acid-inducible protein kinase Triticum aestivum (Wheat) PR
Q5GLH2 TRIB2 Tribbles homolog 2 Bos taurus (Bovine) SS
Q0VCE3 TRIB3 Tribbles homolog 3 Bos taurus (Bovine) SS
Q3SZW1 TSSK1B Testis-specific serine/threonine-protein kinase 1 Bos taurus (Bovine) PR
Q92519 TRIB2 Tribbles homolog 2 Homo sapiens (Human) SS
Q96RU7 TRIB3 Tribbles homolog 3 Homo sapiens (Human) PR
Q14680 MELK Maternal embryonic leucine zipper kinase Homo sapiens (Human) EV
Q96RU8 TRIB1 Tribbles homolog 1 Homo sapiens (Human) EV
Q15831 STK11 Serine/threonine-protein kinase STK11 Homo sapiens (Human) PR
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens (Human) EV
Q96RG2 PASK PAS domain-containing serine/threonine-protein kinase Homo sapiens (Human) EV
P54646 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens (Human) EV
Q9BXA7 TSSK1B Testis-specific serine/threonine-protein kinase 1 Homo sapiens (Human) PR
Q8K4K3 Trib2 Tribbles homolog 2 Mus musculus (Mouse) SS
Q8BRK8 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Mus musculus (Mouse) SS
Q61241 Tssk1b Testis-specific serine/threonine-protein kinase 1 Mus musculus (Mouse) PR
Q8K4K2 Trib3 Tribbles homolog 3 Mus musculus (Mouse) SS
Q61846 Melk Maternal embryonic leucine zipper kinase Mus musculus (Mouse) PR
O54863 Tssk2 Testis-specific serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q5EG47 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus (Mouse) SS
Q8K4K4 Trib1 Tribbles homolog 1 Mus musculus (Mouse) SS
Q28948 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Sus scrofa (Pig) SS
Q9WTQ6 Trib3 Tribbles homolog 3 Rattus norvegicus (Rat) SS
Q09137 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Rattus norvegicus (Rat) EV
P54645 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus (Rat) EV
Q5QNM6 CIPK13 Putative CBL-interacting protein kinase 13 Oryza sativa subsp japonica (Rice) PR
Q5JLQ9 CIPK30 CBL-interacting protein kinase 30 Oryza sativa subsp japonica (Rice) PR
Q852Q0 OSK3 Serine/threonine protein kinase OSK3 Oryza sativa subsp. japonica (Rice) SS
Q75LR7 SAPK1 Serine/threonine-protein kinase SAPK1 Oryza sativa subsp japonica (Rice) PR
Q75H77 SAPK10 Serine/threonine-protein kinase SAPK10 Oryza sativa subsp japonica (Rice) PR
Q7Y0B9 SAPK8 Serine/threonine-protein kinase SAPK8 Oryza sativa subsp japonica (Rice) PR
Q852Q2 OSK1 Serine/threonine protein kinase OSK1 Oryza sativa subsp. japonica (Rice) SS
Q6ZLP5 CIPK23 CBL-interacting protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q0D4J7 SAPK2 Serine/threonine-protein kinase SAPK2 Oryza sativa subsp japonica (Rice) PR
Q8LIG4 CIPK3 CBL-interacting protein kinase 3 Oryza sativa subsp japonica (Rice) PR
Q852Q1 OSK4 Serine/threonine protein kinase OSK4 Oryza sativa subsp. japonica (Rice) SS
Q6ERS4 CIPK16 CBL-interacting protein kinase 16 Oryza sativa subsp japonica (Rice) PR
P0C5D6 SAPK3 Serine/threonine-protein kinase SAPK3 Oryza sativa subsp japonica (Rice) PR
Q2RAX3 CIPK33 CBL-interacting protein kinase 33 Oryza sativa subsp japonica (Rice) PR
Q75V57 SAPK9 Serine/threonine-protein kinase SAPK9 Oryza sativa subsp japonica (Rice) PR
Q5N942 SAPK4 Serine/threonine-protein kinase SAPK4 Oryza sativa subsp japonica (Rice) PR
Q7XQP4 SAPK7 Serine/threonine-protein kinase SAPK7 Oryza sativa subsp japonica (Rice) PR
Q21017 kin-29 Serine/threonine-protein kinase kin-29 Caenorhabditis elegans SS
P45894 aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Caenorhabditis elegans SS
Q95ZQ4 aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans SS
Q2V452 CIPK3 CBL-interacting serine/threonine-protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
O22971 CIPK13 CBL-interacting serine/threonine-protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
O65554 CIPK6 CBL-interacting serine/threonine-protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
P43292 SRK2G Serine/threonine-protein kinase SRK2G Arabidopsis thaliana (Mouse-ear cress) PR
Q39193 SRK2I Serine/threonine-protein kinase SRK2I Arabidopsis thaliana (Mouse-ear cress) PR
Q93VD3 CIPK23 CBL-interacting serine/threonine-protein kinase 23 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CG0 CIPK21 CBL-interacting serine/threonine-protein kinase 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C958 SRK2B Serine/threonine-protein kinase SRK2B Arabidopsis thaliana (Mouse-ear cress) PR
Q9FFP9 SRK2H Serine/threonine-protein kinase SRK2H Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJ54 CIPK20 CBL-interacting serine/threonine-protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLZ3 KIN12 SNF1-related protein kinase catalytic subunit alpha KIN12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LDI3 CIPK24 CBL-interacting serine/threonine-protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9E9 SRK2C Serine/threonine-protein kinase SRK2C Arabidopsis thaliana (Mouse-ear cress) PR
P43291 SRK2A Serine/threonine-protein kinase SRK2A Arabidopsis thaliana (Mouse-ear cress) PR
Q39192 SRK2D Serine/threonine-protein kinase SRK2D Arabidopsis thaliana (Mouse-ear cress) PR
Q940H6 SRK2E Serine/threonine-protein kinase SRK2E Arabidopsis thaliana (Mouse-ear cress) PR
P92958 KIN11 SNF1-related protein kinase catalytic subunit alpha KIN11 Arabidopsis thaliana (Mouse-ear cress) PR
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MEKYEMVKDL GFGNFGLARL MRNKQTNELV AVKFIDRGYK IDENVAREII NHRALNHPNI
70 80 90 100 110 120
VRFKEVVLTP THLGIVMEYA AGGELFERIS SVGRFSEAEA RYFFQQLICG VHYLHALQIC
130 140 150 160 170 180
HRDLKLENTL LDGSPAPRLK ICDFGYSKSS VLHSNPKSTV GTPAYIAPEV FCRSEYDGKS
190 200 210 220 230 240
VDVWSCGVAL YVMLVGAYPF EDPKDPRNFR KTVQKIMAVN YKIPGYVHIS EDCRKLLSRI
250 260 270 280 290 300
FVANPLHRST LKEIKSHAWF LKNLPRELKE PAQAIYYQRN VNLINFSPQR VEEIMKIVGE
310 320 330
ARTIPNLSRP VESLGSDKKD DDEEEYLDAN DEEWYDDYA