O64782
SS
Gene name |
SD129 (LORE, At1g61380, T1F9.13) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 |
Names |
EC 2.7.12.1 , Protein LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION , S-domain-1 , SD1 receptor kinase 29 , SD1-29 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G61380 |
EC number |
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 (SD129) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of SD129.
Autoinhibitory domains (AIDs)
Accessory elements
630-637 (Activation loop from InterPro)
Target domain |
488-773 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
648-655 (Activation loop from InterPro)
Target domain |
488-773 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for O64782
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64782-F1 | Predicted | AlphaFoldDB |
58 variants for O64782
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_22649355_G_C | 16 | P>R | No | 1000Genomes | |
| tmp_1_22649319_G_T | 28 | P>H | No | 1000Genomes | |
| ENSVATH14376383 | 29 | L>F | No | 1000Genomes | |
| tmp_1_22649299_G_C | 35 | L>V | No | 1000Genomes | |
| tmp_1_22649259_C_T | 48 | S>N | No | 1000Genomes | |
| tmp_1_22649245_G_A | 53 | Q>* | No | 1000Genomes | |
| ENSVATH05023243 | 53 | Q>R | No | 1000Genomes | |
| tmp_1_22649176_C_T | 76 | D>N | No | 1000Genomes | |
| ENSVATH05023238 | 101 | Q>E | No | 1000Genomes | |
| tmp_1_22649076_T_A | 109 | K>I | No | 1000Genomes | |
| ENSVATH01423661 | 112 | T>R | No | 1000Genomes | |
| ENSVATH05023237 | 112 | T>S | No | 1000Genomes | |
| ENSVATH05023236 | 115 | K>N | No | 1000Genomes | |
| ENSVATH14376382 | 117 | H>Y | No | 1000Genomes | |
| ENSVATH13682444 | 119 | E>Q | No | 1000Genomes | |
| ENSVATH14376381 | 132 | V>I | No | 1000Genomes | |
| tmp_1_22648999_T_C | 135 | N>D | No | 1000Genomes | |
| tmp_1_22648810_A_C | 198 | S>A | No | 1000Genomes | |
| ENSVATH05023228 | 200 | P>R | No | 1000Genomes | |
| tmp_1_22648775_T_G | 209 | K>N | No | 1000Genomes | |
| ENSVATH05023223 | 259 | K>Q | No | 1000Genomes | |
| ENSVATH05023221 | 269 | N>D | No | 1000Genomes | |
| ENSVATH14376380 | 280 | P>L | No | 1000Genomes | |
| tmp_1_22648548_C_A | 285 | G>V | No | 1000Genomes | |
| tmp_1_22648498_C_T | 302 | E>K | No | 1000Genomes | |
| ENSVATH01423654 | 308 | V>I | No | 1000Genomes | |
| tmp_1_22648472_C_G | 310 | K>N | No | 1000Genomes | |
| ENSVATH01423652 | 312 | D>N | No | 1000Genomes | |
| tmp_1_22648455_C_T | 316 | G>E | No | 1000Genomes | |
| ENSVATH14376379 | 328 | T>R | No | 1000Genomes | |
| ENSVATH01423651 | 329 | K>N | No | 1000Genomes | |
| tmp_1_22648393_A_G | 337 | S>P | No | 1000Genomes | |
| tmp_1_22648390_T_C | 338 | M>V | No | 1000Genomes | |
| ENSVATH05023218 | 363 | A>V | No | 1000Genomes | |
| ENSVATH05023217 | 373 | Q>E | No | 1000Genomes | |
| ENSVATH05023215 | 411 | F>I | No | 1000Genomes | |
| ENSVATH13682440 | 418 | S>N | No | 1000Genomes | |
| ENSVATH00110591 | 438 | S>T | No | 1000Genomes | |
| ENSVATH05023207 | 441 | L>F | No | 1000Genomes | |
| tmp_1_22647968_A_G | 442 | I>T | No | 1000Genomes | |
| tmp_1_22647954_C_A | 447 | A>S | No | 1000Genomes | |
| ENSVATH13682437 | 449 | M>L | No | 1000Genomes | |
| tmp_1_22647943_C_G | 450 | L>F | No | 1000Genomes | |
| tmp_1_22647929_G_T | 455 | A>E | No | 1000Genomes | |
| ENSVATH05023204 | 459 | D>Y | No | 1000Genomes | |
| tmp_1_22647685_A_C | 461 | W>G | No | 1000Genomes | |
| ENSVATH14376376 | 489 | S>N | No | 1000Genomes | |
| ENSVATH13682432 | 570 | D>N | No | 1000Genomes | |
| ENSVATH09349365 | 648 | R>C | No | 1000Genomes | |
| ENSVATH05023175 | 715 | S>A | No | 1000Genomes | |
| tmp_1_22646549_T_C | 716 | N>D | No | 1000Genomes | |
| ENSVATH00110589 | 723 | T>S | No | 1000Genomes | |
| tmp_1_22646500_G_A | 732 | A>V | No | 1000Genomes | |
| ENSVATH01423639 | 737 | I>T | No | 1000Genomes | |
| tmp_1_22646483_C_T | 738 | G>S | No | 1000Genomes | |
| ENSVATH13682420 | 753 | L>I | No | 1000Genomes | |
| ENSVATH05023168 | 765 | L>I | No | 1000Genomes | |
| ENSVATH00110588 | 785 | Q>H | No | 1000Genomes |
No associated diseases with O64782
7 regional properties for O64782
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 488 - 773 | IPR000719 |
| domain | S-locus glycoprotein domain | 202 - 311 | IPR000858 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 491 - 686 | IPR001245 |
| domain | Bulb-type lectin domain | 20 - 170 | IPR001480 |
| domain | PAN/Apple domain | 332 - 418 | IPR003609 |
| active_site | Serine/threonine-protein kinase, active site | 609 - 621 | IPR008271 |
| domain | S-locus receptor kinase, C-terminal | 760 - 805 | IPR021820 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.1 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| pattern recognition receptor activity | Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions |
| protein tyrosine kinase activity | Catalysis of the reaction |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| detection of lipopolysaccharide | The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| lipopolysaccharide-mediated signaling pathway | The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| pattern recognition receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| recognition of pollen | A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. |
46 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LW83 | CES101 | G-type lectin S-receptor-like serine/threonine-protein kinase CES101 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB8 | At1g11330 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGMVLFACLL | LLIIFPTCGY | AAINTSSPLS | IRQTLSSPGG | FYELGFFSPN | NTQNQYVGIW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKKIVPRVVV | WVANRDTPVT | SSAANLTISS | NGSLILLDGK | QDVIWSTGKA | FTSNKCHAEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDTGNFVVID | DVSGNKLWQS | FEHLGNTMLP | QSSLMYDTSN | GKKRVLTTWK | SNSDPSPGEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLEITPQIPT | QGLIRRGSVP | YWRCGPWAKT | RFSGISGIDA | SYVSPFSVVQ | DTAAGTGSFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YSTLRNYNLS | YVTLTPEGKM | KILWDDGNNW | KLHLSLPENP | CDLYGRCGPY | GLCVRSDPPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CECLKGFVPK | SDEEWGKGNW | TSGCVRRTKL | SCQAKSSMKT | QGKDTDIFYR | MTDVKTPDLH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QFASFLNAEQ | CYQGCLGNCS | CTAFAYISGI | GCLVWNGELA | DTVQFLSSGE | FLFIRLASSE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LAGSSRRKII | VGTTVSLSIF | LILVFAAIML | WRYRAKQNDA | WKNGFERQDV | SGVNFFEMHT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRTATNNFSP | SNKLGQGGFG | PVYKGKLVDG | KEIGVKRLAS | SSGQGTEEFM | NEITLISKLQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HRNLVRLLGY | CIDGEEKLLI | YEFMVNKSLD | IFIFDPCLKF | ELDWPKRFNI | IQGIARGLLY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LHRDSRLRVI | HRDLKVSNIL | LDDRMNPKIS | DFGLARMFQG | TQYQDNTRRV | VGTLGYMSPE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YAWAGLFSEK | SDIYSFGVLM | LEIISGKRIS | RFIYGDESKG | LLAYTWDSWC | ETGGSNLLDR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DLTDTCQAFE | VARCVQIGLL | CVQHEAVDRP | NTLQVLSMLT | SATDLPVPKQ | PIFAVHTLND |
| 790 | 800 | ||||
| MPMLQANSQD | FLSVNEMTES | MIQGR |