O64774

PR
Gene name
At1g61460 (T1F9.5)
Protein name
G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G61460
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

366-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O64774

Entry ID Method Resolution Chain Position Source
AF-O64774-F1 Predicted AlphaFoldDB

180 variants for O64774

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01424119 3 I>V No 1000Genomes
tmp_1_22677178_G_T 4 T>K No 1000Genomes
tmp_1_22677176_A_T 5 F>I No 1000Genomes
ENSVATH05023841 6 F>L No 1000Genomes
tmp_1_22677167_A_T 8 S>T No 1000Genomes
ENSVATH13683116 9 L>M No 1000Genomes
ENSVATH13683114 14 N>S No 1000Genomes
ENSVATH14376775 15 T>I No 1000Genomes
tmp_1_22677142_A_C 16 I>S No 1000Genomes
tmp_1_22677130_A_C 20 F>C No 1000Genomes
ENSVATH13683113 20 F>L No 1000Genomes
tmp_1_22677118_A_G 24 I>T No 1000Genomes
tmp_1_22677116_C_T 25 A>T No 1000Genomes
tmp_1_22677113_C_T 26 G>R No 1000Genomes
tmp_1_22677109_A_T 27 I>K No 1000Genomes
ENSVATH13683112 31 S>R No 1000Genomes
ENSVATH13683111 32 P>S No 1000Genomes
tmp_1_22677091_A_G 33 L>S No 1000Genomes
ENSVATH13683110 34 S>L No 1000Genomes
tmp_1_22677080_G_T 37 Q>K No 1000Genomes
tmp_1_22677074_G_A 39 L>F No 1000Genomes
ENSVATH13683109 40 S>N No 1000Genomes
tmp_1_22677056_C_A 45 V>F No 1000Genomes
tmp_1_22677055_A_C 45 V>G No 1000Genomes
tmp_1_22677034_C_G,T 52 S>N No 1000Genomes
tmp_1_22677034_C_G,T 52 S>T No 1000Genomes
tmp_1_22676998_C_T 64 W>* No 1000Genomes
tmp_1_22676993_T_C 66 K>E No 1000Genomes
ENSVATH14376763 72 V>M No 1000Genomes
ENSVATH13683103 77 A>P No 1000Genomes
ENSVATH01424118 77 A>V No 1000Genomes
ENSVATH14376762 78 N>K No 1000Genomes
ENSVATH13683102 81 N>K No 1000Genomes
ENSVATH13683099 87 T>A No 1000Genomes
ENSVATH05023837 88 A>G No 1000Genomes
tmp_1_22676921_G_A 90 L>F No 1000Genomes
tmp_1_22676917_G_A 91 A>V No 1000Genomes
ENSVATH01424117 101 Y>F No 1000Genomes
ENSVATH13683098 106 G>S No 1000Genomes
ENSVATH01424116 108 A>T No 1000Genomes
ENSVATH01424115 108 A>V No 1000Genomes
tmp_1_22676855_C_T 112 G>S No 1000Genomes
ENSVATH05023834 131 I>S No 1000Genomes
ENSVATH13683094 132 V>F No 1000Genomes
ENSVATH05023833 134 D>N No 1000Genomes
ENSVATH13683092 149 G>D No 1000Genomes
ENSVATH13683092 149 G>V No 1000Genomes
tmp_1_22676737_G_C 151 T>S No 1000Genomes
ENSVATH05023832 165 G>C No 1000Genomes
ENSVATH05023831 166 E>Q No 1000Genomes
tmp_1_22676685_C_A 168 Q>H No 1000Genomes
tmp_1_22676679_C_G 170 L>F No 1000Genomes
ENSVATH13683088 171 T>N No 1000Genomes
tmp_1_22676659_G_A 177 T>I No 1000Genomes
ENSVATH00110659 178 N>D No 1000Genomes
tmp_1_22676651_C_A 180 A>S No 1000Genomes
tmp_1_22676650_G_A 180 A>V No 1000Genomes
tmp_1_22676648_C_A,G,T 181 V>F No 1000Genomes
tmp_1_22676648_C_A,G,T 181 V>I No 1000Genomes
tmp_1_22676648_C_A,G,T 181 V>L No 1000Genomes
ENSVATH13683087 182 G>D No 1000Genomes
ENSVATH05023830 182 G>S No 1000Genomes
tmp_1_22676615_C_T 192 V>M No 1000Genomes
tmp_1_22676584_G_A 202 S>L No 1000Genomes
tmp_1_22676567_T_C 208 S>G No 1000Genomes
ENSVATH13683086 210 P>S No 1000Genomes
ENSVATH01424107 219 L>I No 1000Genomes
ENSVATH13683085 226 S>P No 1000Genomes
tmp_1_22676405_G_C 230 L>V No 1000Genomes
ENSVATH05023825 236 S>G No 1000Genomes
tmp_1_22676354_G_T 247 P>T No 1000Genomes
ENSVATH14376761 250 S>P No 1000Genomes
ENSVATH01424105 252 D>V No 1000Genomes
ENSVATH01424106 252 D>Y No 1000Genomes
ENSVATH01424104 253 Y>* No 1000Genomes
ENSVATH13683080 258 G>R No 1000Genomes
tmp_1_22676312_C_G 261 G>R No 1000Genomes
tmp_1_22676306_A_G 263 C>R No 1000Genomes
tmp_1_22676299_T_A 265 K>M No 1000Genomes
ENSVATH13683079 270 C>Y No 1000Genomes
tmp_1_22676279_T_C 272 K>E No 1000Genomes
ENSVATH13683078 273 G>R No 1000Genomes
tmp_1_22676254_T_C 280 E>G No 1000Genomes
tmp_1_22676242_C_T 284 R>K No 1000Genomes
tmp_1_22676203_A_T 297 L>Q No 1000Genomes
tmp_1_22676201_G_T 298 H>N No 1000Genomes
ENSVATH01424100 305 K>E No 1000Genomes
ENSVATH13683077 305 K>R No 1000Genomes
ENSVATH14376759 310 F>L No 1000Genomes
tmp_1_22676155_G_A 313 P>L No 1000Genomes
ENSVATH05023823 315 A>S No 1000Genomes
ENSVATH05023823 315 A>T No 1000Genomes
ENSVATH01424099 321 D>N No 1000Genomes
ENSVATH01424098 327 S>I No 1000Genomes
tmp_1_22676089_T_A 335 Y>F No 1000Genomes
tmp_1_22676083_A_T 337 I>N No 1000Genomes
tmp_1_22676075_G_C,A 340 H>D No 1000Genomes
tmp_1_22676075_G_C,A 340 H>Y No 1000Genomes
tmp_1_22676052_A_T 347 F>L No 1000Genomes
ENSVATH14376758 348 S>F No 1000Genomes
ENSVATH05023822 352 G>* No 1000Genomes
ENSVATH13683075 352 G>E No 1000Genomes
tmp_1_22676018_T_C 359 N>D No 1000Genomes
ENSVATH05023821 361 D>E No 1000Genomes
ENSVATH00110656 362 F>V No 1000Genomes
ENSVATH01424096 369 S>T No 1000Genomes
ENSVATH13683070 370 A>S No 1000Genomes
tmp_1_22675954_G_A 380 A>V No 1000Genomes
ENSVATH13683069 384 L>I No 1000Genomes
tmp_1_22675778_C_G 396 S>T No 1000Genomes
tmp_1_22675752_T_C 405 I>V No 1000Genomes
ENSVATH14376757 415 R>I No 1000Genomes
tmp_1_22675712_A_C 418 V>G No 1000Genomes
ENSVATH13683058 422 A>V No 1000Genomes
tmp_1_22675583_G_A 427 P>L No 1000Genomes
tmp_1_22675554_A_T 437 S>T No 1000Genomes
tmp_1_22675547_G_A 439 S>L No 1000Genomes
tmp_1_22675540_C_G 441 L>F No 1000Genomes
ENSVATH01424090 443 E>K No 1000Genomes
ENSVATH14376755 449 T>P No 1000Genomes
ENSVATH05023817 454 F>L No 1000Genomes
tmp_1_22675489_A_C 458 N>K No 1000Genomes
ENSVATH01424089 460 L>M No 1000Genomes
ENSVATH13683055 462 Q>* No 1000Genomes
ENSVATH05023813 470 K>N No 1000Genomes
tmp_1_22675337_GT_AT,TT,G 483 R>W No 1000Genomes
tmp_1_22675315_T_C,A 490 Q>L No 1000Genomes
tmp_1_22675315_T_C,A 490 Q>R No 1000Genomes
tmp_1_22675313_C_T 491 G>S No 1000Genomes
ENSVATH01424083 504 K>T No 1000Genomes
tmp_1_22675263_G_T 507 H>Q No 1000Genomes
tmp_1_22675249_C_A 512 R>L No 1000Genomes
tmp_1_22675236_A_C 516 C>W No 1000Genomes
ENSVATH13683047 530 M>L No 1000Genomes
tmp_1_22675186_T_C 533 K>R No 1000Genomes
tmp_1_22675163_C_T 541 D>N No 1000Genomes
ENSVATH01424079 542 S>T No 1000Genomes
tmp_1_22675058_C_G 543 R>T No 1000Genomes
tmp_1_22675052_C_A 545 R>M No 1000Genomes
ENSVATH14376749 546 L>F No 1000Genomes
ENSVATH13683046 551 P>L No 1000Genomes
ENSVATH01424078 554 F>L No 1000Genomes
tmp_1_22675026_A_C 554 F>V No 1000Genomes
ENSVATH01424077 555 D>N No 1000Genomes
tmp_1_22674998_C_T 563 G>E No 1000Genomes
tmp_1_22674980_C_A 569 R>L No 1000Genomes
tmp_1_22674954_G_A 578 R>C No 1000Genomes
ENSVATH05023805 584 N>K No 1000Genomes
ENSVATH14376748 586 L>R No 1000Genomes
tmp_1_22674920_T_C 589 E>G No 1000Genomes
ENSVATH13683044 591 M>L No 1000Genomes
ENSVATH05023803 594 K>M No 1000Genomes
ENSVATH01424076 616 V>I No 1000Genomes
tmp_1_22674729_T_C 623 M>V No 1000Genomes
ENSVATH01424072 627 D>Y No 1000Genomes
tmp_1_22674683_G_T 638 S>* No 1000Genomes
tmp_1_22674681_T_A 639 R>* No 1000Genomes
tmp_1_22674660_C_A 646 E>* No 1000Genomes
ENSVATH01424068 655 E>D No 1000Genomes
tmp_1_22674548_C_G 657 W>S No 1000Genomes
ENSVATH01424067 658 C>S No 1000Genomes
ENSVATH13683019 658 C>W No 1000Genomes
ENSVATH13683018 669 D>N No 1000Genomes
ENSVATH05023796 676 P>S No 1000Genomes
tmp_1_22674476_C_A 681 R>I No 1000Genomes
tmp_1_22674473_C_T 682 C>Y No 1000Genomes
ENSVATH13683016 683 I>M No 1000Genomes
ENSVATH13683017 683 I>V No 1000Genomes
tmp_1_22674447_G_A 691 Q>* No 1000Genomes
tmp_1_22674425_G_A 698 P>L No 1000Genomes
ENSVATH13683012 704 M>L No 1000Genomes
tmp_1_22674382_A_T 712 D>E No 1000Genomes
ENSVATH01424065 719 P>S No 1000Genomes
ENSVATH05023793 728 D>N No 1000Genomes
tmp_1_22674331_T_G 729 E>D No 1000Genomes
tmp_1_22674333_C_T 729 E>K No 1000Genomes
tmp_1_22674330_ATTCG_TTTCG,A 730 S>T No 1000Genomes
tmp_1_22674323_G_C 732 S>C No 1000Genomes
tmp_1_22674312_T_G 736 I>L No 1000Genomes
ENSVATH13683008 743 K>T No 1000Genomes

No associated diseases with O64774

10 regional properties for O64774

Type Name Position InterPro Accession
domain PB1 domain 350 - 428 IPR000270
repeat Tetratricopeptide repeat 1 71 - 99 IPR001440
domain SH3 domain 240 - 299 IPR001452-1
domain SH3 domain 456 - 515 IPR001452-2
repeat Tetratricopeptide repeat 37 - 70 IPR019734-1
repeat Tetratricopeptide repeat 71 - 104 IPR019734-2
repeat Tetratricopeptide repeat 121 - 154 IPR019734-3
domain Neutrophil cytosol factor 2, PB1 domain 350 - 428 IPR034885
domain Neutrophil cytosol factor 2, SH3 domain 460 - 511 IPR034889
domain Neutrophil cytosol factor 2, SH3 domain 1 244 - 297 IPR035546

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

3 GO annotations of biological process

Name Definition
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein phosphorylation The process of introducing a phosphate group on to a protein.
recognition of pollen A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma.

46 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06805 TIE1 Tyrosine-protein kinase receptor Tie-1 Bos taurus (Bovine) PR
Q06807 TEK Angiopoietin-1 receptor Bos taurus (Bovine) SS
P43481 KIT Mast/stem cell growth factor receptor Kit Bos taurus (Bovine) SS
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
P09208 InR Insulin-like receptor Drosophila melanogaster (Fruit fly) SS
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 Homo sapiens (Human) PR
Q02763 TEK Angiopoietin-1 receptor Homo sapiens (Human) SS
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P06213 INSR Insulin receptor Homo sapiens (Human) EV
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens (Human) EV
Q01973 ROR1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Homo sapiens (Human) PR
Q01974 ROR2 Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens (Human) EV
P30530 AXL Tyrosine-protein kinase receptor UFO Homo sapiens (Human) PR
Q02858 Tek Angiopoietin-1 receptor Mus musculus (Mouse) SS
Q60751 Igf1r Insulin-like growth factor 1 receptor Mus musculus (Mouse) SS
Q06806 Tie1 Tyrosine-protein kinase receptor Tie-1 Mus musculus (Mouse) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
P15208 Insr Insulin receptor Mus musculus (Mouse) SS
Q9Z139 Ror1 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Mus musculus (Mouse) PR
Q9Z138 Ror2 Tyrosine-protein kinase transmembrane receptor ROR2 Mus musculus (Mouse) SS
P15209 Ntrk2 BDNF/NT-3 growth factors receptor Mus musculus (Mouse) SS
Q6VNS1 Ntrk3 NT-3 growth factor receptor Mus musculus (Mouse) SS
P24062 Igf1r Insulin-like growth factor 1 receptor Rattus norvegicus (Rat) SS
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
Q62838 Musk Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus (Rat) SS
P57097 Mertk Tyrosine-protein kinase Mer Rattus norvegicus (Rat) SS
P15127 Insr Insulin receptor Rattus norvegicus (Rat) SS
O64783 At1g61370 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 Arabidopsis thaliana (Mouse-ear cress) SS
O64780 At1g61400 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 Arabidopsis thaliana (Mouse-ear cress) SS
O64770 At1g61490 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 Arabidopsis thaliana (Mouse-ear cress) SS
O64776 At1g61440 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SYA0 At1g61500 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SY95 At1g61550 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 Arabidopsis thaliana (Mouse-ear cress) SS
O64778 At1g61420 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 Arabidopsis thaliana (Mouse-ear cress) SS
O64782 SD129 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 Arabidopsis thaliana (Mouse-ear cress) SS
O81833 SD11 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB5 At1g11303 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LW83 CES101 G-type lectin S-receptor-like serine/threonine-protein kinase CES101 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDQ3 CRK34 Cysteine-rich receptor-like protein kinase 34 Arabidopsis thaliana (Mouse-ear cress) PR
O64784 At1g61360 G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SXB8 At1g11330 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 Arabidopsis thaliana (Mouse-ear cress) PR
O64793 At1g67520 G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 Arabidopsis thaliana (Mouse-ear cress) PR
O73791 tek Angiopoietin-1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MRITFFASLL LFTNTIFISF SFAIAGINKE SPLSIGQTLS SSNGVYELGF FSFNNSENHY
70 80 90 100 110 120
LGIWFKGIIP RVVVWVANRE NPVTDSTANL AISSNASLLL YNGKHGVAWS SGETLASNGS
130 140 150 160 170 180
RAELSDTGNL IVIDNFSGRT LWQSFDHLGD TMLPFSALMY NLATGEKQVL TSWKSYTNPA
190 200 210 220 230 240
VGDFVLQITT QVPTQALTMR GSKPYWRSGP WAKTRNFKLP RIVITSKGSL EISRHSGTDW
250 260 270 280 290 300
VLNFVAPAHS CDYYGVCGPF GICVKSVCKC FKGFIPKYIE EWKRGNWTDG CVRRTKLHCQ
310 320 330 340 350 360
ENSTKKDANF FHPVANIKPP DFYEFASAVD AEGCYKICLH NCSCLAFSYI HGIGCLIWNQ
370 380 390 400 410 420
DFMDTVQFSA GGEILSIRLA RSELGGNKRK KTITASIVSL SLFLILGSTA FGFWRYRVKH
430 440 450 460 470 480
NASQDAPKYD LEPQDVSGSY LFEMNTIQTA TNNFSLSNKL GQGGFGSVYK GKLQDGKEIA
490 500 510 520 530 540
VKRLSSSSGQ GKEEFMNEIV LISKLQHKNL VRILGCCIEG EERLLIYEFM LNKSLDTFLF
550 560 570 580 590 600
DSRKRLEIDW PKRFDIIQGI ARGIHYLHRD SCLKVIHRDL KVSNILLDEK MNPKISDFGL
610 620 630 640 650 660
ARMYQGTEYQ DNTRRVVGTL GYMSPEDILE IISGEKISRF SYGKEEKTLI AYAWESWCET
670 680 690 700 710 720
GGVDLLDKDV ADSCRPLEVE RCIQIGLLCV QHQPADRPNT LELMSMLTTT SDLPSPKQPT
730 740
FVVHWRDDES SSKDLITVNE MTKSVILGR