O64682
Gene name |
PID (ABR, At2g34650, T31E10.1) |
Protein name |
Protein kinase PINOID |
Names |
Protein kinase ABRUPTUS |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G34650 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
222-239 (Activation loop from InterPro)
Target domain |
75-394 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
288-296 (Activation loop from InterPro)
Target domain |
75-394 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O64682
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64682-F1 | Predicted | AlphaFoldDB |
24 variants for O64682
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_14591540_G_C | 6 | D>E | No | 1000Genomes | |
| ENSVATH00259894 | 29 | S>N | No | 1000Genomes | |
| tmp_2_14591449_G_T | 37 | P>T | No | 1000Genomes | |
| ENSVATH05655821 | 45 | S>G | No | 1000Genomes | |
| tmp_2_14591380_C_T | 60 | A>T | No | 1000Genomes | |
| tmp_2_14591346_G_C | 71 | T>S | No | 1000Genomes | |
| tmp_2_14591266_C_T | 98 | E>K | No | 1000Genomes | |
| tmp_2_14591262_T_C | 99 | E>G | No | 1000Genomes | |
| ENSVATH14584862 | 163 | G>S | No | 1000Genomes | |
| tmp_2_14591065_A_C | 165 | L>V | No | 1000Genomes | |
| ENSVATH00259893 | 166 | H>Y | No | 1000Genomes | |
| ENSVATH13529994 | 224 | F>Y | No | 1000Genomes | |
| tmp_2_14590520_T_G | 244 | E>A | No | 1000Genomes | |
| tmp_2_14590473_G_A | 260 | L>F | No | 1000Genomes | |
| tmp_2_14590454_C_T | 266 | R>Q | No | 1000Genomes | |
| ENSVATH05655813 | 322 | Y>F | No | 1000Genomes | |
| ENSVATH05655812 | 324 | M>I | No | 1000Genomes | |
| tmp_2_14590281_T_G | 324 | M>L | No | 1000Genomes | |
| ENSVATH01947993 | 325 | I>M | No | 1000Genomes | |
| ENSVATH05655810 | 363 | A>S | No | 1000Genomes | |
| tmp_2_14590064_C_T | 396 | G>D | No | 1000Genomes | |
| ENSVATH00259892 | 399 | F>L | No | 1000Genomes | |
| tmp_2_14590007_A_G | 415 | V>A | No | 1000Genomes | |
| tmp_2_14589993_T_G | 420 | K>Q | No | 1000Genomes |
No associated diseases with O64682
No regional properties for O64682
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O64682 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin polar transport | The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. |
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| cotyledon development | The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. |
| phyllome development | The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants. |
| positive gravitropism | The orientation of plant parts towards gravity. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
| root hair elongation | The process in which the root hair grows longer. |
| root hair initiation | The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P83099 | Pkcdelta | Putative protein kinase C delta type homolog | Drosophila melanogaster (Fruit fly) | PR |
| P05130 | Pkc53E | Protein kinase C, brain isozyme | Drosophila melanogaster (Fruit fly) | SS |
| P13677 | inaC | Protein kinase C, eye isozyme | Drosophila melanogaster (Fruit fly) | SS |
| Q8INB9 | Akt | RAC serine/threonine-protein kinase | Drosophila melanogaster (Fruit fly) | SS |
| Q9HBY8 | SGK2 | Serine/threonine-protein kinase Sgk2 | Homo sapiens (Human) | SS |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| O00141 | SGK1 | Serine/threonine-protein kinase Sgk1 | Homo sapiens (Human) | PR |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| Q94E49 | PID2 | Protein kinase PINOID 2 | Oryza sativa subsp japonica (Rice) | PR |
| Q0DCT8 | Os06g0291600 | Protein kinase G11A | Oryza sativa subsp japonica (Rice) | PR |
| Q9LUL2 | WAG2 | Serine/threonine-protein kinase WAG2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUA3 | D6PKL1 | Serine/threonine-protein kinase D6PKL1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48963 | PHOT1 | Phototropin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRESDGEMS | LGTTNSPISS | GTESCSSFSR | LSFDAPPSTI | PEEESFLSLK | PHRSSDFAYA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIRRRKKQGL | TFRDFRLMRR | IGAGDIGTVY | LCRLAGDEEE | SRSSYFAMKV | VDKEALALKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KMHRAEMEKT | ILKMLDHPFL | PTLYAEFEAS | HFSCIVMEYC | SGGDLHSLRH | RQPHRRFSLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SARFYAAEVL | VALEYLHMLG | IIYRDLKPEN | ILVRSDGHIM | LSDFDLSLCS | DSIAAVESSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSPENQQLRS | PRRFTRLARL | FQRVLRSKKV | QTLEPTRLFV | AEPVTARSGS | FVGTHEYVAP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVASGGSHGN | AVDWWAFGVF | LYEMIYGKTP | FVAPTNDVIL | RNIVKRQLSF | PTDSPATMFE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LHARNLISGL | LNKDPTKRLG | SRRGAAEVKV | HPFFKGLNFA | LIRTLTPPEI | PSSVVKKPMK |
| 430 | |||||
| SATFSGRSSN | KPAAFDYF |