O64556
Gene name |
At2g19230 (F27F23.3) |
Protein name |
Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G19230 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
709-716 (Activation loop from InterPro)
Target domain |
569-842 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
727-734 (Activation loop from InterPro)
Target domain |
569-842 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O64556
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64556-F1 | Predicted | AlphaFoldDB |
70 variants for O64556
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_8348244_T_C | 33 | I>V | No | 1000Genomes | |
| tmp_2_8348236_A_C | 35 | C>W | No | 1000Genomes | |
| ENSVATH05532398 | 51 | K>I | No | 1000Genomes | |
| tmp_2_8348133_T_A | 70 | K>* | No | 1000Genomes | |
| tmp_2_8348120_T_G | 74 | K>T | No | 1000Genomes | |
| ENSVATH01843428 | 82 | K>* | No | 1000Genomes | |
| ENSVATH00238369 | 91 | K>R | No | 1000Genomes | |
| ENSVATH13277999 | 102 | K>* | No | 1000Genomes | |
| ENSVATH13277999 | 102 | K>E | No | 1000Genomes | |
| tmp_2_8348031_A_G | 104 | F>L | No | 1000Genomes | |
| ENSVATH01843427 | 123 | A>T | No | 1000Genomes | |
| ENSVATH00238368 | 148 | T>S | No | 1000Genomes | |
| tmp_2_8347857_C_G | 162 | V>L | No | 1000Genomes | |
| tmp_2_8347784_A_T | 186 | I>K | No | 1000Genomes | |
| ENSVATH05532395 | 186 | I>L | No | 1000Genomes | |
| tmp_2_8347756_C_T | 195 | M>I | No | 1000Genomes | |
| ENSVATH13277998 | 206 | G>R | No | 1000Genomes | |
| ENSVATH13277997 | 216 | I>T | No | 1000Genomes | |
| ENSVATH00238365 | 220 | F>L | No | 1000Genomes | |
| ENSVATH13277995 | 227 | P>T | No | 1000Genomes | |
| ENSVATH00238363 | 228 | N>D | No | 1000Genomes | |
| ENSVATH01843424 | 240 | P>L | No | 1000Genomes | |
| ENSVATH05532394 | 244 | N>S | No | 1000Genomes | |
| ENSVATH05532392 | 266 | Q>E | No | 1000Genomes | |
| ENSVATH05532391 | 270 | Y>F | No | 1000Genomes | |
| tmp_2_8347450_G_C | 274 | R>G | No | 1000Genomes | |
| ENSVATH13277972 | 275 | D>N | No | 1000Genomes | |
| ENSVATH00238361 | 276 | P>T | No | 1000Genomes | |
| ENSVATH00238360 | 277 | N>S | No | 1000Genomes | |
| tmp_2_8347412_A_C | 286 | F>L | No | 1000Genomes | |
| ENSVATH01843423 | 332 | S>R | No | 1000Genomes | |
| tmp_2_8347266_A_C | 335 | F>C | No | 1000Genomes | |
| ENSVATH01843422 | 344 | V>F | No | 1000Genomes | |
| tmp_2_8347235_C_A | 345 | K>N | No | 1000Genomes | |
| ENSVATH00238359 | 352 | M>I | No | 1000Genomes | |
| tmp_2_8347204_C_T | 356 | E>K | No | 1000Genomes | |
| ENSVATH13277968 | 359 | R>H | No | 1000Genomes | |
| ENSVATH05532389 | 370 | Q>R | No | 1000Genomes | |
| ENSVATH05532388 | 433 | V>A | No | 1000Genomes | |
| ENSVATH05532385 | 447 | N>D | No | 1000Genomes | |
| tmp_2_8346670_G_A | 451 | T>I | No | 1000Genomes | |
| ENSVATH05532382 | 471 | E>K | No | 1000Genomes | |
| ENSVATH05532378 | 503 | V>M | No | 1000Genomes | |
| ENSVATH05532377 | 508 | R>* | No | 1000Genomes | |
| ENSVATH05532376 | 511 | K>R | No | 1000Genomes | |
| tmp_2_8346284_T_G | 513 | E>A | No | 1000Genomes | |
| tmp_2_8346272_T_G | 517 | Y>S | No | 1000Genomes | |
| ENSVATH01843417 | 537 | S>Y | No | 1000Genomes | |
| tmp_2_8346094_C_T | 548 | V>I | No | 1000Genomes | |
| tmp_2_8346082_G_A | 552 | P>S | No | 1000Genomes | |
| ENSVATH05532372 | 562 | S>* | No | 1000Genomes | |
| ENSVATH05532371 | 566 | E>K | No | 1000Genomes | |
| tmp_2_8345593_C_G | 659 | S>T | No | 1000Genomes | |
| tmp_2_8345577_C_A | 664 | E>D | No | 1000Genomes | |
| ENSVATH05532366 | 695 | P>S | No | 1000Genomes | |
| tmp_2_8345371_C_G | 705 | Q>H | No | 1000Genomes | |
| ENSVATH05532365 | 739 | E>G | No | 1000Genomes | |
| ENSVATH01843415 | 741 | Y>* | No | 1000Genomes | |
| tmp_2_8345151_C_T | 748 | E>K | No | 1000Genomes | |
| ENSVATH01843414 | 778 | R>I | No | 1000Genomes | |
| ENSVATH05532363 | 798 | D>E | No | 1000Genomes | |
| tmp_2_8344965_C_T | 810 | A>T | No | 1000Genomes | |
| ENSVATH01843413 | 819 | A>T | No | 1000Genomes | |
| ENSVATH05532362 | 836 | A>P | No | 1000Genomes | |
| ENSVATH00238346 | 847 | T>S | No | 1000Genomes | |
| tmp_2_8344845_C_T | 850 | D>N | No | 1000Genomes | |
| tmp_2_8344839_C_G | 852 | G>R | No | 1000Genomes | |
| ENSVATH01843412 | 870 | P>L | No | 1000Genomes | |
| tmp_2_8344785_G_A | 870 | P>S | No | 1000Genomes | |
| ENSVATH05532361 | 876 | P>A | No | 1000Genomes |
No associated diseases with O64556
5 regional properties for O64556
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 569 - 842 | IPR000719 |
| repeat | Leucine-rich repeat | 418 - 474 | IPR001611 |
| active_site | Serine/threonine-protein kinase, active site | 688 - 700 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 575 - 596 | IPR017441 |
| domain | Malectin-like domain | 33 - 359 | IPR024788 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P20594 | NPR2 | Atrial natriuretic peptide receptor 2 | Homo sapiens (Human) | PR |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P24786 | NTRK3 | NT-3 growth factor receptor | Sus scrofa (Pig) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNFNFLPLV | SFASFVVVLV | LVCAQDQSGF | VSIDCGIPED | SSYYDEKTDI | KYISDAAFVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGTIHSIDSK | FQKKNLEKQF | QKVRSFPEGK | KNCYDVQPPQ | GKGFKYLIRT | RFMYGNYDNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKAPDFDLYL | GVNLWDSVTL | ENSTTIVTKE | IIYTLRSDKV | HVCLVDKERG | TPFLSVLELR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLKNNIYETA | SDSLMLYRRW | DLGATGDLPA | RYKDDIFDRF | WMPLMFPNFL | ILNTSLMIDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSSNGFLPPS | VVMSTAVAPM | NSSIEQIMVY | WEPRDPNWKF | YIYIHFAEVE | KLPSNETREF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVFLNKEQID | TTSVFRPSYL | YTDTLYVQNP | VSGPFLEFVL | RQGVKSTRPP | IMNAIETYRT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NEFLDLPTDQ | NDVDAIMKIK | TKYKVKKNWL | GDPCAPFGYP | WQGINCSYTA | NNPPRIISVN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSFSGLTGQI | DPVFITLTPL | QKLDLSNNRL | TGTVPDFLAN | LPDLTELNLE | ENKLTGILPE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLLERSKDGS | LSLRVGGNPD | LCVSDSCRNK | KTERKEYIIP | SVASVTGLFF | LLLALISFWQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FKKRQQSVKT | GPLDTKRYYK | YSEIVEITNN | FERVLGQGGF | GKVYYGVLRG | EQVAIKMLSK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSAQGYKEFR | AEVELLLRVH | HKNLIALIGY | CHEGDQMALI | YEYIGNGTLG | DYLSGKNSSI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LSWEERLQIS | LDAAQGLEYL | HNGCKPPIVH | RDVKPTNILI | NEKLQAKIAD | FGLSRSFTLE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GDSQVSTEVA | GTIGYLDPEH | YSMQQFSEKS | DVYSFGVVLL | EVITGQPVIS | RSRTEENRHI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SDRVSLMLSK | GDIKSIVDPK | LGERFNAGLA | WKITEVALAC | ASESTKTRLT | MSQVVAELKE |
| 850 | 860 | 870 | |||
| SLCRARTSGD | SGDISFSEPT | EMNVSMTVDP | GVLPQPR |