O64477
SS
Gene name |
At2g19130 (T20K24.15) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 |
Names |
EC 2.7.11.1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G19130 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 (At2g19130) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of At2g19130.
Autoinhibitory domains (AIDs)
Accessory elements
636-643 (Activation loop from InterPro)
Target domain |
493-770 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
654-660 (Activation loop from InterPro)
Target domain |
493-770 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for O64477
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64477-F1 | Predicted | AlphaFoldDB |
81 variants for O64477
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01842318 | 2 | V>D | No | 1000Genomes | |
| ENSVATH01842319 | 6 | T>N | No | 1000Genomes | |
| ENSVATH01842321 | 8 | T>S | No | 1000Genomes | |
| ENSVATH14519280 | 10 | F>Y | No | 1000Genomes | |
| ENSVATH01842323 | 13 | I>L | No | 1000Genomes | |
| ENSVATH05531111 | 26 | I>M | No | 1000Genomes | |
| tmp_2_8293880_C_T | 31 | T>I | No | 1000Genomes | |
| tmp_2_8293879_A_T | 31 | T>S | No | 1000Genomes | |
| tmp_2_8293896_G_T | 36 | Q>H | No | 1000Genomes | |
| ENSVATH01842324 | 38 | I>F | No | 1000Genomes | |
| ENSVATH05531112 | 39 | V>A | No | 1000Genomes | |
| ENSVATH00238095 | 42 | D>N | No | 1000Genomes | |
| ENSVATH05531113 | 52 | P>S | No | 1000Genomes | |
| tmp_2_8293972_A_G | 62 | M>V | No | 1000Genomes | |
| tmp_2_8294042_A_T | 85 | N>I | No | 1000Genomes | |
| ENSVATH05531114 | 103 | Y>F | No | 1000Genomes | |
| ENSVATH00238096 | 103 | Y>N | No | 1000Genomes | |
| ENSVATH01842326 | 106 | P>S | No | 1000Genomes | |
| ENSVATH14519282 | 133 | L>F | No | 1000Genomes | |
| ENSVATH00238097 | 140 | L>S | No | 1000Genomes | |
| tmp_2_8294222_T_C | 145 | L>S | No | 1000Genomes | |
| tmp_2_8294324_G_A | 179 | S>N | No | 1000Genomes | |
| ENSVATH01842329 | 229 | L>R | No | 1000Genomes | |
| tmp_2_8294500_T_C | 238 | F>L | No | 1000Genomes | |
| ENSVATH01842333 | 250 | I>L | No | 1000Genomes | |
| ENSVATH14519283 | 275 | G>R | No | 1000Genomes | |
| ENSVATH01842337 | 304 | D>E | No | 1000Genomes | |
| ENSVATH01842338 | 307 | E>Q | No | 1000Genomes | |
| tmp_2_8294710_C_T | 308 | P>S | No | 1000Genomes | |
| ENSVATH09471066 | 311 | R>H | No | 1000Genomes | |
| ENSVATH05531120 | 320 | S>L | No | 1000Genomes | |
| ENSVATH00238105 | 351 | R>P | No | 1000Genomes | |
| ENSVATH01842339 | 355 | M>T | No | 1000Genomes | |
| ENSVATH00238106 | 359 | D>Y | No | 1000Genomes | |
| ENSVATH13275468 | 368 | S>R | No | 1000Genomes | |
| ENSVATH13275469 | 388 | D>G | No | 1000Genomes | |
| tmp_2_8294959_T_C | 391 | S>P | No | 1000Genomes | |
| ENSVATH00238107 | 392 | S>N | No | 1000Genomes | |
| ENSVATH01842342 | 398 | S>A | No | 1000Genomes | |
| ENSVATH05531122 | 402 | L>S | No | 1000Genomes | |
| ENSVATH01842345 | 406 | Q>H | No | 1000Genomes | |
| tmp_2_8295007_C_T | 407 | L>F | No | 1000Genomes | |
| ENSVATH01842346 | 409 | D>A | No | 1000Genomes | |
| ENSVATH01842347 | 410 | E>D | No | 1000Genomes | |
| ENSVATH05531123 | 410 | E>G | No | 1000Genomes | |
| ENSVATH14519295 | 412 | S>N | No | 1000Genomes | |
| ENSVATH01842348 | 416 | I>T | No | 1000Genomes | |
| ENSVATH01842349 | 426 | V>I | No | 1000Genomes | |
| ENSVATH01842350 | 428 | N>D | No | 1000Genomes | |
| ENSVATH13275470 | 454 | L>I | No | 1000Genomes | |
| tmp_2_8295163_G_A | 459 | V>I | No | 1000Genomes | |
| tmp_2_8295173_T_C | 462 | I>T | No | 1000Genomes | |
| ENSVATH01842351 | 470 | R>K | No | 1000Genomes | |
| ENSVATH01842352 | 471 | M>V | No | 1000Genomes | |
| tmp_2_8295217_G_A | 477 | D>N | No | 1000Genomes | |
| tmp_2_8295241_T_A | 485 | Y>N | No | 1000Genomes | |
| ENSVATH00238110 | 497 | D>E | No | 1000Genomes | |
| tmp_2_8295392_C_T | 535 | T>M | No | 1000Genomes | |
| tmp_2_8295443_G_A | 552 | R>H | No | 1000Genomes | |
| ENSVATH13275473 | 553 | G>A | No | 1000Genomes | |
| ENSVATH05531124 | 571 | G>R | No | 1000Genomes | |
| ENSVATH01842361 | 579 | L>F | No | 1000Genomes | |
| ENSVATH05531125 | 584 | E>V | No | 1000Genomes | |
| tmp_2_8295550_C_A | 588 | L>I | No | 1000Genomes | |
| tmp_2_8295553_G_A | 589 | G>R | No | 1000Genomes | |
| ENSVATH13275474 | 597 | A>V | No | 1000Genomes | |
| tmp_2_8295885_G_C | 699 | E>D | No | 1000Genomes | |
| ENSVATH14519296 | 703 | V>G | No | 1000Genomes | |
| tmp_2_8295935_A_T | 716 | K>I | No | 1000Genomes | |
| ENSVATH00238111 | 717 | D>G | No | 1000Genomes | |
| ENSVATH14519297 | 725 | D>A | No | 1000Genomes | |
| ENSVATH01842367 | 738 | V>F | No | 1000Genomes | |
| ENSVATH14519298 | 753 | E>D | No | 1000Genomes | |
| ENSVATH13275536 | 754 | S>G | No | 1000Genomes | |
| ENSVATH00238113 | 773 | N>K | No | 1000Genomes | |
| ENSVATH05531129 | 787 | S>F | No | 1000Genomes | |
| tmp_2_8296158_C_G | 790 | D>E | No | 1000Genomes | |
| ENSVATH05531131 | 822 | T>I | No | 1000Genomes | |
| tmp_2_8296257_C_A,CGAT | 823 | N>K | No | 1000Genomes | |
| tmp_2_8296262_A_T | 825 | N>I | No | 1000Genomes | |
| ENSVATH07883466 | 827 | S>Y | No | 1000Genomes |
No associated diseases with O64477
6 regional properties for O64477
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 493 - 770 | IPR000719 |
| domain | S-locus glycoprotein domain | 209 - 319 | IPR000858 |
| domain | Bulb-type lectin domain | 23 - 178 | IPR001480 |
| domain | PAN/Apple domain | 341 - 422 | IPR003609 |
| active_site | Serine/threonine-protein kinase, active site | 615 - 627 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 499 - 521 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| recognition of pollen | A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. |
54 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN94 | At5g59670 | Receptor-like protein kinase At5g59670 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGG3 | At1g51820 | Probable LRR receptor-like serine/threonine-protein kinase At1g51820 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN93 | At5g59680 | Probable LRR receptor-like serine/threonine-protein kinase At5g59680 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SNA3 | At3g46340 | Putative receptor-like protein kinase At3g46340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9ZQR3 | At2g14510 | Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LIG2 | At3g21340 | Receptor-like protein kinase At3g21340 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGW2 | PAM74 | Probable LRR receptor-like serine/threonine-protein kinase PAM74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39203 | SD22 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSFLTLTSF | FFICFFIHGS | SAVDTISGDF | TLSGDQTIVS | SDGTYEMGFF | KPGSSSNFYI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GMWYKQLSQT | ILWVANRDKA | VSDKNSSVFK | ISNGNLILLD | GNYQTPVWST | GLNSTSSVSA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEAVLQDDGN | LVLRTGGSSL | SANVLWQSFD | HPGDTWLPGV | KIRLDKRTGK | SQRLTSWKSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDPSPGLFSL | ELDESTAYKI | LWNGSNEYWS | SGPWNPQSRI | FDSVPEMRLN | YIYNFSFFSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TTDSYFTYSI | YNQLNVSRFV | MDVSGQIKQF | TWLEGNKAWN | LFWSQPRQQC | QVYRYCGSFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICSDKSEPFC | RCPQGFRPMS | QKDWDLKDYS | AGCVRKTELQ | CSRGDINQFF | RLPNMKLADN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEVLTRTSLS | ICASACQGDC | SCKAYAYDEG | SSKCLVWSKD | VLNLQQLEDE | NSEGNIFYLR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LAASDVPNVG | ASGKSNNKGL | IFGAVLGSLG | VIVLVLLVVI | LILRYRRRKR | MRGEKGDGTL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SAFSYRELQN | ATKNFSDKLG | GGGFGSVFKG | ALPDSSDIAV | KRLEGISQGE | KQFRTEVVTI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTIQHVNLVR | LRGFCSEGSK | KLLVYDYMPN | GSLDSHLFLN | QVEEKIVLGW | KLRFQIALGT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ARGLAYLHDE | CRDCIIHCDI | KPENILLDSQ | FCPKVADFGL | AKLVGRDFSR | VLTTMRGTRG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YLAPEWISGV | AITAKADVYS | YGMMLFELVS | GRRNTEQSEN | EKVRFFPSWA | ATILTKDGDI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RSLVDPRLEG | DAVDIEEVTR | ACKVACWCIQ | DEESHRPAMS | QVVQILEGVL | EVNPPPFPRS |
| 790 | 800 | 810 | 820 | ||
| IQALVVSDED | VVFFTESSSS | SSHNSSQNHK | HSSSSSSSKK | MTNDNSSA |