O62846

PR
Gene name
PRKACG
Protein name
cAMP-dependent protein kinase catalytic subunit gamma
Names
PKA C-gamma
Species
Macaca mulatta (Rhesus macaque)
KEGG Pathway
EC number
2.7.11.11: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O62846

Entry ID Method Resolution Chain Position Source
AF-O62846-F1 Predicted AlphaFoldDB

No variants for O62846

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O62846

No associated diseases with O62846

3 regional properties for O62846

Type Name Position InterPro Accession
domain Protein kinase domain 43 - 209 IPR000719
active_site Serine/threonine-protein kinase, active site 162 - 174 IPR008271
binding_site Protein kinase, ATP binding site 49 - 72 IPR017441

Functions

Description
EC Number 2.7.11.11 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cAMP-dependent protein kinase activity cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P00517 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Bos taurus (Bovine) PR
P16911 Pka-C2 cAMP-dependent protein kinase catalytic subunit 2 Drosophila melanogaster (Fruit fly) PR
Q03043 for cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B Drosophila melanogaster (Fruit fly) SS
P17612 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens (Human) PR
P05132 Prkaca cAMP-dependent protein kinase catalytic subunit alpha Mus musculus (Mouse) PR
Q922R0 Prkx cAMP-dependent protein kinase catalytic subunit PRKX Mus musculus (Mouse) PR
P36887 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Sus scrofa (Pig) PR
Q7JP68 F47F2.1 cAMP-dependent protein kinase, catalytic subunit-like Caenorhabditis elegans PR
P21137 kin-1 cAMP-dependent protein kinase catalytic subunit Caenorhabditis elegans PR
10 20 30 40 50 60
MGNAAAKKDT EQETVNEFLA KARGDFLYRW GNPAQNTASS DQFERLKTLG TGSYGRVMLV
70 80 90 100 110 120
RHRETGNHYA MKILDKQKVV RLKQVEHTLN EKRILQAINF PFLVKLQFSF KDNSNLYLVM
130 140 150 160 170 180
EYVPGGEMFS HLRRVGRFSE PQACFYAAQV VLAFQYLHSL DLIHRDLKPE NLLIDQQGYL
190 200
QVTDFGFAKR VKGRTWTLCG TPEYLAPEI