O62305
Gene name |
unc-43 (K11E8.1) |
Protein name |
Calcium/calmodulin-dependent protein kinase type II |
Names |
CaM kinase II, Uncoordinated protein 43 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
|
EC number |
2.7.11.17: Protein-serine/threonine kinases |
Protein Class |
SERINE/THREONINE-PROTEIN KINASE (PTHR24347) |
Descriptions
CaMKII is one of the most important transducers of Ca2+signals in a variety of cell types and is highly conserved across animal species. The calmodulin-responsive regulatory segment forms a coiled coil structure that blocks peptide and ATP binding to the otherwise intrinsically active kinase domain.Ca2+/CaM removes the autoinhibitory regulatory segment located C-terminal to the kinase domain which releases the catalytic activity of the enzyme.
Autoinhibitory domains (AIDs)
Target domain |
12-269 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
Structural analysis |
Accessory elements
154-176 (Activation loop from InterPro)
Target domain |
12-269 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
No variants for O62305
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O62305 | |||||
No associated diseases with O62305
4 regional properties for O62305
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 12 - 269 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 130 - 142 | IPR008271 |
| domain | Calcium/calmodulin-dependent protein kinase II, association-domain | 587 - 711 | IPR013543 |
| binding_site | Protein kinase, ATP binding site | 18 - 41 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.17 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24347 | SERINE/THREONINE-PROTEIN KINASE |
| PANTHER Subfamily | PTHR24347:SF441 | CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA |
| PANTHER Protein Class |
non-receptor serine/threonine protein kinase
protein modifying enzyme |
|
| PANTHER Pathway Category |
Inflammation mediated by chemokine and cytokine signaling pathway CaMK Ionotropic glutamate receptor pathway CaMKII |
|
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon cytoplasm | Any cytoplasm that is part of a axon. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| medium-term memory | The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster). |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| serotonin biosynthetic process | The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2HJF7 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Bos taurus (Bovine) | SS |
| Q3MHJ9 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Bos taurus (Bovine) | SS |
| Q5ZKI0 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II delta chain | Gallus gallus (Chicken) | SS |
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q00168 | CaMKII | Calcium/calmodulin-dependent protein kinase type II alpha chain | Drosophila melanogaster (Fruit fly) | SS |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| P28652 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Mus musculus (Mouse) | SS |
| Q923T9 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Mus musculus (Mouse) | SS |
| P11798 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Mus musculus (Mouse) | PR |
| Q6PHZ2 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Mus musculus (Mouse) | SS |
| Q95266 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Sus scrofa (Pig) | SS |
| P08413 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Rattus norvegicus (Rat) | SS |
| P11730 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Rattus norvegicus (Rat) | SS |
| P11275 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Rat) | PR |
| P15791 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Rattus norvegicus (Rat) | SS |
| P54936 | lin-2 | Protein lin-2 | Caenorhabditis elegans | SS |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| Q6DEH3 | camk2d1 | Calcium/calmodulin-dependent protein kinase type II delta 1 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DGS3 | camk2d2 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMNASTKFSD | NYDVKEELGK | GAFSVVRRCV | HKTTGLEFAA | KIINTKKLSA | RDFQKLEREA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RICRKLQHPN | IVRLHDSIQE | ESFHYLVFDL | VTGGELFEDI | VAREFYSEAD | ASHCIQQILE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIAYCHSNGI | VHRDLKPENL | LLASKAKGAA | VKLADFGLAI | EVNDSEAWHG | FAGTPGYLSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVLKKDPYSK | PVDIWACGVI | LYILLVGYPP | FWDEDQHRLY | AQIKAGAYDY | PSPEWDTVTP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EAKSLIDSML | TVNPKKRITA | DQALKVPWIC | NRERVASAIH | RQDTVDCLKK | FNARRKLKAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ISAVKMVTRM | SGVLRTSDST | GSVASNGSTT | HDASQVAGTS | SQPTSPAAEV | YPNVLLFNPQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KFPRNCVHPF | TTHPYYSPKE | SSKKKLFFTL | LFEVCPHTSR | SHILLRDNTK | NIYHPYHCFT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NKMSNYERAA | PSSHGSSTTK | KIANAIADLV | IRRSSPSIRR | KTEADVHNSN | RNRKVSAPAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LQHALVPVID | VVVATGALAS | SSVDNLSAST | SSDLGRNLLN | KKEQGPPSTI | KESSESSQTI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DDNDSEKGGG | QLKHENTVVR | ADGATGIVSS | SNSSTASKSS | STNLSAQKQD | IVRVTQTLLD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AISCKDFETY | TRLCDTSMTC | FEPEALGNLI | EGIEFHRFYF | DGNRKNQVHT | TMLNPNVHII |
| 670 | 680 | 690 | 700 | 710 | |
| GEDAACVAYV | KLTQFLDRNG | EAHTRQSQES | RVWSKKQGRW | VCVHVHRSTQ | PSTNTTVSEF |