O61460
SS
Gene name |
vab-1 (M03A1.1) |
Protein name |
Ephrin receptor 1 |
Names |
EC 2.7.10.1 , Tyrosine-protein kinase Eph receptor , Variable abnormal protein 1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_M03A1.1 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
692-988 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O61460
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O61460-F1 | Predicted | AlphaFoldDB |
No variants for O61460
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O61460 | |||||
No associated diseases with O61460
7 regional properties for O61460
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 692 - 988 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 31 - 217 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 695 - 982 | IPR001245 |
| domain | Fibronectin type III | 341 - 445 | IPR003961-1 |
| domain | Fibronectin type III | 449 - 537 | IPR003961-2 |
| binding_site | Protein kinase, ATP binding site | 698 - 720 | IPR017441 |
| domain | Ephrin receptor, transmembrane domain | 658 - 686 | IPR027936 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| embryonic body morphogenesis | The process in which the anatomical structures of the embryonic soma are generated and organized. |
| morphogenesis of embryonic epithelium | The process in which the anatomical structures of embryonic epithelia are generated and organized. |
| oocyte maturation | A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| regulation of axon guidance | Any process that modulates the frequency, rate or extent of axon guidance. |
53 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| G5EGK5 | cam-1 | Tyrosine-protein kinase receptor cam-1 | Caenorhabditis elegans | SS |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| Q95ZV7 | ddr-2 | Discoidin domain-containing receptor tyrosine kinase B | Caenorhabditis elegans | PR |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRLYNSRILN | PHQSIFILVL | QCLITIVTSH | QEVLFDLSKV | GSDLKWDQVS | LRHDRDDVWM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EETWRNPAAT | DEKHANQRAY | VTCNYDMINP | SNWLFSHFIE | VKTARRIYIE | LLFNTRDCDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLNPKSCKET | FSVYLKQFKT | SRPGSTKIEK | ERFSEDIDNW | KNIGRLARSN | SNMTTETLGM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIDSDTKTIR | IAFEEQGICL | SLLNVKIYYR | ICDEFTDQLV | YFRPQVTGPK | ETDMVRMNGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CIPNASKKIP | GVDLIGLCMS | TGSGIKTSGE | CVCDSGYSQI | ADSNGARCES | CPTNTYKPKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QSLCKSCPSN | SISSEAASSC | RCLNGYFRAE | DELISMPCTQ | PPSRPIKLVA | NAITATSTRL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SWNEPSSLGG | RPEIWYEVKC | SGRGECGTVV | MTPGDKKLST | RSVQINGLRP | SSDYTFLVFA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KNKVSAQFPE | FSEKNAVIDI | RTRSEEEDVP | PVSHLRVDAS | QSDGITIAWS | VSDSDVSDFE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VEVRPAIVKK | RTFETRHVNM | TYTTFIGLNP | ETVYQFRVRI | RDDLRWSQPI | SYQLGRGLMS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SPSSNEVEES | QFLNQTGSAL | LIIIALILIV | IAVALCMIVV | QKKSKNRKQM | SDLDVLDTYK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QDSMTPDYHT | TSRHHHHQGN | LPATLHEQLR | STTKLNAPLI | PSFGSPISQP | PPYYGGVHPN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SGKYKTYVDP | TTYEDPYQAL | IEFTFDISPN | DVFITQVIGG | GEFGDVCLGG | LSKNSPAAAK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WSVSNTTMGR | GGGGGGYESE | PYETVAIKTL | KSGSSAKAKA | EFLTEATIMG | QFSHPNVIRL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IGVVTSAEPV | MIVAEYMANG | SLDQFLRNTD | QRGEKVHWEK | ITEMLYGIAS | GMKYLTDMGY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VHRVSFLRDL | AARNVLLDME | LRCKIADFGL | SRGVRSEGSS | VEPEYTTNGG | KIPVRWTAPE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AITHRKFTPS | SDVWSFGVVI | WEVCSFGERP | YWDWTNQKVI | SEVMIGYRLP | PPMDCPMGLY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RIAQWCWKME | RHERPTFTQL | LATFHKYILQ | PTLIEHDPGE | LPRRVQSQSA | LNTYGSVNVG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VVPTPPSSAA | PMPSLDDFLR | QIGLNHVYGQ | LVSNNIHSVS | DLANTSHLDL | LAYGLMSAEC |
| 1090 | 1100 | 1110 | 1120 | ||
| STVRDGLNGR | ISGSPPGSSG | TIHATTRGTR | TTRPPREEGF | FV |