AiPD: Autoinhibited Protein Database

O60684

Gene name	KPNA6 (IPOA7)
Protein name	Importin subunit alpha-7
Names	Karyopherin subunit alpha-6
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23633
EC number
Protein Class

Descriptions

Importin subunit alpha functions in the nuclear transport of classical nuclear localization signal (cNLS)-containing cargo. The NLS binding site in importin alpha proteins may be autoinhibited by the N-terminal IBB domain.

Autoinhibitory domains (AIDs)

1-60 (IBB domain) SS

Target domain	112-513 (NLS-binding domain comprising armadillo (Arm) repeats)
Relief mechanism	Partner binding
Assay

AID

1-60 (IBB domain)

Target domain

112-513 (NLS-binding domain comprising armadillo (Arm) repeats)

Relief mechanism

Partner binding (importin-beta binding)

Assay

Accessory elements

No accessory elements

References

Kimoto C et al. (2015) "Functional characterization of importin α8 as a classical nuclear localization signal receptor", Biochimica et biophysica acta, 1853, 2676-83

Kobe B (1999) "Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha", Nature structural biology, 6, 388-97

Miyatake H et al. (2015) "Crystal structure of human importin-α1 (Rch1), revealing a potential autoinhibition mode involving homodimerization", PloS one, 10, e0115995

Catimel B et al. (2001) "Biophysical characterization of interactions involving importin-alpha during nuclear import", The Journal of biological chemistry, 276, 34189-98

Autoinhibited structure

Activated structure

3 structures for O60684

Entry ID	Method	Resolution	Chain	Position	Source
4UAD	X-ray	242 A	A	59-536	PDB
7RHT	X-ray	250 A	A	59-536	PDB
AF-O60684-F1	Predicted				AlphaFoldDB

229 variants for O60684

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1334483659 CA339614837	2	E>D		No	ClinGen TOPMed
CA738255 rs759901192	3	T>N		No	ClinGen ExAC TOPMed gnomAD
CA738256 rs147022148	4	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA738257 rs752210764	5	A>T		No	ClinGen ExAC gnomAD
rs1214369494 CA339614855	5	A>V		No	ClinGen Ensembl
rs753539227 CA738261	9	K>N		No	ClinGen ExAC gnomAD
CA20214847 rs141995585	11	N>S		No	ClinGen ESP TOPMed
rs745701000 CA738263	14	M>L		No	ClinGen ExAC gnomAD
rs1427457708 CA339614924	15	K>R		No	ClinGen gnomAD
CA738264 rs758229202	16	S>N		No	ClinGen ExAC gnomAD
CA20214898 rs763659838	19	N>T		No	ClinGen gnomAD
rs1458797536 CA339614988	22	L>V		No	ClinGen gnomAD
rs747000631 CA738266	24	P>T		No	ClinGen ExAC gnomAD
CA738269 rs138489690	29	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA20214943 rs1037653880	30	R>T		No	ClinGen Ensembl
rs1330205710 CA339615216	37	Q>H		No	ClinGen gnomAD
rs1437487701 CA339615210	37	Q>R		No	ClinGen TOPMed
CA339615248 rs1570052624	39	R>W		No	ClinGen Ensembl
CA339615285 rs1271767994	40	K>N		No	ClinGen gnomAD
CA339615382 rs1365330198	45	Q>R		No	ClinGen TOPMed
CA339616223 rs1483917849	47	L>F		No	ClinGen gnomAD
rs1570056729 CA339616372	55	L>M		No	ClinGen Ensembl
rs749407936 CA738288	56	I>V		No	ClinGen ExAC gnomAD
rs1473114380 CA339616422	57	N>H		No	ClinGen gnomAD
CA339616469 rs1570056760	60	A>G		No	ClinGen Ensembl
CA738289 rs144343640	61	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA738290 rs774597008	61	A>V		No	ClinGen ExAC gnomAD
rs267598552 CA339616512	63	F>L		No	ClinGen gnomAD
rs746123297 CA738291 COSM174279	64	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs772466071 CA339616562	65	S>C		No	ClinGen ExAC gnomAD
rs772466071 CA738292	65	S>G		No	ClinGen ExAC gnomAD
CA20216475 rs963803065	70	S>P		No	ClinGen Ensembl
CA20216478 rs764737482	71	Y>S		No	ClinGen Ensembl
rs776004686 CA738293	73	S>N		No	ClinGen ExAC TOPMed gnomAD
CA339616767 rs764724385	74	S>C		No	ClinGen ExAC TOPMed gnomAD
CA738295 rs764724385	74	S>F		No	ClinGen ExAC TOPMed gnomAD
rs761209062 CA738294	74	S>P		No	ClinGen ExAC gnomAD
rs1027825365 CA20216485	77	G>W		No	ClinGen Ensembl
rs142142441 CA738320	80	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs912459645 CA20216878	80	V>M		No	ClinGen Ensembl
CA738321 rs759292235	82	T>S		No	ClinGen ExAC gnomAD
CA339617252 rs1249386417	92	D>N		No	ClinGen gnomAD
rs752663765 CA738323	93	D>E		No	ClinGen ExAC gnomAD
CA738325 rs778995231	94	S>C		No	ClinGen ExAC gnomAD
CA738324 rs756071005	94	S>P		No	ClinGen ExAC gnomAD
rs758657213 CA738327	95	D>G		No	ClinGen ExAC TOPMed gnomAD
CA738326 rs373657496	95	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA339617374 rs1457214865	99	A>S		No	ClinGen TOPMed gnomAD
rs1457214865 CA339617372	99	A>T		No	ClinGen TOPMed gnomAD
rs1557479868 CA339617409	101	T>A		No	ClinGen Ensembl
rs747284304 CA738329	108	L>P		No	ClinGen ExAC gnomAD
CA738349 rs755257568	115	P>R		No	ClinGen ExAC gnomAD
rs781559441 CA738350	116	I>V		No	ClinGen ExAC gnomAD
rs748481833 CA738351	121	N>S		No	ClinGen ExAC gnomAD
CA738353 rs778111375	122	T>A		No	ClinGen ExAC gnomAD
rs1254398924 CA339618230	123	P>A		No	ClinGen gnomAD
rs1334208325 CA339618265	126	V>M		No	ClinGen TOPMed
CA339618294 rs1369155840	128	R>Q		No	ClinGen TOPMed gnomAD
CA738356 rs773914628	131	E>D		No	ClinGen ExAC gnomAD
CA339618332 rs1570059496	132	F>V		No	ClinGen Ensembl
CA339618381 rs1214809081	135	R>G		No	ClinGen TOPMed
rs1370263862 CA339618390	135	R>K		No	ClinGen gnomAD
rs1321327167 CA339618403	136	N>H		No	ClinGen TOPMed gnomAD
CA339618436 rs1430632423	137	E>D		No	ClinGen gnomAD
rs1207131989 CA339618740	152	I>V		No	ClinGen gnomAD
rs746733176 CA738379	162	I>M		No	ClinGen ExAC
rs768332506 CA738380	163	V>I		No	ClinGen ExAC gnomAD
rs761785742 CA738382	164	I>L		No	ClinGen ExAC gnomAD
CA339618958 rs1207356546	165	E>K		No	ClinGen gnomAD
rs983294663 CA20218280	168	A>S		No	ClinGen TOPMed gnomAD
CA20218286 rs1053970863	177	N>Y		No	ClinGen Ensembl
rs1190770120 CA339619341	179	D>E		No	ClinGen gnomAD
rs1465364959 CA339619334	179	D>G		No	ClinGen gnomAD
rs765286277 CA738383	185	E>G		No	ClinGen ExAC TOPMed gnomAD
CA738398 rs768370964	194	I>V		No	ClinGen ExAC gnomAD
CA20219174 rs866637173	201	C>S		No	ClinGen Ensembl
CA738399 rs781088395	205	V>I		No	ClinGen ExAC gnomAD
rs1219035507 CA339620362	208	C>R		No	ClinGen TOPMed
CA339620386 rs1267155335	208	C>S		No	ClinGen TOPMed
CA339620490 rs747478809	211	L>F		No	ClinGen ExAC TOPMed gnomAD
rs747478809 CA738400	211	L>I		No	ClinGen ExAC TOPMed gnomAD
rs769748870 CA738401	216	T>I		No	ClinGen ExAC TOPMed gnomAD
CA738421 rs747848245	217	L>I		No	ClinGen ExAC gnomAD
CA339621989 rs1398019937	219	T>N		No	ClinGen gnomAD
rs200893401 CA20220277	222	T>I		No	ClinGen TOPMed
rs769694883 CA738422	223	R>Q		No	ClinGen ExAC gnomAD
CA20220288 rs1011650844	225	T>M		No	ClinGen TOPMed gnomAD
rs965307012 CA20220296	226	M>T		No	ClinGen TOPMed gnomAD
CA738425 rs770912747	227	T>I		No	ClinGen ExAC gnomAD
CA20220301 rs1022101050	228	R>W		No	ClinGen gnomAD
rs1308549405 CA339622229	239	R>Q		No	ClinGen TOPMed gnomAD
CA20220327 rs953837253	246	E>D		No	ClinGen TOPMed
CA738458 rs767067967 COSM1321152	251	S>F	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs755776928 CA738460	252	P>L		No	ClinGen ExAC gnomAD
rs752268057 CA738459	252	P>T		No	ClinGen ExAC gnomAD
rs1220892400 CA339622634	254	L>F		No	ClinGen gnomAD
rs1327865800 CA339622681	256	V>L		No	ClinGen gnomAD
CA339622683 rs1327865800	256	V>L		No	ClinGen gnomAD
CA20220657 rs879224843	259	R>C		No	ClinGen Ensembl
rs1269464403 CA339622746	259	R>H		No	ClinGen gnomAD
CA738464 rs778640897	261	L>V		No	ClinGen ExAC gnomAD
rs781203110 CA738467	266	S>L		No	ClinGen ExAC gnomAD
rs1457168018 CA339622998	268	L>F		No	ClinGen gnomAD
rs1570066636 CA339623164	275	A>G		No	ClinGen Ensembl
rs1160066368 CA339623180	276	L>V		No	ClinGen gnomAD
CA738471 rs749527358	279	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1462650669 CA339623289	281	D>H		No	ClinGen TOPMed
CA738472 rs771319209	284	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1249666840 CA339623372	285	E>G		No	ClinGen TOPMed
rs774579162 CA738473	289	A>V		No	ClinGen ExAC gnomAD
rs1570066757 CA339623590	294	G>R		No	ClinGen Ensembl
CA339623615 rs1349857595	296	C>S		No	ClinGen gnomAD
CA339623626 rs1479886582	297	R>Q		No	ClinGen TOPMed
CA738476 rs377221347	297	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs891988562 CA339623639	298	R>K		No	ClinGen TOPMed gnomAD
rs1353593234 CA339623661	298	R>S		No	ClinGen gnomAD
rs891988562 CA20220716	298	R>T		No	ClinGen TOPMed gnomAD
CA339623681 rs1471126613	299	L>S		No	ClinGen TOPMed
CA339623704 rs1157094586	300	V>L		No	ClinGen Ensembl
rs1435781138 CA339624087	305	H>R		No	ClinGen TOPMed
CA339624073 rs1166901812	305	H>Y		No	ClinGen gnomAD
CA339624137 rs1183919944	306	N>K		No	ClinGen TOPMed
CA339624111 rs1389342991	306	N>S		No	ClinGen gnomAD
rs752804375 CA20221328	308	Y>S		No	ClinGen Ensembl
rs776018482 CA738498	312	S>F		No	ClinGen ExAC gnomAD
CA339624328 rs1400054580	313	P>S		No	ClinGen gnomAD
CA738499 rs761481906	314	A>S		No	ClinGen ExAC TOPMed gnomAD
rs761481906 CA339624350	314	A>T		No	ClinGen ExAC TOPMed gnomAD
rs764833156 CA738500	315	L>P		No	ClinGen ExAC gnomAD
CA339624426 rs1384318380	315	L>V		No	ClinGen gnomAD
CA339624506 rs1557483610	317	A>S		No	ClinGen Ensembl
CA339624520 rs1341901080	317	A>V		No	ClinGen gnomAD
rs1570068655 CA339624545	318	V>G		No	ClinGen Ensembl
rs1376471130 CA339624525	318	V>M		No	ClinGen TOPMed
rs1253429804 CA339624640	321	I>F		No	ClinGen gnomAD
rs1253429804 CA339624642 COSM3700704	321	I>V	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1200353435 CA339624660 COSM1341783	322	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA738505 rs754871813	325	D>A		No	ClinGen ExAC gnomAD
rs754871813 CA339624721	325	D>G		No	ClinGen ExAC gnomAD
rs1186917282 CA339624777	327	I>L		No	ClinGen gnomAD
CA339624847 rs1570068746	330	Q>P		No	ClinGen Ensembl
rs781531591 CA738536	337	A>T		No	ClinGen ExAC gnomAD
CA339626744 rs1317546654	337	A>V		No	ClinGen gnomAD
CA339626758 rs1218232485	338	L>P		No	ClinGen gnomAD
CA339626772 rs1260714576	339	P>A		No	ClinGen gnomAD
CA738539 rs149808732	347	S>G		No	ClinGen ESP ExAC gnomAD
CA339626952 rs1471590531	348	P>S		No	ClinGen TOPMed gnomAD
rs1471590531 CA339626950	348	P>T		No	ClinGen TOPMed gnomAD
CA339626969 rs1349577686	349	K>R		No	ClinGen TOPMed
CA20223419 rs1024300063	353	R>W		No	ClinGen TOPMed gnomAD
rs1420291873 CA339627163	357	C>S		No	ClinGen gnomAD
CA339627264 rs1339078049	363	I>V		No	ClinGen TOPMed
rs770588651 CA738541	364	T>A		No	ClinGen ExAC gnomAD
CA738542 rs774154486	367	N>S		No	ClinGen ExAC gnomAD
CA339627358 COSM1602204 rs1304173803	368	R>S	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1021182532 CA20224075	374	V>A		No	ClinGen Ensembl
rs775370186 CA339627551	375	I>L		No	ClinGen ExAC TOPMed gnomAD
rs760640550 CA738568	375	I>R		No	ClinGen ExAC TOPMed gnomAD
rs760640550 CA738567	375	I>T		No	ClinGen ExAC TOPMed gnomAD
rs775370186 CA738566	375	I>V		No	ClinGen ExAC TOPMed gnomAD
rs763107393 CA738570	377	A>E		No	ClinGen ExAC gnomAD
CA738571 rs763107393	377	A>G		No	ClinGen ExAC gnomAD
rs1263904658 CA339627596	378	N>D		No	ClinGen TOPMed
rs1420624436 CA339627605	378	N>S		No	ClinGen TOPMed gnomAD
CA339627617 rs1412159063	379	I>V		No	ClinGen TOPMed gnomAD
CA738572 rs751728717	380	F>L		No	ClinGen ExAC TOPMed gnomAD
CA738573 rs759805893	381	P>A		No	ClinGen ExAC gnomAD
rs767714580 CA738574	381	P>R		No	ClinGen ExAC TOPMed gnomAD
rs753123679 CA738575	382	V>M		No	ClinGen ExAC gnomAD
CA339627677 rs377121386	384	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1324183850 CA339627831	393	R>C		No	ClinGen gnomAD
CA339627834 rs1205083302	393	R>H		No	ClinGen gnomAD
CA738581 rs745454560	394	T>A		No	ClinGen ExAC gnomAD
rs779674597 COSM384181 CA738583	399	A>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1231724300 CA339628018	403	T>S		No	ClinGen gnomAD
rs776700683 CA738586	404	N>S		No	ClinGen ExAC gnomAD
CA339628116 rs1178727836 COSM232647	408	G>R	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs770852785 CA738588	411	P>S		No	ClinGen ExAC gnomAD
CA339628882 rs1225461088	417	L>Q		No	ClinGen TOPMed
CA738610 rs772091470	422	C>F		No	ClinGen ExAC gnomAD
CA738611 rs775674111	424	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1212513529 CA339629022	427	C>S		No	ClinGen TOPMed gnomAD
rs1557487789 CA339629159	435	S>L		No	ClinGen Ensembl
CA738616 rs765746124	443	N>S		No	ClinGen ExAC gnomAD
CA738618 rs369321250	450	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA738617 rs750942954	450	R>W		No	ClinGen ExAC TOPMed gnomAD
CA738619 rs766056787	452	G>*		No	ClinGen ExAC
rs1163113362 CA339630216	456	G>C		No	ClinGen gnomAD
rs1570080815 CA339630229	457	K>R		No	ClinGen Ensembl
CA738620 rs373085364	458	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142180334 CA738621	458	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA339630259 rs142180334	458	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs755898866 CA738624	463	V>A		No	ClinGen ExAC gnomAD
rs747983431 CA339630372	463	V>F		No	ClinGen ExAC TOPMed gnomAD
rs755898866 CA20226013	463	V>G		No	ClinGen ExAC gnomAD
rs747983431 CA738623	463	V>I		No	ClinGen ExAC TOPMed gnomAD
CA20226019 rs986562181	465	P>R		No	ClinGen TOPMed
CA339630573 rs1459849436	470	I>V		No	ClinGen TOPMed
rs1294222394 CA339630641	473	A>P		No	ClinGen TOPMed
CA339630636 rs1294222394	473	A>T		No	ClinGen TOPMed
CA738625 rs777743002	474	Y>C		No	ClinGen ExAC gnomAD
rs1041981237 CA20226363	478	K>T		No	ClinGen TOPMed
CA738645 rs753742692	489	E>K		No	ClinGen ExAC gnomAD
CA339631214 rs1457398779	495	F>L		No	ClinGen TOPMed
CA339631226 rs1260792850 COSM275786	496	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1570082097 CA339631287	498	I>T		No	ClinGen Ensembl
rs370945671 CA738647	500	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1289756756 CA339631451	505	E>D		No	ClinGen gnomAD
rs201663407 COSM1341784 CA738649	507	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs781380097 CA738650	509	S>N		No	ClinGen ExAC
CA20226428 rs903462510	510	S>I		No	ClinGen TOPMed gnomAD
CA339631628 rs1206601526	514	Q>R		No	ClinGen Ensembl
CA339631639 rs1407608161	515	V>I		No	ClinGen gnomAD
rs773466240 CA738653	516	D>N		No	ClinGen ExAC gnomAD
rs997693505 CA20226457	518	T>M		No	ClinGen TOPMed gnomAD
rs763471896 CA738654	518	T>P		No	ClinGen ExAC gnomAD
rs759093362 CA738657	520	Q>*		No	ClinGen ExAC gnomAD
CA339631750 rs759093362	520	Q>K		No	ClinGen ExAC gnomAD
rs752387863 CA738659	523	I>V		No	ClinGen ExAC gnomAD
rs763890077 CA738661	529	A>D		No	ClinGen ExAC gnomAD
rs763890077 CA20226508	529	A>G		No	ClinGen ExAC gnomAD
rs1570082319 CA339631978	531	M>R		No	ClinGen Ensembl
rs867039862 CA20226516	531	M>V		No	ClinGen TOPMed gnomAD
CA339631991 rs1212234390	532	E>G		No	ClinGen TOPMed
rs1486310156 CA339632023	534	F>L		No	ClinGen gnomAD
rs1206726760 CA339632027	535	Q>*		No	ClinGen TOPMed gnomAD
rs1206726760 CA339632024	535	Q>K		No	ClinGen TOPMed gnomAD
rs1266472191 CA339632032	535	Q>R		No	ClinGen TOPMed gnomAD
rs1008018378 CA20226524	537	L>Q		No	ClinGen TOPMed

No associated diseases with O60684

9 regional properties for O60684

Type	Name	Position	InterPro Accession
repeat	Armadillo	112 - 196	IPR000225-1
repeat	Armadillo	197 - 239	IPR000225-2
repeat	Armadillo	242 - 281	IPR000225-3
repeat	Armadillo	283 - 323	IPR000225-4
repeat	Armadillo	325 - 367	IPR000225-5
repeat	Armadillo	367 - 407	IPR000225-6
repeat	Armadillo	410 - 450	IPR000225-7
domain	Importin-alpha, importin-beta-binding domain	1 - 102	IPR002652
repeat	Atypical Arm repeat	464 - 513	IPR032413

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
host cell	A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
NLS-dependent protein nuclear import complex	A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
nuclear import signal receptor activity	Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding	Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

7 GO annotations of biological process

Name	Definition
entry of viral genome into host nucleus through nuclear pore complex via importin	Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.
maternal process involved in female pregnancy	A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
NLS-bearing protein import into nucleus	The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
positive regulation of cytokine production involved in inflammatory response	Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of viral life cycle	Any process that activates or increases the frequency, rate or extent of viral life cycle.
viral genome replication	Any process involved directly in viral genome replication, including viral nucleotide metabolism.

30 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02821	SRP1	Importin subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
C1JZ66	KPNA7	Importin subunit alpha-8	Bos taurus (Bovine)	PR
A2VE08	KPNA1	Importin subunit alpha-5	Bos taurus (Bovine)	SS
Q0V7M0	KPNA6	Importin subunit alpha-7	Bos taurus (Bovine)	SS
Q5ZML1	KPNA1	Importin subunit alpha-5	Gallus gallus (Chicken)	SS
P52295	Pen	Importin subunit alpha	Drosophila melanogaster (Fruit fly)	SS
A9QM74	KPNA7	Importin subunit alpha-8	Homo sapiens (Human)	EV
O00505	KPNA3	Importin subunit alpha-4	Homo sapiens (Human)	SS
O00629	KPNA4	Importin subunit alpha-3	Homo sapiens (Human)	SS
O15131	KPNA5	Importin subunit alpha-6	Homo sapiens (Human)	SS
P52292	KPNA2	Importin subunit alpha-1	Homo sapiens (Human)	EV
P52294	KPNA1	Importin subunit alpha-5	Homo sapiens (Human)	SS
P52293	Kpna2	Importin subunit alpha-1	Mus musculus (Mouse)	EV
O35344	Kpna3	Importin subunit alpha-4	Mus musculus (Mouse)	SS
O35343	Kpna4	Importin subunit alpha-3	Mus musculus (Mouse)	SS
C0LLJ0	Kpna7	Importin subunit alpha-8	Mus musculus (Mouse)	SS
O35345	Kpna6	Importin subunit alpha-7	Mus musculus (Mouse)	PR
Q60960	Kpna1	Importin subunit alpha-5	Mus musculus (Mouse)	SS
C6K7I2	KPNA7	Importin subunit alpha-8	Sus scrofa (Pig)	SS
P83953	Kpna1	Importin subunit alpha-5	Rattus norvegicus (Rat)	SS
Q56R16	Kpna5	Importin subunit alpha-6	Rattus norvegicus (Rat)	SS
Q71VM4	Os01g0253300	Importin subunit alpha-1a	Oryza sativa subsp. japonica (Rice)	SS
P91276	ima-2	Importin subunit alpha-2	Caenorhabditis elegans	SS
Q19969	ima-3	Importin subunit alpha-3	Caenorhabditis elegans	SS
O04294	IMPA3	Importin subunit alpha-3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FJ09	IMPA5	Importin subunit alpha-5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9M9X7	IMPA7	Importin subunit alpha-7	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FWY7	IMPA6	Importin subunit alpha-6	Arabidopsis thaliana (Mouse-ear cress)	SS
O22478		Importin subunit alpha	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS
Q503E9	kpna5	Importin subunit alpha-6	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
METMASPGKD	NYRMKSYKNN	ALNPEEMRRR	REEEGIQLRK	QKREQQLFKR	RNVELINEEA
70	80	90	100	110	120
AMFDSLLMDS	YVSSTTGESV	ITREMVEMLF	SDDSDLQLAT	TQKFRKLLSK	EPSPPIDEVI
130	140	150	160	170	180
NTPRVVDRFV	EFLKRNENCT	LQFEAAWALT	NIASGTSQQT	KIVIEAGAVP	IFIELLNSDF
190	200	210	220	230	240
EDVQEQAVWA	LGNIAGDSSV	CRDYVLNCSI	LNPLLTLLTK	STRLTMTRNA	VWALSNLCRG
250	260	270	280	290	300
KNPPPEFAKV	SPCLPVLSRL	LFSSDSDLLA	DACWALSYLS	DGPNEKIQAV	IDSGVCRRLV
310	320	330	340	350	360
ELLMHNDYKV	ASPALRAVGN	IVTGDDIQTQ	VILNCSALPC	LLHLLSSPKE	SIRKEACWTI
370	380	390	400	410	420
SNITAGNRAQ	IQAVIDANIF	PVLIEILQKA	EFRTRKEAAW	AITNATSGGT	PEQIRYLVSL
430	440	450	460	470	480
GCIKPLCDLL	TVMDSKIVQV	ALNGLENILR	LGEQEGKRSG	SGVNPYCGLI	EEAYGLDKIE
490	500	510	520	530
FLQSHENQEI	YQKAFDLIEH	YFGVEDDDSS	LAPQVDETQQ	QFIFQQPEAP	MEGFQL