AiPD: Autoinhibited Protein Database

O60563

Gene name	CCNT1
Protein name	Cyclin-T1
Names	CycT1, Cyclin-T
Species	Homo sapiens (Human)
KEGG Pathway	hsa:904
EC number
Protein Class	CYCLIN (PTHR10026)

Descriptions

Cyclin-T1 (CycT1) combines with cyclin-dependent kinase (Cdk9) and this complex is called positive transcription elongation factor B (P-TEFb). An intramolecular interaction between the N- and C-terminal regions of cyclin T1 sterically masks the TAR-binding surface, thereby blocking the P-TEFb?TAR interaction. Binding of Tat-SF1 to the CycT1 C-terminal region disrupts the intramolecular interaction in CycT1, stabilizes the P-TEFb-Tat-TAR complex, and stimulates HIV-1 transcription. The efficient interaction between P-TEFb and TAR RNA requires suppression of the autoinhibitory activity of the CycT1 C-terminal region.

Autoinhibitory domains (AIDs)

Target domain	1-333 (N-terminal cyclin box)
Relief mechanism	PTM, Partner binding
Assay	Deletion assay, Split protein assay

AID

402-701 (C-terminal autoinhibitory region)

Target domain

1-333 (N-terminal cyclin box)

Relief mechanism

PTM (Autophosphorylation of Cdk9), Partner binding (Tat-SF1 binding to the C-terminal region of cyclin-T1)

Assay

Deletion assay, Split protein assay

Accessory elements

No accessory elements

References

Fong YW et al. (2000) "Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter", Molecular and cellular biology, 20, 5897-907

Autoinhibited structure

Activated structure

30 structures for O60563

Entry ID	Method	Resolution	Chain	Position	Source
2PK2	X-ray	267 A	A/B/C/D	1-281	PDB
3BLH	X-ray	248 A	B	2-259	PDB
3BLQ	X-ray	290 A	B	2-259	PDB
3BLR	X-ray	280 A	B	2-259	PDB
3LQ5	X-ray	300 A	B	2-259	PDB
3MI9	X-ray	210 A	B	1-266	PDB
3MIA	X-ray	300 A	B	1-266	PDB
3MY1	X-ray	280 A	B	2-259	PDB
3TN8	X-ray	295 A	B	2-259	PDB
3TNH	X-ray	320 A	B	1-259	PDB
3TNI	X-ray	323 A	B	1-259	PDB
4BCF	X-ray	301 A	B	2-259	PDB
4BCG	X-ray	308 A	B	2-259	PDB
4BCH	X-ray	296 A	B	2-259	PDB
4BCI	X-ray	310 A	B	2-259	PDB
4BCJ	X-ray	316 A	B	2-259	PDB
4EC8	X-ray	360 A	B	2-259	PDB
4EC9	X-ray	321 A	B	2-259	PDB
4IMY	X-ray	294 A	B/D/F	1-264	PDB
4OGR	X-ray	300 A	B/F/K	1-264	PDB
4OR5	X-ray	290 A	B/G	1-266	PDB
5L1Z	X-ray	590 A	B	1-264	PDB
6CYT	X-ray	350 A	B	1-264	PDB
6GZH	X-ray	317 A	B	1-726	PDB
6W9E	X-ray	310 A	B	1-259	PDB
6Z45	X-ray	337 A	B	2-259	PDB
7NWK	X-ray	281 A	B	2-259	PDB
8I0L	X-ray	360 A	B	2-259	PDB
8K5R	X-ray	375 A	B	1-259	PDB
AF-O60563-F1	Predicted				AlphaFoldDB

501 variants for O60563

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1333067678 CA384561063	2	E>Q		No	ClinGen TOPMed
rs140731025 CA6540555	3	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA236551043 rs1034105324	8	N>D		No	ClinGen TOPMed gnomAD
CA6540554 rs752408077	9	N>D		No	ClinGen ExAC gnomAD
CA6540553 rs759127329	9	N>K		No	ClinGen ExAC gnomAD
CA384560986 rs1258385672	10	K>R		No	ClinGen gnomAD
rs1366647254 CA384560982	11	R>W		No	ClinGen gnomAD
rs1317413593 CA384560961	13	Y>*		No	ClinGen gnomAD
rs1309144383 CA384560948	15	T>I		No	ClinGen gnomAD
rs888184488 CA236550997 COSM939852	16	R>G	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs775983716 CA6540550	16	R>L		No	ClinGen ExAC gnomAD
CA384560942 rs1592129164	17	E>Q		No	ClinGen Ensembl
rs367772894 CA236550996	20	E>K		No	ClinGen ESP TOPMed
CA6540548 rs761203758	21	N>S		No	ClinGen ExAC TOPMed gnomAD
rs772443903 CA6540546	22	S>C		No	ClinGen ExAC gnomAD
CA384560900 rs1347446179	23	P>A		No	ClinGen gnomAD
CA6540545 rs748495328	23	P>L		No	ClinGen ExAC TOPMed gnomAD
CA384560891 rs1454228200	24	S>F		No	ClinGen gnomAD
rs1396032569 CA384560889	25	R>G		No	ClinGen gnomAD
CA6540544 rs748920111	26	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1434524438 CA384560874	27	F>C		No	ClinGen gnomAD
rs749432480 CA6540542	28	G>D		No	ClinGen ExAC gnomAD
CA6540540 rs756221706	33	K>E		No	ClinGen ExAC gnomAD
rs1050544434 CA236550947	36	S>F		No	ClinGen TOPMed
rs201190553 CA6540539	36	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1050544434 CA384560815	36	S>Y		No	ClinGen TOPMed
CA384560788 rs1461235766	40	Q>R		No	ClinGen gnomAD
CA384560783 rs1352557305	41	A>T		No	ClinGen gnomAD
CA6540536 rs752403698	41	A>V		No	ClinGen ExAC TOPMed gnomAD
CA384560773 rs1565623307	42	A>V		No	ClinGen Ensembl
CA6540535 rs377260056	44	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA384560757 rs1311176749	45	L>H		No	ClinGen gnomAD
CA384560745 rs1414513730	47	D>N		No	ClinGen TOPMed
rs1285350063 CA384560710	51	R>L		No	ClinGen TOPMed
CA6540507 rs752068684	59	I>N		No	ClinGen ExAC gnomAD
rs1449551198 CA384560624	62	A>S		No	ClinGen TOPMed gnomAD
CA6540505 rs763320555	65	Y>F		No	ClinGen ExAC gnomAD
CA384560582 rs1460597404	68	R>*		No	ClinGen gnomAD
CA384560560 rs1592128183	71	M>L		No	ClinGen Ensembl
rs147254693 CA6540503	71	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1468518208 CA384560546	73	Q>E		No	ClinGen gnomAD
rs759737668 CA6540502	76	T>K		No	ClinGen ExAC gnomAD
CA384560518 rs1458970792	77	Q>*		No	ClinGen gnomAD
rs372888067 CA6540499	79	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6540498 rs778849849	80	G>R		No	ClinGen ExAC gnomAD
rs747920750 CA384574966	82	S>A		No	ClinGen ExAC TOPMed gnomAD
rs747920750 CA6540478	82	S>P		No	ClinGen ExAC TOPMed gnomAD
CA384574961 rs1373600090	83	V>L		No	ClinGen gnomAD
CA384574962 rs1373600090	83	V>M		No	ClinGen gnomAD
rs768603622 CA6540477	85	P>S		No	ClinGen ExAC gnomAD
rs749134252 CA384574944	86	A>S		No	ClinGen ExAC gnomAD
rs749134252 CA6540476	86	A>T		No	ClinGen ExAC gnomAD
rs1565619651 CA384574940	87	A>T		No	ClinGen Ensembl
CA384574914 rs1475224352	91	A>T		No	ClinGen gnomAD
rs1592123873 CA384574885	95	E>G		No	ClinGen Ensembl
CA236595907 rs537062191	99	K>Q		No	ClinGen 1000Genomes
rs1242723825 CA384574856	99	K>R		No	ClinGen gnomAD
CA384574815 rs1592123847	104	V>G		No	ClinGen Ensembl
rs1257517961 CA384574783	109	H>R		No	ClinGen gnomAD
rs1212031552 CA384574722	118	L>V		No	ClinGen gnomAD
CA384574711 rs1363927399	120	D>N		No	ClinGen TOPMed
CA6540473 rs745526148	123	S>R		No	ClinGen ExAC gnomAD
rs573583934 CA6540449	125	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384574658 rs1393778383	125	A>V		No	ClinGen TOPMed gnomAD
rs371771671 CA236593775	129	Q>E		No	ClinGen ESP TOPMed gnomAD
CA384574625 rs1406478404	130	V>A		No	ClinGen gnomAD
rs748676352 CA6540447	130	V>I		No	ClinGen ExAC gnomAD
CA6540448 rs748676352	130	V>L		No	ClinGen ExAC gnomAD
CA384574606 rs1315523766	133	L>V		No	ClinGen TOPMed
rs1026391591 CA236593761	134	V>G		No	ClinGen TOPMed
rs1440638816 CA384574565	139	I>L		No	ClinGen gnomAD
rs1207102312 CA384574561	139	I>M		No	ClinGen TOPMed
CA384574559 rs1245312853	140	I>V		No	ClinGen TOPMed
CA384574548 rs1240416698	141	L>F		No	ClinGen TOPMed gnomAD
rs1192268807 CA384574544	142	Q>*		No	ClinGen TOPMed
rs754220349 CA6540444	144	L>V		No	ClinGen ExAC gnomAD
rs766554729 CA6540443	145	G>C		No	ClinGen ExAC gnomAD
rs1401117279 CA384574480	150	I>F		No	ClinGen TOPMed gnomAD
CA384574469 rs1363046022	151	D>G		No	ClinGen gnomAD
CA6540426 rs769259126	161	T>S		No	ClinGen ExAC gnomAD
CA384574375 rs1176255458	165	R>*		No	ClinGen gnomAD
rs751739888 CA6540380	166	A>E		No	ClinGen ExAC gnomAD
CA6540381 rs751739888	166	A>V		No	ClinGen ExAC gnomAD
rs753870569 CA6540377	167	S>I		No	ClinGen ExAC gnomAD
rs753870569 CA6540378	167	S>N		No	ClinGen ExAC gnomAD
rs760556084 CA6540375	167	S>R		No	ClinGen ExAC
CA6540376 rs760556084	167	S>R		No	ClinGen ExAC
rs753870569 CA6540379	167	S>T		No	ClinGen ExAC gnomAD
CA6540373 rs767368303	168	K>N		No	ClinGen ExAC
CA384574344 rs1390096152	169	D>A		No	ClinGen gnomAD
CA384574345 rs1204577561	169	D>Y		No	ClinGen TOPMed gnomAD
rs761593293 CA6540372	171	A>E		No	ClinGen ExAC
rs762359429 CA6540369	172	Q>E		No	ClinGen ExAC
CA6540368 rs776132474	172	Q>H		No	ClinGen ExAC
rs762359429 CA6540370	172	Q>K		No	ClinGen ExAC
rs890612422 CA236590354	185	T>S		No	ClinGen Ensembl
CA236590336 rs971432244	187	F>L		No	ClinGen TOPMed
rs1378703148 CA384574177	192	T>P		No	ClinGen gnomAD
rs1404305116 CA384574169	193	P>S		No	ClinGen gnomAD
CA384574164 rs1390840609	194	P>A		No	ClinGen gnomAD
rs1164859991 CA384574159	195	V>L		No	ClinGen gnomAD
CA6540349 rs762566800	198	C>G		No	ClinGen ExAC gnomAD
CA384574109 rs1379404126	202	H>R		No	ClinGen gnomAD
CA384574105 rs991474879	203	L>M		No	ClinGen TOPMed
rs1331561433 CA384574058	209	N>I		No	ClinGen TOPMed gnomAD
rs1331561433 CA384574059	209	N>S		No	ClinGen TOPMed gnomAD
CA384574025 rs1294811954	214	V>I		No	ClinGen gnomAD
CA6540348 rs774840664	215	S>A		No	ClinGen ExAC gnomAD
rs1441748192 CA384574008	217	D>N		No	ClinGen gnomAD
rs201367358 CA6540346	218	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6540343 rs747368605	222	W>R		No	ClinGen ExAC gnomAD
CA236590201 rs35965578	227	A>P		No	ClinGen Ensembl
CA236590200 rs945602816	231	L>V		No	ClinGen Ensembl
CA6540342 rs773460739	232	E>Q		No	ClinGen ExAC gnomAD
rs11834413 CA236590166	235	D>N		No	ClinGen Ensembl
CA384573876 rs1355388992	236	E>K		No	ClinGen gnomAD
rs147384648 CA6540326	241	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1488989697 CA384573751	250	N>K		No	ClinGen TOPMed
CA384573750 rs1218228262	251	R>G		No	ClinGen gnomAD
rs1211312549 CA384573663	261	C>G		No	ClinGen gnomAD
CA6540310 rs758153792	262	E>K		No	ClinGen ExAC gnomAD
CA6540308 rs778621038	263	A>S		No	ClinGen ExAC gnomAD
rs1220364569 CA384573636	265	K>R		No	ClinGen gnomAD
CA6540306 rs753320814	266	K>E		No	ClinGen ExAC TOPMed gnomAD
rs111231208 CA236588756	266	K>R		No	ClinGen Ensembl
rs765823227 CA6540305	267	T>I		No	ClinGen ExAC TOPMed gnomAD
CA384573621 rs765823227	267	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1360695604 CA384573616	268	K>R		No	ClinGen gnomAD
CA384573606 rs1211207675	270	D>N		No	ClinGen TOPMed
rs575488596 CA384573588	272	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs575488596 CA6540304 COSM189930	272	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA384573583 rs1465328348	273	G>E		No	ClinGen gnomAD
rs558154621 CA6540303	274	T>R		No	ClinGen 1000Genomes ExAC gnomAD
rs201440153 CA384573525	281	Q>H		No	ClinGen 1000Genomes TOPMed
CA6540302 rs767790293	282	T>A		No	ClinGen ExAC gnomAD
rs960729876 CA236588683	283	I>V		No	ClinGen gnomAD
CA6540301 rs566116309	285	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384573498 rs1182795541	286	M>V		No	ClinGen gnomAD
rs1196326092 CA384573474	289	Q>P		No	ClinGen gnomAD
CA384573442 rs1243663377	293	D>E		No	ClinGen Ensembl
rs866673208 CA236588666	295	T>A		No	ClinGen Ensembl
rs768972559 CA6540299	295	T>I		No	ClinGen ExAC gnomAD
rs1170942631 CA384573430	296	I>V		No	ClinGen TOPMed
rs1258106185 CA384573404	300	M>V		No	ClinGen gnomAD
rs1200052315 CA384573387	302	M>V		No	ClinGen gnomAD
CA384573373 rs1319836719	304	T>A		No	ClinGen TOPMed gnomAD
CA6540298 rs140020979	305	S>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384573359 rs1249980231	306	T>I		No	ClinGen gnomAD
rs775736756 CA6540297	307	T>I		No	ClinGen ExAC gnomAD
rs763463430 CA6540296	308	S>G		No	ClinGen ExAC TOPMed gnomAD
CA6540295 rs538696433	308	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771829615 CA6540293	309	A>T		No	ClinGen ExAC gnomAD
CA6540292 rs747942854	309	A>V		No	ClinGen ExAC TOPMed gnomAD
CA384573338 rs1456508143	310	V>A		No	ClinGen gnomAD
rs1349388255 CA384573333	311	P>S		No	ClinGen gnomAD
rs754644478 CA6540291	312	S>A		No	ClinGen ExAC TOPMed gnomAD
CA6540289 rs748896346	312	S>F		No	ClinGen ExAC gnomAD
rs754644478 CA6540290	312	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6540287 rs755560513	316	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6540285 rs768066318	317	E>K		No	ClinGen ExAC gnomAD
CA6540284 rs757605829	324	T>S		No	ClinGen ExAC gnomAD
rs369135021 CA236588488	325	S>R		No	ClinGen ESP TOPMed
rs1592117644 CA384573241	326	V>M		No	ClinGen Ensembl
CA6540281 rs763301494	328	M>K		No	ClinGen ExAC TOPMed gnomAD
CA6540282 rs775724017	328	M>L		No	ClinGen ExAC TOPMed gnomAD
rs775724017 CA384573227	328	M>V		No	ClinGen ExAC TOPMed gnomAD
rs923760801 CA236588461	330	P>A		No	ClinGen TOPMed gnomAD
CA384573210 rs1196798343	330	P>L		No	ClinGen TOPMed
rs775789988 CA6540280	331	G>V		No	ClinGen ExAC gnomAD
rs770192921 CA236588455	332	K>E		No	ClinGen gnomAD
CA384573198 rs1311669376	332	K>N		No	ClinGen TOPMed gnomAD
rs199856816 CA6540279	333	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6540277 rs374791846	333	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs374791846 CA6540278	333	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1451341729 CA384573176	336	S>F		No	ClinGen gnomAD
CA384573168 rs1439180408	338	Q>K		No	ClinGen gnomAD
rs1382557666 CA384573124	344	E>A		No	ClinGen gnomAD
rs774159319 CA6540274	346	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1431115457 CA384573110	346	T>S		No	ClinGen gnomAD
CA236588407 rs866825070	347	Q>*		No	ClinGen Ensembl
CA384573096 rs1398081444	348	G>D		No	ClinGen TOPMed gnomAD
CA6540272 rs748949390	349	H>R		No	ClinGen ExAC gnomAD
rs969621755 CA236588395	349	H>Y		No	ClinGen Ensembl
CA6540270 rs755691198	350	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs113480935 CA6540271	350	R>W		No	ClinGen ExAC TOPMed gnomAD
rs745356084 CA6540269	352	S>G		No	ClinGen ExAC TOPMed gnomAD
CA236588388 rs745574547	354	N>S		No	ClinGen Ensembl
CA384573048 rs1460893856	356	A>E		No	ClinGen TOPMed gnomAD
rs781602950 CA6540268	356	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1262307161 CA384573044	357	L>F		No	ClinGen TOPMed gnomAD
CA6540267 rs757806331	357	L>R		No	ClinGen ExAC gnomAD
rs1452253832 CA384573030	359	G>E		No	ClinGen TOPMed
CA6540266 rs751970461	360	V>A		No	ClinGen ExAC TOPMed gnomAD
rs764560553 CA6540265	362	H>D		No	ClinGen ExAC TOPMed gnomAD
rs17123261 CA384573013	362	H>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_053054 rs17123261 CA6540264	362	H>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA384573016 rs764560553	362	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs753034435 CA6540263	364	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6540260 rs776793211	367	D>E		No	ClinGen ExAC gnomAD
rs759583949 CA6540261	367	D>N		No	ClinGen ExAC TOPMed gnomAD
CA384572977 rs1162276567	368	G>S		No	ClinGen TOPMed
CA384572971 rs1464202890	369	S>P		No	ClinGen gnomAD
CA384572931 rs1176141227	375	Q>K		No	ClinGen gnomAD
CA384572928 rs1406576570	375	Q>R		No	ClinGen TOPMed
CA236588294 rs561375504	376	K>E		No	ClinGen Ensembl
rs1481099310 CA384572913	377	Q>R		No	ClinGen gnomAD
rs766325435 CA6540259	379	S>G		No	ClinGen ExAC gnomAD
rs1192807144 CA384572892	380	K>E		No	ClinGen gnomAD
rs1249551372 CA384572889	380	K>R		No	ClinGen gnomAD
CA6540258 rs761810871	381	S>R		No	ClinGen ExAC gnomAD
rs994102048 CA236588286	383	P>A		No	ClinGen TOPMed
CA384572861 rs1198582652	385	A>T		No	ClinGen gnomAD
CA6540256 rs768494518	387	V>M		No	ClinGen ExAC gnomAD
CA236588268 rs1017044113	389	L>P		No	ClinGen Ensembl
rs1316101009 CA384572819	391	E>V		No	ClinGen gnomAD
CA384572815 rs1277668932	392	Y>H		No	ClinGen gnomAD
rs1592117500 CA384572813	392	Y>S		No	ClinGen Ensembl
CA6540255 rs749080930	393	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6540254 rs775166412	393	R>H		No	ClinGen ExAC TOPMed gnomAD
rs144628875 CA6540252	394	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs770280428 CA6540250	396	H>Y		No	ClinGen ExAC gnomAD
CA384572779 rs1487885855	397	A>V		No	ClinGen TOPMed
CA6540247 rs61751604	399	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA384572692 rs1185341960	410	M>V		No	ClinGen TOPMed gnomAD
CA6540244 rs755256066	416	S>L		No	ClinGen ExAC gnomAD
rs201044557 CA6540241	418	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6540242 rs201044557	418	Y>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1592117455 CA384572593	424	N>D		No	ClinGen Ensembl
CA384572584 rs1328580715	425	L>F		No	ClinGen TOPMed gnomAD
CA6540240 rs751567115	426	L>V		No	ClinGen ExAC gnomAD
CA6540238 rs762789240	428	H>D		No	ClinGen ExAC gnomAD
CA384572558 rs1299341224	429	H>R		No	ClinGen TOPMed
rs1419563073 CA384572560	429	H>Y		No	ClinGen TOPMed
rs891688299 CA236588150	430	D>G		No	ClinGen gnomAD
CA236588146 rs1053011061	431	S>C		No	ClinGen TOPMed gnomAD
rs1341257558 CA384572520	435	V>I		No	ClinGen TOPMed
rs1454229637 CA384572513	436	I>V		No	ClinGen gnomAD
CA384572487 rs1330071784	439	M>I		No	ClinGen gnomAD
rs769436332 CA6540236	439	M>T		No	ClinGen ExAC TOPMed gnomAD
CA384572477 rs1398012327	441	I>T		No	ClinGen gnomAD
CA6540235 rs759231919	441	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384572466 rs1161348111	443	G>S		No	ClinGen gnomAD
CA236588115 rs866465000	443	G>V		No	ClinGen gnomAD
CA384572451 rs1565615485	445	E>G		No	ClinGen Ensembl
CA384572446 rs1368805215	446	N>D		No	ClinGen gnomAD
rs776091944 CA6540234	447	P>A		No	ClinGen ExAC gnomAD
CA384572435 rs1438058803	447	P>L		No	ClinGen TOPMed gnomAD
CA384572431 rs1482257777	448	E>A		No	ClinGen TOPMed
rs1179513215 CA384572433	448	E>K		No	ClinGen gnomAD
rs1179513215 CA384572434	448	E>Q		No	ClinGen gnomAD
rs778472029 CA384572424	449	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6540231 rs778472029	449	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA384572425 rs1199624339	449	R>W		No	ClinGen TOPMed
CA384572419 rs1265399177	450	P>R		No	ClinGen gnomAD
CA236588064 rs925606156	452	L>P		No	ClinGen gnomAD
CA384572400 rs1238517516	453	E>G		No	ClinGen gnomAD
rs1176401365 CA384572393	454	K>R		No	ClinGen TOPMed
rs754145543 CA6540226	456	D>G		No	ClinGen ExAC TOPMed gnomAD
CA384572373 rs1336962902	457	K>Q		No	ClinGen gnomAD
rs1159987955 CA384572371	457	K>R		No	ClinGen TOPMed
CA384572324 rs1366188615	464	I>V		No	ClinGen gnomAD
rs1304717550 CA384572304	467	A>S		No	ClinGen gnomAD
rs1403356969 CA384572297	468	G>D		No	ClinGen TOPMed
CA6540217 rs776385227	470	D>E		No	ClinGen ExAC gnomAD
CA6540216 rs776385227	470	D>E		No	ClinGen ExAC gnomAD
rs765093934 CA6540218	470	D>G		No	ClinGen ExAC TOPMed gnomAD
rs752564300 CA6540221	470	D>H		No	ClinGen ExAC gnomAD
CA6540220 rs752564300	470	D>N		No	ClinGen ExAC gnomAD
CA6540219 rs752564300	470	D>Y		No	ClinGen ExAC gnomAD
CA6540212 rs771638484	472	A>D		No	ClinGen ExAC TOPMed
CA6540214 rs772879712	472	A>S		No	ClinGen ExAC gnomAD
CA6540213 rs772879712	472	A>T		No	ClinGen ExAC gnomAD
CA236587944 rs771638484	472	A>V		No	ClinGen ExAC TOPMed
CA6540211 rs201423333	473	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs201423333 CA6540210	473	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs756355960 CA6540206	478	E>Q		No	ClinGen ExAC
rs1363488133 CA384572209	482	M>I		No	ClinGen TOPMed gnomAD
CA236587904 rs202226049	482	M>K		No	ClinGen 1000Genomes
CA6540202 rs781254287	483	R>C		No	ClinGen ExAC TOPMed gnomAD
CA236587900 rs757269550	483	R>H		No	ClinGen ExAC TOPMed gnomAD
CA6540201 rs757269550	483	R>L		No	ClinGen ExAC TOPMed gnomAD
CA384572205 rs1304809160	484	I>L		No	ClinGen gnomAD
CA384572204 rs1304809160	484	I>V		No	ClinGen gnomAD
rs1398106349 CA384572196	485	K>E		No	ClinGen gnomAD
rs151213150 CA6540199	489	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs558225201 CA236587858	490	A>V		No	ClinGen Ensembl
CA6540197 rs753595809	492	K>E		No	ClinGen ExAC gnomAD
CA384572142 rs1480764528	493	H>P		No	ClinGen gnomAD
rs1431575272 CA384572138	493	H>Q		No	ClinGen gnomAD
CA6540196 rs766158043	494	N>D		No	ClinGen ExAC gnomAD
CA384572134 rs1477807046	494	N>S		No	ClinGen TOPMed gnomAD
rs1471146824 CA384572123	496	V>E		No	ClinGen TOPMed
CA6540195 rs760407470	496	V>I		No	ClinGen ExAC TOPMed gnomAD
CA236587813 rs760407470	496	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1448357643 CA384572118	497	E>*		No	ClinGen TOPMed gnomAD
CA384572119 rs1448357643	497	E>Q		No	ClinGen TOPMed gnomAD
CA6540194 rs772937692	499	S>G		No	ClinGen ExAC gnomAD
CA6540193 rs767190434	499	S>I		No	ClinGen ExAC gnomAD
CA384572101 rs767190434	499	S>N		No	ClinGen ExAC gnomAD
rs761399979 CA6540192	500	V>F		No	ClinGen ExAC gnomAD
rs774960495 CA6540191	501	T>I		No	ClinGen ExAC gnomAD
CA384572083 rs1339807819	502	K>R		No	ClinGen gnomAD
rs1270552362 CA384572076	503	S>N		No	ClinGen gnomAD
rs769023522 CA384572071	504	R>*		No	ClinGen ExAC TOPMed gnomAD
rs769023522 CA6540190	504	R>G		No	ClinGen ExAC TOPMed gnomAD
rs749756750 CA384572069	504	R>L		No	ClinGen ExAC gnomAD
rs749756750 CA6540189	504	R>Q		No	ClinGen ExAC gnomAD
rs775752617 CA6540188	506	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1408358673 CA384572052	507	K>E		No	ClinGen gnomAD
CA384572037 rs1386354143	509	K>E		No	ClinGen TOPMed
rs746103551 CA6540186	509	K>R		No	ClinGen ExAC TOPMed gnomAD
rs373807143 CA6540185	510	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs757395667 CA6540184	511	K>R		No	ClinGen ExAC gnomAD
rs889822518 CA236587737	512	T>A		No	ClinGen TOPMed
CA384572012 rs1237298955	512	T>I		No	ClinGen gnomAD
rs747030494 CA236587724	513	H>D		No	ClinGen ExAC TOPMed gnomAD
rs777859495 CA6540182	513	H>P		No	ClinGen ExAC gnomAD
rs747030494 CA6540183	513	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs753742785 CA6540180	515	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6540178 rs142303037	519	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384571960 rs1349447704	520	H>L		No	ClinGen gnomAD
rs750164387 CA6540177	520	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs767245574 CA6540176	521	H>N		No	ClinGen ExAC TOPMed gnomAD
CA384571957 rs767245574	521	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA384571950 rs1429272115	522	N>H		No	ClinGen TOPMed
CA384571944 rs1283428539	522	N>K		No	ClinGen gnomAD
CA384571881 rs1446054365	531	S>T		No	ClinGen gnomAD
rs1173115408 CA384571869	532	Q>H		No	ClinGen gnomAD
CA384571867 rs1348416388	533	L>I		No	ClinGen TOPMed
CA384571861 rs1404120757	534	P>A		No	ClinGen gnomAD
CA6540171 rs763378412	534	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759891367 CA6540168	535	V>A		No	ClinGen ExAC TOPMed gnomAD
rs770202413 CA6540169	535	V>F		No	ClinGen ExAC gnomAD
rs376022118 CA236587625	537	T>A		No	ClinGen ESP gnomAD
CA384571847 rs376022118	537	T>P		No	ClinGen ESP gnomAD
CA6540166 rs771162889	540	K>R		No	ClinGen ExAC gnomAD
CA6540165 rs201951577 VAR_069400	541	R>C		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs777718139 CA6540164	541	R>H		No	ClinGen ExAC gnomAD
CA384571816 rs1246514234	542	P>T		No	ClinGen gnomAD
rs1565615189 CA384571808	543	G>D		No	ClinGen Ensembl
rs1361344927 CA384571809	543	G>S		No	ClinGen gnomAD
CA384571795 rs1239735432	545	P>S		No	ClinGen gnomAD
CA236587598 rs891616597	547	H>R		No	ClinGen TOPMed gnomAD
CA6540162 rs752671890	548	S>N		No	ClinGen ExAC gnomAD
rs1300020596 CA384571764	549	S>I		No	ClinGen gnomAD
CA6540160 rs756010216	550	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs756010216 CA6540161	550	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA6540158 rs781088360	551	T>A		No	ClinGen ExAC gnomAD
rs572552049 CA6540157	552	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751161192 CA6540156	552	S>N		No	ClinGen ExAC gnomAD
rs763529662 CA6540155	553	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6540154 rs762511698	556	H>N		No	ClinGen ExAC TOPMed gnomAD
rs753271104 CA6540153	557	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1215092061 CA384571715	557	K>T		No	ClinGen TOPMed
CA6540152 rs61751603	558	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6540151 rs759944560	559	Y>C		No	ClinGen ExAC gnomAD
CA236587532 rs759944560	559	Y>F		No	ClinGen ExAC gnomAD
rs777008956 CA6540150	560	S>N		No	ClinGen ExAC gnomAD
CA6540149 rs143862407	560	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs760819965 CA384571688	561	L>F		No	ClinGen ExAC TOPMed gnomAD
rs760819965 CA6540148	561	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1475938919 CA384571690	561	L>S		No	ClinGen TOPMed
CA384571680 rs1317135713	563	S>G		No	ClinGen Ensembl
rs752700019 CA384571669	564	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6540147 rs752700019	564	S>F		No	ClinGen ExAC TOPMed gnomAD
CA384571670 rs752700019	564	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA236587506 rs939546736	565	F>L		No	ClinGen Ensembl
rs1164245033 CA384571656	566	S>F		No	ClinGen TOPMed
CA384571652 rs1216137507	567	S>F		No	ClinGen gnomAD
rs1216137507 CA384571650	567	S>Y		No	ClinGen gnomAD
CA384571644 rs1317788585	568	S>F		No	ClinGen gnomAD
rs918754389 CA236587488	569	S>G		No	ClinGen Ensembl
CA236587478 rs754742528	569	S>N		No	ClinGen Ensembl
rs772107541 CA6540146	570	S>C		No	ClinGen ExAC gnomAD
CA6540145 rs748225152	572	R>C		No	ClinGen ExAC TOPMed gnomAD
rs61751602 CA6540144	572	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384571610 rs1284416847	574	R>K		No	ClinGen gnomAD
CA236587456 rs909900930	575	G>E		No	ClinGen Ensembl
rs745762876 CA6540142	576	P>R		No	ClinGen ExAC gnomAD
CA6540143 rs61758364	576	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs139927295 CA384571592	577	S>C		No	ClinGen ESP gnomAD
rs139927295 CA236587440	577	S>F		No	ClinGen ESP gnomAD
rs1298010909 CA384571595	577	S>P		No	ClinGen gnomAD
CA384571586 rs1565615071	578	E>V		No	ClinGen Ensembl
rs1445921681 CA384571583	579	E>Q		No	ClinGen gnomAD
CA236587430 rs965962764	581	G>R		No	ClinGen TOPMed gnomAD
rs757022710 CA6540140	582	G>R		No	ClinGen ExAC gnomAD
rs1428024640 CA384571557	583	A>S		No	ClinGen gnomAD
CA384571551 rs1377926770	584	V>M		No	ClinGen TOPMed
CA384571543 rs1481406209	585	F>S		No	ClinGen gnomAD
CA384571535 rs1210197532	586	D>G		No	ClinGen gnomAD
rs1204406116 CA384571531	587	H>N		No	ClinGen gnomAD
CA6540137 rs757887677	589	A>G		No	ClinGen ExAC gnomAD
rs752182045 CA6540136	590	K>E		No	ClinGen ExAC TOPMed gnomAD
rs760038677 CA6540134	591	I>M		No	ClinGen ExAC TOPMed gnomAD
rs764684605 CA6540135	591	I>V		No	ClinGen ExAC gnomAD
CA6540133 rs754284307	592	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1225854070 CA384571494	593	K>E		No	ClinGen gnomAD
rs1238869240 CA384571491	593	K>R		No	ClinGen TOPMed
rs1285904276 CA384571484	594	S>I		No	ClinGen TOPMed
rs766712057 CA6540132	596	K>I		No	ClinGen ExAC
CA6540131 rs761091842	597	S>F		No	ClinGen ExAC gnomAD
rs1448123165 CA384571466	597	S>P		No	ClinGen TOPMed
rs768792886 CA6540126	603	S>F		No	ClinGen ExAC gnomAD
CA384571420 rs1404693991	604	F>Y		No	ClinGen gnomAD
CA384571413 rs1236111564	605	P>S		No	ClinGen TOPMed
CA384571392 rs1176574446	608	P>L		No	ClinGen TOPMed gnomAD
rs745817704 CA6540125	610	M>K		No	ClinGen ExAC gnomAD
rs1184450292 CA384571384	610	M>V		No	ClinGen TOPMed
rs571449247 CA6540124	611	G>C		No	ClinGen 1000Genomes ExAC gnomAD
CA236587223 rs751608033	612	Q>E		No	ClinGen Ensembl
CA384571358 rs770699363	613	M>I		No	ClinGen ExAC gnomAD
CA6540123 rs770699363	613	M>I		No	ClinGen ExAC gnomAD
rs1428830457 CA384571352	614	P>L		No	ClinGen gnomAD
CA6540122 rs199971712	616	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6540119 rs747730511	618	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1316152397 CA384571313	620	T>R		No	ClinGen gnomAD
rs1251189662 CA384571308	621	S>N		No	ClinGen gnomAD
rs754404849 CA6540116	623	L>F		No	ClinGen ExAC gnomAD
CA384571294 rs1565614946	623	L>P		No	ClinGen Ensembl
rs766874197 CA6540115	624	S>A		No	ClinGen ExAC gnomAD
CA384571279 rs1381660505	626	S>T		No	ClinGen gnomAD
rs1173622086 CA384571254	629	S>I		No	ClinGen TOPMed
CA6540113 rs750819468	630	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA384571243 rs1318683935	631	K>E		No	ClinGen TOPMed gnomAD
rs1397516301 CA384571229 COSM224426	633	R>C	oesophagus skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA6540112 rs767735381	633	R>H		No	ClinGen ExAC TOPMed gnomAD
CA384571227 rs767735381	633	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6540110 rs756415806	635	P>L		No	ClinGen ExAC TOPMed gnomAD
rs762133213 CA6540111	635	P>S		No	ClinGen ExAC gnomAD
rs1444235204 CA384571215	636	H>Y		No	ClinGen gnomAD
rs149815658 CA6540109	637	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149815658 CA6540108	637	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149815658 CA236587127	637	S>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6540106 rs770880033	640	D>G		No	ClinGen ExAC gnomAD
CA6540105 rs746874868	641	K>E		No	ClinGen ExAC gnomAD
rs773063080 CA6540104	642	G>R		No	ClinGen ExAC gnomAD
rs139863721 CA6540103	643	P>L		No	ClinGen ESP ExAC gnomAD
CA384571159 rs1245785133	645	G>R		No	ClinGen gnomAD
rs747855198 CA6540102	647	N>S		No	ClinGen ExAC TOPMed gnomAD
CA384571140 rs1565614887	648	G>C		No	ClinGen Ensembl
rs778528112 CA6540101	648	G>D		No	ClinGen ExAC TOPMed gnomAD
rs754521934 CA6540100	650	N>S		No	ClinGen ExAC gnomAD
rs748773472 CA6540099	651	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1592116837 CA384571115	652	T>P		No	ClinGen Ensembl
rs1398633639 CA384571092	655	I>R		No	ClinGen TOPMed gnomAD
CA6540096 rs546928425	657	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757684573 CA6540094	658	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA6540093 rs751897992	659	D>G		No	ClinGen ExAC TOPMed gnomAD
CA236587000 rs1013508291	660	T>S		No	ClinGen TOPMed
CA6540090 rs752847584	661	V>G		No	ClinGen ExAC gnomAD
rs763177246 CA6540091	661	V>M		No	ClinGen ExAC gnomAD
rs765193521 CA6540088	662	N>S		No	ClinGen ExAC TOPMed gnomAD
CA236586903 rs895471410	663	M>I		No	ClinGen Ensembl
rs760672546 CA6540087	665	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1592116801 CA384571029	665	H>Y		No	ClinGen Ensembl
CA236586867 rs150673875	666	S>F		No	ClinGen ESP
CA384571007 rs1348176415	669	S>R		No	ClinGen TOPMed gnomAD
rs771917240 CA6540085	670	A>V		No	ClinGen ExAC gnomAD
rs1054933462 CA236586859	671	Q>*		No	ClinGen TOPMed
CA384570985 rs1433743728	672	G>D		No	ClinGen TOPMed
rs561401967 CA6540084	672	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs774039295 CA6540083	674	Q>E		No	ClinGen ExAC gnomAD
CA384570974 rs1281248823	674	Q>R		No	ClinGen gnomAD
CA6540082 rs768318667	677	Q>L		No	ClinGen ExAC gnomAD
CA384570948 rs1273555289	678	P>R		No	ClinGen TOPMed
CA6540080 rs779622632	679	T>A		No	ClinGen ExAC gnomAD
rs769129728 CA6540079	679	T>S		No	ClinGen ExAC gnomAD
rs781546103 CA6540077	681	F>S		No	ClinGen ExAC gnomAD
CA236586761 rs766303563	684	V>A		No	ClinGen gnomAD
rs1199274008 CA384570905	685	R>C		No	ClinGen TOPMed gnomAD
rs374924592 CA6540076	685	R>H		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA6540073 rs138497401	687	Y>C		No	ClinGen ESP ExAC TOPMed
CA6540075 rs778237254	687	Y>D		No	ClinGen ExAC gnomAD
rs778237254 CA6540074	687	Y>H		No	ClinGen ExAC gnomAD
CA6540072 rs571399920	688	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA6540071 rs145928871	690	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1048778191 CA236586705	692	N>H		No	ClinGen TOPMed gnomAD
CA236586700 rs910151845	693	P>R		No	ClinGen Ensembl
CA236586688 rs763437613	694	R>P		No	ClinGen ExAC gnomAD
rs763437613 CA6540068	694	R>Q		No	ClinGen ExAC gnomAD
CA6540069 rs578225263	694	R>W		No	ClinGen ExAC gnomAD
rs774161411 CA6540066	695	S>C		No	ClinGen ExAC gnomAD
COSM3398751 rs374831967 CA6540064	700	S>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs768371674 CA6540065	700	S>P		No	ClinGen ExAC gnomAD
CA384570816 rs1319169519	701	R>G		No	ClinGen gnomAD
rs745339049 CA6540061	703	G>S		No	ClinGen ExAC gnomAD
CA6540060 rs781777925	704	N>K		No	ClinGen ExAC gnomAD
rs1592116692 CA384570772	707	K>N		No	ClinGen Ensembl
rs771591632 CA6540059	707	K>R		No	ClinGen ExAC gnomAD
rs758820620 CA6540056	709	R>Q		No	ClinGen ExAC gnomAD
rs776054514 CA6540057	709	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6540055 rs753027417	712	P>R		No	ClinGen ExAC gnomAD
rs1477256318 CA384570743	713	L>V		No	ClinGen TOPMed
rs755131101 CA6540053	717	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6540052 rs372868253	718	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA384570712 rs1240712357	718	P>S		No	ClinGen gnomAD
CA384570687 rs1322335040	722	P>L		No	ClinGen TOPMed
CA6540051 rs368473561	722	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA384570683 rs1176610393	723	P>H		No	ClinGen TOPMed gnomAD
CA6540047 rs762651446	727	K>K		No	ClinGen ExAC gnomAD

No associated diseases with O60563

3 regional properties for O60563

Type	Name	Position	InterPro Accession
domain	Cyclin, N-terminal	13 - 148	IPR006671
domain	Cyclin-like domain	43 - 142	IPR013763
domain	Cyclin-T1, second cyclin box	151 - 259	IPR047320

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family	PTHR10026	CYCLIN
PANTHER Subfamily	PTHR10026:SF42	CYCLIN-T1
PANTHER Protein Class	kinase activator
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cyclin/CDK positive transcription elongation factor complex	A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-TEFb complex	A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T.

9 GO annotations of molecular function

Name	Definition
7SK snRNA binding	Binding to a 7SK small nuclear RNA (7SK snRNA).
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
cyclin-dependent protein serine/threonine kinase activator activity	Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.
cyclin-dependent protein serine/threonine kinase regulator activity	Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
RNA polymerase binding	Binding to an RNA polymerase molecule or complex.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

13 GO annotations of biological process

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
negative regulation of mRNA polyadenylation	Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.
phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter	Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter.
phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter	Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter.
positive regulation by host of viral transcription	Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
positive regulation of DNA-templated transcription, elongation	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription elongation from RNA polymerase II promoter	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6T8E9	CCNT1	Cyclin-T1	Bos taurus (Bovine)	SS
Q8HXN7	CCNT1	Cyclin-T1	Pan troglodytes (Chimpanzee)	SS
Q9XT26	CCNT1	Cyclin-T1	Equus caballus (Horse)	SS
P24863	CCNC	Cyclin-C	Homo sapiens (Human)	PR
P51946	CCNH	Cyclin-H	Homo sapiens (Human)	PR
O75909	CCNK	Cyclin-K	Homo sapiens (Human)	PR
Q8N1B3	CCNQ	Cyclin-Q	Homo sapiens (Human)	PR
O88874	Ccnk	Cyclin-K	Mus musculus (Mouse)	PR
Q9QWV9	Ccnt1	Cyclin-T1	Mus musculus (Mouse)	SS
Q2QQS5	CYCT1-1	Cyclin-T1-4	Oryza sativa subsp japonica (Rice)	PR
Q6Z7H3	CYCT1_2	Cyclin-T1-2	Oryza sativa subsp japonica (Rice)	PR
Q2RAC5	CYCT1-3	Cyclin-T1-3	Oryza sativa subsp japonica (Rice)	PR
Q8GYM6	CYCT1-4	Cyclin-T1-4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q503D6	ccnq	Cyclin-Q	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEGERKNNNK	RWYFTREQLE	NSPSRRFGVD	PDKELSYRQQ	AANLLQDMGQ	RLNVSQLTIN
70	80	90	100	110	120
TAIVYMHRFY	MIQSFTQFPG	NSVAPAALFL	AAKVEEQPKK	LEHVIKVAHT	CLHPQESLPD
130	140	150	160	170	180
TRSEAYLQQV	QDLVILESII	LQTLGFELTI	DHPHTHVVKC	TQLVRASKDL	AQTSYFMATN
190	200	210	220	230	240
SLHLTTFSLQ	YTPPVVACVC	IHLACKWSNW	EIPVSTDGKH	WWEYVDATVT	LELLDELTHE
250	260	270	280	290	300
FLQILEKTPN	RLKRIWNWRA	CEAAKKTKAD	DRGTDEKTSE	QTILNMISQS	SSDTTIAGLM
310	320	330	340	350	360
SMSTSTTSAV	PSLPVSEESS	SNLTSVEMLP	GKRWLSSQPS	FKLEPTQGHR	TSENLALTGV
370	380	390	400	410	420
DHSLPQDGSN	AFISQKQNSK	SVPSAKVSLK	EYRAKHAEEL	AAQKRQLENM	EANVKSQYAY
430	440	450	460	470	480
AAQNLLSHHD	SHSSVILKMP	IEGSENPERP	FLEKADKTAL	KMRIPVAGGD	KAASSKPEEI
490	500	510	520	530	540
KMRIKVHAAA	DKHNSVEDSV	TKSREHKEKH	KTHPSNHHHH	HNHHSHKHSH	SQLPVGTGNK
550	560	570	580	590	600
RPGDPKHSSQ	TSNLAHKTYS	LSSSFSSSSS	TRKRGPSEET	GGAVFDHPAK	IAKSTKSSSL
610	620	630	640	650	660
NFSFPSLPTM	GQMPGHSSDT	SGLSFSQPSC	KTRVPHSKLD	KGPTGANGHN	TTQTIDYQDT
670	680	690	700	710	720
VNMLHSLLSA	QGVQPTQPTA	FEFVRPYSDY	LNPRSGGISS	RSGNTDKPRP	PPLPSEPPPP

LPPLPK