AiPD: Autoinhibited Protein Database

O60229

Gene name	KALRN (DUET, DUO, HAPIP, TRAD)
Protein name	Kalirin
Names	EC 2.7.11.1 , Huntingtin-associated protein-interacting protein , Protein Duo , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8997
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Dbl-family GEFs are the major class of exchange factors for Rho GTPases. The Dbl-family GEF p63RhoGEF, called ARHGEF25, is a mediator of Gαq/11 signaling to RhoA based on its ability to synergize with Gαq/11 resulting in enhanced RhoA signaling. Activated Gαq directly engages and stimulates ARHGEF25. Basically, ARHGEF25 is autoinhibited by the Dbl homology (DH)-associated pleckstrin homology (PH) domain. Activated Gαq relieves this autoinhibition by interacting with a highly conserved C-terminal extension of the PH domain.

Autoinhibitory domains (AIDs)

2116-2226 (PH domain) SS

Target domain	1924-2115 (DH domain)
Relief mechanism	Partner binding
Assay

AID

2116-2226 (PH domain)

Target domain

1924-2115 (DH domain)

Relief mechanism

Partner binding (Binding of activated Gαq to the C-terminal extension of the PH domain)

Assay

Accessory elements

2823-2845 (Activation loop from InterPro)

Target domain	2684-2938 (Protein kinase domain)
Relief mechanism
Assay

References

Rojas RJ et al. (2007) "Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain", The Journal of biological chemistry, 282, 29201-10

Lutz S et al. (2007) "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs", Science (New York, N.Y.), 318, 1923-7

Autoinhibited structure

Activated structure

13 structures for O60229

Entry ID	Method	Resolution	Chain	Position	Source
5QQD	X-ray	191 A	B	1280-1459	PDB
5QQE	X-ray	195 A	B	1280-1459	PDB
5QQF	X-ray	226 A	B	1280-1459	PDB
5QQG	X-ray	223 A	B	1280-1459	PDB
5QQH	X-ray	209 A	B	1280-1459	PDB
5QQI	X-ray	208 A	B	1280-1459	PDB
5QQJ	X-ray	190 A	B	1280-1459	PDB
5QQK	X-ray	224 A	B	1280-1459	PDB
5QQL	X-ray	225 A	B	1280-1459	PDB
5QQM	X-ray	202 A	B	1280-1459	PDB
5QQN	X-ray	226 A	B	1280-1459	PDB
5QU9	X-ray	200 A	B	1280-1459	PDB
8C7D	X-ray	186 A	A	1916-2114	PDB

2672 variants for O60229

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM1037456 COSM1037454 RCV001262907 rs145790621	724	S>L	endometrium Coronary heart disease, susceptibility to, 5 [Cosmic, ClinVar]	Yes	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1242888757	2	T>M		No	gnomAD
rs774343717	3	D>G		No	ExAC gnomAD
rs1162252325	4	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1162252325	4	R>G		No	TOPMed gnomAD
rs1200030011	4	R>H		No	TOPMed gnomAD
rs767942900	6	W>R		No	Ensembl
rs1369842479	6	W>S		No	gnomAD
rs1577991471	7	D>G		No	Ensembl
rs2061334555	7	D>N		No	Ensembl
rs2149384118	8	Q>E		No	Ensembl
rs761715314	8	Q>H		No	ExAC TOPMed gnomAD
rs1428228013	8	Q>R		No	Ensembl
rs1211194969	9	W>*		No	Ensembl
rs2061335415	10	Y>H		No	gnomAD
rs1465719025	11	L>F		No	TOPMed gnomAD
rs1465719025	11	L>V		No	TOPMed gnomAD
rs1005426222	12	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs2061336006	13	Y>C		No	Ensembl
rs767031719	15	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1306357826	18	R>Q		No	gnomAD
rs375111358	18	R>W		No	ESP gnomAD
rs1467089799	19	L>Q		No	gnomAD
rs1381756344	20	L>P		No	gnomAD
COSM3391998 COSM3391999	22	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs753159455	22	R>L		No	ExAC gnomAD
rs753159455	22	R>Q		No	ExAC gnomAD
rs1259546679	23	G>R		No	TOPMed gnomAD
rs1560290554	24	S>A		No	gnomAD
rs780167418	24	S>C		No	ExAC TOPMed gnomAD
COSM1037401 COSM1037399	24	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3846051 COSM3846050	25	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754069791 COSM4112935 COSM4112936	26	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM3586549 COSM3586550	26	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs992756679	27	N>S		No	Ensembl
rs1279597047	29	G>D		No	gnomAD
rs755195866	29	G>R		No	ExAC gnomAD
rs779217003	31	K>E		No	ExAC gnomAD
rs2078761471	32	A>T		No	TOPMed
rs992794173	35	V>I		No	TOPMed
rs769492450	37	P>R		No	Ensembl
rs777847805	38	I>V		No	ExAC TOPMed gnomAD
COSM3586552 COSM3586551	41	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2078762952	41	E>Q		No	TOPMed
rs1043150761	44	A>V		No	TOPMed gnomAD
rs926123706	46	V>L		No	TOPMed gnomAD
rs926123706	46	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs2079561892	49	G>S		No	Ensembl
COSM5525117 COSM5525116	50	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs530848505	50	R>H		No	Ensembl
rs1411312460	51	D>H		No	TOPMed
rs781215006	53	R>Q		No	ExAC gnomAD
rs2079563022	55	G>R		No	gnomAD
rs2079563381	56	P>S		No	TOPMed
rs573227442	57	I>V		No	1000Genomes gnomAD
rs1190359315	61	P>L		No	TOPMed
rs1283177292	61	P>S		No	gnomAD
rs769353974 COSM3914774 COSM3914775	63	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs775004208	63	R>H		No	ExAC TOPMed gnomAD
rs775004208	63	R>L		No	ExAC TOPMed gnomAD
rs2148579012	65	N>S		No	Ensembl
rs1316809493	68	R>G		No	TOPMed gnomAD
rs2079566226	69	I>R		No	Ensembl
TCGA novel	69	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs370661492	69	I>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	70	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1227140076	73	D>E		No	TOPMed
rs772405317	73	D>N		No	ExAC gnomAD
rs1235896186	74	L>V		No	gnomAD
rs978430945	75	R>Q		No	TOPMed gnomAD
rs144465315	75	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs777198177	78	V>M		No	ExAC TOPMed gnomAD
rs759529176	79	T>M		No	ExAC TOPMed gnomAD
rs758731038	82	A>V		No	ExAC gnomAD
rs1449739109	83	S>R		No	gnomAD
rs574386011	83	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs751354420	84	V>M		No	ExAC gnomAD
rs2079570141	85	P>L		No	gnomAD
rs1020279770	86	S>N		No	TOPMed
rs1160137462 COSM203195 COSM203194	89	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA TOPMed gnomAD
rs898030291 COSM1291590 COSM1291589	92	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated TOPMed gnomAD
COSM445464 rs377636182 COSM445465	92	R>H	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs765392431	93	G>S		No	Ensembl
rs1481079723	95	T>A		No	Ensembl
rs142301867	98	I>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2073283262	100	M>T		No	Ensembl
rs2073283729	101	R>Q		No	TOPMed
rs1220317537	101	R>W		No	TOPMed gnomAD
rs371306814	102	G>A		No	ESP ExAC gnomAD
COSM1037410 COSM1037408	102	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs371306814	102	G>D		No	ESP ExAC gnomAD
rs371306814	102	G>V		No	ESP ExAC gnomAD
rs1580234569	106	D>A		No	Ensembl
rs371412369	110	P>L		No	ESP TOPMed
rs754488298	110	P>S		No	ExAC
rs754488298	110	P>T		No	ExAC
rs778530203	111	L>I		No	ExAC gnomAD
rs750456225 COSM1418469 COSM1418468	114	T>M	lung Variant assessed as Somatic; MODERATE impact. large_intestine [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
TCGA novel	114	T>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs901620253	124	H>R		No	Ensembl
rs746245547	124	H>Y		No	ExAC gnomAD
rs1178611748	125	V>A		No	gnomAD
rs2073288809	125	V>L		No	Ensembl
rs1236708306	127	L>P		No	gnomAD
rs1180122748	132	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel	134	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs763062554	135	W>*		No	ExAC gnomAD
TCGA novel	135	W>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774706026	141	N>T		No	ExAC TOPMed gnomAD
rs1391658619	143	G>S		No	Ensembl
rs762145667	146	K>R		No	ExAC gnomAD
rs2073293089	148	I>T		No	Ensembl
rs767185496	148	I>V		No	ExAC gnomAD
rs774614237	151	T>A		No	ExAC gnomAD
rs565525175	151	T>K		No	1000Genomes TOPMed gnomAD
rs565525175	151	T>M		No	1000Genomes TOPMed gnomAD
rs565525175	151	T>R		No	1000Genomes TOPMed gnomAD
rs774614237	151	T>S		No	ExAC gnomAD
rs2073849607	153	M>R		No	Ensembl
rs2073849386	153	M>V		No	TOPMed
rs1334297228	154	V>I		No	TOPMed gnomAD
rs1334297228	154	V>L		No	TOPMed gnomAD
rs773320991	156	V>M		No	ExAC gnomAD
rs1356176088	158	G>S		No	gnomAD
rs760513110	160	T>K		No	ExAC TOPMed gnomAD
TCGA novel	160	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1360520595	165	P>H		No	TOPMed gnomAD
rs1360520595	165	P>L		No	TOPMed gnomAD
rs2073851710	165	P>S		No	Ensembl
TCGA novel	166	S>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	169	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2073853237	172	F>L		No	TOPMed
TCGA novel	177	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2073854004	179	N>H		No	Ensembl
rs1215782059	179	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1257842203	181	E>K		No	gnomAD
COSM419871	181	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763739407	182	E>D		No	ExAC gnomAD
rs2073855110	182	E>G		No	Ensembl
rs151088783	182	E>K		No	ESP ExAC gnomAD
rs2073855622	184	I>F		No	TOPMed
rs751239598	184	I>T		No	ExAC gnomAD
COSM3057466 rs546138856 COSM3057467	185	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1016340742	187	R>Q		No	Ensembl
rs749782159	187	R>W		No	ExAC gnomAD
TCGA novel	188	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs963435305	189	S>A		No	gnomAD
COSM3586558 COSM3586557	189	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM203197 COSM203196	193	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1304743134	195	N>D		No	TOPMed gnomAD
rs2148922485	195	N>S		No	Ensembl
VAR_041898	196	S>L		No	UniProt
rs199923777	196	S>R		No	ESP ExAC TOPMed gnomAD
rs748202694	197	A>S		No	ExAC TOPMed gnomAD
rs748202694	197	A>T		No	ExAC TOPMed gnomAD
COSM6095931 COSM6095932	198	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2073859417 COSM1037414 COSM1037412	198	V>M	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs2073859820	199	H>R		No	Ensembl
COSM4112939 COSM4112940	201	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747243242	202	S>L		No	ExAC TOPMed gnomAD
COSM1582553 rs776366541 COSM1582552	203	R>C	stomach [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs776366541	203	R>G		No	ExAC TOPMed gnomAD
rs1235906165	203	R>H		No	gnomAD
TCGA novel rs2073861636	205	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs868144047	207	L>F		No	TOPMed
rs775290866	208	Q>R		No	ExAC gnomAD
rs371783045	210	M>I		No	ESP TOPMed gnomAD
rs369521014	210	M>T		No	ESP ExAC TOPMed gnomAD
rs2073863106	212	A>V		No	gnomAD
rs758996837	213	R>L		No	TOPMed gnomAD
COSM5746171 COSM5746170 rs758996837	213	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
COSM33699 VAR_035976 rs1187034389 COSM1418470	213	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine a colorectal cancer sample; somatic mutation [NCI-TCGA, Cosmic, UniProt]	No	NCI-TCGA Cosmic cosmic curated UniProt NCI-TCGA TOPMed dbSNP gnomAD
rs147943506	217	P>S		No	ESP ExAC gnomAD
rs2073864749	218	V>A		No	Ensembl
rs1395880205	219	D>G		No	TOPMed gnomAD
COSM3586559 COSM3586560	219	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1395880205	219	D>V		No	TOPMed gnomAD
rs757014696	220	V>M		No	ExAC gnomAD
COSM419869	221	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201371514	223	S>C		No	gnomAD
rs754207770	224	R>Q		No	ExAC TOPMed gnomAD
rs2073866134 COSM1418471 COSM1418472	224	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed gnomAD
COSM167940 COSM167939 rs955692370	225	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA TOPMed gnomAD
rs2073867233	226	L>F		No	TOPMed
rs2073867233	226	L>V		No	TOPMed
rs779412797	227	I>T		No	ExAC TOPMed gnomAD
rs200074249	228	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs748659408	228	D>V		No	ExAC gnomAD
rs2073868149	229	E>*		No	TOPMed
rs2073868149	229	E>K		No	TOPMed
rs1213746877	230	H>L		No	Ensembl
rs1238959225	233	L>F		No	gnomAD
TCGA novel	234	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1283525207	234	K>R		No	gnomAD
rs777754688	235	K>Q		No	ExAC gnomAD
rs988543950	235	K>R		No	gnomAD
TCGA novel	235	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747144139	236	K>N		No	ExAC TOPMed gnomAD
TCGA novel	237	V>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4928998 COSM4928997	240	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1453781646	241	P>R		No	gnomAD
COSM6162918 COSM6162917	244	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs745593277	244	E>Q		No	ExAC gnomAD
rs1253377965	245	L>V		No	TOPMed gnomAD
rs1580287196	246	D>A		No	Ensembl
COSM479330 COSM479331	246	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1176928133	247	R>L		No	gnomAD
rs1176928133	247	R>Q		No	gnomAD
rs769640788	247	R>W		No	ExAC TOPMed gnomAD
rs775488440	248	E>D		No	ExAC TOPMed gnomAD
rs1348249425	251	R>Q		No	TOPMed gnomAD
COSM1255177 COSM1255178 rs763633331	251	R>W	Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs767223024	255	C>R		No	ExAC TOPMed gnomAD
rs927106953	256	I>L		No	Ensembl
rs759964034	257	R>H		No	ExAC TOPMed gnomAD
rs2148924116	257	R>S		No	Ensembl
rs2073875672	258	C>S		No	TOPMed
rs765568473	259	S>G		No	ExAC gnomAD
rs2073876095	259	S>N		No	gnomAD
rs1407730598 COSM3767212 COSM3767213	259	S>R	liver [Cosmic]	No	cosmic curated TOPMed gnomAD
rs141564219	260	D>E		No	ESP ExAC TOPMed gnomAD
rs753215758	260	D>N		No	ExAC gnomAD
rs527852522	261	G>C		No	1000Genomes ExAC TOPMed gnomAD
rs1580288002 COSM4900597 COSM4900596	261	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs527852522	261	G>S		No	1000Genomes ExAC TOPMed gnomAD
rs996749611	262	F>S		No	TOPMed gnomAD
rs2073877713	262	F>V		No	TOPMed
rs1400621156	264	G>R		No	TOPMed gnomAD
rs1273741730	265	R>C		No	TOPMed gnomAD
rs2073879146	265	R>H		No	Ensembl
rs1273741730	265	R>S		No	TOPMed gnomAD
rs376230974	266	N>S		No	ESP ExAC TOPMed gnomAD
rs1560415752	267	C>G		No	Ensembl
rs955352199	270	G>D		No	TOPMed gnomAD
rs779756637	271	S>I		No	ExAC gnomAD
rs779756637	271	S>N		No	ExAC gnomAD
rs2148924676	271	S>R		No	Ensembl
TCGA novel	272	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2073881639	276	S>N		No	Ensembl
rs2073881849	277	L>P		No	Ensembl
rs2148924767	279	P>H		No	Ensembl
rs1464349618	283	S>N		No	gnomAD
rs2148924832	284	L>F		No	Ensembl
rs768428705	286	D>E		No	ExAC TOPMed gnomAD
rs1442459337	289	H>D		No	gnomAD
rs771777430	290	S>C		No	ExAC TOPMed gnomAD
rs772974571	292	R>G		No	ExAC TOPMed gnomAD
COSM1195816 COSM1195817 rs1293775314	292	R>Q	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs772974571	292	R>W		No	ExAC TOPMed gnomAD
rs760442264	294	H>N		No	ExAC gnomAD
rs1275974427	295	L>M		No	gnomAD
rs2148925164	296	H>N		No	Ensembl
rs2073885436	296	H>R		No	Ensembl
rs974673495	299	W>*		No	TOPMed gnomAD
rs2272486	300	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs763385799	301	V>L		No	ExAC TOPMed gnomAD
rs763385799	301	V>M		No	ExAC TOPMed gnomAD
rs2073887348 TCGA novel	302	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
COSM1211325 rs1486661865 COSM1211326	302	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1486661865	302	R>L		No	TOPMed gnomAD
rs1477112890	307	D>G		No	gnomAD
rs757313652	309	C>Y		No	ExAC TOPMed gnomAD
rs779344452	311	Q>E		No	Ensembl
rs1458418566	313	R>Q		No	gnomAD
COSM75062 rs2148925540 COSM1037416	313	R>W	ovary Variant assessed as Somatic; MODERATE impact. pancreas large_intestine endometrium [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs2073889403	314	L>I		No	TOPMed gnomAD
rs202144425	315	F>L		No	ExAC TOPMed gnomAD
rs750616980	315	F>V		No	ExAC gnomAD
rs200361341	316	E>K		No	ExAC gnomAD
rs200361341	316	E>Q		No	ExAC gnomAD
rs2073890715	317	Q>*		No	Ensembl
COSM4112944 COSM4112943 rs768503730	317	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs778991469	318	D>H		No	ExAC TOPMed gnomAD
rs1339336597	320	E>V		No	TOPMed gnomAD
rs2073891850	321	K>R		No	Ensembl
rs1386584872	324	D>V		No	TOPMed gnomAD
rs1580674727	326	I>K		No	Ensembl
rs754157855	327	S>G		No	ExAC gnomAD
rs754718379	327	S>N		No	ExAC
rs754157855	327	S>R		No	ExAC gnomAD
rs1285523607	328	H>Q		No	TOPMed gnomAD
rs143158095	329	N>D		No	ESP ExAC TOPMed gnomAD
COSM4112945 COSM4112946	330	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747987292	331	E>K		No	ExAC
rs1451361257	334	L>R		No	Ensembl
rs758361379 COSM321088 COSM321087	335	Q>R	lung [Cosmic]	No	cosmic curated ExAC gnomAD
rs777866244	338	T>K		No	ExAC TOPMed gnomAD
rs777866244	338	T>M		No	ExAC TOPMed gnomAD
rs553248799	339	E>D		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	339	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3722230 rs2149214219 COSM3722229	341	G>R	upper_aerodigestive_tract [Cosmic]	No	cosmic curated Ensembl
TCGA novel	344	Y>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs146706912	347	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1321579749	347	A>V		No	gnomAD
rs1396411645	349	D>E		No	TOPMed gnomAD
rs1039047840	351	Q>R		No	Ensembl
rs762191401	352	T>A		No	ExAC TOPMed
COSM203200 COSM203199 rs767954772	352	T>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs762191401	352	T>P		No	ExAC TOPMed
rs1219770714	354	H>R		No	Ensembl
rs2077050404	354	H>Y		No	Ensembl
rs2077050855	355	N>S		No	TOPMed
COSM445468 COSM445467	356	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs200318501	357	F>L		No	1000Genomes
COSM5983034 COSM5983033	358	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1220622389	358	A>T		No	TOPMed gnomAD
rs1280186140	358	A>V		No	gnomAD
rs766540759	359	M>R		No	ExAC TOPMed gnomAD
rs766540759	359	M>T		No	ExAC TOPMed gnomAD
rs202139324	359	M>V		No	1000Genomes ExAC gnomAD
rs1580675946	360	N>D		No	TOPMed gnomAD
rs1275604494	360	N>I		No	gnomAD
rs373123729	360	N>K		No	ESP ExAC TOPMed gnomAD
rs1275604494	360	N>T		No	gnomAD
rs765577380	362	M>R		No	ExAC gnomAD
rs765577380	362	M>T		No	ExAC gnomAD
rs755186379	362	M>V		No	ExAC TOPMed gnomAD
COSM4894018 COSM4894019	364	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs945697999	365	Y>C		No	TOPMed gnomAD
rs945697999	365	Y>S		No	TOPMed gnomAD
TCGA novel	366	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs200722793	367	N>Y		No	1000Genomes ExAC
rs1580982931	369	N>T		No	Ensembl
rs765485010	370	R>C		No	ExAC TOPMed gnomAD
rs765485010	370	R>G		No	ExAC TOPMed gnomAD
rs762826694	370	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs765485010	370	R>S		No	ExAC TOPMed gnomAD
rs764027557	371	I>L		No	ExAC TOPMed gnomAD
rs764027557	371	I>V		No	ExAC TOPMed gnomAD
rs751419394	372	M>I		No	ExAC gnomAD
rs1463336252	372	M>T		No	gnomAD
rs1012568707	372	M>V		No	TOPMed gnomAD
rs1161094085 COSM1693357 COSM1693358	373	S>F	Variant assessed as Somatic; MODERATE impact. skin [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl NCI-TCGA
rs1580983271	373	S>P		No	Ensembl
rs749891135 COSM1418475 COSM1418476	374	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs201405841	376	S>F		No	ExAC gnomAD
rs779681212	376	S>P		No	ExAC
rs564023716	377	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs778157076	377	R>H		No	ExAC TOPMed gnomAD
rs778157076	377	R>L		No	ExAC TOPMed gnomAD
rs778157076	377	R>P		No	ExAC TOPMed gnomAD
rs1228636476	378	L>F		No	gnomAD
rs777005096	378	L>P		No	ExAC
rs1251483120	379	S>P		No	gnomAD
TCGA novel	380	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1037422 COSM1037420	381	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763305275	382	G>A		No	ExAC TOPMed gnomAD
TCGA novel	382	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs775831111	382	G>S		No	ExAC TOPMed gnomAD
COSM1037425 rs764255455 COSM1037423	384	Y>C	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1232182380	385	A>D		No	TOPMed
rs1232182380	385	A>G		No	TOPMed
rs751320978	389	I>F		No	ExAC gnomAD
rs1490848802	389	I>M		No	TOPMed gnomAD
rs1003519497	392	I>L		No	TOPMed gnomAD
rs1003519497	392	I>V		No	TOPMed gnomAD
rs1193671850	394	T>I		No	TOPMed gnomAD
TCGA novel	395	Q>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2079877033	397	D>N		No	Ensembl
rs368108358	399	E>K		No	Ensembl
rs142370141	401	K>R		No	ESP ExAC TOPMed gnomAD
rs750398446	402	S>N		No	ExAC gnomAD
rs1376143446	402	S>R		No	gnomAD
rs2289778	403	F>L		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	404	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1287577678	404	A>T		No	gnomAD
rs1226894346	404	A>V		No	TOPMed gnomAD
rs2149403091	405	A>S		No	Ensembl
TCGA novel	405	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs754572975 COSM1037428 COSM1037426	410	R>C	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs139591910	410	R>H		No	TOPMed gnomAD
rs778440570	411	S>N		No	ExAC TOPMed gnomAD
rs1445082655	412	T>N		No	TOPMed
rs1282025271	412	T>S		No	gnomAD
rs2079881212	413	I>V		No	TOPMed
rs1215285323	415	A>S		No	TOPMed gnomAD
rs1215285323	415	A>T		No	TOPMed gnomAD
rs747328303	416	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs771263399	418	A>T		No	ExAC gnomAD
rs2079883340	421	H>R		No	TOPMed
rs1321067563	421	H>Y		No	TOPMed gnomAD
rs1460566800	422	Q>R		No	TOPMed
rs781715049	423	K>Q		No	ExAC gnomAD
TCGA novel	424	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs138624947	424	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	424	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4825266 COSM4825267	425	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM581307 COSM581308 rs754353572	426	Q>K	lung [Cosmic]	No	cosmic curated gnomAD
TCGA novel	427	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	427	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781448055	429	S>L		No	ExAC gnomAD
rs2149431810	430	G>V		No	Ensembl
rs2080332139	431	V>E		No	Ensembl
rs780720857	431	V>M		No	ExAC gnomAD
rs1273521942	433	A>D		No	gnomAD
rs749314623	433	A>T		No	ExAC gnomAD
rs1581027495	435	C>G		No	Ensembl
rs768685899	437	M>T		No	ExAC TOPMed gnomAD
rs774623456	440	E>K		No	ExAC gnomAD
rs1181397779	441	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1255533658	442	G>D		No	gnomAD
rs748371425	445	S>P		No	ExAC gnomAD
rs1408634891	446	E>K		No	TOPMed gnomAD
rs1408634891	446	E>Q		No	TOPMed gnomAD
rs2080336267	447	M>I		No	gnomAD
rs2080336105	447	M>T		No	gnomAD
rs2080336520	448	Q>K		No	TOPMed
COSM1308499 COSM1308498	449	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs111472457	451	E>D		No	ExAC gnomAD
rs145154359	452	L>Q		No	1000Genomes ExAC TOPMed gnomAD
rs575848633	452	L>V		No	1000Genomes ExAC TOPMed gnomAD
COSM3800979 COSM3800980	453	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs950036349	454	I>T		No	TOPMed gnomAD
COSM4935570 COSM4935571	455	H>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1051582363	455	H>Q		No	TOPMed gnomAD
rs1360998481	456	H>Q		No	TOPMed gnomAD
rs2080338370	456	H>R		No	gnomAD
rs555007733	457	H>N		No	1000Genomes gnomAD
rs555007733	457	H>Y		No	1000Genomes gnomAD
rs768120788	459	T>I		No	ExAC gnomAD
rs1560582010	467	A>T		No	Ensembl
rs1278212375	469	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1278212375	469	T>R		No	TOPMed gnomAD
rs752576805	471	V>A		No	Ensembl
rs2080900906	472	S>R		No	gnomAD
rs544049520	474	D>G		No	1000Genomes
TCGA novel	475	G>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM203207 COSM203208	475	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3974128 COSM3974127	476	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1037431 COSM1037429 rs1373087480	477	A>V	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs1320211256	480	D>E		No	gnomAD
rs1345558885	481	V>M		No	gnomAD
rs763644292	484	R>L		No	ExAC TOPMed gnomAD
rs763644292	484	R>Q		No	ExAC TOPMed gnomAD
rs201924423	484	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs779499911	487	S>G		No	ExAC gnomAD
rs1468302262	488	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs752649073	488	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs758537308	489	G>R		No	ExAC TOPMed gnomAD
rs777954894	490	N>K		No	ExAC TOPMed gnomAD
COSM3586566 COSM3586565	491	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1375131220	491	S>P		No	TOPMed
rs912846821	492	E>D		No	TOPMed gnomAD
rs770680654	492	E>K		No	ExAC TOPMed gnomAD
COSM5863372 COSM5863371	493	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1037434 COSM1037432	493	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs753457795	495	T>M		No	ExAC TOPMed gnomAD
rs769559282	497	T>A		No	ExAC gnomAD
rs1193038388	498	A>T		No	TOPMed gnomAD
rs2080907590	499	N>S		No	TOPMed
rs142387311	502	K>E		No	ESP ExAC gnomAD
rs768339670	502	K>R		No	ExAC TOPMed gnomAD
rs2080908821	504	V>M		No	Ensembl
rs1444242851	506	Q>E		No	gnomAD
TCGA novel	508	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	509	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs369079208	510	V>L		No	ESP ExAC TOPMed gnomAD
rs369079208	510	V>M		No	ESP ExAC TOPMed gnomAD
rs2080910519	512	H>L		No	Ensembl
TCGA novel	512	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs766098131	513	E>D		No	ExAC TOPMed gnomAD
rs1560594705 COSM3586570 COSM3586569	513	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs1560594754	514	V>L		No	Ensembl
rs765655082	516	H>Y		No	ExAC gnomAD
rs950358380	518	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1560594838	519	R>Q		No	TOPMed
rs35057827	520	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs35057827	520	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM2154299 rs147539685 COSM2154300	520	R>W	pancreas central_nervous_system [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM727794 COSM727793	522	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1581078329	522	E>G		No	Ensembl
rs1435543271	523	S>N		No	TOPMed gnomAD
rs757420104	527	H>D		No	ExAC gnomAD
rs757420104	527	H>Y		No	ExAC gnomAD
rs781489605	528	R>C		No	ExAC TOPMed gnomAD
rs781489605	528	R>G		No	ExAC TOPMed gnomAD
rs745583948 COSM1037440 COSM1037438	528	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs745583948	528	R>P		No	ExAC gnomAD
rs1581078564	530	V>G		No	Ensembl
rs145372611	530	V>M		No	ESP ExAC TOPMed gnomAD
rs559509346	531	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs200426937	531	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs1581078764	533	H>P		No	Ensembl
rs765678789	535	R>Q		No	ExAC TOPMed gnomAD
rs373695522	535	R>W		No	ESP ExAC TOPMed gnomAD
rs933226210	536	L>V		No	Ensembl
COSM6162913 COSM6162914	539	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1227217399	540	V>D		No	gnomAD
rs1056310843 RCV002249056	540	V>I		No	ClinVar TOPMed dbSNP gnomAD
rs1056310843	540	V>L		No	TOPMed gnomAD
rs1239242304	550	D>G		No	gnomAD
rs1031039993	550	D>N		No	gnomAD
rs1031039993	550	D>Y		No	gnomAD
COSM6095925 COSM6095926	551	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	551	W>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777885226	552	I>V		No	ExAC TOPMed gnomAD
rs1204492703	553	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1430155437	556	G>D		No	gnomAD
rs753908960	558	A>G		No	ExAC TOPMed gnomAD
rs1189439510	558	A>T		No	gnomAD
rs753908960	558	A>V		No	ExAC TOPMed gnomAD
rs989671927	559	F>Y		No	TOPMed gnomAD
rs1560631756	563	H>Q		No	Ensembl
rs2082337974	564	T>A		No	Ensembl
rs1453598096	564	T>S		No	TOPMed gnomAD
rs2082338325	565	G>A		No	Ensembl
rs915365444	566	V>A		No	Ensembl
rs537533367	568	K>M		No	1000Genomes ExAC
rs557200353	571	H>R		No	1000Genomes ExAC gnomAD
rs756322644	574	R>G		No	ExAC TOPMed gnomAD
rs766536285	574	R>Q		No	ExAC TOPMed gnomAD
rs756322644	574	R>W		No	ExAC TOPMed gnomAD
TCGA novel	576	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM5420873 COSM5420874	581	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2082340890	582	D>E		No	Ensembl
rs754827445	582	D>N		No	ExAC
rs2082341506	585	E>D		No	TOPMed
rs1231654429	585	E>G		No	TOPMed gnomAD
rs61746078	585	E>Q		No	ExAC TOPMed gnomAD
rs1231654429	585	E>V		No	TOPMed gnomAD
rs2082341703	587	A>D		No	Ensembl
rs752728212	588	Q>*		No	ExAC
rs752728212	588	Q>K		No	ExAC
rs777294280	588	Q>L		No	ExAC
rs777294280	588	Q>R		No	ExAC
COSM1037443 COSM1037441	590	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1037444 COSM1037446	590	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1658158752	592	T>I		No	gnomAD
rs1461199372	594	A>E		No	gnomAD
COSM3426986 rs1461199372 COSM3426985	594	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated gnomAD
rs1214930111	596	K>R		No	TOPMed
rs1295895983	598	L>P		No	gnomAD
rs768979505	599	E>Q		No	ExAC TOPMed gnomAD
rs779210976	602	E>A		No	ExAC TOPMed
rs779210976	602	E>G		No	ExAC TOPMed
rs1410285689	603	Q>H		No	TOPMed gnomAD
rs371608281	605	A>P		No	ESP ExAC TOPMed gnomAD
rs371608281	605	A>S		No	ESP ExAC TOPMed gnomAD
rs2087969095	607	T>M		No	TOPMed
rs760808499	608	G>R		No	ExAC TOPMed gnomAD
TCGA novel	609	E>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1459444810	611	D>E		No	TOPMed gnomAD
rs771180721	612	P>A		No	ExAC gnomAD
rs765575292	613	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1483462479	615	I>T		No	gnomAD
rs2087975349	616	Y>C		No	gnomAD
rs1576479506	616	Y>H		No	Ensembl
COSM3992690 COSM3992691	617	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1476372037	619	A>S		No	gnomAD
rs2087977126	620	R>G		No	TOPMed gnomAD
rs943574312	620	R>P		No	Ensembl
COSM1255179 COSM1255180 rs943574312	620	R>Q	Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1039448876	621	H>P		No	Ensembl
rs548490375	621	H>Q		No	1000Genomes ExAC gnomAD
rs1231883400	621	H>Y		No	TOPMed
rs1427491805	622	L>M		No	gnomAD
COSM6095924 COSM6095923	622	L>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs751509204	624	V>G		No	ExAC gnomAD
rs377421115	625	R>C		No	ESP ExAC TOPMed gnomAD
rs377421115	625	R>G		No	ESP ExAC TOPMed gnomAD
rs749969083	625	R>H		No	ExAC TOPMed gnomAD
rs749969083	625	R>L		No	ExAC TOPMed gnomAD
rs749969083	625	R>P		No	ExAC TOPMed gnomAD
rs141013560	626	I>V		No	ESP ExAC TOPMed gnomAD
COSM3586573 COSM3586574	627	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2087983869	628	D>G		No	TOPMed
COSM1037447 COSM1037449	628	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1450157789	630	V>L		No	gnomAD
rs1450157789	630	V>M		No	gnomAD
COSM4955979 rs1400105743 COSM4955980	631	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
COSM4112949 rs748480747 COSM4112950	631	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs748480747	631	R>L		No	ExAC TOPMed gnomAD
COSM6162911 COSM6162912	632	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2087987387	634	E>D		No	TOPMed
rs1422971968	634	E>G		No	TOPMed
COSM1566304 COSM1566303	634	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	636	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4112951 COSM4112952 rs2087988200	636	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1417596326	637	K>E		No	Ensembl
rs1172076286	639	L>I		No	TOPMed gnomAD
rs2087991616	643	S>T		No	Ensembl
rs2087992428	644	V>A		No	TOPMed
COSM1693366 COSM1693365	645	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1444586301	648	T>A		No	gnomAD
rs141149712	648	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs141149712	648	T>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2087995330	649	H>Q		No	TOPMed
rs145738438	650	T>I		No	ESP
rs1560759361	651	K>E		No	Ensembl
TCGA novel	651	K>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	652	E>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs2089992924	653	L>M		No	Ensembl
rs148882611	654	W>C		No	ESP ExAC TOPMed gnomAD
rs13074913	654	W>G		No	Ensembl
COSM3586576 COSM3586575	656	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs189745979	657	M>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs189745979	657	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM1037451 COSM1037453	659	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs141371914	660	L>F		No	1000Genomes gnomAD
rs141371914	660	L>I		No	1000Genomes gnomAD
rs13095390	661	Q>H		No	Ensembl
rs761612101	664	M>I		No	ExAC TOPMed gnomAD
rs1212666711	665	L>V		No	gnomAD
TCGA novel	667	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1414173758	668	V>I		No	gnomAD
rs538115022	670	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs773202936	672	S>C		No	ExAC gnomAD
rs773202936	672	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs760169259	674	D>H		No	ExAC TOPMed gnomAD
rs1184266369	677	Q>R		No	gnomAD
TCGA novel	681	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs9841322	681	K>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1576558407	683	F>V		No	Ensembl
COSM727792 COSM727791	684	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	685	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1393194522	688	T>P		No	gnomAD
rs141093471	689	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs2090002029	689	A>V		No	gnomAD
TCGA novel	691	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1412222592	692	D>N		No	gnomAD
rs1289591044	696	N>D		No	TOPMed gnomAD
rs757760603	696	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	697	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772163857	697	V>I		No	TOPMed gnomAD
rs1462181059	699	K>Q		No	TOPMed
rs756232057	702	E>K		No	ExAC TOPMed gnomAD
rs2150060768	703	D>N		No	Ensembl
rs749410144	705	I>M		No	ExAC gnomAD
rs376459385	705	I>N		No	ESP ExAC TOPMed gnomAD
rs376459385	705	I>S		No	ESP ExAC TOPMed gnomAD
rs1237023124	705	I>V		No	TOPMed gnomAD
rs2090005802	707	Q>K		No	Ensembl
rs1252507260	707	Q>R		No	TOPMed gnomAD
rs1185089231	710	S>*		No	gnomAD
rs779202679	710	S>A		No	ExAC TOPMed
rs369298361	711	A>V		No	ESP ExAC gnomAD
rs773114910	712	P>L		No	ExAC gnomAD
rs1312603937	712	P>S		No	TOPMed gnomAD
rs267599582	714	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1373234506	715	L>F		No	gnomAD
rs770918810	716	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs770918810	716	G>W		No	ExAC TOPMed gnomAD
rs2090011648	717	E>A		No	TOPMed
rs752454092	717	E>D		No	ExAC gnomAD
rs944511609	718	P>S		No	Ensembl
rs2090012870	719	S>G		No	Ensembl
rs138531803	719	S>N		No	ESP ExAC TOPMed gnomAD
rs768033121	719	S>R		No	ExAC gnomAD
rs756529548	720	E>K		No	ExAC gnomAD
rs756529548	720	E>Q		No	ExAC gnomAD
rs1560792214	721	A>T		No	Ensembl
TCGA novel	721	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2090480291	723	D>E		No	TOPMed
rs1487526596	725	A>P		No	TOPMed gnomAD
rs1166624148	726	V>M		No	TOPMed gnomAD
rs61745397	727	S>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1560804184	728	N>I		No	Ensembl
rs1576587745	731	T>P		No	Ensembl
rs1458141208	732	P>H		No	TOPMed gnomAD
rs1458141208	732	P>L		No	TOPMed gnomAD
rs775092304	732	P>S		No	1000Genomes ExAC gnomAD
rs748821534	733	H>N		No	ExAC gnomAD
rs2090484629	734	S>N		No	TOPMed gnomAD
rs768358120	734	S>R		No	ExAC TOPMed gnomAD
rs2150096412	735	S>G		No	Ensembl
rs1576587863	736	S>P		No	Ensembl
rs774215335	737	I>T		No	ExAC gnomAD
COSM1418483 COSM1418484	738	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150096471	739	H>N		No	Ensembl
rs1265098734	741	E>G		No	gnomAD
rs760936416	741	E>K		No	ExAC gnomAD
rs766818886	742	S>L		No	ExAC TOPMed gnomAD
COSM6162909 COSM6162910	743	V>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs762878763	743	V>L		No	Ensembl
rs369602016	745	Q>R		No	ESP ExAC TOPMed gnomAD
rs752703180	746	Q>K		No	ExAC TOPMed gnomAD
rs1021976643	747	L>F		No	TOPMed
rs1576588072	749	D>N		No	Ensembl
rs1448085432	751	Q>E		No	gnomAD
rs2090488607	752	V>M		No	TOPMed
TCGA novel	753	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1241536596	754	M>T		No	TOPMed gnomAD
rs758537143	755	E>D		No	ExAC gnomAD
rs764284502	756	E>*		No	ExAC gnomAD
rs1224063744	756	E>A		No	TOPMed gnomAD
COSM3914779 COSM3914778	756	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764284502	756	E>Q		No	ExAC gnomAD
rs1482804299	758	F>L		No	TOPMed gnomAD
rs375653971	759	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs780999875	760	E>K		No	ExAC TOPMed gnomAD
rs2090490862	760	E>V		No	TOPMed
rs996622312	761	R>Q		No	TOPMed gnomAD
rs745673540 COSM367336 COSM367337	761	R>W	lung [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1421624620	763	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	765	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1166553932	766	D>G		No	gnomAD
rs2090492379	766	D>N		No	TOPMed
rs1428592753	767	I>V		No	gnomAD
rs1306069095	768	F>L		No	gnomAD
rs150500689	770	Q>K		No	Ensembl
rs2090493766	771	L>M		No	gnomAD
COSM3396510 COSM3396511 rs768341806	772	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs778689129	772	R>H		No	ExAC TOPMed gnomAD
rs768341806	772	R>S		No	ExAC TOPMed gnomAD
rs747879072	775	E>D		No	ExAC gnomAD
rs1341508925	779	I>N		No	gnomAD
COSM3057565 COSM3057564 rs1285210270	780	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1423941122	781	V>L		No	gnomAD
rs201826068	783	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs375061022	785	L>I		No	ESP ExAC gnomAD
COSM1308502 COSM1308503	786	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150266707	786	D>H		No	Ensembl
rs2150266707	786	D>N		No	Ensembl
rs755363438	787	A>S		No	ExAC TOPMed gnomAD
COSM1037459 rs755363438 COSM1037457	787	A>T	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs779442681	792	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD NCI-TCGA
rs147503705	793	L>F		No	ESP ExAC gnomAD
rs2150266960	793	L>H		No	1000Genomes
rs147503705	793	L>I		No	ESP ExAC gnomAD
rs368587035	794	R>Q		No	ESP ExAC TOPMed gnomAD
rs773381868	794	R>W		No	ExAC gnomAD
rs2150267112 COSM1285638 COSM1285637	796	M>I	autonomic_ganglia Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs2150267081	796	M>T		No	Ensembl
rs1656215830	796	M>V		No	TOPMed
rs771268887	800	N>S		No	ExAC gnomAD
rs2092316802	801	T>K		No	TOPMed gnomAD
rs777064745	801	T>S		No	ExAC gnomAD
rs759346797	803	D>N		No	ExAC TOPMed gnomAD
rs1239392325	804	L>V		No	gnomAD
COSM4399053 rs764993094 COSM4399052	805	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1576717041	805	T>P		No	Ensembl
rs762761398	806	L>V		No	ExAC gnomAD
rs538556913	807	A>E		No	ExAC TOPMed gnomAD
rs538556913	807	A>V		No	ExAC TOPMed gnomAD
rs140243919	808	E>G		No	ESP ExAC TOPMed gnomAD
rs1560857325	808	E>K		No	Ensembl
rs1560857325	808	E>Q		No	Ensembl
rs755345910	810	R>Q		No	ExAC gnomAD
rs767151194	810	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2150267735	811	L>V		No	Ensembl
rs1576717326	812	Q>*		No	Ensembl
rs1576717326	812	Q>E		No	Ensembl
rs753133795	812	Q>R		No	ExAC gnomAD
COSM1037460 COSM1037462 rs758760625	813	R>C	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs367667422	813	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3586579 COSM3586580	814	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs988749057	814	H>Q		No	TOPMed gnomAD
rs747085989	814	H>Y		No	ExAC TOPMed gnomAD
rs1576717478	815	T>K		No	Ensembl
rs2150268120 COSM5863373 COSM5863374	817	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs781546248	817	R>W		No	ExAC gnomAD
rs1576717546	818	K>N		No	Ensembl
rs912979158	819	L>P		No	TOPMed gnomAD
rs912979158	819	L>Q		No	TOPMed gnomAD
rs746030902	819	L>V		No	ExAC TOPMed gnomAD
rs770088606	820	A>D		No	ExAC TOPMed gnomAD
rs2150268338	821	M>I		No	Ensembl
rs2150268401	822	N>K		No	Ensembl
rs775081836	822	N>S		No	ExAC TOPMed gnomAD
rs2150268453	824	M>I		No	Ensembl
rs768566780	825	T>A		No	ExAC TOPMed gnomAD
rs776598696	825	T>I		No	ExAC TOPMed gnomAD
rs776598696	825	T>N		No	ExAC TOPMed gnomAD
rs776598696	825	T>S		No	ExAC TOPMed gnomAD
rs2150268605 TCGA novel	827	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
TCGA novel	829	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2150268641	830	Q>K		No	Ensembl
rs2150268696	831	Q>*		No	Ensembl
rs2092320778	831	Q>P		No	Ensembl
rs760201688	832	G>A		No	ExAC gnomAD
rs2150268757	832	G>R		No	Ensembl
rs752943086	833	Q>R		No	ExAC TOPMed gnomAD
rs972711554	834	D>G		No	Ensembl
rs758868403	835	L>M		No	ExAC gnomAD
rs752164062	836	H>Q		No	ExAC TOPMed gnomAD
rs2092321555	836	H>Y		No	TOPMed
rs112304715	837	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs769850350	840	T>M		No	ExAC TOPMed gnomAD
COSM3846053 COSM3846052	841	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs749031723	841	E>A		No	ExAC TOPMed gnomAD
rs768479973	842	V>A		No	ExAC TOPMed gnomAD
rs2092322828	842	V>F		No	gnomAD
rs1159456558	846	G>E		No	gnomAD
rs1204410868	851	C>*		No	Ensembl
rs1455971505	851	C>S		No	gnomAD
rs771239842	852	E>D		No	gnomAD
rs1430346617	852	E>K		No	TOPMed
rs2092842206	853	K>E		No	Ensembl
rs770526424	854	D>H		No	ExAC TOPMed gnomAD
COSM300477 COSM300478	854	D>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1366064489	855	I>V		No	TOPMed gnomAD
rs776030651	856	D>H		No	ExAC TOPMed gnomAD
rs776030651	856	D>N		No	ExAC TOPMed gnomAD
rs2092842776	858	A>T		No	TOPMed
rs2092842873	858	A>V		No	Ensembl
rs193116930	859	A>T		No	1000Genomes ExAC gnomAD
rs1051553828	861	V>A		No	Ensembl
rs762327137	862	Q>*		No	ExAC gnomAD
rs750978589	863	E>K		No	ExAC TOPMed gnomAD
rs1017889688	864	L>S		No	TOPMed
COSM4411877 COSM4411878	864	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs964778183	865	L>F		No	TOPMed gnomAD
rs766432482	866	E>K		No	ExAC gnomAD
rs753948334	867	F>L		No	ExAC gnomAD
rs753948334	867	F>V		No	ExAC gnomAD
rs1481194638	868	L>F		No	gnomAD
rs2150364762	869	H>N		No	Ensembl
rs1177397551	869	H>P		No	gnomAD
rs1576798965	869	H>Q		No	TOPMed
rs1576798996	873	H>Q		No	Ensembl
COSM727787 COSM727788	873	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150364876	875	L>F		No	Ensembl
rs2092845207	877	L>F		No	Ensembl
rs1032315445	878	N>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1032315445	878	N>H		No	gnomAD
rs2092845495	878	N>S		No	Ensembl
rs1164868672	879	A>S		No	gnomAD
rs2092845805	880	E>*		No	Ensembl
rs1429019381	880	E>G		No	gnomAD
TCGA novel	881	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1275911494	881	Q>E		No	TOPMed gnomAD
rs893784782	882	T>I		No	Ensembl
rs2092846231	883	H>Y		No	gnomAD
rs758252421	885	R>Q		No	ExAC TOPMed gnomAD
rs779118555	885	R>W		No	ExAC TOPMed gnomAD
COSM1037465 COSM1037463	886	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2092846718	887	E>D		No	TOPMed gnomAD
rs1310212200	887	E>Q		No	TOPMed gnomAD
rs746919230	893	R>C		No	ExAC gnomAD
rs770807961	893	R>H		No	ExAC TOPMed gnomAD
rs770807961	893	R>L		No	ExAC TOPMed gnomAD
rs1315816214	894	H>R		No	TOPMed gnomAD
rs776142699	900	K>R		No	ExAC TOPMed gnomAD
rs375809932	902	V>A		No	ESP ExAC gnomAD
COSM5521713 COSM5521712	904	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs769469581	905	W>C		No	ExAC gnomAD
rs1422873567	905	W>G		No	TOPMed gnomAD
rs559612435	907	R>C		No	1000Genomes ExAC TOPMed gnomAD
rs369008691	907	R>H		No	ESP ExAC TOPMed gnomAD
rs369008691	907	R>L		No	ESP ExAC TOPMed gnomAD
rs1030945839	909	G>A		No	Ensembl
rs1030945839	909	G>E		No	Ensembl
rs1181997211	910	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs760956956	912	M>I		No	ExAC TOPMed gnomAD
rs771452399	914	N>S		No	ExAC TOPMed gnomAD
rs956518670	915	A>P		No	TOPMed gnomAD
rs956518670 COSM1670521 COSM1670522	915	A>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated TOPMed gnomAD
rs777184569	915	A>V		No	ExAC TOPMed gnomAD
rs2093232053	917	L>P		No	TOPMed
rs765256087	918	V>L		No	ExAC TOPMed gnomAD
COSM270937 COSM270938	919	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752809322	921	S>I		No	ExAC TOPMed gnomAD
rs752809322	921	S>T		No	ExAC TOPMed gnomAD
rs1022349879	922	S>C		No	gnomAD
rs1022349879	922	S>F		No	gnomAD
rs147315682	924	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	927	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	927	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs201657548	931	R>Q		No	ExAC TOPMed gnomAD
rs376556713	931	R>W		No	ESP ExAC TOPMed gnomAD
rs370659528	933	H>Q		No	ESP ExAC TOPMed gnomAD
rs2093233516	934	E>Q		No	Ensembl
rs2093233799	938	L>V		No	Ensembl
COSM3940250 COSM3940249 rs1005052466	939	A>T	oesophagus [Cosmic]	No	cosmic curated TOPMed gnomAD
rs2093234174	940	I>V		No	Ensembl
rs2093234393 COSM727785 COSM727786	941	E>K	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs2093389130	945	H>N		No	Ensembl
rs1560927763	946	A>D		No	Ensembl
COSM3057591 COSM3057590 rs2093389397	948	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs1170244221	950	Q>K		No	TOPMed gnomAD
rs879442495	950	Q>L		No	TOPMed
rs532130353	952	T>M		No	1000Genomes ExAC TOPMed gnomAD
rs766431991	954	Q>E		No	ExAC gnomAD
COSM581299 COSM581300	954	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2093390050	956	A>T		No	TOPMed
rs1485607922	959	V>I		No	TOPMed
rs148718158	960	Q>R		No	ESP ExAC TOPMed gnomAD
rs1001691505	964	E>K		No	TOPMed gnomAD
rs142259596	965	V>M		No	ESP ExAC TOPMed gnomAD
rs1217616932	968	Q>K		No	TOPMed gnomAD
rs2093390952	969	A>V		No	TOPMed
COSM4760953 COSM4760954 rs758082655	970	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
COSM1418489 COSM1418490 rs746247182	973	D>N	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs139299626	974	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1371798406	975	D>G		No	gnomAD
rs1188042863	975	D>N		No	gnomAD
rs774545116	978	R>Q		No	Ensembl
COSM245116 COSM245117 rs1255029861	978	R>W	prostate [Cosmic]	No	cosmic curated TOPMed gnomAD
TCGA novel	979	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	979	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774513024	980	C>Y		No	ExAC TOPMed gnomAD
rs761899767	984	V>L		No	ExAC gnomAD
rs1576899617	985	A>P		No	Ensembl
COSM1037468 rs1466309558 COSM1037466	985	A>V	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs767857150	986	L>F		No	ExAC gnomAD
rs1402769598	986	L>R		No	TOPMed gnomAD
rs1294257800	987	H>L		No	TOPMed gnomAD
rs760601629	987	H>Y		No	ExAC TOPMed gnomAD
rs753754354	991	L>F		No	ExAC TOPMed gnomAD
rs2093393060	992	M>I		No	TOPMed
rs1469104497	995	M>I		No	TOPMed gnomAD
rs1201974871	995	M>T		No	gnomAD
rs2093393372	997	D>V		No	TOPMed
rs764616767	998	R>Q		No	ExAC gnomAD
rs1265188394	998	R>W		No	TOPMed gnomAD
rs369397521	999	L>V		No	ESP ExAC TOPMed gnomAD
rs1576900023	1001	L>M		No	Ensembl
COSM1418491 COSM1418492	1001	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1576900090	1002	V>G		No	Ensembl
rs757990788	1002	V>I		No	ExAC gnomAD
rs1449234865	1003	N>S		No	gnomAD
rs1194597403	1004	A>T		No	gnomAD
rs2093394279	1006	V>A		No	gnomAD
rs1456728329	1008	F>S		No	gnomAD
rs1259621731	1012	S>C		No	TOPMed gnomAD
COSM3586590 COSM3586589	1013	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1377398299	1014	Q>R		No	gnomAD
rs776504013	1016	C>Y		No	ExAC gnomAD
rs374025165	1018	V>A		No	ESP ExAC gnomAD
rs2093571091	1020	E>D		No	Ensembl
TCGA novel	1020	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2093571174	1021	S>C		No	Ensembl
rs748844790	1026	Y>H		No	Ensembl
rs547990015	1027	R>Q		No	gnomAD
rs765238695	1027	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
TCGA novel	1028	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1237806 COSM1237805	1029	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2093571490	1030	E>K		No	Ensembl
rs922061791	1031	D>H		No	TOPMed gnomAD
rs922061791	1031	D>N		No	TOPMed gnomAD
rs922061791	1031	D>Y		No	TOPMed gnomAD
rs1304729291	1033	C>*		No	gnomAD
rs1560944122	1033	C>R		No	Ensembl
rs752139764	1033	C>Y		No	ExAC gnomAD
rs762520416	1034	G>S		No	ExAC gnomAD
rs763705498	1036	R>G		No	ExAC TOPMed gnomAD
rs756927820	1036	R>Q		No	ExAC gnomAD
rs754233348	1037	D>N		No	ExAC gnomAD
rs1244106396	1041	P>L		No	TOPMed gnomAD
rs987462182	1041	P>S		No	TOPMed gnomAD
rs748232934	1043	A>T		No	ExAC gnomAD
rs1482962032	1044	E>D		No	TOPMed gnomAD
COSM3426987 COSM3426988	1045	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2093572946	1046	D>N		No	TOPMed gnomAD
rs2093572946	1046	D>Y		No	TOPMed gnomAD
rs772315044	1047	H>P		No	ExAC gnomAD
rs1420514784	1050	P>H		No	gnomAD
TCGA novel	1051	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1051	L>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs183838131	1060	E>Q		No	1000Genomes gnomAD
rs2093573484	1060	E>V		No	Ensembl
COSM1037471 COSM1037469	1061	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1063	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2150597235	1065	A>S		No	Ensembl
rs745622605	1067	T>S		No	ExAC gnomAD
rs867737888	1069	A>T		No	Ensembl
rs1308494409	1070	R>W		No	gnomAD
rs143413360	1074	E>D		No	1000Genomes ExAC gnomAD
rs1576968912	1075	V>G		No	TOPMed
rs1204959221	1075	V>M		No	gnomAD
COSM6095921 COSM6095922	1078	K>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4112958 COSM4112957	1078	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2093683135	1080	I>N		No	TOPMed
rs2093683264	1082	R>K		No	Ensembl
rs772957046	1083	N>D		No	ExAC gnomAD
rs2150597778	1085	V>I		No	Ensembl
rs1175482214	1086	S>G		No	gnomAD
rs2093683640	1086	S>T		No	TOPMed
rs1427389692	1088	P>A		No	TOPMed gnomAD
rs1427389692	1088	P>T		No	TOPMed gnomAD
rs2093683850	1089	S>G		No	TOPMed
rs1471080700	1089	S>T		No	TOPMed gnomAD
rs753140895	1091	A>P		No	ExAC TOPMed gnomAD
rs753140895	1091	A>T		No	ExAC TOPMed gnomAD
rs1373231312	1093	H>L		No	TOPMed gnomAD
rs757401330	1095	R>Q		No	ExAC TOPMed gnomAD
rs375108520	1095	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs781249162	1096	G>E		No	ExAC gnomAD
rs1403752792	1098	E>K		No	TOPMed gnomAD
rs756323157	1100	Q>H		No	ExAC gnomAD
rs1424573484	1103	A>V		No	gnomAD
rs1456266446	1104	I>V		No	gnomAD
rs2150670853	1106	S>C		No	Ensembl
rs1367817563	1106	S>N		No	gnomAD
TCGA novel	1108	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1109	L>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2093833696	1111	R>K		No	TOPMed
rs77832285	1112	E>*		No	Ensembl
COSM3586592 COSM3586591	1112	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM5478491 COSM5478490	1114	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3660149 COSM3660150 rs375081975	1114	R>H	liver Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs954989552	1115	V>L		No	TOPMed gnomAD
rs954989552 COSM1418496 COSM1418495	1115	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1266832189	1117	H>R		No	TOPMed
rs778799753	1117	H>Y		No	ExAC gnomAD
TCGA novel	1118	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs748065907	1120	T>A		No	ExAC TOPMed gnomAD
COSM42874 COSM3586593	1120	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1377057020	1123	K>R		No	gnomAD
rs987606026	1124	R>L		No	TOPMed gnomAD
COSM1719195 rs987606026 COSM1719194	1124	R>Q	NS Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1245112892 COSM1418498 COSM1418497	1124	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs777267764	1125	R>Q		No	ExAC TOPMed gnomAD
COSM1165250 COSM1165251 rs771930077	1125	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1577005164	1126	L>V		No	Ensembl
rs1238845751	1131	Q>E		No	TOPMed gnomAD
rs1560969490	1133	V>M		No	Ensembl
rs1577005307	1134	V>G		No	Ensembl
rs776467881	1135	F>L		No	ExAC gnomAD
rs769093448	1137	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs373031459	1137	R>H		No	ESP ExAC TOPMed gnomAD
rs373031459	1137	R>L		No	ESP ExAC TOPMed gnomAD
rs376875291	1139	A>T		No	ESP ExAC TOPMed gnomAD
COSM71242	1142	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4583869 COSM4583870 rs762144643	1142	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs773631408	1143	L>F		No	ExAC gnomAD
rs1221976524	1144	D>E		No	gnomAD
rs760720956	1144	D>N		No	ExAC gnomAD
rs760720956	1144	D>Y		No	ExAC gnomAD
COSM3846057 COSM3846056	1146	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766396402	1148	E>K		No	ExAC TOPMed gnomAD
rs766396402	1148	E>Q		No	ExAC TOPMed gnomAD
COSM4934242 COSM4934241	1154	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM727778 COSM727777	1156	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150680189	1157	H>Y		No	Ensembl
rs1204661866	1158	T>A		No	gnomAD
rs890446175	1159	S>F		No	TOPMed
rs1449245214	1160	T>S		No	TOPMed gnomAD
rs2093855567	1162	E>K		No	TOPMed gnomAD
rs199727098	1163	T>N		No	1000Genomes ExAC TOPMed gnomAD
rs765387746	1164	T>A		No	ExAC TOPMed gnomAD
TCGA novel rs2093855961	1165	E>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs201706242	1166	E>G		No	1000Genomes
rs758171598	1167	T>A		No	ExAC TOPMed gnomAD
rs2093856280	1167	T>I		No	TOPMed gnomAD
TCGA novel	1167	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2093856349	1168	Q>H		No	TOPMed
rs2093856407	1169	E>K		No	TOPMed
rs1466070030	1170	L>R		No	gnomAD
TCGA novel	1172	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2093856676	1173	E>A		No	Ensembl
COSM1757064 rs1382621747 COSM1757065	1174	Y>C	urinary_tract [Cosmic]	No	cosmic curated gnomAD
TCGA novel	1175	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751497689	1175	G>R		No	ExAC gnomAD
rs1298568038	1176	E>A		No	gnomAD
rs757292256	1176	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA
rs1403300510	1178	R>G		No	gnomAD
rs745386897	1178	R>S		No	ExAC TOPMed gnomAD
TCGA novel	1179	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1331920809	1180	P>S		No	TOPMed gnomAD
rs2093857425	1181	A>S		No	TOPMed
TCGA novel	1183	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1357956440	1184	T>I		No	gnomAD
rs189586882	1186	E>D		No	1000Genomes ExAC TOPMed gnomAD
COSM1693374 COSM1693373	1186	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2107563870	1186	E>Q		No	Ensembl
rs374383575	1189	K>E		No	ESP ExAC TOPMed gnomAD
rs748843236	1190	L>F		No	ExAC
rs2059191168	1192	I>V		No	TOPMed
COSM6095919 COSM6095920	1194	L>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1488601534	1194	L>R		No	gnomAD
rs754690715	1195	A>G		No	ExAC TOPMed gnomAD
rs747383247	1196	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1442702708	1200	E>D		No	TOPMed gnomAD
rs771832826	1202	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1295872116	1204	I>L		No	gnomAD
rs1166640661	1206	A>S		No	TOPMed gnomAD
rs771412100	1206	A>V		No	ExAC TOPMed gnomAD
rs139468141 COSM3057631 COSM3057630	1207	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs2059194637	1213	V>A		No	gnomAD
rs201801993 COSM1162738 COSM1162737	1214	T>N	pancreas [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
RCV000884695 rs148828057	1215	T>K		No	ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs148828057	1215	T>M		No	ESP ExAC TOPMed gnomAD
rs1381138640	1216	V>M		No	gnomAD
rs1230600629	1218	K>E		No	gnomAD
rs2059196559	1218	K>T		No	Ensembl
COSM4112960 COSM4112959	1219	H>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1268621262	1224	S>Y		No	TOPMed
rs368438979	1227	M>L		No	ESP ExAC TOPMed gnomAD
COSM1308504 COSM1308505	1228	G>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3767218 COSM3767219 rs767529555	1231	R>Q	liver Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs750434014	1237	A>T		No	ExAC gnomAD
rs2059198951	1241	N>H		No	Ensembl
rs1459913150	1241	N>S		No	gnomAD
rs760822519	1242	T>I		No	Ensembl
rs760822519	1242	T>K		No	Ensembl
rs750813370	1244	D>N		No	ExAC gnomAD
rs750813370	1244	D>Y		No	ExAC gnomAD
COSM275619 COSM275618	1247	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs866766522	1249	E>K		No	Ensembl
TCGA novel	1249	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs756566236	1250	L>M		No	ExAC TOPMed gnomAD
rs2107591156	1251	D>N		No	Ensembl
rs1400192975	1252	I>M		No	gnomAD
rs1248551186	1253	I>F		No	TOPMed gnomAD
rs980944354	1254	P>L		No	Ensembl
rs749299134	1255	A>S		No	ExAC gnomAD
rs749299134	1255	A>T		No	ExAC gnomAD
rs768903468	1255	A>V		No	ExAC gnomAD
rs1014023160	1256	S>R		No	TOPMed gnomAD
rs1220400741	1256	S>T		No	TOPMed gnomAD
COSM3426989 COSM3426990 rs867536649	1258	S>L	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs867536649	1258	S>W		No	gnomAD
rs1287866570	1259	D>N		No	gnomAD
rs1221493763	1260	R>P		No	TOPMed gnomAD
rs1221493763	1260	R>Q		No	TOPMed gnomAD
COSM3586596 COSM3586597 rs748339297	1260	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2059332346	1261	E>D		No	TOPMed gnomAD
rs2059332494	1262	V>G		No	Ensembl
rs772820320	1265	R>P		No	ExAC gnomAD
COSM1243329 COSM1243330 rs772820320	1265	R>Q	oesophagus [Cosmic]	No	cosmic curated ExAC gnomAD
rs1025185719 COSM4973401 COSM4973400	1265	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs770766778	1266	D>E		No	ExAC TOPMed gnomAD
rs776667972	1267	A>G		No	ExAC TOPMed gnomAD
rs796691406	1267	A>T		No	gnomAD
rs561361571	1268	N>S		No	TOPMed gnomAD
rs1361773277	1269	H>N		No	gnomAD
rs1361773277	1269	H>Y		No	gnomAD
rs148014867	1270	E>K		No	ESP ExAC TOPMed gnomAD
rs148014867	1270	E>Q		No	ESP ExAC TOPMed gnomAD
rs143519745	1271	V>I		No	ESP ExAC TOPMed gnomAD
rs200906284	1272	N>D		No	1000Genomes ExAC gnomAD
rs1274912240	1272	N>S		No	TOPMed gnomAD
rs778311282	1273	E>*		No	ExAC TOPMed gnomAD
rs778311282	1273	E>K		No	ExAC TOPMed gnomAD
rs147099139	1274	E>D		No	ESP TOPMed gnomAD
rs999815040	1275	K>Q		No	TOPMed
rs899670932	1276	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM4491568 rs1038128039 COSM4491569	1276	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs750752559	1279	A>T		No	ExAC TOPMed gnomAD
rs1032511540	1280	R>Q		No	gnomAD
rs1221373420	1280	R>W		No	gnomAD
rs2059336569	1281	K>R		No	Ensembl
rs1395347752	1283	E>D		No	gnomAD
rs1332061896	1284	F>L		No	gnomAD
TCGA novel	1286	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1342216807	1286	M>V		No	gnomAD
rs2059902377	1287	A>T		No	TOPMed
rs766722901	1290	L>F		No	ExAC gnomAD
TCGA novel	1290	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4112962 rs1220758686 COSM4112961	1291	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	gnomAD NCI-TCGA Cosmic
COSM1037480 COSM1037478	1295	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1322971246	1297	V>A		No	gnomAD
rs1198834498	1298	R>S		No	gnomAD
rs1701222700	1300	L>S		No	TOPMed
rs2059904023	1301	H>Y		No	Ensembl
rs2059904376	1304	L>V		No	TOPMed
rs760043740	1306	T>I		No	ExAC gnomAD
COSM3586598 COSM3586599	1309	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2059951798	1311	M>K		No	Ensembl
rs1385366054	1312	T>I		No	gnomAD
rs1325583270	1313	S>C		No	TOPMed gnomAD
rs1325583270	1313	S>G		No	TOPMed gnomAD
rs764170666	1313	S>N		No	ExAC gnomAD
rs1044941148	1314	G>S		No	Ensembl
rs1307640945	1315	V>A		No	gnomAD
rs751605897	1315	V>M		No	ExAC gnomAD
rs2059953081	1316	E>A		No	TOPMed
rs779848977	1319	P>R		No	ExAC gnomAD
rs369756232	1319	P>S		No	ESP ExAC TOPMed gnomAD
rs551346771	1320	P>A		No	1000Genomes ExAC TOPMed gnomAD
rs1215771573	1320	P>L		No	Ensembl
rs551346771	1320	P>S		No	1000Genomes ExAC TOPMed gnomAD
rs551346771	1320	P>T		No	1000Genomes ExAC TOPMed gnomAD
rs1451637199	1321	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1055464623	1324	N>K		No	TOPMed gnomAD
rs747665988	1324	N>S		No	ExAC TOPMed gnomAD
rs2289838 VAR_020192	1326	E>D		No	UniProt ExAC TOPMed dbSNP gnomAD
rs2059955391	1326	E>K		No	TOPMed
COSM3800982 COSM3800981	1326	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3586602 COSM3586603	1326	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1456550513	1327	H>P		No	gnomAD
TCGA novel	1327	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs770232422	1329	I>V		No	ExAC gnomAD
COSM1197494 COSM1197493 rs916941927	1331	G>C	lung [Cosmic]	No	cosmic curated TOPMed
rs949934663	1331	G>V		No	TOPMed
rs1448245114	1335	E>D		No	gnomAD
rs1447772363	1335	E>G		No	TOPMed gnomAD
COSM3914781 COSM3914780 rs139954729	1338	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs2059959128 TCGA novel	1339	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
TCGA novel	1339	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2059959364	1340	H>Y		No	TOPMed
rs1178485531	1341	N>K		No	gnomAD
rs149360410	1341	N>S		No	ESP ExAC TOPMed gnomAD
rs760825511	1343	I>V		No	ExAC TOPMed gnomAD
rs2061277151	1344	F>S		No	Ensembl
TCGA novel	1349	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1382006517	1352	E>K		No	Ensembl
rs2108020021	1356	E>D		No	Ensembl
rs2061279206	1358	V>L		No	TOPMed
COSM3914783 COSM3914782	1359	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1362	F>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs144667540	1363	V>I		No	ESP TOPMed gnomAD
rs2061515800	1367	D>E		No	Ensembl
rs1292415250	1368	K>T		No	TOPMed gnomAD
rs2061516203	1370	Q>R		No	Ensembl
rs2061516741	1373	V>I		No	gnomAD
rs773264205	1374	T>A		No	ExAC gnomAD
COSM4401289 COSM4401288	1377	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2061517167	1378	N>D		No	TOPMed
rs2061517670 TCGA novel	1380	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
rs1257325588	1381	D>N		No	gnomAD
rs145688850	1383	N>S		No	1000Genomes ExAC TOPMed gnomAD
COSM6095917 COSM6095918	1384	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2061518580	1384	Q>R		No	TOPMed gnomAD
TCGA novel	1387	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs866590966	1388	E>K		No	Ensembl
rs74389479	1389	H>N		No	Ensembl
COSM1211330 rs759826348 COSM1211329	1390	A>V	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs764898643	1393	F>Y		No	ExAC TOPMed gnomAD
rs752539205	1395	D>E		No	ExAC TOPMed gnomAD
rs2061520105	1395	D>Y		No	TOPMed
rs2108252781	1396	E>V		No	Ensembl
rs2062129759	1397	I>L		No	TOPMed
rs759608802	1397	I>T		No	ExAC TOPMed gnomAD
rs770113483	1398	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs200295956	1400	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200295956	1400	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3846060 COSM3846061 rs775145320	1400	R>W	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM6095916 COSM6095915	1402	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1693375 COSM1693376	1406	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1048418653	1410	Y>H		No	TOPMed
rs2062132467	1413	K>Q		No	Ensembl
rs761877603	1417	R>K		No	ExAC gnomAD
TCGA novel	1420	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755706470	1423	L>M		No	ExAC TOPMed gnomAD
rs778043500	1428	L>I		No	ExAC gnomAD
rs781743389	1437	G>R		No	ExAC gnomAD
rs745913088	1440	K>R		No	ExAC
COSM4402950 COSM4402951	1441	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1443	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1450	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1277059683	1453	A>V		No	gnomAD
rs774277207	1455	D>G		No	ExAC gnomAD
COSM3914787 COSM3914786	1455	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1284394701	1457	M>I		No	gnomAD
rs748039238	1457	M>V		No	ExAC gnomAD
rs773247077	1459	V>L		No	ExAC gnomAD
rs1262030959	1460	S>N		No	gnomAD
rs1450490876	1461	M>R		No	gnomAD
TCGA novel	1466	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1561116630	1466	D>N		No	Ensembl
rs1561116630	1466	D>Y		No	Ensembl
rs753934958	1467	E>K		No	ExAC gnomAD
rs753934958	1467	E>Q		No	ExAC gnomAD
rs1426047052	1470	D>Y		No	TOPMed
rs1294563766	1471	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1334882900	1472	Q>R		No	TOPMed gnomAD
rs1197488396	1473	G>E		No	gnomAD
rs2063069457	1473	G>R		No	gnomAD
rs779153128	1474	E>V		No	ExAC gnomAD
rs1481612331	1476	I>V		No	gnomAD
rs752921197	1477	L>I		No	ExAC gnomAD
rs1255270266	1486	P>A		No	gnomAD
rs758552417	1486	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs746838131	1488	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs2063072134 COSM1037483 COSM1037481	1491	R>Q	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated TOPMed
rs781157532	1491	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
COSM1037487 COSM1037489	1494	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1037484 rs2063072358 COSM1037486	1494	R>W	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1577376236	1495	E>G		No	Ensembl
rs774869083	1496	R>Q		No	ExAC gnomAD
rs1302616639	1496	R>W		No	TOPMed gnomAD
rs1264301330	1497	H>D		No	Ensembl
rs1264301330	1497	H>Y		No	Ensembl
rs761165982	1503	I>T		No	ExAC
rs773625957	1503	I>V		No	ExAC gnomAD
rs2063075269	1504	S>A		No	Ensembl
rs866008860	1506	V>I		No	gnomAD
COSM3800984 COSM3800983	1508	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752730760	1512	K>R		No	ExAC gnomAD
COSM3586611 COSM3586610	1514	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758633178	1515	S>T		No	ExAC gnomAD
rs529612300	1517	H>R		No	1000Genomes ExAC gnomAD
rs751347515	1517	H>Y		No	ExAC gnomAD
rs1421803746	1518	T>A		No	TOPMed gnomAD
rs780998165 COSM460929 COSM460928	1518	T>M	cervix Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1421803746	1518	T>P		No	TOPMed gnomAD
rs1376459832	1519	K>I		No	gnomAD
COSM3586612 COSM3586613	1530	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1238125303	1532	G>C		No	gnomAD
rs1179323692	1533	V>L		No	gnomAD
rs1179323692	1533	V>M		No	gnomAD
COSM4112966 COSM4112965	1534	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1163436733	1537	V>L		No	TOPMed gnomAD
rs1163436733	1537	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs942398849	1540	D>E		No	TOPMed gnomAD
rs868845385	1540	D>N		No	Ensembl
rs2063143512	1541	P>A		No	TOPMed
COSM3914789 COSM3914788	1541	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1542	C>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs774429172	1545	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM1327915 COSM1327914	1549	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs762012859	1549	G>R		No	ExAC gnomAD
rs373617742	1550	R>C		No	ESP ExAC TOPMed gnomAD
rs750192369	1550	R>H		No	ExAC gnomAD
rs1291696798	1551	T>I		No	TOPMed gnomAD
rs1577381973	1551	T>P		No	Ensembl
rs2108443806	1559	V>A		No	Ensembl
rs753674413	1559	V>L		No	ExAC gnomAD
rs753674413	1559	V>M		No	ExAC gnomAD
TCGA novel	1564	N>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM6162906 rs1033137258 COSM1536149 COSM1536150 COSM6162905	1564	N>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic Ensembl NCI-TCGA
rs760985257	1565	I>T		No	ExAC gnomAD
rs766018442	1567	T>I		No	ExAC gnomAD
rs759377501	1569	Q>H		No	ExAC gnomAD
rs1428416626	1569	Q>R		No	TOPMed
COSM1037493 rs1433794431 COSM1037495	1573	K>E	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1377489600	1574	N>S		No	gnomAD
rs1415679291	1575	I>V		No	TOPMed gnomAD
rs201046827 COSM3586614 COSM3586615	1576	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
rs752223174	1576	R>L		No	ExAC gnomAD
rs752223174	1576	R>Q		No	ExAC gnomAD
rs2063312108	1577	E>D		No	TOPMed
rs2063312413	1578	V>L		No	TOPMed
rs772381582	1579	I>V		No	Ensembl
rs1420922134	1581	E>Q		No	TOPMed gnomAD
rs1211103304	1584	I>V		No	gnomAD
rs933531951	1585	H>Q		No	TOPMed
rs1260633172	1587	K>E		No	gnomAD
rs1062749	1588	G>E		No	Ensembl
rs1577395393	1589	A>T		No	Ensembl
TCGA novel	1590	L>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2063315311	1592	E>*		No	TOPMed
rs1444718625	1594	L>F		No	TOPMed gnomAD
rs1242625916	1598	K>E		No	gnomAD
rs2063316404	1598	K>R		No	TOPMed
COSM1418501 COSM1418502	1599	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs758030428	1606	N>S		No	ExAC TOPMed gnomAD
COSM1536148 COSM1536147 COSM6162904 rs2063317509 COSM6162903	1607	S>N	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic TOPMed gnomAD
rs2063317509	1607	S>T		No	TOPMed gnomAD
TCGA novel	1609	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1274907269	1610	D>G		No	gnomAD
rs1274907269	1610	D>V		No	gnomAD
rs1161615057	1611	G>R		No	gnomAD
rs1468485736	1612	V>G		No	Ensembl
rs1577440555	1613	E>G		No	Ensembl
rs1577440650	1614	D>G		No	Ensembl
rs867890492	1614	D>N		No	Ensembl
COSM4112969 COSM4112968 rs2063846138	1619	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs1417424509	1620	D>A		No	gnomAD
rs1417424509 COSM4837420 COSM4837421	1620	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs780940425 COSM479334 COSM479335	1620	D>N	kidney Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1417424509	1620	D>V		No	gnomAD
rs1577440877	1622	S>G		No	Ensembl
rs754133728	1622	S>N		No	ExAC TOPMed gnomAD
rs755291078	1623	S>T		No	ExAC gnomAD
rs2063847788	1625	P>L		No	gnomAD
rs2063847788	1625	P>Q		No	gnomAD
rs2063849172	1627	T>P		No	Ensembl
rs779284875	1627	T>S		No	ExAC gnomAD
rs772578254	1629	S>C		No	ExAC TOPMed gnomAD
rs772578254	1629	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs747178985	1630	I>F		No	ExAC gnomAD
rs747178985	1630	I>L		No	ExAC gnomAD
rs369574031	1631	A>S		No	ESP ExAC TOPMed gnomAD
rs369574031	1631	A>T		No	ESP ExAC TOPMed gnomAD
rs2063850980	1632	S>C		No	TOPMed
rs1354441367	1633	R>M		No	gnomAD
rs2063851929	1635	S>F		No	TOPMed
rs2063852167	1640	D>G		No	TOPMed
rs2063852397	1641	S>G		No	Ensembl
rs746100366	1641	S>R		No	ExAC gnomAD
TCGA novel	1642	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs186739814	1644	L>F		No	1000Genomes ESP ExAC TOPMed gnomAD
rs186739814	1644	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1172262971	1645	S>F		No	Ensembl
rs1448856576	1647	G>R		No	gnomAD
rs761264541	1648	C>Y		No	ExAC gnomAD
rs368090212	1649	E>K		No	ESP ExAC TOPMed gnomAD
rs755227447	1650	L>M		No	ExAC TOPMed gnomAD
rs1342404641	1650	L>P		No	gnomAD
TCGA novel	1650	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2072237556	1651	T>R		No	gnomAD
rs779047572	1654	L>F		No	ExAC TOPMed gnomAD
rs779047572	1654	L>I		No	ExAC TOPMed gnomAD
rs1277783302	1655	Q>R		No	TOPMed gnomAD
rs1473708533	1656	D>N		No	Ensembl
rs2072238872	1658	S>N		No	TOPMed gnomAD
rs976640084	1659	A>T		No	TOPMed gnomAD
rs769031992 COSM3057683	1659	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs777576720	1660	G>C		No	ExAC TOPMed gnomAD
rs777576720	1660	G>R		No	ExAC TOPMed gnomAD
rs781613761	1662	S>R		No	TOPMed gnomAD
rs539171441	1664	E>K		No	gnomAD
rs576618251	1667	I>L		No	1000Genomes ExAC gnomAD
rs1404637724	1667	I>S		No	gnomAD
rs2072241783	1668	Q>K		No	Ensembl
rs2072242014	1668	Q>L		No	Ensembl
rs757199913	1669	V>M		No	ExAC gnomAD
rs2072242784	1670	G>E		No	Ensembl
COSM3586623	1670	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3927344 rs375684753	1672	T>M	Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs375684753	1672	T>R		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3586624 rs774954951	1673	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1040378811	1674	E>Q		No	TOPMed gnomAD
rs937409791	1676	L>P		No	Ensembl
rs748997964	1677	E>G		No	ExAC gnomAD
rs372360457	1678	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs368179672	1678	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA gnomAD
rs2072245965	1679	P>S		No	TOPMed
rs544705578	1680	S>R		No	1000Genomes ExAC TOPMed gnomAD
COSM727771	1681	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3914790 rs776744233	1681	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs752824553	1682	R>P		No	ExAC TOPMed gnomAD
rs752824553	1682	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
COSM1418505 rs748367644	1682	R>W	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs758651833	1683	P>S		No	ExAC gnomAD
rs1478502383	1684	G>D		No	gnomAD
rs763819696	1684	G>R		No	ExAC TOPMed gnomAD
rs1158043091	1686	C>R		No	gnomAD
rs745837958	1689	R>C		No	ExAC TOPMed gnomAD
COSM1037499 rs1439137300	1689	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs202002851	1690	T>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1192024161	1691	T>I		No	Ensembl
COSM1757068 rs368604430	1692	E>K	urinary_tract [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs371408668	1693	R>G		No	1000Genomes ESP ExAC TOPMed gnomAD
rs374734060	1693	R>Q		No	ESP ExAC TOPMed gnomAD
rs371408668	1693	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1468030129	1694	S>G		No	gnomAD
rs747421477	1694	S>N		No	ExAC gnomAD
rs771544833	1694	S>R		No	ExAC TOPMed gnomAD
rs78202770	1695	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs78202770	1695	P>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1362281273	1696	P>S		No	gnomAD
rs1366431825	1697	L>F		No	Ensembl
rs1309846713	1698	E>K		No	TOPMed gnomAD
rs2072254524	1698	E>V		No	Ensembl
rs775653956	1699	G>D		No	ExAC TOPMed gnomAD
RCV001527348 rs775653956	1699	G>V		No	ClinVar ExAC TOPMed dbSNP gnomAD
TCGA novel	1701	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1484531	1702	P>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764339645	1702	P>S		No	ExAC gnomAD
rs764339645	1702	P>T		No	ExAC gnomAD
rs1358010223 COSM6095914 COSM581288	1703	S>N	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed
rs540920510	1705	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs767329081	1706	L>P		No	ExAC gnomAD
rs1381969149	1706	L>V		No	TOPMed
rs138275414	1710	H>Y		No	Ensembl
rs868216680	1711	S>F		No	Ensembl
COSM6162902	1712	R>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs369690103	1712	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1327700759	1714	S>N		No	gnomAD
rs373473712	1714	S>R		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM3057689 RCV001356442 rs201338676	1715	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1334041254	1716	E>A		No	gnomAD
rs145432562	1717	M>L		No	Ensembl
rs2072260090	1717	M>T		No	Ensembl
rs781624752	1718	D>G		No	ExAC TOPMed gnomAD
rs771385123	1718	D>Y		No	ExAC gnomAD
rs746304761	1721	F>L		No	ExAC TOPMed gnomAD
rs770391355	1722	P>L		No	1000Genomes ExAC gnomAD
rs377555886	1723	L>M		No	ESP ExAC TOPMed gnomAD
rs1186947816	1723	L>S		No	TOPMed gnomAD
rs1186947816	1723	L>W		No	TOPMed gnomAD
rs1182966361	1724	V>M		No	gnomAD
rs769832888	1726	D>V		No	ExAC gnomAD
rs775528206	1727	A>T		No	ExAC gnomAD
rs902354649	1727	A>V		No	TOPMed
rs1470478157	1728	Y>H		No	TOPMed gnomAD
rs762802448	1730	H>D		No	ExAC TOPMed gnomAD
rs762802448	1730	H>N		No	ExAC TOPMed gnomAD
rs762802448	1730	H>Y		No	ExAC TOPMed gnomAD
rs2149830440	1732	S>L		No	Ensembl
rs78260191	1733	S>C		No	Ensembl
COSM1418507 rs78260191 COSM1418506	1733	S>G	large_intestine [Cosmic]	No	cosmic curated Ensembl
rs773788884	1733	S>N		No	ExAC gnomAD
rs367903538	1733	S>R		No	ESP ExAC TOPMed gnomAD
rs200603405	1734	E>K		No	ExAC TOPMed gnomAD
COSM1418508 COSM1418509	1735	N>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs759848460	1736	G>R		No	ExAC gnomAD
rs1389263997	1737	G>C		No	gnomAD
rs765624928	1737	G>D		No	ExAC gnomAD
COSM3586627 COSM3586626	1737	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs753183084	1738	K>E		No	ExAC TOPMed gnomAD
rs1413978253	1738	K>N		No	gnomAD
rs758846084	1738	K>R		No	ExAC TOPMed gnomAD
rs1419236808	1739	S>F		No	gnomAD
rs145880669	1740	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs781614121	1742	V>L		No	ExAC TOPMed gnomAD
rs781614121	1742	V>M		No	ExAC TOPMed gnomAD
rs530459271	1743	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs768540751	1744	N>S		No	ExAC gnomAD
rs768540751	1744	N>T		No	ExAC gnomAD
rs2149831116	1746	Q>P		No	Ensembl
rs2080894083	1747	A>G		No	Ensembl
rs761274205	1747	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1372715997	1748	Q>*		No	gnomAD
rs2080894747	1750	S>F		No	TOPMed
TCGA novel	1750	S>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1578496982	1752	N>T		No	Ensembl
rs1463368738	1753	S>C		No	TOPMed gnomAD
rs1463368738	1753	S>F		No	TOPMed gnomAD
rs1343154479	1754	I>L		No	TOPMed gnomAD
rs1390990891	1754	I>M		No	gnomAD
rs1190353237	1754	I>T		No	gnomAD
rs760328888	1756	S>I		No	ExAC TOPMed gnomAD
rs760328888	1756	S>N		No	ExAC TOPMed gnomAD
rs753063935	1757	S>C		No	ExAC TOPMed gnomAD
rs753063935	1757	S>Y		No	ExAC TOPMed gnomAD
rs2080897596	1758	P>A		No	gnomAD
rs145875180	1758	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs751637871	1759	G>R		No	ExAC gnomAD
TCGA novel	1760	P>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2149831796	1760	P>S		No	Ensembl
rs1321688218	1761	K>R		No	gnomAD
rs757363589	1762	R>C		No	ExAC TOPMed gnomAD
COSM312130 COSM312131 rs1232010971	1762	R>H	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1232010971	1762	R>L		No	gnomAD
rs1232010971	1762	R>P		No	gnomAD
rs2080899982	1765	N>K		No	TOPMed
rs375116917	1767	L>V		No	ESP ExAC gnomAD
rs1327051082	1769	K>*		No	gnomAD
rs1327051082	1769	K>E		No	gnomAD
rs754674010	1772	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs779890939	1772	T>S		No	ExAC TOPMed gnomAD
rs2080902154	1774	P>S		No	Ensembl
COSM203253 COSM203254 rs1241849175	1776	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes NCI-TCGA TOPMed
COSM26590 COSM5439359 rs368927353	1776	R>H	kidney Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1418511 COSM1418510 rs368927353	1776	R>L	large_intestine [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1241849175	1776	R>S		No	1000Genomes TOPMed
rs1410358187	1777	R>Q		No	gnomAD
rs1158608009	1777	R>W		No	gnomAD
TCGA novel	1778	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772725306	1780	S>R		No	ExAC
rs770637844	1781	G>R		No	ExAC TOPMed gnomAD
COSM727770 COSM727769	1782	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763277006	1783	A>S		No	ExAC TOPMed gnomAD
COSM3586631 COSM3586630 rs2080905525	1785	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl
rs558315603	1786	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs1405000476	1787	I>N		No	gnomAD
rs111238042	1790	Q>R		No	ESP ExAC TOPMed gnomAD
rs752107116	1791	K>N		No	Ensembl
rs2080906689	1792	K>R		No	gnomAD
rs1326487416	1793	V>A		No	TOPMed gnomAD
rs143334749 COSM1161442 COSM1161441	1794	R>C	Variant assessed as Somatic; MODERATE impact. skin haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs148384593	1794	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs148384593	1794	R>P		No	ESP ExAC TOPMed gnomAD
rs1176240567	1795	D>G		No	gnomAD
rs754110701	1795	D>N		No	ExAC TOPMed gnomAD
rs2080909176	1796	G>C		No	Ensembl
rs1292286156	1796	G>V		No	gnomAD
rs778776390	1797	R>G		No	ExAC gnomAD
rs201792111	1797	R>L		No	ESP ExAC TOPMed gnomAD
COSM4112975 COSM4112976 rs201792111	1797	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs778776390	1797	R>W		No	ExAC gnomAD
rs758392093	1799	S>I		No	ExAC TOPMed gnomAD
rs2080910697	1800	F>C		No	Ensembl
rs777264253	1803	G>A		No	ExAC gnomAD
TCGA novel	1804	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1407824265	1807	P>A		No	TOPMed
rs543842940	1808	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs770595671	1808	G>R		No	ExAC TOPMed gnomAD
rs2080912952	1809	D>N		No	gnomAD
rs2080913288	1810	E>K		No	TOPMed
rs1187453433	1811	T>K		No	TOPMed gnomAD
rs2080914251	1813	P>S		No	TOPMed
rs768843442	1815	G>R		No	ExAC gnomAD
rs376017889	1817	S>R		No	ESP ExAC TOPMed gnomAD
rs768175968	1818	A>T		No	ExAC TOPMed gnomAD
rs2080915947	1819	D>E		No	Ensembl
rs376876751	1819	D>G		No	ESP ExAC TOPMed gnomAD
rs1383167036	1821	K>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs1257169358	1822	S>N		No	TOPMed gnomAD
rs1257169358	1822	S>T		No	TOPMed gnomAD
rs1227408257	1824	K>N		No	gnomAD
rs1266338957	1825	G>D		No	gnomAD
rs2081065023	1826	W>*		No	Ensembl
rs2081065240	1827	G>S		No	Ensembl
TCGA novel	1827	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2081065432	1828	E>D		No	Ensembl
rs751723982	1831	P>L		No	ExAC TOPMed gnomAD
COSM1037504 rs751723982 COSM1037502	1831	P>R	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs2081066351	1832	D>V		No	Ensembl
COSM1037507 COSM1037505	1834	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1482338156	1837	T>S		No	TOPMed gnomAD
rs56375410	1845	I>V		No	ExAC TOPMed gnomAD
rs1187137767	1846	F>L		No	gnomAD
rs371623469	1848	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1467572793	1849	D>E		No	TOPMed gnomAD
rs575776197	1849	D>H		No	1000Genomes ExAC TOPMed gnomAD
rs575776197	1849	D>N		No	1000Genomes ExAC TOPMed gnomAD
rs544279723	1850	P>A		No	1000Genomes ExAC gnomAD
rs2081069167	1850	P>L		No	TOPMed gnomAD
TCGA novel	1857	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2081450308	1857	S>T		No	Ensembl
rs1317836614	1858	S>F		No	gnomAD
rs1270580232	1858	S>T		No	TOPMed gnomAD
rs778280357	1859	L>W		No	ExAC gnomAD
COSM727768 COSM727767	1860	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs55755864	1861	A>S		No	ESP ExAC TOPMed gnomAD
rs565356196	1862	A>G		No	1000Genomes ExAC TOPMed gnomAD
rs746394553	1863	R>Q		No	ExAC TOPMed gnomAD
rs534581552	1863	R>W		No	1000Genomes ExAC TOPMed gnomAD
rs2081455077	1864	Q>E		No	TOPMed
COSM273651 COSM273650	1864	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs775561803	1864	Q>R		No	ExAC gnomAD
rs34157843	1865	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs34157843	1865	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1266199993	1865	A>V		No	TOPMed
rs761619140	1868	E>D		No	ExAC gnomAD
rs773995262	1868	E>V		No	ExAC gnomAD
rs767244430	1870	P>L		No	ExAC TOPMed gnomAD
rs767244430	1870	P>R		No	ExAC TOPMed gnomAD
rs1304009551	1870	P>S		No	gnomAD
rs1408093008	1871	T>A		No	gnomAD
rs148492046	1871	T>I		No	ESP ExAC TOPMed gnomAD
rs2081459813	1872	A>T		No	TOPMed
rs1214010728	1873	A>T		No	TOPMed
TCGA novel	1873	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1316711148	1874	D>N		No	Ensembl
rs760698252	1875	L>F		No	ExAC TOPMed gnomAD
rs753467573	1876	V>A		No	ExAC gnomAD
rs1561488984	1876	V>I		No	Ensembl
rs1561488984	1876	V>L		No	Ensembl
rs142702465	1877	N>S		No	ESP ExAC TOPMed gnomAD
rs150997940	1879	I>T		No	ESP TOPMed
rs764993437	1879	I>V		No	ExAC TOPMed gnomAD
rs2081463404	1882	L>F		No	Ensembl
rs1578537821	1883	V>A		No	Ensembl
rs2081463750	1884	K>R		No	Ensembl
rs1482437325	1886	K>E		No	TOPMed gnomAD
COSM1536141 COSM1536142 rs116780710	1886	K>N	lung [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM6162900 COSM6162899	1886	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs114877509	1887	L>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1287344716	1887	L>P		No	TOPMed gnomAD
rs1453800220	1888	S>R		No	gnomAD
rs780489184	1889	L>P		No	ExAC TOPMed gnomAD
rs780489184	1889	L>Q		No	ExAC TOPMed gnomAD
rs2083329393	1890	E>G		No	Ensembl
COSM3914794 COSM3914793	1891	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2083329829	1892	S>N		No	TOPMed
rs56098940	1893	S>*		No	1000Genomes ESP ExAC TOPMed gnomAD
rs56098940	1893	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs201749166	1894	Y>C		No	1000Genomes TOPMed gnomAD
rs2083330558	1894	Y>H		No	Ensembl
COSM727766 rs772252798 COSM727765	1895	R>L	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs772252798	1895	R>Q		No	ExAC TOPMed gnomAD
rs150257895 COSM3781068 COSM3781067	1895	R>W	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1204032635	1896	G>A		No	TOPMed gnomAD
rs1204032635	1896	G>E		No	TOPMed gnomAD
VAR_035625	1897	S>C	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
rs746853235	1898	L>M		No	ExAC TOPMed gnomAD
rs2083333025	1901	P>S		No	TOPMed
rs759552317	1902	A>G		No	ExAC
rs776670607	1902	A>S		No	ExAC TOPMed gnomAD
rs1337477189	1903	G>A		No	TOPMed gnomAD
rs1337477189	1903	G>D		No	TOPMed gnomAD
rs376489541	1903	G>S		No	ESP ExAC TOPMed gnomAD
rs898352246	1906	N>S		No	Ensembl
rs1470563056	1908	G>E		No	gnomAD
COSM4112977 COSM4112978	1910	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1159110066	1911	P>A		No	TOPMed gnomAD
rs762634197	1911	P>L		No	ExAC TOPMed gnomAD
rs762634197	1911	P>R		No	ExAC TOPMed gnomAD
rs762353391	1912	P>H		No	ExAC
rs762353391	1912	P>R		No	ExAC
rs763702249	1912	P>S		No	ExAC gnomAD
rs766730133	1913	T>I		No	ExAC gnomAD
rs1559769637	1914	P>L		No	Ensembl
rs2083337574	1915	P>A		No	Ensembl
rs755492318	1915	P>L		No	ExAC gnomAD
COSM3722227 COSM3722228	1915	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs779043939	1916	K>E		No	ExAC gnomAD
rs2046669240	1917	N>D		No	Ensembl
rs909288140	1918	P>L		No	TOPMed gnomAD
rs909288140	1918	P>R		No	TOPMed gnomAD
TCGA novel rs2083339400	1921	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
TCGA novel	1924	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1925	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2083340126	1926	A>D		No	Ensembl
rs2083340600	1927	L>P		No	TOPMed
rs2083340600	1927	L>R		No	TOPMed
rs770782461	1927	L>V		No	ExAC gnomAD
rs1020068848	1928	R>S		No	Ensembl
rs745789056	1929	G>D		No	ExAC TOPMed gnomAD
rs781148073	1929	G>S		No	ExAC gnomAD
rs745789056	1929	G>V		No	ExAC TOPMed gnomAD
COSM1037511 COSM1037513	1930	R>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs35298864 RCV000949264 VAR_057190	1930	R>M		No	ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs547281807	1931	M>I		No	Ensembl
rs1271086984	1931	M>T		No	TOPMed gnomAD
rs372024978	1931	M>V		No	ESP ExAC
rs2083923606	1932	F>S		No	TOPMed
TCGA novel	1933	V>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1184218137	1933	V>I		No	TOPMed gnomAD
rs1184218137	1933	V>L		No	TOPMed gnomAD
rs1370276338	1938	V>A		No	TOPMed
TCGA novel	1939	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1443433944	1940	T>S		No	TOPMed gnomAD
rs755958107	1943	D>E		No	ExAC TOPMed gnomAD
rs1386781370	1943	D>G		No	TOPMed gnomAD
rs2083926327	1943	D>H		No	TOPMed
rs768092038	1945	V>A		No	ExAC TOPMed gnomAD
rs749251959	1945	V>I		No	ExAC TOPMed gnomAD
rs773904610	1946	K>E		No	ExAC TOPMed gnomAD
rs989523251	1947	D>H		No	TOPMed
COSM382297 COSM382298 rs989523251	1947	D>Y	lung [Cosmic]	No	cosmic curated TOPMed
TCGA novel	1948	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2083929834	1948	L>P		No	Ensembl
rs1394002227	1949	G>D		No	TOPMed gnomAD
rs747791697	1951	V>A		No	ExAC TOPMed gnomAD
rs1243570148	1951	V>L		No	gnomAD
rs142800005	1952	V>L		No	ESP ExAC TOPMed gnomAD
rs142800005	1952	V>M		No	ESP ExAC TOPMed gnomAD
TCGA novel	1953	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1249638976	1953	E>G		No	gnomAD
rs776961555	1953	E>Q		No	ExAC gnomAD
COSM3586632 COSM3586633	1954	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1037519 COSM1037517	1955	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4845678 COSM4845677	1957	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2084209193	1958	R>S		No	TOPMed
rs959010171	1959	I>M		No	Ensembl
rs772703622	1959	I>T		No	ExAC TOPMed gnomAD
rs746682116	1961	E>Q		No	ExAC TOPMed gnomAD
rs1277816274	1962	K>E		No	TOPMed
rs769995775	1962	K>N		No	ExAC gnomAD
rs1193327605	1963	G>R		No	gnomAD
rs1193327605	1963	G>S		No	gnomAD
rs200997995	1967	D>G		No	1000Genomes
rs775981309	1967	D>H		No	ExAC TOPMed gnomAD
rs775981309	1967	D>N		No	ExAC TOPMed gnomAD
rs1644906492	1969	R>G		No	Ensembl
rs186931113	1969	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA gnomAD
rs1466957492	1970	G>E		No	TOPMed gnomAD
rs2084214743	1970	G>R		No	TOPMed
rs2084216065	1972	D>G		No	Ensembl
rs2084216511	1973	K>R		No	gnomAD
rs2084216966	1974	I>L		No	Ensembl
rs537115296	1975	V>A		No	1000Genomes ExAC TOPMed gnomAD
rs1287328692	1975	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs775018855	1976	F>L		No	ExAC gnomAD
rs761942959	1977	G>A		No	ExAC gnomAD
rs761942959	1977	G>E		No	ExAC gnomAD
rs1225823582	1979	I>V		No	gnomAD
rs372617720	1980	H>R		No	ESP ExAC TOPMed gnomAD
rs2084220850	1981	Q>K		No	Ensembl
rs761015860	1984	D>E		No	ExAC gnomAD
rs2084221753	1985	W>*		No	gnomAD
TCGA novel	1986	H>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM3586634 COSM3586635	1987	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1258546519	1988	D>A		No	TOPMed gnomAD
rs754027509	1988	D>E		No	ExAC gnomAD
rs1258546519	1988	D>G		No	TOPMed gnomAD
rs1279734937	1988	D>H		No	TOPMed gnomAD
rs1279734937	1988	D>N		No	TOPMed gnomAD
rs1258546519	1988	D>V		No	TOPMed gnomAD
rs1480241441	1989	F>I		No	gnomAD
rs1480241441	1989	F>L		No	gnomAD
rs1480241441	1989	F>V		No	gnomAD
rs779211349	1990	F>I		No	gnomAD
rs765021406	1991	L>M		No	ExAC gnomAD
rs765021406	1991	L>V		No	ExAC gnomAD
rs138911697	1992	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs138911697	1992	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs777148067	1996	K>R		No	ExAC TOPMed gnomAD
TCGA novel	1999	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs112835381	2000	E>G		No	Ensembl
rs2084263431	2002	D>E		No	Ensembl
rs1303884980	2005	A>P		No	gnomAD
rs1303884980	2005	A>T		No	gnomAD
rs2084264781	2007	L>H		No	TOPMed
rs1045333047	2011	H>L		No	TOPMed gnomAD
rs751124475	2011	H>Y		No	ExAC gnomAD
rs780400062	2013	R>Q		No	ExAC TOPMed gnomAD
rs755893667	2013	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1472924614	2014	K>Q		No	TOPMed
rs748571994	2015	L>V		No	ExAC gnomAD
rs758711235	2016	H>D		No	ExAC gnomAD
rs1244557879	2016	H>P		No	TOPMed
rs1244557879	2016	H>R		No	TOPMed
COSM4112981 COSM4112982	2016	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1037522 COSM1037520	2017	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs139149462	2019	V>L		No	ESP ExAC TOPMed gnomAD
rs139149462	2019	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1259077338	2021	Y>C		No	TOPMed gnomAD
rs200637679	2023	Q>E		No	Ensembl
rs2084376232	2023	Q>R		No	Ensembl
rs1184376917	2025	K>R		No	gnomAD
rs775246399	2026	P>L		No	ExAC gnomAD
rs149923815	2027	R>C		No	ESP ExAC TOPMed gnomAD
RCV000921806 rs144160219	2027	R>H		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs56106611 RCV000954402	2028	S>A		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1408688930	2028	S>L		No	gnomAD
rs749992756	2030	Y>C		No	ExAC gnomAD
rs61745758	2031	I>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs376402588	2031	I>V		No	ESP ExAC TOPMed gnomAD
rs147771207	2032	V>I		No	1000Genomes ESP ExAC TOPMed gnomAD
rs758725005	2033	A>T		No	ExAC TOPMed gnomAD
rs778013452	2033	A>V		No	ExAC gnomAD
rs757771267	2034	E>D		No	ExAC TOPMed gnomAD
rs1325403601	2034	E>V		No	gnomAD
rs544425646	2037	A>D		No	1000Genomes ExAC TOPMed gnomAD
rs769887578	2037	A>S		No	ExAC TOPMed gnomAD
rs769887578	2037	A>T		No	ExAC TOPMed gnomAD
rs2150203057	2041	E>G		No	Ensembl
rs1345311075	2041	E>K		No	gnomAD
rs1345311075	2041	E>Q		No	gnomAD
rs2084523139	2042	V>I		No	Ensembl
rs1423420623	2046	I>T		No	gnomAD
rs780163028	2047	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1366932646	2049	R>G		No	gnomAD
rs141343989	2049	R>K		No	TOPMed
rs2084525420	2052	L>P		No	TOPMed
rs2084526432	2055	F>L		No	gnomAD
rs778745851	2055	F>L		No	ExAC gnomAD
rs2150203508	2056	L>F		No	Ensembl
rs1402663574	2057	I>S		No	TOPMed gnomAD
rs747849348	2058	K>N		No	ExAC gnomAD
rs2084527666	2058	K>R		No	gnomAD
rs2084528167	2059	P>A		No	gnomAD
rs1310226964	2063	I>V		No	gnomAD
rs1170536705	2064	T>A		No	TOPMed
rs772022707	2064	T>I		No	ExAC TOPMed gnomAD
rs772022707	2064	T>K		No	ExAC TOPMed gnomAD
rs772022707	2064	T>R		No	ExAC TOPMed gnomAD
rs2084530697	2067	Q>E		No	gnomAD
COSM6162893 COSM6162894	2067	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150203886	2068	L>F		No	Ensembl
rs1460269844	2072	D>E		No	gnomAD
rs2084791742	2074	L>R		No	Ensembl
rs2084792075	2075	R>K		No	TOPMed
rs199799341	2075	R>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1184944926	2077	S>N		No	TOPMed gnomAD
rs1479521774	2078	E>G		No	TOPMed
rs987476258	2080	A>S		No	TOPMed gnomAD
rs987476258	2080	A>T		No	TOPMed gnomAD
rs924219935	2080	A>V		No	Ensembl
TCGA novel	2084	C>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2084795229	2084	C>R		No	Ensembl
rs868092366	2085	S>L		No	Ensembl
rs935592383	2087	I>T		No	Ensembl
rs1248246339	2088	E>K		No	gnomAD
rs1578751516	2088	E>V		No	Ensembl
rs1383772875	2090	A>S		No	Ensembl
rs754944438	2091	V>M		No	ExAC gnomAD
COSM727764 COSM727763	2092	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1378011596	2094	M>I		No	TOPMed gnomAD
rs1181851356	2094	M>T		No	TOPMed gnomAD
rs2084917724	2094	M>V		No	gnomAD
rs1453242530	2095	C>G		No	TOPMed gnomAD
rs752955221	2096	L>F		No	ExAC gnomAD
rs1224035274	2098	P>A		No	TOPMed gnomAD
rs140557803	2100	R>C		No	ESP ExAC TOPMed gnomAD
rs759225248	2100	R>H		No	ExAC TOPMed gnomAD
rs746851048	2102	N>K		No	ExAC gnomAD
rs2084920493	2102	N>S		No	TOPMed
rs1212562099	2103	D>E		No	gnomAD
rs1258798240	2103	D>G		No	gnomAD
rs757102532	2103	D>N		No	ExAC TOPMed gnomAD
rs757102532	2103	D>Y		No	ExAC TOPMed gnomAD
COSM1037525 COSM1037523	2104	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1209315006	2104	M>T		No	gnomAD
rs1485404830	2104	M>V		No	TOPMed gnomAD
rs2084922545 COSM419865 COSM419864	2105	M>I	urinary_tract Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated Ensembl NCI-TCGA Cosmic
rs780956100	2105	M>K		No	ExAC gnomAD
TCGA novel	2107	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1237812399	2109	R>C		No	gnomAD
rs527332843	2109	R>H		No	1000Genomes ExAC gnomAD
rs1488983759	2110	L>R		No	gnomAD
rs748906244	2111	Q>R		No	ExAC gnomAD
rs1489825689	2112	G>A		No	TOPMed gnomAD
rs1489825689	2112	G>V		No	TOPMed gnomAD
COSM4760978 COSM4760979	2114	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1325890592	2115	G>D		No	TOPMed gnomAD
rs1325890592	2115	G>V		No	TOPMed gnomAD
rs2085638333	2116	T>I		No	TOPMed
rs2150311142	2117	L>P		No	Ensembl
rs2085638978	2118	T>N		No	TOPMed
rs201108531	2120	Q>R		No	1000Genomes ExAC gnomAD
rs1216557962	2121	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1290476215	2124	L>V		No	gnomAD
rs560018785	2127	D>E		No	1000Genomes ExAC gnomAD
rs970560022	2128	T>I		No	Ensembl
rs139843692	2130	Y>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2085642289	2130	Y>H		No	Ensembl
rs201076232	2131	V>M		No	ExAC TOPMed gnomAD
rs762156107	2132	I>T		No	ExAC TOPMed gnomAD
rs267599584 COSM1037528 COSM1037526	2133	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs267599584	2133	E>Q		No	TOPMed gnomAD
rs750279317	2134	L>P		No	ExAC gnomAD
rs750279317	2134	L>R		No	ExAC gnomAD
rs2085644608	2134	L>V		No	Ensembl
rs1407815919	2135	D>E		No	TOPMed gnomAD
COSM4910436 COSM4910437	2135	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1173463640	2137	G>D		No	gnomAD
rs1427219151	2137	G>S		No	gnomAD
rs1469670718	2138	M>I		No	gnomAD
rs779922674	2138	M>T		No	ExAC TOPMed gnomAD
TCGA novel	2139	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs950729303	2140	S>C		No	Ensembl
rs2085647103	2140	S>P		No	Ensembl
rs368791560	2141	R>L		No	ESP ExAC TOPMed gnomAD
rs368791560	2141	R>P		No	ESP ExAC TOPMed gnomAD
rs368791560	2141	R>Q		No	ESP ExAC TOPMed gnomAD
rs573768804	2141	R>W		No	ExAC TOPMed gnomAD
rs1028914518	2142	T>S		No	TOPMed
rs138817318	2143	K>E		No	ESP ExAC TOPMed gnomAD
rs2150311978	2143	K>N		No	Ensembl
rs138817318	2143	K>Q		No	ESP ExAC TOPMed gnomAD
rs770314288	2144	E>D		No	ExAC TOPMed gnomAD
rs776077977	2146	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs149338497	2146	R>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs149338497	2146	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs144745311	2147	V>M		No	ESP ExAC TOPMed gnomAD
rs761915647	2150	F>L		No	ExAC TOPMed gnomAD
rs2085651376	2150	F>S		No	gnomAD
rs1484942723	2151	E>G		No	gnomAD
rs767728290	2151	E>K		No	ExAC TOPMed gnomAD
rs767728290	2151	E>Q		No	ExAC TOPMed gnomAD
rs1425022225	2152	Q>*		No	gnomAD
rs961834888	2153	I>T		No	TOPMed gnomAD
rs760450028	2153	I>V		No	ExAC TOPMed gnomAD
rs2085654708	2154	V>A		No	TOPMed
rs1461817118	2154	V>I		No	TOPMed gnomAD
rs2085654976	2155	I>V		No	Ensembl
TCGA novel	2160	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2161	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1404148966	2162	K>N		No	TOPMed gnomAD
COSM3586637 COSM3586636	2163	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1415754327	2167	P>L		No	TOPMed gnomAD
rs1446455434	2168	G>A		No	TOPMed gnomAD
rs1028131001	2170	M>I		No	TOPMed gnomAD
rs753761954	2170	M>K		No	ExAC TOPMed gnomAD
rs1344082922	2170	M>L		No	gnomAD
rs753761954	2170	M>T		No	ExAC TOPMed gnomAD
TCGA novel	2172	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2173	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs377746113	2173	R>T		No	ESP ExAC TOPMed gnomAD
rs1251712700	2174	S>G		No	TOPMed
rs1222850890	2175	I>T		No	TOPMed gnomAD
rs2085660281	2176	K>E		No	gnomAD
rs2085660526	2176	K>R		No	Ensembl
rs1056954426	2177	M>I		No	TOPMed gnomAD
rs2085724449	2180	L>F		No	TOPMed
rs2085724878	2181	V>I		No	TOPMed
rs751214264	2183	E>A		No	ExAC gnomAD
rs199695356	2184	E>D		No	1000Genomes ExAC TOPMed gnomAD
rs749616690	2185	N>D		No	ExAC gnomAD
rs754198426	2186	V>A		No	Ensembl
rs1222867114	2187	D>H		No	gnomAD
rs757843330	2188	N>S		No	ExAC gnomAD
rs1181605841	2189	D>H		No	gnomAD
rs1181605841	2189	D>N		No	gnomAD
rs2085728644	2190	P>L		No	TOPMed
COSM3914796 COSM3914795	2190	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2085728351	2190	P>T		No	Ensembl
rs375121715	2191	C>Y		No	ESP ExAC gnomAD
rs2085729129	2192	K>Q		No	TOPMed gnomAD
rs1290140312	2193	F>Y		No	TOPMed gnomAD
rs2085729837	2194	A>S		No	TOPMed
rs748614645	2194	A>V		No	ExAC TOPMed gnomAD
rs1245358663	2195	L>F		No	TOPMed
rs1245358663	2195	L>I		No	TOPMed
rs2085731333	2196	M>K		No	Ensembl
rs773232245	2196	M>L		No	ExAC gnomAD
rs2085731333	2196	M>T		No	Ensembl
rs773232245	2196	M>V		No	ExAC gnomAD
rs2085731616 COSM673902 COSM673903	2198	R>K	endometrium [Cosmic]	No	cosmic curated TOPMed
rs2085731882	2199	E>Q		No	TOPMed
rs747200936	2200	T>N		No	ExAC TOPMed gnomAD
rs2085732449	2202	E>K		No	Ensembl
rs1161360237	2203	R>G		No	TOPMed gnomAD
rs771193440	2203	R>T		No	ExAC TOPMed gnomAD
rs1279189490	2204	V>A		No	gnomAD
rs759288506	2205	V>F		No	ExAC gnomAD
rs759288506	2205	V>I		No	ExAC gnomAD
rs762859959	2207	Q>*		No	ExAC gnomAD
rs751074018	2209	A>S		No	ExAC TOPMed gnomAD
rs751074018	2209	A>T		No	ExAC TOPMed gnomAD
rs963442699	2210	N>S		No	Ensembl
rs767235200	2211	A>T		No	ExAC TOPMed gnomAD
rs750102941	2214	Q>H		No	ExAC gnomAD
rs755333342	2215	Q>R		No	ExAC gnomAD
rs140660780	2216	A>T		No	ESP ExAC TOPMed gnomAD
rs1459380119	2216	A>V		No	gnomAD
rs1200127122	2218	V>M		No	gnomAD
rs2085739595	2220	D>H		No	TOPMed gnomAD
rs1183875716	2221	I>T		No	TOPMed gnomAD
rs1468332959	2222	N>H		No	Ensembl
rs777886239	2222	N>K		No	ExAC TOPMed gnomAD
rs758868856	2222	N>S		No	ExAC TOPMed gnomAD
rs2085741408	2226	E>D		No	TOPMed
rs2085741694	2227	T>A		No	gnomAD
rs1473046966	2228	Q>E		No	gnomAD
rs1439864563	2228	Q>R		No	TOPMed
rs1167272064	2229	R>G		No	gnomAD
RCV001356748 rs747043605	2229	R>Q		No	ClinVar ExAC dbSNP gnomAD
rs1467048641	2230	D>E		No	TOPMed gnomAD
rs746104897	2231	F>C		No	ExAC gnomAD
rs771030176	2231	F>I		No	ExAC TOPMed gnomAD
rs771030176	2231	F>L		No	ExAC TOPMed gnomAD
rs769621632	2231	F>L		No	ExAC gnomAD
rs775218572	2232	L>S		No	ExAC gnomAD
rs775218572	2232	L>W		No	ExAC gnomAD
rs2085745104	2233	N>D		No	TOPMed
rs753559897	2237	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs753559897	2237	S>W		No	ExAC gnomAD
rs948871324	2238	P>L		No	Ensembl
rs2086470046	2238	P>S		No	TOPMed
rs757831396	2239	I>T		No	ExAC TOPMed gnomAD
rs752049201	2239	I>V		No	ExAC gnomAD
rs750520760	2240	E>G		No	ExAC TOPMed gnomAD
rs767555973	2240	E>K		No	ExAC gnomAD
rs750520760	2240	E>V		No	ExAC TOPMed gnomAD
rs374234847	2243	R>L		No	ESP ExAC TOPMed gnomAD
rs374234847	2243	R>P		No	ESP ExAC TOPMed gnomAD
rs374234847	2243	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs780069173	2243	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1355250729	2244	K>Q		No	TOPMed gnomAD
rs2086474906	2245	E>G		No	TOPMed
COSM3586638 COSM3586639	2245	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1566301 COSM1566302	2246	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2086475179	2247	S>N		No	Ensembl
rs2150371471	2251	M>T		No	Ensembl
rs748067012	2252	R>M		No	ExAC gnomAD
rs748067012	2252	R>T		No	ExAC gnomAD
rs1487366324	2253	S>C		No	gnomAD
rs1578853129	2254	Q>H		No	Ensembl
rs1192756407	2254	Q>L		No	TOPMed gnomAD
rs1192756407	2254	Q>R		No	TOPMed gnomAD
TCGA novel	2255	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1439244084	2255	P>R		No	gnomAD
rs143835330	2255	P>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143835330	2255	P>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs773304128	2256	A>S		No	ExAC TOPMed gnomAD
rs940946966	2256	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1215135367	2257	R>K		No	TOPMed
TCGA novel	2257	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746462251	2257	R>S		No	ExAC TOPMed gnomAD
rs2086480760	2259	P>L		No	TOPMed
rs1163467077	2259	P>S		No	TOPMed gnomAD
rs1578853499	2261	A>V		No	Ensembl
rs1294450209	2262	S>N		No	TOPMed gnomAD
rs1396235480	2262	S>R		No	gnomAD
rs377636885	2263	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs774741290	2264	R>K		No	ExAC
rs767967212	2265	P>H		No	ExAC TOPMed gnomAD
rs146809556 COSM99071	2265	P>S	stomach [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
COSM3586643 COSM3586642	2268	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756086389	2269	V>F		No	ExAC TOPMed gnomAD
rs1265751212	2270	P>L		No	gnomAD
COSM1693383 COSM1693384 rs139050770	2270	P>S	skin [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs753999093	2271	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	2274	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1432415544	2274	E>Q		No	TOPMed
rs747901386	2276	P>T		No	ExAC TOPMed gnomAD
rs746980775	2277	P>L		No	ExAC TOPMed gnomAD
rs746980775	2277	P>Q		No	ExAC TOPMed gnomAD
rs777786497	2277	P>S		No	ExAC TOPMed gnomAD
rs2086490026	2278	K>E		No	Ensembl
rs770335571	2279	G>S		No	ExAC gnomAD
rs776273508	2279	G>V		No	ExAC gnomAD
rs2086491475	2280	S>P		No	TOPMed gnomAD
rs745481870	2282	Y>C		No	ExAC gnomAD
rs2150372961	2283	N>K		No	Ensembl
rs1328834626	2284	P>S		No	gnomAD
COSM1037534 COSM1037532	2284	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1301681501	2285	P>L		No	gnomAD
rs775150045	2285	P>S		No	ExAC gnomAD
rs2086492912	2286	L>M		No	Ensembl
rs574388819	2288	P>L		No	gnomAD
rs1265356828	2288	P>S		No	TOPMed
rs767877274	2291	I>T		No	ExAC gnomAD
rs773576120	2292	S>P		No	ExAC TOPMed gnomAD
rs773576120	2292	S>T		No	ExAC TOPMed gnomAD
rs1259772811	2294	S>F		No	gnomAD
rs1259772811	2294	S>Y		No	gnomAD
rs761308468	2295	N>D		No	ExAC TOPMed gnomAD
rs766337334	2295	N>S		No	ExAC TOPMed gnomAD
rs140582792	2296	G>C		No	ExAC TOPMed gnomAD
rs759710043	2296	G>D		No	ExAC gnomAD
rs759710043	2296	G>V		No	ExAC gnomAD
rs545817282	2297	S>R		No	gnomAD
rs1293385472	2299	G>E		No	TOPMed gnomAD
rs1263153578	2299	G>R		No	gnomAD
rs1293385472	2299	G>V		No	TOPMed gnomAD
rs752973251	2300	F>L		No	ExAC TOPMed gnomAD
TCGA novel	2301	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs758210307	2302	Y>F		No	ExAC TOPMed gnomAD
rs1412610252	2303	H>Y		No	TOPMed gnomAD
rs777683651	2305	P>H		No	ExAC TOPMed gnomAD
rs35653635	2306	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2086501870	2307	D>G		No	TOPMed
rs957429915	2307	D>N		No	Ensembl
rs745336547	2308	K>E		No	ExAC TOPMed gnomAD
rs769328981	2309	F>L		No	ExAC TOPMed gnomAD
rs1010135527	2309	F>L		No	TOPMed gnomAD
COSM232568 RCV000889933 COSM232569 rs142947301	2310	E>K	skin [Cosmic]	No	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2086503569	2311	A>T		No	TOPMed
rs2086503897	2312	S>N		No	gnomAD
rs1324038181	2312	S>R		No	gnomAD
rs2086504609	2313	K>N		No	TOPMed gnomAD
rs1219425319	2314	Q>H		No	gnomAD
rs565585638	2315	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs936955573	2316	D>E		No	TOPMed
COSM3586646 rs775753465 COSM3586647	2316	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs2086900578	2318	G>E		No	gnomAD
rs763247639 COSM3728122 COSM3728121	2318	G>R	Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA
rs1285442067	2319	G>C		No	gnomAD
rs1358371082	2319	G>D		No	gnomAD
rs2086902522	2320	C>F		No	Ensembl
rs184999164	2320	C>R		No	1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	2320	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1291099153	2321	N>K		No	gnomAD
rs774472087	2321	N>S		No	ExAC TOPMed gnomAD
rs370369188	2323	T>I		No	ESP ExAC TOPMed gnomAD
rs767269208	2324	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1379141731	2324	S>P		No	gnomAD
rs756081490	2325	S>C		No	ExAC gnomAD
rs558112961	2326	M>L		No	1000Genomes ExAC TOPMed gnomAD
rs558112961	2326	M>V		No	1000Genomes ExAC TOPMed gnomAD
rs373630403	2328	V>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs1441897453	2330	K>Q		No	gnomAD
rs1429302725	2332	Y>C		No	TOPMed gnomAD
rs1308886788	2333	Y>C		No	TOPMed gnomAD
rs1559827297	2333	Y>N		No	Ensembl
rs1374721018	2334	A>V		No	gnomAD
rs2086908610	2335	L>P		No	TOPMed
rs778559837	2336	K>T		No	ExAC
rs1247897277	2339	E>K		No	gnomAD
rs1242466422	2340	I>T		No	gnomAD
rs2086909858	2341	C>S		No	TOPMed gnomAD
rs2086910105	2342	V>M		No	TOPMed
rs2086910348	2344	Q>R		No	Ensembl
rs41264665	2345	G>D		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2086911634	2347	V>E		No	TOPMed
rs1041209235	2348	V>F		No	TOPMed gnomAD
rs746348119	2350	V>I		No	ExAC gnomAD
rs202061265	2352	A>T		No	ExAC TOPMed gnomAD
COSM269409 COSM269410 rs774580265	2353	V>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs2086913705	2354	N>D		No	Ensembl
rs2086913942	2356	Q>R		No	TOPMed
rs145164918	2358	M>V		No	ESP ExAC TOPMed gnomAD
rs767344058	2359	C>G		No	ExAC gnomAD
rs767344058	2359	C>R		No	ExAC gnomAD
rs767344058	2359	C>S		No	ExAC gnomAD
rs1578877701	2362	Y>S		No	Ensembl
TCGA novel	2364	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs773051646	2366	S>C		No	ExAC TOPMed gnomAD
rs1578877837	2367	D>A		No	Ensembl
rs953197853	2367	D>E		No	TOPMed gnomAD
COSM3914798 COSM3914797 rs760479725	2367	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs1319825943	2368	H>P		No	gnomAD
rs1327922356	2368	H>Y		No	TOPMed
rs368115319	2370	P>L		No	ESP ExAC TOPMed gnomAD
rs1389202113	2370	P>S		No	gnomAD
TCGA novel	2371	A>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs764702445	2371	A>T		No	ExAC gnomAD
rs56085806	2371	A>V		No	ExAC TOPMed gnomAD
rs1218462793	2372	A>D		No	TOPMed gnomAD
rs1218462793	2372	A>G		No	TOPMed gnomAD
rs781679134	2372	A>S		No	ExAC TOPMed gnomAD
rs781679134	2372	A>T		No	ExAC TOPMed gnomAD
rs749778361	2373	E>K		No	ExAC gnomAD
rs1285550614	2374	G>A		No	TOPMed gnomAD
rs1200150543	2374	G>C		No	gnomAD
rs1285550614	2374	G>D		No	TOPMed gnomAD
rs112911419	2375	W>*		No	Ensembl
COSM4796349 COSM4796350	2376	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1441404451	2377	P>L		No	gnomAD
rs1239183045	2378	G>A		No	gnomAD
rs1239183045	2378	G>D		No	gnomAD
rs2086924372	2380	I>S		No	TOPMed
rs143716563	2382	A>E		No	1000Genomes ExAC TOPMed gnomAD
rs143716563	2382	A>V		No	1000Genomes ExAC TOPMed gnomAD
rs1421213497	2384	L>V		No	gnomAD
rs770735721	2385	T>I		No	ExAC gnomAD
rs1578878687	2385	T>P		No	Ensembl
rs776608758	2386	K>R		No	ExAC gnomAD
rs1401581378	2388	T>A		No	gnomAD
rs1394405403	2388	T>I		No	TOPMed gnomAD
rs759431023	2390	A>V		No	ExAC gnomAD
RCV002249067 rs992438028	2392	S>G		No	ClinVar TOPMed dbSNP gnomAD
rs752205306	2392	S>I		No	ExAC TOPMed gnomAD
rs752205306	2392	S>N		No	ExAC TOPMed gnomAD
rs369924314	2393	S>I		No	ESP TOPMed gnomAD
rs150398770	2395	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs756493850	2396	S>I		No	ExAC TOPMed
rs756493850	2396	S>N		No	ExAC TOPMed
rs2086934592	2397	I>V		No	Ensembl
rs2086935507	2398	K>Q		No	Ensembl
rs536434991	2398	K>R		No	gnomAD
rs2087408550	2399	K>N		No	gnomAD
rs1436349032	2401	C>R		No	TOPMed gnomAD
TCGA novel	2402	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2087409096	2402	S>L		No	Ensembl
TCGA novel	2403	W>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs775239180	2403	W>R		No	ExAC gnomAD
rs1328607696 COSM727755 COSM727756	2404	H>N	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs371805011	2404	H>P		No	ESP ExAC TOPMed gnomAD
rs371805011	2404	H>R		No	ESP ExAC TOPMed gnomAD
rs768245754	2405	T>I		No	ExAC TOPMed gnomAD
COSM1037540 COSM1037538	2406	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1234850146	2406	L>P		No	gnomAD
rs1319671756	2406	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs747606269 COSM3392005 COSM3392004	2407	R>C	Variant assessed as Somatic; MODERATE impact. pancreas [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs767013745	2407	R>H		No	ExAC TOPMed gnomAD
rs1196998968	2408	M>V		No	TOPMed gnomAD
rs760299802	2410	K>Q		No	Ensembl
rs35729834	2411	R>L		No	ESP ExAC TOPMed gnomAD
rs35729834	2411	R>P		No	ESP ExAC TOPMed gnomAD
rs35729834	2411	R>Q		No	ESP ExAC TOPMed gnomAD
rs1010276863	2411	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs1197217291	2412	A>E		No	TOPMed gnomAD
rs1197217291	2412	A>V		No	TOPMed gnomAD
rs753171260	2416	N>T		No	ExAC TOPMed gnomAD
rs758971263	2417	T>A		No	ExAC gnomAD
rs375472024	2417	T>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs375472024	2417	T>M		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1355771288	2418	G>R		No	TOPMed gnomAD
rs1355771288	2418	G>S		No	TOPMed gnomAD
rs2087418509	2419	K>E		No	TOPMed
rs1301775659	2420	N>S		No	gnomAD
rs867470182	2421	E>K		No	Ensembl
COSM1037543 COSM1037541	2423	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs138278618	2424	G>E		No	1000Genomes ExAC TOPMed gnomAD
rs746121650	2425	P>H		No	ExAC gnomAD
COSM3914800 COSM3914799 rs576463141	2426	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs576463141	2426	R>G		No	1000Genomes ExAC TOPMed gnomAD
rs779935599	2426	R>H		No	ExAC TOPMed gnomAD
rs779935599	2426	R>L		No	ExAC TOPMed gnomAD
rs2087421557	2427	K>E		No	TOPMed
rs1308221080	2427	K>N		No	gnomAD
rs1275428141	2431	I>N		No	gnomAD
rs768660105	2432	L>V		No	ExAC TOPMed
rs2150447483	2434	N>S		No	Ensembl
rs747623775	2436	V>A		No	ExAC gnomAD
rs556441458	2436	V>I		No	1000Genomes ExAC gnomAD
COSM727751 COSM727752	2438	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs369756088	2438	V>L		No	ESP ExAC TOPMed gnomAD
rs1383181904	2439	K>N		No	TOPMed
rs1412004657	2439	K>Q		No	TOPMed gnomAD
rs766672025	2441	T>M		No	ExAC TOPMed gnomAD
rs754800493	2442	N>I		No	ExAC gnomAD
rs2087549057	2442	N>Y		No	TOPMed
rs752573214	2443	S>G		No	ExAC gnomAD
rs1370881839	2443	S>N		No	gnomAD
rs1448302467	2444	S>Y		No	gnomAD
COSM4793336 COSM4793337	2445	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1285372467	2449	C>Y		No	TOPMed gnomAD
rs2087551473	2450	D>E		No	TOPMed
rs2087551653	2451	D>Y		No	TOPMed
TCGA novel	2453	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2087551835	2453	D>N		No	gnomAD
rs1250804033	2454	P>L		No	gnomAD
rs1250804033	2454	P>R		No	gnomAD
rs1220335058	2454	P>S		No	gnomAD
rs577419294	2456	T>A		No	1000Genomes ExAC TOPMed gnomAD
rs2087553300	2456	T>I		No	TOPMed
rs746461538	2457	S>C		No	ExAC TOPMed gnomAD
rs746461538	2457	S>G		No	ExAC TOPMed gnomAD
COSM6095910 COSM6095911	2458	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150593804	2460	I>L		No	Ensembl
rs1213499961	2460	I>T		No	TOPMed gnomAD
rs762758916	2461	L>F		No	ExAC gnomAD
rs1401602156	2468	E>A		No	gnomAD
rs747507245	2470	A>T		No	ExAC TOPMed gnomAD
TCGA novel	2475	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs138839944	2476	P>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2061959988	2477	L>W		No	Ensembl
rs745901858	2481	T>I		No	ExAC TOPMed gnomAD
rs745901858	2481	T>N		No	ExAC TOPMed gnomAD
rs1559858989	2482	C>Y		No	Ensembl
TCGA novel	2483	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs775758176	2484	L>F		No	ExAC TOPMed gnomAD
rs1052906504	2484	L>P		No	TOPMed gnomAD
rs1435006871	2485	G>R		No	gnomAD
rs1348419996	2486	D>N		No	TOPMed gnomAD
rs763771768	2489	I>K		No	Ensembl
rs763771768	2489	I>R		No	Ensembl
rs763942950	2491	Q>K		No	ExAC TOPMed gnomAD
rs2061960934	2492	C>R		No	Ensembl
rs1321364099	2493	K>E		No	TOPMed gnomAD
rs2061961116	2494	V>L		No	TOPMed
rs761606230	2497	R>Q		No	ExAC TOPMed
COSM1732382 rs774067123 COSM1732381	2497	R>W	NS Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM75063	2498	P>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs767406418	2498	P>S		No	ExAC gnomAD
rs750386686	2499	K>N		No	ExAC gnomAD
rs760158908	2500	P>S		No	ExAC gnomAD
rs1195538624	2501	T>A		No	gnomAD
rs370244700	2502	I>M		No	ESP TOPMed gnomAD
COSM3586652 COSM3586653	2504	W>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2061962120	2506	G>S		No	TOPMed
rs1439564455	2508	D>E		No	TOPMed gnomAD
rs1280921143	2508	D>N		No	TOPMed gnomAD
COSM3586655 COSM3586654	2509	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765850843	2509	Q>R		No	ExAC gnomAD
rs754646887	2510	N>K		No	ExAC TOPMed gnomAD
rs374016191	2510	N>Y		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1463505475	2511	I>T		No	TOPMed gnomAD
rs778641408	2514	T>I		No	ExAC gnomAD
rs751906517	2515	D>G		No	ExAC TOPMed gnomAD
rs1343899545	2516	N>D		No	TOPMed gnomAD
TCGA novel	2516	N>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs757727525	2517	S>G		No	ExAC gnomAD
rs1158538180	2518	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs2061963193	2520	T>I		No	Ensembl
rs1371168724	2521	Y>H		No	gnomAD
rs1371168724	2521	Y>N		No	gnomAD
rs781745800	2522	T>M		No	ExAC TOPMed gnomAD
rs865839452	2527	D>G		No	Ensembl
COSM3586656 COSM3586657	2527	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2062040207	2529	G>A		No	Ensembl
rs1578998665	2530	E>D		No	Ensembl
rs781718965	2531	I>N		No	ExAC TOPMed gnomAD
rs781718965	2531	I>T		No	ExAC TOPMed gnomAD
rs1253150430	2532	T>S		No	gnomAD
TCGA novel	2533	L>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1210868168	2533	L>V		No	gnomAD
rs780621634	2535	I>F		No	ExAC gnomAD
rs921430834	2535	I>M		No	Ensembl
rs1476415151	2536	C>S		No	gnomAD
rs1198782370	2536	C>Y		No	TOPMed gnomAD
rs768806315	2538	L>V		No	ExAC gnomAD
rs1050115806	2539	M>I		No	TOPMed gnomAD
rs1578998887	2541	Q>R		No	Ensembl
rs867926749	2544	G>R		No	Ensembl
COSM1418520 COSM1418519	2545	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3586661 COSM3586660	2548	C>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1312237546	2549	I>L		No	gnomAD
rs1287008238	2553	D>Y		No	TOPMed
rs2062042450	2555	G>E		No	Ensembl
rs1293710603 COSM3586662 COSM3586663	2555	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs2150618637	2558	S>T		No	Ensembl
rs148476909	2559	T>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs776663754	2559	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1167634983	2561	A>T		No	TOPMed gnomAD
rs1359566969	2561	A>V		No	TOPMed
rs1486954279	2562	T>K		No	TOPMed gnomAD
rs1486954279	2562	T>R		No	TOPMed gnomAD
rs1241898725 COSM1536136 COSM6162892 COSM1536135 COSM6162891	2563	V>D	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA gnomAD
rs141643479	2563	V>I		No	ESP ExAC TOPMed gnomAD
rs2062043685	2565	V>M		No	TOPMed
rs2062114380	2569	P>S		No	TOPMed gnomAD
TCGA novel	2571	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1173155139	2571	A>V		No	gnomAD
rs1406938418	2573	N>K		No	gnomAD
rs369528078	2574	R>C		No	ExAC TOPMed gnomAD
rs369528078	2574	R>G		No	ExAC TOPMed gnomAD
COSM4112990 COSM4112989 rs369115824	2574	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	2574	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs369528078	2574	R>S		No	ExAC TOPMed gnomAD
rs574569949	2576	I>T		No	1000Genomes ExAC gnomAD
rs2062115076	2576	I>V		No	TOPMed gnomAD
COSM3586664 COSM3586665	2577	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774080841	2578	Q>R		No	ExAC gnomAD
rs1373364720	2579	E>K		No	gnomAD
rs1279533462	2580	R>G		No	gnomAD
rs878897171	2581	S>C		No	Ensembl
rs1371833838	2581	S>R		No	gnomAD
rs2062115965	2582	C>Y		No	TOPMed
rs766808885	2583	T>I		No	ExAC gnomAD
rs1579005936	2583	T>P		No	Ensembl
rs1329347278	2584	S>Y		No	gnomAD
rs373744782 COSM272835 COSM272834	2585	V>M	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs150508568	2588	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs374214808	2588	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1232184605	2591	P>S		No	TOPMed gnomAD
rs1232184605	2591	P>T		No	TOPMed gnomAD
rs371432218	2592	P>A		No	ESP ExAC TOPMed gnomAD
rs756968542	2592	P>H		No	ExAC TOPMed gnomAD
rs756968542	2592	P>L		No	ExAC TOPMed gnomAD
rs756968542	2592	P>R		No	ExAC TOPMed gnomAD
rs371432218	2592	P>S		No	ESP ExAC TOPMed gnomAD
rs371432218	2592	P>T		No	ESP ExAC TOPMed gnomAD
rs2062117704	2593	S>C		No	TOPMed gnomAD
rs866229918	2596	G>E		No	gnomAD
rs1396755586	2597	N>S		No	gnomAD
rs552227061	2599	T>A		No	1000Genomes ExAC TOPMed gnomAD
rs552227061	2599	T>P		No	1000Genomes ExAC TOPMed gnomAD
rs919750972	2600	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs370996133	2604	T>I		No	ESP ExAC TOPMed gnomAD
rs1355296546	2606	E>G		No	gnomAD
TCGA novel	2607	Y>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs2062119076	2608	R>K		No	Ensembl
rs373713643	2609	E>D		No	ESP ExAC gnomAD
rs1291109271	2609	E>G		No	gnomAD
rs2062119367	2610	E>Q		No	Ensembl
rs2062236324	2613	Q>E		No	gnomAD
rs756002014	2620	A>S		No	ExAC gnomAD
rs747203034	2621	S>L		No	TOPMed gnomAD
rs1282330437	2621	S>T		No	TOPMed gnomAD
rs762351590 COSM1418522 COSM1418521	2628	V>I	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs370254434	2629	I>M		No	ESP ExAC TOPMed gnomAD
rs778547375	2629	I>V		No	ExAC gnomAD
rs139538191	2630	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA
rs759846493	2631	D>A		No	ExAC TOPMed gnomAD
rs759846493	2631	D>G		No	ExAC TOPMed gnomAD
rs770194151	2632	L>V		No	ExAC gnomAD
rs1403413225	2633	S>G		No	gnomAD
rs374215079	2633	S>N		No	ESP ExAC TOPMed gnomAD
rs200600368	2634	P>A		No	TOPMed gnomAD
rs763517719	2634	P>L		No	ExAC gnomAD
rs200600368	2634	P>S		No	TOPMed gnomAD
rs948857399	2635	G>A		No	TOPMed gnomAD
rs948857399	2635	G>E		No	TOPMed gnomAD
COSM273652 rs751599377 COSM273653	2635	G>R	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1347002667	2636	C>Y		No	gnomAD
rs2062238677	2637	P>L		No	gnomAD
rs2062238898	2638	Y>F		No	Ensembl
rs144682399	2639	Q>R		No	1000Genomes ExAC gnomAD
rs2062239076	2640	F>L		No	TOPMed
rs1579016988	2643	S>C		No	Ensembl
rs1046255209	2643	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1046255209	2643	S>T		No	gnomAD
rs767734817	2644	A>S		No	ExAC gnomAD
rs2062239464	2645	S>T		No	Ensembl
rs766532456	2646	N>I		No	Ensembl
rs1259844655	2647	P>R		No	gnomAD
rs2150667645	2647	P>S		No	1000Genomes
rs866480769	2649	G>R		No	Ensembl
rs1189253488	2652	L>F		No	TOPMed gnomAD
RCV001529545 rs56320013	2655	E>K		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM6095908 COSM581277 COSM581276 rs754909011 COSM6095909	2657	S>L	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
COSM3057823 COSM3057822	2658	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1306365931	2659	F>S		No	TOPMed gnomAD
rs1458513726	2660	V>L		No	TOPMed gnomAD
COSM1670524 COSM1670523 rs1369664710	2661	R>*	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated gnomAD
rs143766292	2661	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs143766292	2661	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs866554548	2663	P>S		No	Ensembl
TCGA novel	2663	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2664	E>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs537142542	2666	D>G		No	1000Genomes ExAC gnomAD
rs2062242059	2666	D>N		No	TOPMed
rs1194631241	2667	A>V		No	gnomAD
rs2062367027	2669	A>V		No	gnomAD
rs768921250	2670	D>N		No	ExAC gnomAD
rs2062367284	2671	G>D		No	TOPMed
TCGA novel	2671	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774897060	2671	G>S		No	ExAC gnomAD
rs2150691712	2672	A>T		No	Ensembl
rs1206406752	2672	A>V		No	gnomAD
rs1328909837	2674	I>V		No	TOPMed
rs1324625533	2675	S>C		No	TOPMed
rs748640926	2675	S>P		No	ExAC TOPMed
rs772181764	2677	K>E		No	ExAC gnomAD
COSM4112992 COSM4112991	2678	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM3586667 COSM3586666	2678	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	2680	F>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs899197914	2682	S>T		No	TOPMed gnomAD
rs2062368304	2683	A>P		No	Ensembl
rs773371256	2683	A>V		No	ExAC TOPMed gnomAD
TCGA novel	2686	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1409138684	2686	E>K		No	TOPMed
TCGA novel	2687	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs766672372	2688	N>D		No	ExAC TOPMed gnomAD
TCGA novel	2691	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1303706054	2694	R>C		No	gnomAD
rs143682793	2694	R>H		No	ESP ExAC gnomAD
rs776962977	2697	I>V		No	ExAC TOPMed gnomAD
rs2062964727	2698	V>E		No	TOPMed
TCGA novel	2703	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2703	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1343439293	2705	A>D		No	gnomAD
rs371482945	2707	R>C		No	ESP ExAC TOPMed gnomAD
rs756112179	2707	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
COSM365251 rs756112179 COSM365252	2707	R>L	lung [Cosmic]	No	cosmic curated TOPMed gnomAD
rs2062965467	2708	K>N		No	TOPMed
rs2062965371	2708	K>R		No	TOPMed
rs769615739	2709	D>E		No	ExAC gnomAD
rs2062965661	2709	D>V		No	TOPMed
rs2062965553	2709	D>Y		No	TOPMed
rs867242568	2711	A>D		No	Ensembl
rs79062158	2712	V>G		No	ExAC gnomAD
rs75973551	2713	K>E		No	ExAC gnomAD
rs1579076467	2714	F>I		No	Ensembl
COSM1642073 COSM1642074	2719	M>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1419021575	2719	M>K		No	TOPMed
rs1249367467 COSM5202873 COSM5202872	2719	M>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
TCGA novel	2720	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751516356	2721	K>N		No	ExAC TOPMed gnomAD
rs2062966768	2723	E>D		No	TOPMed gnomAD
rs1347875934	2725	A>T		No	gnomAD
rs2150788620	2726	A>D		No	Ensembl
rs143920760	2726	A>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs140915036	2730	A>S		No	ESP TOPMed gnomAD
rs140915036	2730	A>T		No	ESP TOPMed gnomAD
rs1579076605	2731	L>P		No	Ensembl
rs1369128965	2731	L>V		No	gnomAD
rs1176532387	2734	H>L		No	TOPMed gnomAD
rs750083202	2734	H>Q		No	ExAC gnomAD
TCGA novel	2735	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1003233948	2735	L>P		No	Ensembl
rs755667727	2737	H>Y		No	ExAC gnomAD
COSM6162890 COSM6162889	2738	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs950996979	2741	I>L		No	Ensembl
COSM6095907 COSM6095906	2743	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2062968838	2744	H>R		No	Ensembl
rs779764159	2744	H>Y		No	ExAC gnomAD
rs1440814680	2746	T>I		No	TOPMed gnomAD
rs146561755	2750	P>A		No	ESP ExAC TOPMed gnomAD
TCGA novel	2750	P>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2751	T>H	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2755	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1315906215	2756	I>V		No	TOPMed gnomAD
rs1269478585	2759	L>M		No	gnomAD
rs930329305	2761	D>H		No	TOPMed gnomAD
rs930329305	2761	D>N		No	TOPMed gnomAD
rs2063172647	2762	D>G		No	TOPMed
rs1366351795	2763	G>A		No	TOPMed
rs2063172800	2764	R>G		No	gnomAD
COSM1211316 COSM1211315 rs758806191	2764	R>Q	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs778349797	2767	D>E		No	ExAC gnomAD
COSM4112993 COSM4112994	2767	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2063173445	2770	M>I		No	Ensembl
rs757778781	2770	M>T		No	ExAC gnomAD
rs2063173534	2771	N>K		No	TOPMed
rs781723516	2772	H>Q		No	ExAC TOPMed gnomAD
rs2063173721	2775	L>M		No	Ensembl
rs2150826318	2777	E>K		No	Ensembl
rs1469880870	2779	K>R		No	gnomAD
COSM3586669 COSM3586668 rs200993632	2780	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic Ensembl NCI-TCGA
TCGA novel	2782	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1232087424	2783	Y>H		No	gnomAD
rs745892459	2784	I>T		No	ExAC gnomAD
rs201835992	2785	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs373541267	2785	R>Q		No	ESP ExAC TOPMed gnomAD
rs865932760	2788	M>I		No	Ensembl
rs768434968	2788	M>T		No	ExAC TOPMed gnomAD
rs377011587	2788	M>V		No	ESP ExAC TOPMed gnomAD
TCGA novel	2789	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1406460321	2789	E>Q		No	TOPMed gnomAD
COSM1243332 COSM1243331	2792	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs943310108	2792	Q>K		No	TOPMed gnomAD
COSM4112996 COSM4112995	2792	Q>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1411994764	2793	Y>C		No	TOPMed gnomAD
rs747943551	2796	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs771866378	2799	V>F		No	ExAC gnomAD
rs771866378	2799	V>I		No	ExAC gnomAD
rs572242981	2801	H>Y		No	Ensembl
TCGA novel	2802	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs753876534	2812	D>G		No	ExAC gnomAD
rs926477357	2813	L>V		No	TOPMed gnomAD
rs779085925	2814	R>Q		No	ExAC TOPMed gnomAD
rs755074404	2814	R>W		No	ExAC gnomAD
rs752956591	2815	I>V		No	ExAC gnomAD
rs867893767	2819	R>*		No	Ensembl
rs2063294343	2819	R>Q		No	TOPMed
rs2063294538	2822	L>I		No	Ensembl
rs1330456087	2826	E>*		No	gnomAD
rs770837121	2832	S>*		No	ExAC TOPMed gnomAD
rs770837121	2832	S>L		No	ExAC TOPMed gnomAD
rs2063295254	2832	S>T		No	TOPMed
rs1454110867	2833	G>R		No	TOPMed gnomAD
rs1454110867	2833	G>S		No	TOPMed gnomAD
rs1559891345	2835	F>L		No	TOPMed
rs1365393077	2835	F>S		No	TOPMed gnomAD
rs1579104507	2839	H>P		No	Ensembl
rs2063295906	2839	H>Y		No	TOPMed
rs2150845305	2845	E>A		No	Ensembl
COSM727746 COSM727745	2846	F>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	2847	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM4112997 COSM4112998	2848	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2063296337	2849	P>L		No	TOPMed
rs2063296562	2851	V>I		No	Ensembl
rs2063296562	2851	V>L		No	Ensembl
rs373436261	2857	V>I		No	ESP ExAC TOPMed gnomAD
rs1047463289	2860	G>E		No	TOPMed
rs1378621086	2860	G>R		No	gnomAD
TCGA novel	2862	D>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2063297350	2867	G>R		No	TOPMed
rs2150845616	2873	M>I		No	Ensembl
rs2150845665	2877	V>I		No	1000Genomes
TCGA novel	2880	F>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs941220413	2882	D>G		No	Ensembl
COSM3586677 COSM3586676	2882	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150845837	2887	E>D		No	Ensembl
rs759580809	2887	E>K		No	ExAC gnomAD
rs112771126	2888	T>I		No	Ensembl
rs752905629	2889	C>Y		No	ExAC TOPMed gnomAD
COSM1037553 COSM1037555 rs904131570	2892	V>I	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs904131570	2892	V>L		No	TOPMed gnomAD
COSM3392006 COSM3392007	2894	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1536131 COSM1536132	2894	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2150846043	2895	V>M		No	Ensembl
TCGA novel	2898	S>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1001116641	2898	S>T		No	TOPMed gnomAD
rs1487776594	2899	F>Y		No	gnomAD
rs2063299540	2901	H>D		No	Ensembl
rs1559891628	2901	H>M	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs751326872	2901	H>R		No	ExAC gnomAD
rs1579105087	2903	Y>S		No	Ensembl
COSM1037558 COSM1037556 rs757021659	2904	F>I	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs781248712	2905	C>R		No	ExAC TOPMed gnomAD
TCGA novel	2905	C>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	2906	G>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1050387621	2907	V>L		No	TOPMed
rs1409264332	2909	N>H		No	TOPMed gnomAD
rs1473384350	2909	N>S		No	gnomAD
rs146977122	2910	A>S		No	ESP ExAC TOPMed gnomAD
rs146977122	2910	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs267599585	2910	A>V		No	Ensembl
COSM6162887 COSM6162888	2911	A>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	2911	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1456325978	2912	R>T		No	gnomAD
rs2063300685	2913	D>Y		No	TOPMed gnomAD
TCGA novel	2917	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs779767633	2917	V>G		No	ExAC gnomAD
rs1295283373	2917	V>L		No	gnomAD
rs1408920905	2920	Q>R		No	gnomAD
COSM3914804 COSM3914803 rs184120997	2921	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	2922	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs138111643	2923	F>V		No	ESP ExAC
COSM1037564 COSM1037562	2924	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs773899376	2924	R>Q		No	ExAC gnomAD
rs889918445 COSM4113000 COSM4112999	2924	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
COSM1037567 COSM1037565 rs761079499	2926	R>W	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs2063301425	2927	P>R		No	gnomAD
rs2150846727	2928	T>S		No	Ensembl
rs1312051017	2929	A>T		No	gnomAD
rs1388812717	2930	A>S		No	Ensembl
rs2063301657	2931	T>A		No	Ensembl
rs771326367	2932	C>S		No	ExAC gnomAD
TCGA novel	2935	H>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs777119108	2936	P>S		No	ExAC
rs1007277124	2940	P>L		No	TOPMed gnomAD
rs1007277124	2940	P>R		No	TOPMed gnomAD
rs2063302381	2942	N>D		No	Ensembl
rs56410073	2944	S>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1579105531	2945	Y>H		No	Ensembl
rs61742365	2946	S>F		No	Ensembl
TCGA novel	2947	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs891159734	2948	I>L		No	TOPMed gnomAD
rs762977163	2948	I>M		No	ExAC gnomAD
rs1579105590	2948	I>T		No	Ensembl
rs2150847110	2949	P>H		No	Ensembl
rs2063303058	2950	L>V		No	Ensembl
TCGA novel	2950	L>W	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs764326162	2952	T>A		No	ExAC gnomAD
rs1166296826	2952	T>I		No	gnomAD
rs764326162	2952	T>P		No	ExAC gnomAD
rs2063303503	2954	R>C		No	Ensembl
rs1559891981 COSM727743 COSM727744	2954	R>H	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed
rs1181671916	2958	F>L		No	TOPMed
rs2063304007	2959	I>V		No	Ensembl
COSM3800990 COSM3800989	2960	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	2961	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1484533 rs1368942316 COSM1484532	2961	R>H	Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
TCGA novel	2961	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1383359664 COSM3586683 COSM3586682	2962	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
COSM376401 rs144099513 COSM376402	2962	R>H	lung large_intestine [Cosmic]	No	cosmic curated ESP ExAC gnomAD
rs1331799203	2964	H>L		No	gnomAD
rs767482749	2966	N>S		No	ExAC gnomAD
rs1430635505	2967	D>H		No	gnomAD
rs2063304786	2968	V>A		No	TOPMed
rs756057258	2969	R>Q		No	ExAC TOPMed gnomAD
rs201528333	2969	R>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2063305140	2971	I>T		No	Ensembl
rs1397822018	2971	I>V		No	gnomAD
rs2063305222	2972	P>A		No	Ensembl
COSM3586684 COSM3586685	2972	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs16835896	2973	N>S		No	1000Genomes ExAC TOPMed gnomAD
rs1365077553	2975	K>R		No	gnomAD
rs1343390519	2976	S>I		No	TOPMed gnomAD
rs1343390519	2976	S>N		No	TOPMed gnomAD
rs754497724	2977	Y>C		No	ExAC gnomAD
rs2063306052	2978	I>V		No	TOPMed gnomAD
COSM3748211 COSM3748210	2979	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs778598503	2980	N>K		No	ExAC gnomAD
rs2063306138	2980	N>S		No	Ensembl
rs747822809	2981	R>L		No	ExAC TOPMed gnomAD
rs747822809	2981	R>Q		No	ExAC TOPMed gnomAD
rs957655134	2981	R>W		No	TOPMed gnomAD
rs2063306537	2984	Q>E		No	TOPMed
rs201184140	2984	Q>R		No	ESP ExAC TOPMed gnomAD
rs776926854	2986	T>M		No	ExAC TOPMed gnomAD
rs776926854	2986	T>R		No	ExAC TOPMed gnomAD
rs2063307089	2987	T>Q		No	TOPMed
rs2063307172	2987	T>W		No	TOPMed

No associated diseases with O60229

26 regional properties for O60229

Type	Name	Position	InterPro Accession
domain	Dbl homology (DH) domain	1281 - 1456	IPR000219-1
domain	Dbl homology (DH) domain	1929 - 2104	IPR000219-2
domain	Protein kinase domain	2684 - 2938	IPR000719
domain	CRAL-TRIO lipid binding domain	35 - 181	IPR001251
domain	SH3 domain	1646 - 1711	IPR001452-1
domain	SH3 domain	2321 - 2386	IPR001452-2
domain	Pleckstrin homology domain	1468 - 1582	IPR001849-1
domain	Pleckstrin homology domain	2116 - 2228	IPR001849-2
repeat	Spectrin repeat	311 - 414	IPR002017-1
repeat	Spectrin repeat	540 - 640	IPR002017-2
repeat	Spectrin repeat	891 - 998	IPR002017-3
repeat	Spectrin repeat	1132 - 1227	IPR002017-4
domain	Immunoglobulin subtype 2	2483 - 2555	IPR003598
domain	Immunoglobulin subtype	2477 - 2566	IPR003599
domain	Fibronectin type III	2569 - 2665	IPR003961
domain	Immunoglobulin-like domain	2471 - 2564	IPR007110
active_site	Serine/threonine-protein kinase, active site	2799 - 2811	IPR008271
domain	Immunoglobulin I-set	2471 - 2565	IPR013098
binding_site	Protein kinase, ATP binding site	2690 - 2713	IPR017441
repeat	Spectrin/alpha-actinin	190 - 536	IPR018159-1
repeat	Spectrin/alpha-actinin	537 - 766	IPR018159-2
repeat	Spectrin/alpha-actinin	891 - 1129	IPR018159-3
repeat	Spectrin/alpha-actinin	1133 - 1235	IPR018159-4
domain	Kalirin/Triple functional domain protein, SH3 domain 1	1649 - 1708	IPR028570
domain	Kalirin/Triple functional domain protein, SH3 domain 2	2325 - 2383	IPR047053
domain	Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1	1461 - 1583	IPR047054

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton	Associated with the cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extrinsic component of membrane	The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions
protein serine/threonine kinase activity	Catalysis of the reactions

8 GO annotations of biological process

Name	Definition
axon guidance	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
ephrin receptor signaling pathway	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86YR7	MCF2L2	Probable guanine nucleotide exchange factor MCF2L2	Homo sapiens (Human)	SS
O75962	TRIO	Triple functional domain protein	Homo sapiens (Human)	EV
Q86VW2	ARHGEF25	Rho guanine nucleotide exchange factor 25	Homo sapiens (Human)	EV
P10911	MCF2	Proto-oncogene DBL	Homo sapiens (Human)	EV
O15068	MCF2L	Guanine nucleotide exchange factor DBS	Homo sapiens (Human)	SS
Q0KL02	Trio	Triple functional domain protein	Mus musculus (Mouse)	SS
Q64096	Mcf2l	Guanine nucleotide exchange factor DBS	Mus musculus (Mouse)	SS
A2CG49	Kalrn	Kalirin	Mus musculus (Mouse)	SS
F1M0Z1	Trio	Triple functional domain protein	Rattus norvegicus (Rat)	SS
Q63406	Mcf2l	Guanine nucleotide exchange factor DBS	Rattus norvegicus (Rat)	SS
P97924	Kalrn	Kalirin	Rattus norvegicus (Rat)	SS
Q1LUA6	trio	Triple functional domain protein	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MTDRFWDQWY	LWYLRLLRLL	DRGSFRNDGL	KASDVLPILK	EKVAFVSGGR	DKRGGPILTF
70	80	90	100	110	120
PARSNHDRIR	QEDLRKLVTY	LASVPSEDVC	KRGFTVIIDM	RGSKWDLIKP	LLKTLQEAFP
130	140	150	160	170	180
AEIHVALIIK	PDNFWQKQKT	NFGSSKFIFE	TSMVSVEGLT	KLVDPSQLTE	EFDGSLDYNH
190	200	210	220	230	240
EEWIELRLSL	EEFFNSAVHL	LSRLEDLQEM	LARKEFPVDV	EGSRRLIDEH	TQLKKKVLKA
250	260	270	280	290	300
PVEELDREGQ	RLLQCIRCSD	GFSGRNCIPG	SADFQSLVPK	ITSLLDKLHS	TRQHLHQMWH
310	320	330	340	350	360
VRKLKLDQCF	QLRLFEQDAE	KMFDWISHNK	ELFLQSHTEI	GVSYQYALDL	QTQHNHFAMN
370	380	390	400	410	420
SMNAYVNINR	IMSVASRLSE	AGHYASQQIK	QISTQLDQEW	KSFAAALDER	STILAMSAVF
430	440	450	460	470	480
HQKAEQFLSG	VDAWCKMCSE	GGLPSEMQDL	ELAIHHHQTL	YEQVTQAYTE	VSQDGKALLD
490	500	510	520	530	540
VLQRPLSPGN	SESLTATANY	SKAVHQVLDV	VHEVLHHQRR	LESIWQHRKV	RLHQRLQLCV
550	560	570	580	590	600
FQQDVQQVLD	WIENHGEAFL	SKHTGVGKSL	HRARALQKRH	DDFEEVAQNT	YTNADKLLEA
610	620	630	640	650	660
AEQLAQTGEC	DPEEIYKAAR	HLEVRIQDFV	RRVEQRKLLL	DMSVSFHTHT	KELWTWMEDL
670	680	690	700	710	720
QKEMLEDVCA	DSVDAVQELI	KQFQQQQTAT	LDATLNVIKE	GEDLIQQLRS	APPSLGEPSE
730	740	750	760	770	780
ARDSAVSNNK	TPHSSSISHI	ESVLQQLDDA	QVQMEELFHE	RKIKLDIFLQ	LRIFEQYTIE
790	800	810	820	830	840
VTAELDAWNE	DLLRQMNDFN	TEDLTLAEQR	LQRHTERKLA	MNNMTFEVIQ	QGQDLHQYIT
850	860	870	880	890	900
EVQASGIELI	CEKDIDLAAQ	VQELLEFLHE	KQHELELNAE	QTHKRLEQCL	QLRHLQAEVK
910	920	930	940	950	960
QVLGWIRNGE	SMLNASLVNA	SSLSEAEQLQ	REHEQFQLAI	ESLFHATSLQ	KTHQSALQVQ
970	980	990	1000	1010	1020
QKAEVLLQAG	HYDADAIREC	AEKVALHWQQ	LMLKMEDRLK	LVNASVAFYK	TSEQVCSVLE
1030	1040	1050	1060	1070	1080
SLEQEYRRDE	DWCGGRDKLG	PAAEIDHVIP	LISKHLEQKE	AFLKACTLAR	RNAEVFLKYI
1090	1100	1110	1120	1130	1140
HRNNVSMPSV	ASHTRGPEQQ	VKAILSELLQ	RENRVLHFWT	LKKRRLDQCQ	QYVVFERSAK
1150	1160	1170	1180	1190	1200
QALDWIQETG	EFYLSTHTST	GETTEETQEL	LKEYGEFRVP	AKQTKEKVKL	LIQLADSFVE
1210	1220	1230	1240	1250	1260
KGHIHATEIR	KWVTTVDKHY	RDFSLRMGKY	RYSLEKALGV	NTEDNKDLEL	DIIPASLSDR
1270	1280	1290	1300	1310	1320
EVKLRDANHE	VNEEKRKSAR	KKEFIMAELL	QTEKAYVRDL	HECLETYLWE	MTSGVEEIPP
1330	1340	1350	1360	1370	1380
GILNKEHIIF	GNIQEIYDFH	NNIFLKELEK	YEQLPEDVGH	CFVTWADKFQ	MYVTYCKNKP
1390	1400	1410	1420	1430	1440
DSNQLILEHA	GTFFDEIQQR	HGLANSISSY	LIKPVQRITK	YQLLLKELLT	CCEEGKGELK
1450	1460	1470	1480	1490	1500
DGLEVMLSVP	KKANDAMHVS	MLEGFDENLD	VQGELILQDA	FQVWDPKSLI	RKGRERHLFL
1510	1520	1530	1540	1550	1560
FEISLVFSKE	IKDSSGHTKY	VYKNKLLTSE	LGVTEHVEGD	PCKFALWSGR	TPSSDNKTVL
1570	1580	1590	1600	1610	1620
KASNIETKQE	WIKNIREVIQ	ERIIHLKGAL	KEPLQLPKTP	AKQRNNSKRD	GVEDIDSQGD
1630	1640	1650	1660	1670	1680
GSSQPDTISI	ASRTSQNTVD	SDKLSGGCEL	TVVLQDFSAG	HSSELTIQVG	QTVELLERPS
1690	1700	1710	1720	1730	1740
ERPGWCLVRT	TERSPPLEGL	VPSSALCISH	SRSSVEMDCF	FPLVKDAYSH	SSSENGGKSE
1750	1760	1770	1780	1790	1800
SVANLQAQPS	LNSIHSSPGP	KRSTNTLKKW	LTSPVRRLNS	GKADGNIKKQ	KKVRDGRKSF
1810	1820	1830	1840	1850	1860
DLGSPKPGDE	TTPQGDSADE	KSKKGWGEDE	PDEESHTPLP	PPMKIFDNDP	TQDEMSSSLL
1870	1880	1890	1900	1910	1920
AARQASTEVP	TAADLVNAIE	KLVKNKLSLE	GSSYRGSLKD	PAGCLNEGMA	PPTPPKNPEE
1930	1940	1950	1960	1970	1980
EQKAKALRGR	MFVLNELVQT	EKDYVKDLGI	VVEGFMKRIE	EKGVPEDMRG	KDKIVFGNIH
1990	2000	2010	2020	2030	2040
QIYDWHKDFF	LAELEKCIQE	QDRLAQLFIK	HERKLHIYVW	YCQNKPRSEY	IVAEYDAYFE
2050	2060	2070	2080	2090	2100
EVKQEINQRL	TLSDFLIKPI	QRITKYQLLL	KDFLRYSEKA	GLECSDIEKA	VELMCLVPKR
2110	2120	2130	2140	2150	2160
CNDMMNLGRL	QGFEGTLTAQ	GKLLQQDTFY	VIELDAGMQS	RTKERRVFLF	EQIVIFSELL
2170	2180	2190	2200	2210	2220
RKGSLTPGYM	FKRSIKMNYL	VLEENVDNDP	CKFALMNRET	SERVVLQAAN	ADIQQAWVQD
2230	2240	2250	2260	2270	2280
INQVLETQRD	FLNALQSPIE	YQRKERSTAV	MRSQPARLPQ	ASPRPYSSVP	AGSEKPPKGS
2290	2300	2310	2320	2330	2340
SYNPPLPPLK	ISTSNGSPGF	EYHQPGDKFE	ASKQNDLGGC	NGTSSMAVIK	DYYALKENEI
2350	2360	2370	2380	2390	2400
CVSQGEVVQV	LAVNQQNMCL	VYQPASDHSP	AAEGWVPGSI	LAPLTKATAA	ESSDGSIKKS
2410	2420	2430	2440	2450	2460
CSWHTLRMRK	RAEVENTGKN	EATGPRKPKD	ILGNKVSVKE	TNSSEESECD	DLDPNTSMEI
2470	2480	2490	2500	2510	2520
LNPNFIQEVA	PEFLVPLVDV	TCLLGDTVIL	QCKVCGRPKP	TITWKGPDQN	ILDTDNSSAT
2530	2540	2550	2560	2570	2580
YTVSSCDSGE	ITLKICNLMP	QDSGIYTCIA	TNDHGTTSTS	ATVKVQGVPA	APNRPIAQER
2590	2600	2610	2620	2630	2640
SCTSVILRWL	PPSSTGNCTI	SGYTVEYREE	GSQIWQQSVA	STLDTYLVIE	DLSPGCPYQF
2650	2660	2670	2680	2690	2700
RVSASNPWGI	SLPSEPSEFV	RLPEYDAAAD	GATISWKENF	DSAYTELNEI	GRGRFSIVKK
2710	2720	2730	2740	2750	2760
CIHKATRKDV	AVKFVSKKMK	KKEQAAHEAA	LLQHLQHPQY	ITLHDTYESP	TSYILILELM
2770	2780	2790	2800	2810	2820
DDGRLLDYLM	NHDELMEEKV	AFYIRDIMEA	LQYLHNCRVA	HLDIKPENLL	IDLRIPVPRV
2830	2840	2850	2860	2870	2880
KLIDLEDAVQ	ISGHFHIHHL	LGNPEFAAPE	VIQGIPVSLG	TDIWSIGVLT	YVMLSGVSPF
2890	2900	2910	2920	2930	2940
LDESKEETCI	NVCRVDFSFP	HEYFCGVSNA	ARDFINVILQ	EDFRRRPTAA	TCLQHPWLQP
2950	2960	2970	2980
HNGSYSKIPL	DTSRLACFIE	RRKHQNDVRP	IPNVKSYIVN	RVNQGT