AiPD: Autoinhibited Protein Database

Gene name	Stk10 (Lok)
Protein name	Serine/threonine-protein kinase 10
Names	Lymphocyte-oriented kinase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:20868
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-58 (Predicted disordered autoinhibitory region) PR

1-58 (Predicted disordered autoinhibitory region)

cis-regPred

Target domain	23-314 (Catalytic domain of the Serine/Threonine Kinase, STK10, also called Lymphocyte-Oriented Kinase or LOK)
Relief mechanism
Assay

Entry ID	Method	Resolution	Chain	Position	Source
AF-O55098-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389159329	65	K>E	No	EVA
rs3389120660	76	E>D	No	EVA
rs26847322	79	I>M	No	EVA
rs3389149444	109	M>I	No	EVA
rs3389144171	116	G>E	No	EVA
rs3389086831	174	A>S	No	EVA
rs3389149817	198	W>R	No	EVA
rs3389142402	295	S>N	No	EVA
rs3389124754	297	V>I	No	EVA
rs3389086800	327	E>*	No	EVA
rs3389148103	334	V>I	No	EVA
rs3389144215	356	K>M	No	EVA
rs231848163	364	P>H	No	EVA
rs6236287	375	S>N	No	EVA
rs6236299	377	S>P	No	EVA
rs3389124749	418	D>E	No	EVA
rs3389159388	421	I>N	No	EVA
rs264163408	429	I>V	No	EVA
rs3389146979	475	V>L	No	EVA
rs3389124724	555	E>*	No	EVA
rs3413021015	565	L>F	No	EVA
rs3389149401	633	R>C	No	EVA
rs239352741	633	R>H	No	EVA
rs3389113074	635	K>I	No	EVA
rs3389124763	639	K>*	No	EVA
rs3389124763	639	K>E	No	EVA
rs3389144176	646	D>N	No	EVA
rs3389146963	668	E>K	No	EVA
rs3402138939	672	R>G	No	EVA
rs241313948	680	K>R	No	EVA
rs3389142469	712	L>I	No	EVA
rs3389144221	714	T>A	No	EVA
rs3401686540	741	A>S	No	EVA
rs3389148268	760	Q>E	No	EVA
rs215599555	908	S>N	No	EVA
rs3389124688	949	T>S	No	EVA
rs219660344	953	K>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	58 - 313	IPR000719
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	62 - 308	IPR001245
active_site	Tyrosine-protein kinase, active site	172 - 184	IPR008266
binding_site	Protein kinase, ATP binding site	64 - 87	IPR017441

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
lymphocyte aggregation	The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of lymphocyte migration	Any process that modulates the frequency, rate or extent of lymphocyte migration.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
E1BK52	STK10	Serine/threonine-protein kinase 10	Bos taurus (Bovine)	PR
Q9H2G2	SLK	STE20-like serine/threonine-protein kinase	Homo sapiens (Human)	PR
O94804	STK10	Serine/threonine-protein kinase 10	Homo sapiens (Human)	PR
O54988	Slk	STE20-like serine/threonine-protein kinase	Mus musculus (Mouse)	PR
Q6P9R2	Oxsr1	Serine/threonine-protein kinase OSR1	Mus musculus (Mouse)	PR
Q9Z1W9	Stk39	STE20/SPS1-related proline-alanine-rich protein kinase	Mus musculus (Mouse)	PR
P70218	Map4k1	Mitogen-activated protein kinase kinase kinase kinase 1	Mus musculus (Mouse)	PR
Q61161	Map4k2	Mitogen-activated protein kinase kinase kinase kinase 2	Mus musculus (Mouse)	SS
Q99JP0	Map4k3	Mitogen-activated protein kinase kinase kinase kinase 3	Mus musculus (Mouse)	SS
Q99JT2	Stk26	Serine/threonine-protein kinase 26	Mus musculus (Mouse)	PR
Q99KH8	Stk24	Serine/threonine-protein kinase 24	Mus musculus (Mouse)	PR
Q9Z2W1	Stk25	Serine/threonine-protein kinase 25	Mus musculus (Mouse)	PR
Q8BPM2	Map4k5	Mitogen-activated protein kinase kinase kinase kinase 5	Mus musculus (Mouse)	PR
E9PTG8	Stk10	Serine/threonine-protein kinase 10	Rattus norvegicus (Rat)	PR
Q0IHQ8	stk10	Serine/threonine-protein kinase 10	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR