O54988
Gene name |
Slk (Kiaa0204, Stk2) |
Protein name |
STE20-like serine/threonine-protein kinase |
Names |
STE20-like kinase, mSLK, Etk4, STE20-related kinase SMAK, STE20-related serine/threonine-protein kinase, STE20-related kinase, Serine/threonine-protein kinase 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20874 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
172-195 (Activation loop from InterPro)
Target domain |
34-292 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O54988
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O54988-F1 | Predicted | AlphaFoldDB |
50 variants for O54988
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3409339462 | 88 | H>Q | No | EVA | |
| rs3409524430 | 92 | V>F | No | EVA | |
| rs3389538457 | 111 | C>Y | No | EVA | |
| rs3389511459 | 123 | L>I | No | EVA | |
| rs3389538500 | 164 | T>S | No | EVA | |
| rs3389511510 | 174 | F>L | No | EVA | |
| rs3389544829 | 188 | D>N | No | EVA | |
| rs241676065 | 263 | S>A | No | EVA | |
| rs3389557281 | 308 | K>* | No | EVA | |
| rs3389540989 | 367 | T>I | No | EVA | |
| rs212553921 | 393 | A>S | No | EVA | |
| rs3389539283 | 401 | V>L | No | EVA | |
| rs3389546224 | 413 | T>I | No | EVA | |
| rs3389494734 | 433 | D>N | No | EVA | |
| rs3389554704 | 447 | E>* | No | EVA | |
| rs38916703 | 448 | E>G | No | EVA | |
| rs3389540984 | 451 | N>K | No | EVA | |
| rs3389557297 | 453 | R>K | No | EVA | |
| rs36646746 | 483 | Q>K | No | EVA | |
| rs3389501440 | 493 | Q>R | No | EVA | |
| rs3389557244 | 516 | V>F | No | EVA | |
| rs3389494724 | 519 | T>R | No | EVA | |
| rs251565764 | 537 | I>V | No | EVA | |
| rs3389501393 | 538 | T>I | No | EVA | |
| rs3389549411 | 547 | T>A | No | EVA | |
| rs3389545489 | 548 | D>Y | No | EVA | |
| rs234345660 | 568 | E>D | No | EVA | |
| rs3389544858 | 588 | E>D | No | EVA | |
| rs261609285 | 592 | A>T | No | EVA | |
| rs3389453552 | 596 | P>H | No | EVA | |
| rs3389525255 | 629 | A>T | No | EVA | |
| rs220594819 | 634 | P>S | No | EVA | |
| rs1134047440 | 636 | T>M | No | EVA | |
| rs3389501409 | 666 | S>N | No | EVA | |
| rs219437584 | 691 | E>G | No | EVA | |
| rs3389546278 | 713 | I>T | No | EVA | |
| rs37013078 | 740 | H>N | No | EVA | |
| rs3389560497 | 750 | T>I | No | EVA | |
| rs259027719 | 756 | N>T | No | EVA | |
| rs3389554651 | 760 | D>N | No | EVA | |
| rs37241710 | 772 | A>T | No | EVA | |
| rs3389501406 | 840 | Q>L | No | EVA | |
| rs3389540976 | 850 | L>M | No | EVA | |
| rs3389549420 | 944 | K>T | No | EVA | |
| rs3389554658 | 1004 | A>T | No | EVA | |
| rs3407315659 | 1024 | Q>L | No | EVA | |
| rs3408613207 | 1025 | L>V | No | EVA | |
| rs3389544809 | 1031 | M>L | No | EVA | |
| rs3389540922 | 1200 | V>L | No | EVA | |
| rs3389539325 | 1224 | P>H | No | EVA |
No associated diseases with O54988
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of focal adhesion assembly | Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| E1BK52 | STK10 | Serine/threonine-protein kinase 10 | Bos taurus (Bovine) | PR |
| O94804 | STK10 | Serine/threonine-protein kinase 10 | Homo sapiens (Human) | PR |
| Q9H2G2 | SLK | STE20-like serine/threonine-protein kinase | Homo sapiens (Human) | PR |
| O55098 | Stk10 | Serine/threonine-protein kinase 10 | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| P70218 | Map4k1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q61161 | Map4k2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Mus musculus (Mouse) | SS |
| Q99JP0 | Map4k3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Mus musculus (Mouse) | SS |
| Q99JT2 | Stk26 | Serine/threonine-protein kinase 26 | Mus musculus (Mouse) | PR |
| Q99KH8 | Stk24 | Serine/threonine-protein kinase 24 | Mus musculus (Mouse) | PR |
| Q9Z2W1 | Stk25 | Serine/threonine-protein kinase 25 | Mus musculus (Mouse) | PR |
| Q8BPM2 | Map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5 | Mus musculus (Mouse) | PR |
| E9PTG8 | Stk10 | Serine/threonine-protein kinase 10 | Rattus norvegicus (Rat) | PR |
| Q0IHQ8 | stk10 | Serine/threonine-protein kinase 10 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFFNFRKIF | KLGSEKKKKQ | YEHVKRDLNP | EEFWEIIGEL | GDGAFGKVYK | AQNKETNVLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AAKVIDTKSE | EELEDYMVEI | DILASCDHPN | IVKLLDAFYY | ENNLWILIEF | CAGGAVDAVM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LELERPLTES | QIQVVCKQTL | EALNYLHDNK | IIHRDLKAGN | ILFTLDGDIK | LADFGVSAKN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TRTIQRRDSF | IGTPYWMAPE | VVMCETSKDR | PYDYKADVWS | LGITLIEMAE | IEPPHHELNP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MRVLLKIAKS | EPPTLAQPSK | WSSNFKDFLR | KCLEKNVDAR | WTTSQLLQHP | FVTVDSNKPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RELIAEAKAE | VTEEVEDGKE | EDEEEEAENA | LPIPANKRAS | SDLSIASSEE | DKLSQNACIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ESVSERTEQS | TSEDKFSNKI | LNEKPTTDGP | EKAVDEHASD | VNLETGAELN | DQTVGIHENG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REKKRPKLEN | LPDTQDQQTV | DVNSVSEENE | NNRVTLETNT | DCLKPEEDRN | KENQETLESK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LIQSEEINDT | HIQTMDLVSQ | ETGEKEADFQ | AVDNEVGLTK | EETQEKLGKD | GTAQKVITSD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSSEVGTDEA | LDDTQKAAEL | SKAAQSGEGD | EALAPTQTLA | EKPTEGPEAG | GAEEEPPGGE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RVEDKQPEQQ | PAVCEAEGQL | TSTSETTRAT | LEQPETDEVE | QVSESNSIEE | LERLVVTGAE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ARALGSEGEA | AATEVDLERK | ENAQKVPVKA | ESQAPAASQP | SEPHPVLIPS | ININSETTEN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KEEMGALPKP | ETILPPEPEH | EKGNDTDSGT | GSTVENSSGD | LNLSISSFLS | KAKDSGSVSL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QETRRQKKTL | KKTRKFIVDG | VEVSVTTSKI | VTDSDSKTEE | LRFLRRQELR | ELRLLQKEEQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RAQQQLNGKL | QQQREQIFRR | FEQEMLSKKR | QYDQEIENLE | KQQKQTIERL | EQEHTNRLRD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EAKRIKGEQE | KELSKFQNVL | KNRKKEVMNE | VEKAPRELRR | ELTKRRKEEL | AQSQHAQEQE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FVQKQQQELD | GSLKKIIQQQ | KAELANIERE | CLNNKQQLMR | AREAAIWELE | ERHLQEKHQL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LKQQLKDQYF | MQRHQLLKRH | EKETEQMQRY | NQRLIEELKN | RQTQERARLP | KIQRSEAKTR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| MAMFKKSLRI | NSTATPDQDR | EKIKQFAAQE | EKRQKNERMA | QHQKHESQMR | DLQLQCEANV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RELHQLQNEK | CHLLVEHETQ | KLKELDEEHS | QELKEWREKL | RPRKKTLEEE | FARKLQEQEV |
| 1210 | 1220 | 1230 | |||
| FFKMTGESEC | LNPSAQSRIS | KFYPIPTLHS | TGS |