O54829
PR
Gene name |
Rgs7 |
Protein name |
Regulator of G-protein signaling 7 |
Names |
RGS7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:24012 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O54829
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O54829-F1 | Predicted | AlphaFoldDB |
17 variants for O54829
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388520567 | 8 | G>V | No | EVA | |
| rs3388516844 | 52 | K>M | No | EVA | |
| rs3388519156 | 142 | R>W | No | EVA | |
| rs3388520556 | 174 | Q>P | No | EVA | |
| rs3388519921 | 203 | V>M | No | EVA | |
| rs3388519391 | 217 | S>A | No | EVA | |
| rs3388520510 | 227 | R>* | No | EVA | |
| rs239855037 | 235 | N>T | No | EVA | |
| rs3391012948 | 255 | E>V | No | EVA | |
| rs3388514926 | 263 | K>E | No | EVA | |
| rs3388516916 | 274 | L>F | No | EVA | |
| rs3388520508 | 275 | K>E | No | EVA | |
| rs3388514952 | 280 | A>D | No | EVA | |
| rs3388519635 | 294 | D>E | No | EVA | |
| rs3388516832 | 380 | R>* | No | EVA | |
| rs3388521681 | 383 | E>G | No | EVA | |
| rs3388517235 | 414 | P>A | No | EVA |
No associated diseases with O54829
Functions
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite terminus | A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| G-protein alpha-subunit binding | Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. |
| G-protein beta-subunit binding | Binding to a G-protein beta subunit. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of potassium ion transmembrane transport | Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
| regulation of postsynaptic membrane potential | Any process that modulates the potential difference across a post-synaptic membrane. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O46471 | RGS16 | Regulator of G-protein signaling 16 | Bos taurus (Bovine) | PR |
| Q3T0T8 | RGS5 | Regulator of G-protein signaling 5 | Bos taurus (Bovine) | PR |
| O15539 | RGS5 | Regulator of G-protein signaling 5 | Homo sapiens (Human) | PR |
| P49802 | RGS7 | Regulator of G-protein signaling 7 | Homo sapiens (Human) | PR |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| Q9Z2H1 | Rgs11 | Regulator of G-protein signaling 11 | Mus musculus (Mouse) | PR |
| Q18312 | rgs-3 | Regulator of G-protein signaling rgs-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQGNNYGQT | SNGVADESPN | MLVYRKMEDV | IARMQDEKNG | IPIRTVKSFL | SKIPSVFSGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DIVQWLIKNL | TIEDPVEALH | LGTLMAAHGY | FFPISDHVLT | LKDDGTFYRF | QTPYFWPSNC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WEPENTDYAV | YLCKRTMQNK | ARLELADYEA | ESLARLQRAF | ARKWEFIFMQ | AEAQAKVDKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDKIERKILD | SQERAFWDVH | RPVPGCVNTT | EVDIKKSSRM | RNPHKTRKSV | YGLQNDIRSH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPTHTPTPET | KPPTEDELHQ | QIKYWQIQLD | RHRLKMSKVA | DSLLSYTEQY | VEYDPFLVPP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DPSNPWLSDD | TTFWELEASK | EPSQQRVKRW | GFGMDEALKD | PVGREQFLKF | LESEFSSENL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFWLAVEDLK | RRPIREVPSR | VQEIWQEFLA | PGAPSAINLD | SKSYDKTTQN | VKEPGRYTFE |
| 430 | 440 | 450 | 460 | ||
| DAQEHIYKLM | KSDSYPRFIR | SSAYQELLQA | KRKGKTLTSK | RLTSLVQSY |