O54751

PR
Gene name
Crx
Protein name
Cone-rod homeobox protein
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12951
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

103-292 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O54751

Entry ID Method Resolution Chain Position Source
AF-O54751-F1 Predicted AlphaFoldDB

13 variants for O54751

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388885844 54 L>P No EVA
rs3388879347 55 E>* No EVA
rs3388872588 56 A>G No EVA
rs3388843342 70 E>G No EVA
rs239230641 117 A>V No EVA
rs3388841009 164 S>N No EVA
rs252080798 169 A>S No EVA
rs3388841087 178 G>V No EVA
rs3412746205 226 V>M No EVA
rs3388876198 235 S>T No EVA
rs3388868674 249 S>P No EVA
rs3388860822 268 E>V No EVA
rs3388873193 276 W>L No EVA

No associated diseases with O54751

5 regional properties for O54751

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 431 - 555 IPR000595
domain Ion transport domain 119 - 358 IPR005821
conserved_site Cyclic nucleotide-binding, conserved site 458 - 474 IPR018488-1
conserved_site Cyclic nucleotide-binding, conserved site 496 - 519 IPR018488-2
domain Cyclic nucleotide-gated channel, C-terminal leucine zipper domain 547 - 616 IPR032406

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

12 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
leucine zipper domain binding Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
nuclear receptor binding Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

8 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9XSK0 CRX Cone-rod homeobox protein Bos taurus (Bovine) PR
Q8SQ03 CRX Cone-rod homeobox protein Canis lupus familiaris (Dog) (Canis familiaris) PR
P32243 OTX2 Homeobox protein OTX2 Homo sapiens (Human) PR
O43186 CRX Cone-rod homeobox protein Homo sapiens (Human) PR
P80206 Otx2 Homeobox protein OTX2 Mus musculus (Mouse) PR
Q6H6S3 HOX24 Homeobox-leucine zipper protein HOX24 Oryza sativa subsp japonica (Rice) PR
Q7XUJ5 HOX22 Homeobox-leucine zipper protein HOX22 Oryza sativa subsp japonica (Rice) PR
A3BYC1 HOX25 Homeobox-leucine zipper protein HOX25 Oryza sativa subsp japonica (Rice) PR
Q9M276 ATHB-12 Homeobox-leucine zipper protein ATHB-12 Arabidopsis thaliana (Mouse-ear cress) PR
Q28FN6 otx2 Homeobox protein OTX2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q91994 otx1b Homeobox protein OTX1 B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ LEELEALFAK
70 80 90 100 110 120
TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGA QTKARPAKRK
130 140 150 160 170 180
AGTSPRPSTD VCTDPLGISD SYSPSLPGPS GSPTTAVATV SIWSPASEAP LPEAQRAGLV
190 200 210 220 230 240
ASGPSLTSAP YAMTYAPASA FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP
250 260 270 280 290
SVGPSLAQSP TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL