Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for O49513

Entry ID Method Resolution Chain Position Source
AF-O49513-F1 Predicted AlphaFoldDB

4 variants for O49513

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06715423 99 I>L No 1000Genomes
tmp_4_10184148_G_A 137 P>S No 1000Genomes
ENSVATH11976668 182 A>V No 1000Genomes
ENSVATH14247003 190 M>L No 1000Genomes

No associated diseases with O49513

1 regional properties for O49513

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 12 - 170 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

2 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TA29 RAB11A Ras-related protein Rab-11A Bos taurus (Bovine) PR
Q3MHP2 RAB11B Ras-related protein Rab-11B Bos taurus (Bovine) PR
Q5ZJN2 RAB11A Ras-related protein Rab-11A Gallus gallus (Chicken) PR
P62490 RAB11A Ras-related protein Rab-11A Canis lupus familiaris (Dog) (Canis familiaris) PR
Q15907 RAB11B Ras-related protein Rab-11B Homo sapiens (Human) PR
P62491 RAB11A Ras-related protein Rab-11A Homo sapiens (Human) PR
P46638 Rab11b Ras-related protein Rab-11B Mus musculus (Mouse) PR
P62492 Rab11a Ras-related protein Rab-11A Mus musculus (Mouse) PR
Q52NJ1 RAB11A Ras-related protein Rab-11A Sus scrofa (Pig) PR
O35509 Rab11b Ras-related protein Rab-11B Rattus norvegicus (Rat) PR
P62494 Rab11a Ras-related protein Rab-11A Rattus norvegicus (Rat) PR
O04486 RABA2A Ras-related protein RABA2a Arabidopsis thaliana (Mouse-ear cress) PR
Q9FE79 RABA4C Ras-related protein RABA4c Arabidopsis thaliana (Mouse-ear cress) PR
Q9LH50 RABA4D Ras-related protein RABA4d Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNK1 RABA3 Ras-related protein RABA3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNW1 RABA2B Ras-related protein RABA2b Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGAYRADDDY DYLFKLVLIG DSGVGKSNLL SRFTRNEFSI ESKSTIGVEF ATRSVHVDEK
70 80 90 100 110 120
IIKAQLWDTA GQERYRAITS AYYRGAVGAL LVYDITRHIT FENVERWLKE LRDHTDANVV
130 140 150 160 170 180
IMLVGNKADL RHLRAVPTEE ARSFSERENM FFMETSALDA TNVEQAFTHV LTQIYRVMSR
190 200 210
KALDGTGDPM SLPKGQTIDI GNKDDVTAVK SSGCCSG