O49298
SS
Gene name |
PME6 (ARATH6, At1g23200, T26J12.4) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 6 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G23200 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
250-540 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for O49298
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O49298-F1 | Predicted | AlphaFoldDB |
48 variants for O49298
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_8227284_T_G | 17 | C>G | No | 1000Genomes | |
| ENSVATH11866084 | 17 | C>Y | No | 1000Genomes | |
| tmp_1_8227388_G_C,A | 51 | M>I | No | 1000Genomes | |
| tmp_1_8227388_G_C,A | 51 | M>I | No | 1000Genomes | |
| ENSVATH04629039 | 54 | S>P | No | 1000Genomes | |
| ENSVATH00039318 | 58 | T>P | No | 1000Genomes | |
| tmp_1_8227441_A_T | 69 | H>L | No | 1000Genomes | |
| tmp_1_8227456_G_C | 74 | S>T | No | 1000Genomes | |
| ENSVATH00039321 | 90 | L>V | No | 1000Genomes | |
| ENSVATH11866136 | 97 | H>Q | No | 1000Genomes | |
| ENSVATH00039322 | 116 | D>G | No | 1000Genomes | |
| tmp_1_8227711_C_T | 159 | S>F | No | 1000Genomes | |
| tmp_1_8227743_C_T | 170 | H>Y | No | 1000Genomes | |
| tmp_1_8227806_G_A | 191 | E>K | No | 1000Genomes | |
| tmp_1_8227828_C_T | 198 | P>L | No | 1000Genomes | |
| ENSVATH01092558 | 199 | S>L | No | 1000Genomes | |
| ENSVATH00039323 | 201 | G>E | No | 1000Genomes | |
| ENSVATH04629041 | 212 | A>V | No | 1000Genomes | |
| ENSVATH01092559 | 233 | P>S | No | 1000Genomes | |
| tmp_1_8227936_T_A | 234 | L>H | No | 1000Genomes | |
| tmp_1_8227956_G_C | 241 | E>Q | No | 1000Genomes | |
| ENSVATH11866138 | 250 | D>N | No | 1000Genomes | |
| ENSVATH04629043 | 262 | T>R | No | 1000Genomes | |
| ENSVATH11866139 | 269 | N>D | No | 1000Genomes | |
| ENSVATH00039325 | 287 | A>V | No | 1000Genomes | |
| ENSVATH11866140 | 291 | R>S | No | 1000Genomes | |
| ENSVATH04629044 | 302 | N>S | No | 1000Genomes | |
| tmp_1_8228172_A_T | 313 | T>S | No | 1000Genomes | |
| tmp_1_8228738_G_A | 335 | V>I | No | 1000Genomes | |
| tmp_1_8228744_G_T | 337 | G>C | No | 1000Genomes | |
| ENSVATH13950999 | 340 | F>L | No | 1000Genomes | |
| ENSVATH04629055 | 342 | A>T | No | 1000Genomes | |
| ENSVATH04629057 | 346 | T>A | No | 1000Genomes | |
| ENSVATH00039328 | 347 | F>V | No | 1000Genomes | |
| ENSVATH04629058 | 355 | K>N | No | 1000Genomes | |
| ENSVATH13951000 | 369 | V>I | No | 1000Genomes | |
| tmp_1_8228877_C_G | 381 | T>S | No | 1000Genomes | |
| tmp_1_8228964_T_A | 410 | I>N | No | 1000Genomes | |
| ENSVATH13951001 | 415 | N>K | No | 1000Genomes | |
| tmp_1_8228987_G_A | 418 | A>T | No | 1000Genomes | |
| ENSVATH01092571 | 470 | F>Y | No | 1000Genomes | |
| tmp_1_8229217_C_G | 494 | S>R | No | 1000Genomes | |
| ENSVATH04629061 | 506 | A>T | No | 1000Genomes | |
| tmp_1_8229270_G_A | 512 | G>D | No | 1000Genomes | |
| tmp_1_8229275_G_A | 514 | V>I | No | 1000Genomes | |
| ENSVATH00039331 | 522 | I>L | No | 1000Genomes | |
| ENSVATH01092572 | 534 | E>G | No | 1000Genomes | |
| tmp_1_8229351_G_T | 539 | G>V | No | 1000Genomes |
No associated diseases with O49298
12 regional properties for O49298
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Actinin-type actin-binding domain, conserved site | 52 - 61 | IPR001589-1 |
| conserved_site | Actinin-type actin-binding domain, conserved site | 126 - 150 | IPR001589-2 |
| domain | Calponin homology domain | 50 - 154 | IPR001715-1 |
| domain | Calponin homology domain | 163 - 269 | IPR001715-2 |
| repeat | Spectrin repeat | 293 - 402 | IPR002017-1 |
| repeat | Spectrin repeat | 413 - 517 | IPR002017-2 |
| repeat | Spectrin repeat | 530 - 639 | IPR002017-3 |
| repeat | Spectrin repeat | 650 - 751 | IPR002017-4 |
| domain | EF-hand domain | 765 - 841 | IPR002048 |
| domain | EF-hand, Ca insensitive | 841 - 907 | IPR014837 |
| repeat | Spectrin/alpha-actinin | 296 - 754 | IPR018159 |
| binding_site | EF-Hand 1, calcium-binding site | 778 - 790 | IPR018247 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDHKILLTPP | KSLYTKCIIT | IIYVVSISHL | NAHFITSCKQ | TPYPSVCDHH | MSNSPLKTLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQTDGFTFHD | LVVSSTMDQA | VQLHRLVSSL | KQHHSLHKHA | TSALFDCLEL | YEDTIDQLNH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRRSYGQYSS | PHDRQTSLSA | AIANQDTCRN | GFRDFKLTSS | YSKYFPVQFH | RNLTKSISNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAVTKAAAEA | EAVAEKYPST | GFTKFSKQRS | SAGGGSHRRL | LLFSDEKFPS | WFPLSDRKLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDSKTTAKAD | LVVAKDGSGH | YTSIQQAVNA | AAKLPRRNQR | LVIYVKAGVY | RENVVIKKSI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KNVMVIGDGI | DSTIVTGNRN | VQDGTTTFRS | ATFAVSGNGF | IAQGITFENT | AGPEKHQAVA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRSSSDFSVF | YACSFKGYQD | TLYLHSSRQF | LRNCNIYGTV | DFIFGDATAI | LQNCNIYARK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PMSGQKNTIT | AQSRKEPDET | TGFVIQSSTV | ATASETYLGR | PWRSHSRTVF | MKCNLGALVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PAGWLPWSGS | FALSTLYYGE | YGNTGAGASV | SGRVKWPGYH | VIKTVTEAEK | FTVENFLDGN |
| 550 | |||||
| YWITATGVPV | NDGL |