O49139

PR
Gene name
CMT1 (At1g80740, F23A5.9)
Protein name
Putative DNA (cytosine-5)-methyltransferase CMT1
Names
Chromomethylase 1, Protein CHROMOMETHYLASE 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G80740
EC number
2.1.1.37: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O49139

Entry ID Method Resolution Chain Position Source
AF-O49139-F1 Predicted AlphaFoldDB

130 variants for O49139

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_30342398_C_A 2 A>E No 1000Genomes
tmp_1_30342397_G_A 2 A>T No 1000Genomes
ENSVATH13846231 4 R>G No 1000Genomes
tmp_1_30342418_A_C 9 K>Q No 1000Genomes
tmp_1_30342422_G_A 10 R>H No 1000Genomes
tmp_1_30342424_G_T 11 A>S No 1000Genomes
ENSVATH05180575 14 E>D No 1000Genomes
ENSVATH13846232 18 C>R No 1000Genomes
ENSVATH01563514 18 C>S No 1000Genomes
ENSVATH13846233 20 A>T No 1000Genomes
tmp_1_30342455_G_C 21 G>A No 1000Genomes
ENSVATH13846234 41 K>N No 1000Genomes
ENSVATH13846235 47 P>A No 1000Genomes
ENSVATH13846236 49 K>T No 1000Genomes
tmp_1_30342551_A_G 53 N>S No 1000Genomes
ENSVATH01563515 56 G>C No 1000Genomes
tmp_1_30342639_A_T 58 K>N No 1000Genomes
tmp_1_30342655_A_T 64 I>L No 1000Genomes
ENSVATH14497188 87 V>A No 1000Genomes
ENSVATH13846238 88 Y>D No 1000Genomes
tmp_1_30342965_C_T 93 P>S No 1000Genomes
ENSVATH05180588 130 R>K No 1000Genomes
148 D>G strain: cv. Metz-0 [UniProt] No
ENSVATH05180589 151 L>F No 1000Genomes
ENSVATH13846250 164 P>A No 1000Genomes
tmp_1_30343394_G_T 180 C>F No 1000Genomes
tmp_1_30343393_T_C 180 C>R No 1000Genomes
tmp_1_30343422_A_C 189 E>D No 1000Genomes
ENSVATH13846258 196 T>I strain: cv. Kl-0 [UniProt] No 1000Genomes
ENSVATH01563526 198 A>T strain: cv. No-0 [UniProt] No 1000Genomes
tmp_1_30343849_G_A 203 D>N No 1000Genomes
ENSVATH05180599 212 S>Y No 1000Genomes
tmp_1_30343892_T_C 217 F>S No 1000Genomes
ENSVATH05180600 218 E>K No 1000Genomes
ENSVATH01563529 227 L>I No 1000Genomes
tmp_1_30343942_T_G 234 C>G No 1000Genomes
ENSVATH13846261 237 M>I No 1000Genomes
ENSVATH13846262 239 T>I No 1000Genomes
249 G>del strain: cv. Metz-0 [UniProt] No
tmp_1_30343999_A_T 253 I>F No 1000Genomes
tmp_1_30344098_G_A 259 D>N No 1000Genomes
tmp_1_30344120_A_G 266 D>G No 1000Genomes
ENSVATH13846264 267 S>N No 1000Genomes
tmp_1_30344126_T_G 268 L>R No 1000Genomes
tmp_1_30344137_C_T 272 H>Y No 1000Genomes
tmp_1_30344150_A_G 276 E>G No 1000Genomes
ENSVATH05180604 282 A>T No 1000Genomes
ENSVATH07699754 285 F>I No 1000Genomes
ENSVATH14497206 297 E>K No 1000Genomes
ENSVATH05180605 301 L>H No 1000Genomes
tmp_1_30344318_G_A 302 V>I No 1000Genomes
tmp_1_30344384_G_C 324 D>H No 1000Genomes
tmp_1_30344424_G_A 337 G>E No 1000Genomes
tmp_1_30344443_G_C 343 K>N No 1000Genomes
tmp_1_30344451_G_C 346 G>A No 1000Genomes
tmp_1_30344495_C_T,CAA 361 Q>* No 1000Genomes
ENSVATH14497208 369 Y>* No 1000Genomes
tmp_1_30344628_T_G 370 N>K No 1000Genomes
tmp_1_30344633_G_A 372 S>N No 1000Genomes
ENSVATH14497209 377 E>* No 1000Genomes
ENSVATH05180608 381 G>S No 1000Genomes
ENSVATH05180609 381 G>V No 1000Genomes
tmp_1_30344784_C_A 400 H>N No 1000Genomes
ENSVATH05180615 407 T>I No 1000Genomes
tmp_1_30344899_G_T 411 V>L No 1000Genomes
ENSVATH14497213 418 Q>L No 1000Genomes
ENSVATH05180616 432 P>T No 1000Genomes
tmp_1_30345040_A_T 458 M>L No 1000Genomes
ENSVATH05180617 458 M>T No 1000Genomes
tmp_1_30345046_A_C 460 N>H No 1000Genomes
tmp_1_30345101_C_T 478 A>V No 1000Genomes
tmp_1_30345124_C_T 486 Q>* No 1000Genomes
ENSVATH05180618 486 Q>P No 1000Genomes
tmp_1_30345136_G_A 490 G>S No 1000Genomes
tmp_1_30345139_A_C 491 M>L No 1000Genomes
tmp_1_30345145_G_C 493 A>P No 1000Genomes
tmp_1_30345184_G_T 506 V>F No 1000Genomes
tmp_1_30345202_C_A 512 Q>K No 1000Genomes
ENSVATH05180620 519 P>A No 1000Genomes
tmp_1_30345312_C_T 519 P>L No 1000Genomes
ENSVATH13846273 523 P>L No 1000Genomes
tmp_1_30345332_G_A 526 E>K No 1000Genomes
ENSVATH05180621 530 K>M No 1000Genomes
ENSVATH01563539 544 R>H No 1000Genomes
tmp_1_30345477_A_C 546 Q>P No 1000Genomes
tmp_1_30345481_G_C 547 M>I No 1000Genomes
ENSVATH05180623 553 D>V No 1000Genomes
560 D>V strain: cv. Landsberg erecta, cv. No-0 and cv. RLD [UniProt] No
561 A>del strain: cv. Landsberg erecta, cv. No-0 and cv. RLD [UniProt] No
tmp_1_30345528_G_C 563 S>T No 1000Genomes
ENSVATH05180626 575 D>G No 1000Genomes
tmp_1_30345796_C_T 602 P>L No 1000Genomes
ENSVATH01563543 604 F>C strain: cv. Nd-1, Nd-0 and cv. Kl-0 [UniProt] No 1000Genomes
ENSVATH05180628 604 F>L No 1000Genomes
tmp_1_30345804_G_A 605 G>S No 1000Genomes
ENSVATH14497217 634 Q>* No 1000Genomes
tmp_1_30345987_A_C 638 N>T No 1000Genomes
ENSVATH05180631 639 Y>* No 1000Genomes
ENSVATH00800459 641 D>N No 1000Genomes
tmp_1_30346007_G_A 645 V>I No 1000Genomes
tmp_1_30346205_CA_AA,C 681 S>* No 1000Genomes
tmp_1_30346211_A_T 683 K>M No 1000Genomes
tmp_1_30346324_C_T 688 L>F No 1000Genomes
ENSVATH01563548 699 T>P No 1000Genomes
ENSVATH05180644 708 V>L No 1000Genomes
tmp_1_30346480_C_T 710 H>Y No 1000Genomes
tmp_1_30346494_C_A 714 N>K No 1000Genomes
ENSVATH05180645 715 R>L No 1000Genomes
tmp_1_30346495_C_A 715 R>S No 1000Genomes
ENSVATH00800462 721 E>D No 1000Genomes
tmp_1_30346531_G_A 727 G>R No 1000Genomes
ENSVATH05180646 732 Y>F No 1000Genomes
ENSVATH14497219 748 A>V No 1000Genomes
ENSVATH13846288 750 A>E No 1000Genomes
ENSVATH13846287 750 A>T No 1000Genomes
ENSVATH05180650 751 V>F No 1000Genomes
ENSVATH13846289 755 V>I No 1000Genomes
ENSVATH13846290 756 A>T No 1000Genomes
tmp_1_30346736_T_G 761 F>V No 1000Genomes
ENSVATH13846291 764 A>T No 1000Genomes
ENSVATH05180651 767 G>E No 1000Genomes
tmp_1_30346754_G_A 767 G>R No 1000Genomes
tmp_1_30346768_T_A 771 D>E No 1000Genomes
ENSVATH14497220 778 P>L No 1000Genomes
tmp_1_30346792_C_A 779 F>L No 1000Genomes
tmp_1_30346797_A_G 781 Y>C No 1000Genomes
tmp_1_30346799_C_G 782 P>A No 1000Genomes
tmp_1_30346800_C_G 782 P>R No 1000Genomes
ENSVATH13846292 783 E>K No 1000Genomes
ENSVATH00800464 788 K>N No 1000Genomes

No associated diseases with O49139

7 regional properties for O49139

Type Name Position InterPro Accession
domain Chromo/chromo shadow domain 338 - 397 IPR000953
domain Bromo adjacent homology (BAH) domain 79 - 199 IPR001025
domain Chromo domain subgroup 336 - 344 IPR017984-1
domain Chromo domain subgroup 355 - 369 IPR017984-2
domain Chromo domain subgroup 370 - 382 IPR017984-3
conserved_site Chromo domain, conserved site 362 - 382 IPR023779
domain Chromo domain 355 - 392 IPR023780

Functions

Description
EC Number 2.1.1.37 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

2 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
DNA-mediated transformation The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q24K09 DNMT1 DNA (cytosine-5)-methyltransferase 1 Bos taurus (Bovine) SS
Q92072 DNMT1 DNA Gallus gallus (Chicken) SS
P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 Homo sapiens (Human) EV
P13864 Dnmt1 DNA (cytosine-5)-methyltransferase 1 Mus musculus (Mouse) EV
Q9Z330 Dnmt1 DNA (cytosine-5)-methyltransferase 1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MAARNKQKKR AEPESDLCFA GKPMSVVEST IRWPHRYQSK KTKLQAPTKK PANKGGKKED
70 80 90 100 110 120
EEIIKQAKCH FDKALVDGVL INLNDDVYVT GLPGKLKFIA KVIELFEADD GVPYCRFRWY
130 140 150 160 170 180
YRPEDTLIER FSHLVQPKRV FLSNDENDNP LTCIWSKVNI AKVPLPKITS RIEQRVIPPC
190 200 210 220 230 240
DYYYDMKYEV PYLNFTSADD GSDASSSLSS DSALNCFENL HKDEKFLLDL YSGCGAMSTG
250 260 270 280 290 300
FCMGASISGV KLITKWSVDI NKFACDSLKL NHPETEVRNE AAEDFLALLK EWKRLCEKFS
310 320 330 340 350 360
LVSSTEPVES ISELEDEEVE ENDDIDEAST GAELEPGEFE VEKFLGIMFG DPQGTGEKTL
370 380 390 400 410 420
QLMVRWKGYN SSYDTWEPYS GLGNCKEKLK EYVIDGFKSH LLPLPGTVYT VCGGPPCQGI
430 440 450 460 470 480
SGYNRYRNNE APLEDQKNQQ LLVFLDIIDF LKPNYVLMEN VVDLLRFSKG FLARHAVASF
490 500 510 520 530 540
VAMNYQTRLG MMAAGSYGLP QLRNRVFLWA AQPSEKLPPY PLPTHEVAKK FNTPKEFKDL
550 560 570 580 590 600
QVGRIQMEFL KLDNALTLAD AISDLPPVTN YVANDVMDYN DAAPKTEFEN FISLKRSETL
610 620 630 640 650 660
LPAFGGDPTR RLFDHQPLVL GDDDLERVSY IPKQKGANYR DMPGVLVHNN KAEINPRFRA
670 680 690 700 710 720
KLKSGKNVVP AYAISFIKGK SKKPFGRLWG DEIVNTVVTR AEPHNQCVIH PMQNRVLSVR
730 740 750 760 770 780
ENARLQGFPD CYKLCGTIKE KYIQVGNAVA VPVGVALGYA FGMASQGLTD DEPVIKLPFK
790
YPECMQAKDQ I