O48538
PR
Gene name |
RBOHF (RBOHAP108, At1g64060, F22C12.18) |
Protein name |
Respiratory burst oxidase homolog protein F |
Names |
Cytochrome b245 beta chain homolog RbohAp108, NADPH oxidase RBOHF, AtRBOHF |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G64060 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O48538
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O48538-F1 | Predicted | AlphaFoldDB |
52 variants for O48538
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14405305 | 25 | G>E | No | 1000Genomes | |
| ENSVATH14405306 | 36 | S>F | No | 1000Genomes | |
| ENSVATH05053379 | 65 | T>N | No | 1000Genomes | |
| ENSVATH14405307 | 67 | I>T | No | 1000Genomes | |
| ENSVATH01457442 | 70 | I>M | No | 1000Genomes | |
| tmp_1_23770485_T_C,G | 74 | S>A | No | 1000Genomes | |
| tmp_1_23770485_T_C,G | 74 | S>P | No | 1000Genomes | |
| tmp_1_23770488_G_A | 75 | D>N | No | 1000Genomes | |
| ENSVATH13717036 | 77 | N>T | No | 1000Genomes | |
| ENSVATH13717041 | 140 | T>P | No | 1000Genomes | |
| ENSVATH07675365 | 141 | A>P | No | 1000Genomes | |
| tmp_1_23770697_A_T | 144 | Q>H | No | 1000Genomes | |
| tmp_1_23770701_G_A | 146 | G>S | No | 1000Genomes | |
| tmp_1_23770710_G_A | 149 | G>S | No | 1000Genomes | |
| ENSVATH13717042 | 150 | G>S | No | 1000Genomes | |
| ENSVATH13717043 | 166 | R>L | No | 1000Genomes | |
| tmp_1_23770803_C_T | 180 | L>F | No | 1000Genomes | |
| ENSVATH13717044 | 206 | F>I | No | 1000Genomes | |
| tmp_1_23770899_A_C | 212 | I>L | No | 1000Genomes | |
| tmp_1_23770909_C_A | 215 | S>Y | No | 1000Genomes | |
| ENSVATH13717050 | 224 | K>N | No | 1000Genomes | |
| ENSVATH14405313 | 244 | K>R | No | 1000Genomes | |
| ENSVATH14405313 | 244 | K>T | No | 1000Genomes | |
| ENSVATH05053390 | 248 | I>V | No | 1000Genomes | |
| ENSVATH00118869 | 251 | D>E | No | 1000Genomes | |
| tmp_1_23771172_G_C | 274 | D>H | No | 1000Genomes | |
| ENSVATH13717062 | 287 | E>G | No | 1000Genomes | |
| ENSVATH13717104 | 367 | K>T | No | 1000Genomes | |
| tmp_1_23772842_T_A | 371 | H>Q | No | 1000Genomes | |
| ENSVATH05053426 | 375 | S>L | No | 1000Genomes | |
| tmp_1_23772915_A_G | 396 | M>V | No | 1000Genomes | |
| tmp_1_23772919_T_G | 397 | I>S | No | 1000Genomes | |
| tmp_1_23773056_G_C | 443 | V>L | No | 1000Genomes | |
| ENSVATH13717105 | 455 | R>I | No | 1000Genomes | |
| ENSVATH01457499 | 459 | F>L | No | 1000Genomes | |
| tmp_1_23774211_C_T | 525 | P>S | No | 1000Genomes | |
| ENSVATH00118881 | 538 | I>M | No | 1000Genomes | |
| tmp_1_23774304_C_T | 556 | P>S | No | 1000Genomes | |
|
ENSVATH05053465 tmp_1_23774400_T_C |
588 | F>L | No | 1000Genomes | |
| ENSVATH14405358 | 602 | M>I | No | 1000Genomes | |
| tmp_1_23775192_G_T | 744 | R>M | No | 1000Genomes | |
| tmp_1_23775196_A_C | 745 | K>N | No | 1000Genomes | |
| tmp_1_23775245_A_G | 762 | I>V | No | 1000Genomes | |
| ENSVATH00118896 | 791 | Y>H | No | 1000Genomes | |
| tmp_1_23775434_C_A | 795 | S>R | No | 1000Genomes | |
| tmp_1_23775438_G_T | 797 | G>C | No | 1000Genomes | |
| ENSVATH01457561 | 798 | D>N | No | 1000Genomes | |
| tmp_1_23775448_C_T | 800 | P>L | No | 1000Genomes | |
| tmp_1_23775457_A_G | 803 | K>R | No | 1000Genomes | |
| ENSVATH05053490 | 829 | V>I | No | 1000Genomes | |
| tmp_1_23775552_G_A | 835 | E>K | No | 1000Genomes | |
| tmp_1_23776232_T_C | 917 | V>A | No | 1000Genomes |
No associated diseases with O48538
5 regional properties for O48538
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PAS domain | 220 - 324 | IPR000014 |
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 480 - 820 | IPR002073 |
| domain | HD/PDEase domain | 553 - 749 | IPR003607 |
| domain | PAS fold | 219 - 324 | IPR013767 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 596 - 607 | IPR023174 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| ferric-chelate reductase activity | Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. |
| NAD(P)H oxidase H2O2-forming activity | Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. |
| peroxidase activity | Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| abscisic acid-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription. |
| carbohydrate homeostasis | A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. |
| defense response by callose deposition | Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. |
| ethylene-activated signaling pathway | The series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription. |
| hydrogen peroxide biosynthetic process | The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. |
| negative regulation of programmed cell death | Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. |
| osmosensory signaling pathway | The series of molecular signals initiated in response to osmotic change. |
| regulation of stomatal movement | Any process that modulates the frequency, rate or extent of stomatal movement. |
| respiratory burst involved in defense response | A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. |
| response to ethylene | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96PH1 | NOX5 | NADPH oxidase 5 | Homo sapiens (Human) | EV |
| Q948T9 | RBOHB | Respiratory burst oxidase homolog protein B | Solanum tuberosum (Potato) | PR |
| Q948U0 | RBOHA | Respiratory burst oxidase homolog protein A | Solanum tuberosum (Potato) | PR |
| Q5ZAJ0 | RBOHB | Respiratory burst oxidase homolog protein B | Oryza sativa subsp japonica (Rice) | PR |
| P92949 | CDC5 | Ferric reduction oxidase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W110 | FRO4 | Ferric reduction oxidase 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIJ0 | RBOHD | Respiratory burst oxidase homolog protein D | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJD6 | RBOHH | Putative respiratory burst oxidase homolog protein H | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUT8 | RBOHI | Probable respiratory burst oxidase homolog protein I | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4I4K7 | FRO3 | Ferric reduction oxidase 3, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81211 | RBOHE | Respiratory burst oxidase homolog protein E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPFSKNDRR | RWSFDSVSAG | KTAVGSASTS | PGTEYSINGD | QEFVEVTIDL | QDDDTIVLRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VEPATAINVI | GDISDDNTGI | MTPVSISRSP | TMKRTSSNRF | RQFSQELKAE | AVAKAKQLSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELKRFSWSRS | FSGNLTTTST | AANQSGGAGG | GLVNSALEAR | ALRKQRAQLD | RTRSSAQRAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGLRFISNKQ | KNVDGWNDVQ | SNFEKFEKNG | YIYRSDFAQC | IGMKDSKEFA | LELFDALSRR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RRLKVEKINH | DELYEYWSQI | NDESFDSRLQ | IFFDIVDKNE | DGRITEEEVK | EIIMLSASAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLSRLKEQAE | EYAALIMEEL | DPERLGYIEL | WQLETLLLQK | DTYLNYSQAL | SYTSQALSQN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQGLRGKSRI | HRMSSDFVYI | MQENWKRIWV | LSLWIMIMIG | LFLWKFFQYK | QKDAFHVMGY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CLLTAKGAAE | TLKFNMALIL | FPVCRNTITW | LRSTRLSYFV | PFDDNINFHK | TIAGAIVVAV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ILHIGDHLAC | DFPRIVRATE | YDYNRYLFHY | FQTKQPTYFD | LVKGPEGITG | ILMVILMIIS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FTLATRWFRR | NLVKLPKPFD | RLTGFNAFWY | SHHLFVIVYI | LLILHGIFLY | FAKPWYVRTT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WMYLAVPVLL | YGGERTLRYF | RSGSYSVRLL | KVAIYPGNVL | TLQMSKPTQF | RYKSGQYMFV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QCPAVSPFEW | HPFSITSAPE | DDYISIHIRQ | LGDWTQELKR | VFSEVCEPPV | GGKSGLLRAD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ETTKKSLPKL | LIDGPYGAPA | QDYRKYDVLL | LVGLGIGATP | FISILKDLLN | NIVKMEEHAD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SISDFSRSSE | YSTGSNGDTP | RRKRILKTTN | AYFYWVTREQ | GSFDWFKGVM | NEVAELDQRG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VIEMHNYLTS | VYEEGDARSA | LITMVQALNH | AKNGVDIVSG | TRVRTHFARP | NWKKVLTKLS |
| 910 | 920 | 930 | 940 | ||
| SKHCNARIGV | FYCGVPVLGK | ELSKLCNTFN | QKGSTKFEFH | KEHF |