O46471
Gene name |
RGS16 |
Protein name |
Regulator of G-protein signaling 16 |
Names |
RGS16, Retinal-specific RGS, RGS-r, Retinally abundant regulator of G-protein signaling |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282035 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O46471
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O46471-F1 | Predicted | AlphaFoldDB |
51 variants for O46471
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs439752614 | 7 | A>G | No | EVA | |
| rs457457808 | 12 | C>S | No | EVA | |
| rs435879579 | 13 | L>Q | No | EVA | |
| rs468003013 | 15 | R>T | No | EVA | |
| rs463697391 | 27 | L>R | No | EVA | |
| rs442127591 | 28 | H>R | No | EVA | |
| rs1116007210 | 35 | D>N | No | EVA | |
| rs722989384 | 52 | G>A | No | EVA | |
| rs471553720 | 76 | V>G | No | EVA | |
| rs438520584 | 76 | V>L | No | EVA | |
| rs462630855 | 78 | A>S | No | EVA | |
| rs444291450 | 79 | F>C | No | EVA | |
| rs473866487 | 82 | F>L | No | EVA | |
| rs472665378 | 96 | L>R | No | EVA | |
| rs436326892 | 96 | L>V | No | EVA | |
| rs454118982 | 102 | K>E | No | EVA | |
| rs432503993 | 112 | S>P | No | EVA | |
| rs442251267 | 118 | F>L | No | EVA | |
| rs465511257 | 121 | F>L | No | EVA | |
| rs482157965 | 131 | N>T | No | EVA | |
| rs463662419 | 136 | T>N | No | EVA | |
| rs450874157 | 138 | E>Q | No | EVA | |
| rs480638625 | 146 | A>S | No | EVA | |
| rs137380157 | 148 | T>P | No | EVA | |
| rs462221745 | 149 | A>D | No | EVA | |
| rs440531053 | 154 | A>S | No | EVA | |
| rs458313316 | 159 | V>G | No | EVA | |
| rs439769594 | 163 | M>K | No | EVA | |
| rs439769594 | 163 | M>R | No | EVA | |
| rs475863027 | 166 | D>A | No | EVA | |
| rs457496547 | 168 | Y>S | No | EVA | |
| rs435119765 | 170 | R>P | No | EVA | |
| rs474643303 | 171 | F>S | No | EVA | |
| rs452957382 | 172 | L>R | No | EVA | |
| rs434525524 | 174 | S>P | No | EVA | |
| rs445822883 | 177 | Y>C | No | EVA | |
| rs445822883 | 177 | Y>S | No | EVA | |
| rs436995167 | 178 | R>P | No | EVA | |
| rs470049472 | 179 | D>A | No | EVA | |
| rs448407651 | 179 | D>E | No | EVA | |
| rs470049472 | 179 | D>G | No | EVA | |
| rs480600087 | 180 | L>P | No | EVA | |
| rs480600087 | 180 | L>R | No | EVA | |
| rs462150930 | 181 | A>T | No | EVA | |
| rs446927765 | 182 | T>P | No | EVA | |
| rs458245485 | 183 | Q>* | No | EVA | |
| rs458245485 | 183 | Q>K | No | EVA | |
| rs439732670 | 185 | T>K | No | EVA | |
| rs721728256 | 190 | S>T | No | EVA | |
| rs475826027 | 195 | S>R | No | EVA | |
| rs463873655 | 199 | P>A | No | EVA |
No associated diseases with O46471
1 regional properties for O46471
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RGS domain | 62 - 181 | IPR016137 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| intrinsic component of membrane | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T0T8 | RGS5 | Regulator of G-protein signaling 5 | Bos taurus (Bovine) | PR |
| P49802 | RGS7 | Regulator of G-protein signaling 7 | Homo sapiens (Human) | PR |
| O15539 | RGS5 | Regulator of G-protein signaling 5 | Homo sapiens (Human) | PR |
| Q9Z2H1 | Rgs11 | Regulator of G-protein signaling 11 | Mus musculus (Mouse) | PR |
| O54829 | Rgs7 | Regulator of G-protein signaling 7 | Mus musculus (Mouse) | PR |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| Q18312 | rgs-3 | Regulator of G-protein signaling rgs-3 | Caenorhabditis elegans | PR |
| Q8H1F2 | RGS1 | Regulator of G-protein signaling 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCRTLAAFPT | SCLERAKEFK | TRLGIFLHKS | ELGSDTGSVG | KFEWGSKHSK | EGKNFSEDVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GWKESFDLLL | SSKNGVAAFH | AFLKTEFSEE | NLEFWLACEE | FKKLRSATKL | GSRAHRIFEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FICSEAPKEV | NIDHETRELT | RTNLQAATAV | CFDAAQWKVR | ALMEKDSYPR | FLKSPAYRDL |
| 190 | 200 | ||||
| ATQATAASAS | PSSSSPAEPL | HT |