O45460

PR
Gene name
nhr-54 (F36D3.2)
Protein name
Nuclear hormone receptor family member nhr-54
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F36D3.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

61-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O45460

Entry ID Method Resolution Chain Position Source
AF-O45460-F1 Predicted AlphaFoldDB

No variants for O45460

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O45460

No associated diseases with O45460

3 regional properties for O45460

Type Name Position InterPro Accession
domain Protein kinase domain 9 - 287 IPR000719
active_site Serine/threonine-protein kinase, active site 124 - 136 IPR008271
binding_site Protein kinase, ATP binding site 15 - 38 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TTR7 NR2F2 COUP transcription factor 2 Bos taurus (Bovine) PR
O18971 PPARG Peroxisome proliferator-activated receptor gamma Bos taurus (Bovine) PR
Q90733 NR2F2 COUP transcription factor 2 Gallus gallus (Chicken) PR
P68306 THRB Thyroid hormone receptor beta Gallus gallus (Chicken) PR
A7X8B3 PGR Progesterone receptor Pan troglodytes (Chimpanzee) SS
P37231 PPARG Peroxisome proliferator-activated receptor gamma Homo sapiens (Human) PR
P10588 NR2F6 Nuclear receptor subfamily 2 group F member 6 Homo sapiens (Human) PR
P06401 PGR Progesterone receptor Homo sapiens (Human) EV
P10589 NR2F1 COUP transcription factor 1 Homo sapiens (Human) PR
O75469 NR1I2 Nuclear receptor subfamily 1 group I member 2 Homo sapiens (Human) PR
P24468 NR2F2 COUP transcription factor 2 Homo sapiens (Human) PR
P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 Homo sapiens (Human) PR
P35396 Ppard Peroxisome proliferator-activated receptor delta Mus musculus (Mouse) PR
P43136 Nr2f6 Nuclear receptor subfamily 2 group F member 6 Mus musculus (Mouse) PR
P43135 Nr2f2 COUP transcription factor 2 Mus musculus (Mouse) PR
Q00175 Pgr Progesterone receptor Mus musculus (Mouse) SS
Q9Z0Y9 Nr1h3 Oxysterols receptor LXR-alpha Mus musculus (Mouse) PR
O62807 PPARG Peroxisome proliferator-activated receptor gamma Sus scrofa (Pig) PR
O09018 Nr2f2 COUP transcription factor 2 Rattus norvegicus (Rat) PR
Q63449 Pgr Progesterone receptor Rattus norvegicus (Rat) SS
Q8SQ01 NR1I2 Nuclear receptor subfamily 1 group I member 2 Macaca mulatta (Rhesus macaque) PR
G5EFF5 daf-12 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans PR
Q20765 nhr-7 Nuclear hormone receptor family member nhr-7 Caenorhabditis elegans PR
Q21006 nhr-34 Nuclear hormone receptor family member nhr-34 Caenorhabditis elegans PR
O17928 nhr-52 Nuclear hormone receptor family member nhr-52 Caenorhabditis elegans PR
Q21878 nhr-1 Nuclear hormone receptor family member nhr-1 Caenorhabditis elegans PR
O18141 nhr-79 Nuclear hormone receptor family member nhr-79 Caenorhabditis elegans PR
O17025 nhr-90 Nuclear hormone receptor family member nhr-90 Caenorhabditis elegans PR
Q9TXJ1 nhr-59 Nuclear hormone receptor family member nhr-59 Caenorhabditis elegans PR
O16662 nhr-115 Nuclear hormone receptor family member nhr-115 Caenorhabditis elegans PR
Q95X91 nhr-96 Nuclear hormone receptor family member nhr-96 Caenorhabditis elegans PR
O16962 nhr-55 Nuclear hormone receptor family member nhr-55 Caenorhabditis elegans PR
O18048 nhr-213 Nuclear hormone receptor family member nhr-213 Caenorhabditis elegans PR
Q966I0 nhr-98 Nuclear hormone receptor family member nhr-98 Caenorhabditis elegans PR
Q6PH18 nr2f1b Nuclear receptor subfamily 2 group F member 1-B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEIPSTSSEM TYFSVKCAIC YKAGHGQHFG VETCRACAAF FRRTVVLNRK YKCTRKSGKC
70 80 90 100 110 120
KIGSDETKDV MCKFCRFKKC IDLGMTTENV RTDQVINLNV EPSTSQSLVR LEMTSLQPET
130 140 150 160 170 180
DDSNRVQYQI IHPRTRGPAI LIDVNAIIKR SKTILETHFF PDDDVIVELN PLEKMTFCLR
190 200 210 220 230 240
KLRSKQSWNP NFFTKINFLD LFEFWESQME DTATWLMYSG EFRKLPNHEK IAIFKIVWAV
250 260 270 280 290 300
WRRLERYTMT AQVFGQKCYD EQILLHSHQD AARFTDYDVD YSYITDQGFE KINGLFGGKM
310 320 330 340 350 360
IQYFDIIVKP YLELELSDTE IAYILCQIVW NYAGRRLQGQ TQAAGERFLE VISNNLHKYY
370 380 390 400 410 420
EDKSGNRKRA EDKQNYVARL AKMMQIVNQM LNAQLKMENT MDVAMLFNTF NIVFTEPEFF
RV