AiPD: Autoinhibited Protein Database

O43633

Gene name	CHMP2A (BC2, CHMP2)
Protein name	Charged multivesicular body protein 2a
Names	Chromatin-modifying protein 2a, CHMP2a, Putative breast adenocarcinoma marker BC-2, Vacuolar protein sorting-associated protein 2-1, Vps2-1, hVps2-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27243
EC number
Protein Class	CHARGED MULTIVESICULAR BODY PROTEIN (PTHR10476)

Descriptions

CHMP2A is a core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. Removing 42 amino acids from the C-terminal of the protein unmasks a common ability to associate with endosomal membranes and assemble into large polymeric complexes, and the C-terminal sequences are also important for interaction of ESCRT-III protein with VPS4. Thus, ESCRT-III proteins cycle between a closed state and an activated open state is under control of sequences at the C-terminus and associated factors.

Autoinhibitory domains (AIDs)

Target domain	1-144 (N-terminal α1-α4 domains)
Relief mechanism	Partner binding
Assay	Deletion assay

AID

181-222 (C-terminal α6 domain)

Target domain

1-144 (N-terminal α1-α4 domains)

Relief mechanism

Partner binding (Binding of Vps4 to C-terminal α6 domain)

Assay

Deletion assay

Accessory elements

No accessory elements

References

Shim S et al. (2007) "Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain", Traffic (Copenhagen, Denmark), 8, 1068-79

Autoinhibited structure

Activated structure

3 structures for O43633

Entry ID	Method	Resolution	Chain	Position	Source
7ZCG	EM	330 A	B	8-154	PDB
7ZCH	EM	360 A	B	8-154	PDB
AF-O43633-F1	Predicted				AlphaFoldDB

185 variants for O43633

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1255752892 CA407935987	3	L>Q		No	ClinGen TOPMed
CA310614461 rs981971580	4	L>W		No	ClinGen Ensembl
CA9719877 rs758966430	5	F>L		No	ClinGen ExAC TOPMed gnomAD
CA407935899 rs1166533738	6	G>R		No	ClinGen gnomAD
CA407935880 rs1568668219	7	R>C		No	ClinGen Ensembl
rs949340234 CA310614459	8	R>P		No	ClinGen TOPMed
CA310614456 rs1044565	13	E>G		No	ClinGen Ensembl
CA407935656 rs1239326026	13	E>K		No	ClinGen gnomAD
rs773101288 CA9719873	15	L>Q		No	ClinGen ExAC gnomAD
rs1568668148 CA407935548	17	Q>L		No	ClinGen Ensembl
rs1600089259 CA407935512	18	N>S		No	ClinGen Ensembl
CA407935476 rs1222634863	19	Q>R		No	ClinGen gnomAD
CA407935418 rs1284040289	21	A>T		No	ClinGen gnomAD
CA310614449 rs1023876786	26	M>T		No	ClinGen Ensembl
rs866674822 CA310614448	27	R>Q		No	ClinGen TOPMed gnomAD
rs775433926 CA9719870	28	E>D		No	ClinGen ExAC gnomAD
CA407935115 rs1218523927	30	D>N		No	ClinGen gnomAD
CA407935101 rs1365279794	30	D>V		No	ClinGen gnomAD
rs748088651 CA310614445	31	R>C		No	ClinGen ExAC gnomAD
CA9719869 rs748088651	31	R>G		No	ClinGen ExAC gnomAD
rs1436829673 CA407935074	31	R>H		No	ClinGen TOPMed gnomAD
CA9719868 rs745916847	34	Q>H		No	ClinGen ExAC gnomAD
CA310614442 rs893544316	37	E>Q		No	ClinGen TOPMed
rs757434481 CA9719865	38	T>A		No	ClinGen ExAC gnomAD
CA407934793 rs1176041886	39	Q>*		No	ClinGen gnomAD
rs1338551455 CA407934758	40	E>K		No	ClinGen TOPMed
CA310614438 rs776623849	40	E>V		No	ClinGen Ensembl
CA407934564 rs1192124915	42	K>T		No	ClinGen gnomAD
CA310614434 rs1055130374	44	I>T		No	ClinGen TOPMed
CA9719862 rs778055563	44	I>V		No	ClinGen ExAC gnomAD
CA9719859 rs779276855	47	I>N		No	ClinGen ExAC
rs753315789 CA9719860	47	I>V		No	ClinGen ExAC gnomAD
rs548744646 CA9719857	52	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA310614430 rs937989967	52	K>R		No	ClinGen TOPMed
CA9719855 rs766161099	54	G>S		No	ClinGen ExAC gnomAD
rs1339557310 CA407933939	56	M>I		No	ClinGen gnomAD
CA407933981 rs1223901907	56	M>V		No	ClinGen gnomAD
CA407932255 rs1457256423	57	D>H		No	ClinGen gnomAD
CA9719827 rs760731461	59	V>I		No	ClinGen ExAC gnomAD
rs773474943 CA310613542	60	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773474943 CA9719826	60	R>G		No	ClinGen ExAC TOPMed gnomAD
rs772152550 CA9719825 COSM1743009	60	R>H	biliary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs773474943 CA310613544	60	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1045368903 CA310613539	62	M>I		No	ClinGen Ensembl
rs1242100512 CA407932093	64	K>E		No	ClinGen gnomAD
rs779096961 CA9719822	66	L>F		No	ClinGen ExAC gnomAD
rs748574916 CA9719823	66	L>S		No	ClinGen ExAC gnomAD
rs1216396709 CA407931996	67	V>A		No	ClinGen TOPMed
CA9719821 COSM1681475 rs769219232	68	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC
COSM714031 rs749741448 CA9719820	68	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9719819 rs369929153	69	T>N		No	ClinGen ESP ExAC gnomAD
rs755740005 CA9719818	70	R>Q		No	ClinGen ExAC gnomAD
rs1466949169 CA407931959	70	R>W		No	ClinGen TOPMed
rs781025283 CA9719816	71	R>H		No	ClinGen ExAC TOPMed gnomAD
rs376979258 CA9719814 COSM274538	74	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA9719813 COSM1641264 rs763733145	74	R>H	stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs763733145 CA407931838	74	R>L		No	ClinGen ExAC gnomAD
CA9719811 rs758208886	75	K>R		No	ClinGen ExAC gnomAD
CA310613529 rs950335550	77	V>E		No	ClinGen Ensembl
rs916170048 CA310613528	78	L>S		No	ClinGen Ensembl
CA407931705 rs146786448	80	R>G		No	ClinGen ESP gnomAD
rs765137954 CA9719809	80	R>Q		No	ClinGen ExAC gnomAD
rs146786448 CA310613526	80	R>W		No	ClinGen ESP gnomAD
CA407931567 rs1419062527	84	Q>R		No	ClinGen TOPMed
CA310613524 rs529552077	86	V>M		No	ClinGen Ensembl
rs773233623 CA9719807	87	S>F		No	ClinGen ExAC gnomAD
CA310613522 rs753745398	87	S>P		No	ClinGen Ensembl
rs774782757 CA9719805	89	K>M		No	ClinGen ExAC TOPMed gnomAD
CA9719804 rs774782757	89	K>R		No	ClinGen ExAC TOPMed gnomAD
CA9719802 rs143635425	91	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1325589161 CA407931291	92	T>A		No	ClinGen TOPMed
CA407931239 rs1568666405	93	L>I		No	ClinGen Ensembl
rs1321987514 CA407931215	94	K>E		No	ClinGen gnomAD
rs1388799491 CA407931163	95	S>F		No	ClinGen gnomAD
CA407931084 rs1297745371	97	N>S		No	ClinGen gnomAD
rs1438168135 CA407931063	98	S>A		No	ClinGen TOPMed
CA9719801 rs776185223	98	S>L		No	ClinGen ExAC gnomAD
CA407931026 rs745397145	99	M>R		No	ClinGen ExAC gnomAD
CA9719799 rs745397145	99	M>T		No	ClinGen ExAC gnomAD
CA407931002 rs1470453514	100	A>T		No	ClinGen gnomAD
rs780514546 CA9719798	101	Q>K		No	ClinGen ExAC gnomAD
CA9719797 rs756942841	105	G>S		No	ClinGen ExAC gnomAD
rs1434621947 CA407930770	105	G>V		No	ClinGen gnomAD
rs746707272 CA9719796	111	G>D		No	ClinGen ExAC gnomAD
rs1228975817 CA407930512	111	G>S		No	ClinGen TOPMed
CA310613512 rs957576851	112	T>I		No	ClinGen Ensembl
CA407930378 rs1206311342	113	M>I		No	ClinGen TOPMed gnomAD
rs1206311342 CA407930375	113	M>I		No	ClinGen TOPMed gnomAD
CA407930386 rs1287504375	113	M>T		No	ClinGen gnomAD
rs1262462964 CA407930353	114	N>D		No	ClinGen gnomAD
rs1235222910 CA407929967	121	Q>H		No	ClinGen TOPMed gnomAD
rs1271180892 CA407929944	122	I>M		No	ClinGen TOPMed
CA9719772 rs754914078	124	K>R		No	ClinGen ExAC gnomAD
CA407929764 rs1320400002	126	M>I		No	ClinGen gnomAD
CA407929790 rs1197159892	126	M>R		No	ClinGen TOPMed gnomAD
CA407929750 rs1274002003	127	M>T		No	ClinGen gnomAD
CA407929687 rs1254068409	128	E>D		No	ClinGen TOPMed
CA9719770 rs753785301 COSM1236597	131	R>Q	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs960083867 CA310613486	131	R>W		No	ClinGen TOPMed gnomAD
rs1383450597 CA407929497	134	E>K		No	ClinGen gnomAD
rs1238456522 CA407929438	135	I>V		No	ClinGen TOPMed
rs757326974 CA9719768	136	M>I		No	ClinGen ExAC gnomAD
CA310613482 rs980225414	136	M>K		No	ClinGen TOPMed gnomAD
CA407929375 rs980225414	136	M>T		No	ClinGen TOPMed gnomAD
CA9719767 rs751625630	137	D>H		No	ClinGen ExAC TOPMed gnomAD
CA407929321 rs751625630	137	D>N		No	ClinGen ExAC TOPMed gnomAD
CA310613479 rs970335404	138	M>I		No	ClinGen TOPMed
CA407929266 rs1404363876	138	M>T		No	ClinGen gnomAD
CA407929270 rs1418369334	138	M>V		No	ClinGen TOPMed
rs1411082318 CA407929227	139	K>E		No	ClinGen TOPMed gnomAD
rs1027639495 CA310613478	139	K>T		No	ClinGen TOPMed
rs1600086997 CA407929201	140	E>K		No	ClinGen Ensembl
rs1380258678 CA407929101	141	E>A		No	ClinGen gnomAD
CA9719763 rs753120384	142	M>I		No	ClinGen ExAC gnomAD
CA9719761 rs759965981	143	M>I		No	ClinGen ExAC gnomAD
rs1422972057 CA407928960	143	M>K		No	ClinGen gnomAD
rs765768118 CA9719762	143	M>V		No	ClinGen ExAC TOPMed gnomAD
CA9719760 rs777054240	145	D>Y		No	ClinGen ExAC
CA407928801 rs1246804598	146	A>T		No	ClinGen gnomAD
CA9719758 rs760136138	147	I>T		No	ClinGen ExAC gnomAD
CA310613470 rs369433950	149	D>A		No	ClinGen ESP gnomAD
rs1341808043 CA407928508	152	G>D		No	ClinGen TOPMed
CA407928516 rs1435388230	152	G>S		No	ClinGen gnomAD
rs1028258425 CA310613467	153	D>N		No	ClinGen TOPMed gnomAD
rs1600086915 CA407928347	156	D>E		No	ClinGen Ensembl
rs749084452 CA9719752	156	D>H		No	ClinGen ExAC gnomAD
rs749084452 CA9719751	156	D>N		No	ClinGen ExAC gnomAD
rs375168365 CA9719749	158	E>D		No	ClinGen ESP ExAC TOPMed
COSM3797649 rs1440468684 CA407928294	158	E>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs751607738 CA407928248	159	E>*		No	ClinGen ExAC TOPMed gnomAD
CA9719748 rs751607738	159	E>K		No	ClinGen ExAC TOPMed gnomAD
CA407928228 rs1409245486	159	E>V		No	ClinGen gnomAD
rs1241885185 CA407928188	160	S>T		No	ClinGen TOPMed
CA9719719 rs755182193	162	A>T		No	ClinGen ExAC TOPMed gnomAD
rs146139219 CA9719718	164	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs187800344 CA310613432	165	S>A		No	ClinGen 1000Genomes gnomAD
CA407927837 rs1237576842	165	S>F		No	ClinGen TOPMed
CA310613431 rs936234835	166	Q>H		No	ClinGen TOPMed gnomAD
CA310613428 rs201891984	170	E>G		No	ClinGen TOPMed gnomAD
rs1255518400 CA407927578	172	G>V		No	ClinGen gnomAD
CA407927542 rs1181275546	173	L>R		No	ClinGen gnomAD
rs773810226 CA9719712	174	S>N		No	ClinGen ExAC TOPMed gnomAD
CA9719713 rs773810226	174	S>T		No	ClinGen ExAC TOPMed gnomAD
CA9719710 rs762601677	175	L>I		No	ClinGen ExAC gnomAD
rs775002155 CA9719709	177	D>N		No	ClinGen ExAC gnomAD
rs745628642 CA9719708	178	E>D		No	ClinGen ExAC gnomAD
CA407927391 rs1229134555	178	E>K		No	ClinGen gnomAD
CA310613420 rs977579289	179	L>V		No	ClinGen Ensembl
CA9719706 rs144804005 COSM1002788	180	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs778121638 CA310613388	182	L>I		No	ClinGen ExAC gnomAD
rs778121638 CA9719675	182	L>V		No	ClinGen ExAC gnomAD
rs891673180 CA310613385	185	T>I		No	ClinGen TOPMed gnomAD
rs1396990938 CA407926956	185	T>P		No	ClinGen TOPMed
CA9719673 rs752113260	187	G>D		No	ClinGen ExAC TOPMed gnomAD
rs149478183 CA9719674	187	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs541443283 CA9719671	188	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760530137 CA9719668	189	L>F		No	ClinGen ExAC gnomAD
CA9719667 rs773247293	190	S>G		No	ClinGen ExAC gnomAD
rs1255363145 CA407926616	192	A>T		No	ClinGen TOPMed
CA407926581 rs1454141226	193	A>G		No	ClinGen gnomAD
rs556423277 CA9719666	193	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA310613379 rs938655319	194	G>R		No	ClinGen TOPMed gnomAD
rs938655319 CA407926576	194	G>S		No	ClinGen TOPMed gnomAD
CA9719665 rs183266343	195	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA310613377 rs76948000	196	K>E		No	ClinGen Ensembl
rs1431733496 CA407926425	198	A>T		No	ClinGen TOPMed
CA9719663 rs770015701	199	E>K		No	ClinGen ExAC gnomAD
rs1467001606 CA407926319	200	A>S		No	ClinGen TOPMed
CA9719660 rs138058612	201	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM290638 CA407926231 rs1568665125	202	A>S	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs974233538 CA310613373	203	S>L		No	ClinGen TOPMed
rs200224355 CA9719659	204	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA407926120 rs1277732919	204	A>V		No	ClinGen gnomAD
rs1600086200 CA407926080	205	L>P		No	ClinGen Ensembl
CA9719658 rs553668807	206	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs368139604 CA9719657	207	D>H		No	ClinGen ESP ExAC gnomAD
CA407925927 rs1382682787	208	A>D		No	ClinGen gnomAD
CA407925872 rs1405154683	209	D>V		No	ClinGen TOPMed gnomAD
rs778221913 CA9719655	210	A>T		No	ClinGen ExAC TOPMed gnomAD
CA407925729 rs1429593090	214	E>K		No	ClinGen gnomAD
CA407925579 rs1600086104	218	N>T		No	ClinGen Ensembl
rs756008421 CA9719651	220	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9719652 rs766103995	220	R>W		No	ClinGen ExAC TOPMed gnomAD
rs904782704 CA310613366	222	D>N		No	ClinGen Ensembl
CA9719649 rs767511825	223	D>W		No	ClinGen ExAC

No associated diseases with O43633

No regional properties for O43633

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O43633

Functions

		Description
EC Number
Subcellular Localization	Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side Nucleus envelope	Localizes to the midbody of dividing cells Localized in two distinct rings on either side of the Fleming body Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (PubMed:28242692)
PANTHER Family	PTHR10476	CHARGED MULTIVESICULAR BODY PROTEIN
PANTHER Subfamily	PTHR10476:SF4	CHARGED MULTIVESICULAR BODY PROTEIN 2A
PANTHER Protein Class	membrane traffic protein
PANTHER Pathway Category	No pathway information available

16 GO annotations of cellular component

Name	Definition
amphisome membrane	Any membrane that is part of an amphisome.
autophagosome membrane	The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ESCRT III complex	A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
kinetochore microtubule	Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane coat	Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
multivesicular body	A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
multivesicular body membrane	The lipid bilayer surrounding a multivesicular body.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
phosphatidylcholine binding	Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.
protein domain specific binding	Binding to a specific domain of a protein.

29 GO annotations of biological process

Name	Definition
autophagosome maturation	Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
endosome transport via multivesicular body sorting pathway	The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.
ESCRT III complex disassembly	The disaggregation of an ESCRT III complex into its constituent components.
establishment of protein localization	The directed movement of a protein to a specific location.
exit from mitosis	The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
late endosome to lysosome transport	The directed movement of substances from late endosome to lysosome.
late endosome to vacuole transport	The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
macroautophagy	The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
membrane invagination	The infolding of a membrane.
midbody abscission	The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells.
mitotic metaphase plate congression	The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
multivesicular body assembly	The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
multivesicular body sorting pathway	A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
negative regulation of cell death	Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
negative regulation of centriole elongation	Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation.
nuclear membrane reassembly	The reformation of the nuclear membranes following their breakdown in the context of a normal process.
nucleus organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
plasma membrane repair	The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
positive regulation of exosomal secretion	Any process that activates or increases the frequency, rate or extent of exosomal secretion.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein polymerization	The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of centrosome duplication	Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
regulation of mitotic spindle assembly	Any process that modulates the frequency, rate or extent of mitotic spindle assembly.
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
viral budding from plasma membrane	A viral budding that starts with formation of a membrane curvature in the host plasma membrane.
viral budding via host ESCRT complex	Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.
viral release from host cell	The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZHN1	CHMP2A	Charged multivesicular body protein 2a	Gallus gallus (Chicken)	SS
Q7LBR1	CHMP1B	Charged multivesicular body protein 1b	Homo sapiens (Human)	PR
Q9Y3E7	CHMP3	Charged multivesicular body protein 3	Homo sapiens (Human)	EV
Q9DB34	Chmp2a	Charged multivesicular body protein 2a	Mus musculus (Mouse)	SS
Q9SKI2	VPS2.1	Vacuolar protein sorting-associated protein 2 homolog 1	Arabidopsis thaliana (Mouse-ear cress)	SS
Q6DFS6	chmp2a	Charged multivesicular body protein 2a	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q7ZW25	chmp2a	Charged multivesicular body protein 2a	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MDLLFGRRKT	PEELLRQNQR	ALNRAMRELD	RERQKLETQE	KKIIADIKKM	AKQGQMDAVR
70	80	90	100	110	120
IMAKDLVRTR	RYVRKFVLMR	ANIQAVSLKI	QTLKSNNSMA	QAMKGVTKAM	GTMNRQLKLP
130	140	150	160	170	180
QIQKIMMEFE	RQAEIMDMKE	EMMNDAIDDA	MGDEEDEEES	DAVVSQVLDE	LGLSLTDELS
190	200	210	220
NLPSTGGSLS	VAAGGKKAEA	AASALADADA	DLEERLKNLR	RD